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International Journal of Toxicology最新文献

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Editor's Note. 编者按
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-01-01 Epub Date: 2023-12-06 DOI: 10.1177/10915818231220244
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引用次数: 0
Book Review: Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology 书评:药物处置与药代动力学:医学、毒理学和生物技术的原理与应用
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-23 DOI: 10.1177/10915818231224018
Leanne L. Bedard
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引用次数: 0
American College of Toxicology 美国毒理学学院
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-18 DOI: 10.1177/10915818231220242
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引用次数: 0
The Spontaneous Incidence of Neurological Clinical Signs in Preclinical Species Using Cage-side Observations or High-definition Video Monitoring: A Retrospective Analysis 使用笼边观察或高清视频监控临床前物种神经临床症状的自发发生率:回顾性分析
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-08 DOI: 10.1177/10915818231218984
Chiara Orciani, Cristina Ballesteros, E. Troncy, Clemence Berthome, K. Bujold, Nehla Bennamoune, Samantha Sparapani, M. Pugsley, Dominique Paquette, Emmanuel Boulay, S. Authier
When conducting toxicology studies, the interpretation of drug-related neurological clinical signs such as convulsions, myoclonus/myoclonic jerks, tremors, ataxia, and salivation requires an understanding of the spontaneous incidence of those observations in commonly used laboratory animal species. The spontaneous incidence of central nervous system clinical signs in control animals from a single facility using cage-side observations or high definition video monitoring was retrospectively analyzed. Spontaneous convulsions were observed at low incidence in Beagle dogs and Sprague–Dawley rats but were not identified in cynomolgus monkeys and Göttingen minipigs. Spontaneous myoclonic jerks and muscle twitches were observed at low incidence in Beagle dogs, cynomolgus monkeys, and Sprague–Dawley rats but were not seen in Göttingen minipigs. Spontaneous ataxia/incoordination was identified in all species and generally with a higher incidence when using video monitoring. Salivation and tremors were the two most frequent spontaneous clinical signs and both were observed in all species. Data from the current study unveil potential limitations when using control data obtained from a single study for toxicology interpretation related to low incidence neurological clinical signs while providing historical control data from Beagle dogs, cynomolgus monkeys, Sprague–Dawley rats, and Göttingen minipigs.
在进行毒理学研究时,解释与药物相关的神经学临床症状,如抽搐、肌阵挛/肌阵挛抽搐、震颤、共济失调和流涎,需要了解这些在常用实验动物物种中观察到的自发发生率。采用笼侧观察或高清视频监控,回顾性分析单一设施对照动物中枢神经系统临床症状的自发发生率。在比格犬和Sprague-Dawley大鼠中自发性惊厥发生率低,但在食蟹猴和Göttingen迷你猪中未发现自发性惊厥。自发性肌阵挛性抽搐和肌肉抽搐在Beagle犬、食蟹猴和Sprague-Dawley大鼠中发生率低,但在Göttingen迷你猪中未见。在所有物种中都发现了自发性共济失调/不协调,并且在使用视频监控时通常具有更高的发生率。流涎和震颤是两种最常见的自发临床症状,在所有物种中都观察到这两种症状。当前研究的数据揭示了从单一研究中获得的对照数据在提供Beagle犬、食蟹猴、Sprague-Dawley大鼠和Göttingen迷你猪的历史对照数据的同时,用于与低发病率神经临床症状相关的毒理学解释时的潜在局限性。
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引用次数: 0
Isopropyl Lanolate. Lanolate异丙基。
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-01 Epub Date: 2023-09-25 DOI: 10.1177/10915818231203383
Monice Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Lisa A Peterson, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Bart Heldreth

The Expert Panel for Cosmetic Ingredient Safety reviewed updated information that has become available since their original assessment from 1980, along with updated information regarding product types, and frequency and concentrations of use, and reaffirmed their original conclusion that Isopropyl Lanolate is safe as a cosmetic ingredient in the practices of use and concentration as described in this report.

化妆品成分安全专家小组审查了自1980年最初评估以来获得的最新信息,以及关于产品类型、使用频率和浓度的最新资料,并重申了他们的原始结论,即在本报告所述的使用和浓缩实践中,Lanolate异丙酯作为化妆品成分是安全的。
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引用次数: 0
Polyamino Sugar Condensate. 聚酰胺糖冷凝液。
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-01 Epub Date: 2023-09-27 DOI: 10.1177/10915818231204239
Preethi S Raj, Wilma F Bergfeld, Donald V Belsito, David E Cohen, Curtis D Klaassen, Allan E Rettie, David Ross, Thomas J Slaga, Paul W Snyder, Susan Tilton, Monice Fiume, Bart Heldreth

The Expert Panel for Cosmetic Ingredient Safety reviewed updated information that has become available since their original assessment from 1982, along with updated information regarding product types, and frequency and concentrations of use, and reaffirmed their original conclusion that Polyamino Sugar Condensate is safe for topical application to humans in the practices of use and concentration as described in this report.

