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Multiple cerebral venous thrombosis as the first presentation of Behçet syndrome: case report and literature review. 多发性脑静脉血栓形成为behet综合征的首发表现:病例报告及文献复习。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-13 DOI: 10.1007/s11845-025-04236-4
Asuman Orhan Varoglu, Bahadir Hosver, Basak Atalay

Introduction: Cerebral venous thrombosis as the first manifestation of Behçet's Syndrome (BS) is very rare. We describe a case of BS in which all four major cerebral venous sinuses, including the bilateral sigmoid sinuses, transverse sinuses, and superior sagittal sinuses, exhibited severe cerebral venous thrombosis.

Case report: An 18-year-old man was brought to our hospital with a three-month-old, wide, throbbing headache in both hemispheres and double, blurred vision while looking to the right for the last week. Magnetic Resonance Imaging (MRI) showed extensive thrombosis involving the bilateral sigmoid sinuses, transverse sinuses, and superior sagittal sinus. Collagen tissue diseases and systemic thrombophilia were ruled out. The patient, who had a history of erythema nodosum and genital and oral aphthae, was evaluated as 3/6 (+) positive by the pathergy test, leading to the diagnosis of BS. Prednisolone 48 mg/day and azathioprine 2 × 50 mg/day were started, and the prednisolone dosage was lowered to be stopped in three to four months. For nine months, anticoagulant medicine was administered. Partial recanalization was seen on control MRI venography.

Conclusions: It may be life-saving to consider Behçet syndrome as a differential diagnosis in patients with multiple cerebral venous thrombosis.

简介:以脑静脉血栓形成为首发表现的behet综合征(BS)非常罕见。我们描述了一个病例,其中所有四个主要的脑静脉窦,包括双侧乙状窦、横窦和上矢状窦,都表现出严重的脑静脉血栓形成。病例报告:一名18岁男子,因三个月大,双脑剧烈跳动性头痛,双眼向右看时视力模糊,上周入院。磁共振成像(MRI)显示广泛的血栓形成累及双侧乙状窦、横窦和上矢状窦。排除胶原组织疾病和全身性血栓形成。患者既往有结节性红斑、生殖器和口腔溃疡病史,病理检查为3/6(+)阳性,诊断为BS。开始使用强的松龙48 mg/天、硫唑嘌呤2 × 50 mg/天,3 ~ 4个月后降低剂量停用。9个月,给予抗凝药物治疗。对照MRI静脉造影显示部分再通。结论:将behaperet综合征作为多发性脑静脉血栓患者的鉴别诊断可能挽救生命。
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引用次数: 0
IHC analysis of estrogen receptor (ER) and progesterone receptor (PR) expression in endometrial carcinomas. 子宫内膜癌中雌激素受体(ER)和孕激素受体(PR)表达的IHC分析。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-13 DOI: 10.1007/s11845-025-04264-0
Kumudhini Priya Gunasekaran, Anbu Lenin Kulandaivel, K S B Ramanees, Gowri Sankar Ramalingam
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引用次数: 0
Exploring secondary prevention after stroke: a survey of Irish stroke clinical nurse specialists and advanced nurse practitioners. 探索中风后的二级预防:爱尔兰中风临床护理专家和高级护士从业人员的调查。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-13 DOI: 10.1007/s11845-025-04266-y
Sarah-Jane Byrne, David Williams, Declan Patton, Frances Horgan

Background: ESD enables stroke patients to leave hospital earlier and continue receiving nursing and therapy at home over a 6-8-week period. The CNS role within ESD is relatively new, and its involvement in stroke secondary prevention is not well defined.

Aims & objectives: To describe the current role, knowledge, and practice of Stroke Clinical Nurse Specialists (CNSs) and Advanced Nurse Practitioners (ANPs) in secondary prevention and their contribution to early supported discharge (ESD) for stroke patients.

Design: Cross-sectional survey.

Methods: An online survey was distributed to Stroke CNSs and ANPs working in inpatient stroke services or ESD teams. It explored three domains: (i) secondary prevention at initial hospital contact, (ii) secondary prevention at discharge, (iii) secondary prevention during ESD.

Results: The respondents described the pivotal role of stroke clinical nurse specialists (CNSs) and advanced nurse practitioners (ANPs) in delivering secondary prevention from hospital admission through to discharge. Persistent challenges in patient information retention during acute care were highlighted. Participants identified structured national resources-particularly printed materials over apps-as essential tools for effective secondary prevention.

Conclusion: Despite broad recognition of their value, integration of stroke CNSs into Early Supported Discharge (ESD) teams remains inconsistent, signalling a key area for service development in Ireland. There is a clear need to enhance continuity of nurse-led secondary prevention in community settings, particularly within ESD pathways.