化妆品成分安全专家小组审查了自1982年最初评估以来获得的最新信息,以及关于产品类型、使用频率和浓度的最新资料,并重申了他们的原始结论,即在本报告所述的使用和浓缩实践中,多胺糖缩合物对人类局部应用是安全的。
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引用次数: 0
PEG Soy Sterols. PEG大豆甾醇。
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-01 Epub Date: 2023-09-26 DOI: 10.1177/10915818231204279
Priya Cherian, Wilma F Bergfeld, Donald V Belsito, David E Cohen, Curtis D Klaassen, Daniel C Liebler, Allan E Rettie, David Ross, Thomas J Slaga, Paul W Snyder, Susan Tilton, Monice Fiume, Bart Heldreth

The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in year 2000, along with updated information regarding product types and concentrations of use, and confirmed that PEG-5, -10, -16, -25, -30, and -40 Soy Sterol are safe as cosmetic ingredients in the practices of use and concentration as described in this report.

化妆品成分安全专家小组审查了自2000年最初评估以来的最新研究,以及关于产品类型和使用浓度的最新信息,并确认PEG-5、-10、-16、-25、-30和-40大豆甾醇在本报告所述的使用和浓缩实践中作为化妆品成分是安全的。
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引用次数: 0
Sulfites. 亚硫酸盐。
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-01 Epub Date: 2023-10-16 DOI: 10.1177/10915818231204569
Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Curtis D Klaassen, Daniel C Liebler, James G Marks, Lisa A Peterson, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1998, along with updated information regarding product types and concentrations of use, and confirmed that Sodium Sulfite, Potassium Sulfite, Ammonium Sulfite, Sodium Bisulfite, Ammonium Bisulfite, Sodium Metabisulfite, and Potassium Metabisulfite are safe as cosmetic ingredients in the practices of use and concentration as described in this report.

化妆品成分安全专家小组审查了自1998年最初评估以来的新研究,以及有关产品类型和使用浓度的最新信息,并确认亚硫酸氢钠、亚硫酸钾、亚硫酸铵、亚硫酸氢钠,和偏亚硫酸钾在本报告所述的使用和浓缩实践中作为化妆品成分是安全的。
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引用次数: 0
Recent Advances in Drug Discovery Toxicology. 药物发现与毒理学的最新进展。
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-01 Epub Date: 2023-07-15 DOI: 10.1177/10915818231189659
Bowen Tang, Vijay More

Major advances in scientific discovery and insights that stem from the development and use of new techniques and models can bring remarkable progress to conventional toxicology. Although animal testing is still considered as the "gold standard" in traditional toxicity testing, there is a necessity for shift from animal testing to alternative methods regarding the drug safety testing owing to the emerging state-of-art techniques and the proposal of 3Rs (replace, reduce, and refine) towards animal welfare. This review describes some recent research methods in drug discovery toxicology, including in vitro cell and organ-on-a-chip, imaging systems, model organisms (C. elegans, Danio rerio, and Drosophila melanogaster), and toxicogenomics in modern toxicology testing.

科学发现和见解的重大进展源于新技术和模型的开发和使用,可以为传统毒理学带来显著进步。尽管动物试验仍然被认为是传统毒性试验的“金标准”,但由于新兴的技术和3R(取代、减少和完善)对动物福利的建议,有必要从动物试验转向药物安全性试验的替代方法。这篇综述介绍了药物发现毒理学的一些最新研究方法,包括体外细胞和芯片上的器官、成像系统、模式生物(秀丽隐杆线虫、灰蝶和黑腹果蝇)以及现代毒理学测试中的毒代基因组学。
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引用次数: 0
Erythorbic Acid and Sodium Erythorbate. 赤霉素和赤霉素钠。
IF 2.2 4区 医学 Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-12-01 Epub Date: 2023-09-28 DOI: 10.1177/10915818231204257
Preethi S Raj, Wilma F Bergfeld, Donald V Belsito, David E Cohen, Curtis D Klaassen, Daniel C Liebler, Allan E Rettie, David Ross, Thomas J Slaga, Paul W Snyder, Susan Tilton, Monice Fiume, Bart Heldreth

The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1999, along with updated information regarding product types and concentrations of use, and confirmed that Erythorbic Acid and Sodium Erythorbate are safe as cosmetic ingredients in the practices of use and concentration as described in this report.

化妆品成分安全专家小组审查了自1999年最初评估以来最新的研究,以及有关产品类型和使用浓度的最新信息,并确认在本报告所述的使用和浓缩实践中,红胸酸和红胸酸钠作为化妆品成分是安全的。
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引用次数: 0
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International Journal of Toxicology
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