背景:ESD可使脑卒中患者提前出院,并在家中继续接受6-8周的护理和治疗。中枢神经系统在ESD中的作用相对较新,其在卒中二级预防中的作用尚未明确。目的:描述卒中临床专科护士(CNSs)和高级执业护士(ANPs)在二级预防中的作用、知识和实践,以及他们对卒中患者早期支持出院(ESD)的贡献。设计:横断面调查。方法:对在卒中住院服务或ESD团队工作的卒中CNSs和ANPs进行在线调查。它探索了三个领域:(i)初次接触医院时的二级预防,(ii)出院时的二级预防,(iii)可持续发展教育期间的二级预防。结果:受访者描述了卒中临床专科护士(CNSs)和高级执业护士(ANPs)在从入院到出院提供二级预防方面的关键作用。强调了急性护理期间患者信息保留的持续挑战。与会者确定了结构化的国家资源,特别是应用程序上的印刷材料,是有效二级预防的重要工具。结论:尽管其价值得到了广泛认可,但卒中CNSs与早期支持出院(ESD)团队的整合仍然不一致,这标志着爱尔兰服务发展的关键领域。显然需要在社区环境中加强护士主导的二级预防的连续性,特别是在可持续发展教育途径中。
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引用次数: 0
Resveratrol potentiates chemotherapeutic efficacy of olaparib in MCF7 human breast cancer cells by inducing apoptosis. 白藜芦醇通过诱导凋亡增强奥拉帕尼对MCF7人乳腺癌细胞的化疗疗效。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-10 DOI: 10.1007/s11845-025-04240-8
Mehmet Kadir Erdoğan, Ramazan Gundogdu, Yusuf Toy, Esra Polat, Can Ali Agca, Aydın Sever, Burak Tüzün
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引用次数: 0
Effects of different kinesiology taping applications on Pain, muscular Fitness, Proprioception, Mobility, Functionality, and disability in patients with lumbar disc herniation. 不同运动机能学应用对腰椎间盘突出症患者疼痛、肌肉健康、本体感觉、活动、功能和残疾的影响。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-09 DOI: 10.1007/s11845-025-04250-6
Elif Umay Altaş, Hilal Uzunlar, Ecem Beytorun, Eylem Çağla Danacı, Filiz Meryem Sertpoyraz, Sevtap Günay Uçurum

Objective: This study aimed to compare the effects of different kinesiology taping techniques added to a standard treatment regimen.

Methods: Ninety patients with disc herniation were grouped into three groups: physical therapy + star taping (Group 1), physical therapy + I-taping (Group 2), and physical therapy alone (Group 3). Pain intensity, pressure pain threshold (PPT), back extensor muscle strength and endurance, proprioception, lumbar lordosis angle (LLA), lumbar range of motion, functional level, and disability level were assessed. All measurements were recorded before treatment, immediately after treatment, and at the 12-week follow-up.

Results: In Group 3, an improvement was observed in pain intensity, disability, functionality, joint range of motion, and proprioception at 60° and extension. In addition to improvements observed in Group3, Groups1 and 2 showed significant improvements in PPT, extensor muscle strength, LLA, and 45° proprioception (p < 0.05). Group1 exhibited an increase in LLA compared to baseline (p < 0.05). Compared to Group3, disability decreased in Group1, while extensor muscle strength increased in Group2. At the 12-week follow-up, LLA increased in Group1 but decreased in Group2 compared to post-treatment measurements (p < 0.05).

Conclusion: The addition of kinesiology taping to standard physical therapy has been shown to provide additional benefits for pressure pain threshold, extensor muscle strength, 45-degree proprioception, and lumbar lordosis angle in patients with LDH. Selecting specific taping techniques based on clinical goals may increase the effectiveness of treatment programs.

Clinical trials registration number: NCT06777095 (retrospectively registered).

目的:本研究旨在比较在标准治疗方案中加入不同运动机能学胶带技术的效果。方法:将90例椎间盘突出症患者分为物理治疗+星形贴敷组(1组)、物理治疗+ i型贴敷组(2组)和单纯物理治疗组(3组)。评估疼痛强度、压痛阈值(PPT)、背伸肌力量和耐力、本体感觉、腰椎前凸角(LLA)、腰椎活动度、功能水平和残疾水平。在治疗前、治疗后和12周随访时记录所有测量值。结果:在第3组,观察到疼痛强度、残疾、功能、关节活动范围和60°和伸展本体感觉的改善。除了在第3组观察到的改善外,第1组和第2组在PPT、伸肌力量、LLA和45°本体感觉方面均有显著改善(p结论:在标准物理治疗中添加运动学胶带已被证明对LDH患者的压痛阈值、伸肌力量、45度本体感觉和腰椎前凸角提供了额外的好处。根据临床目标选择特定的贴敷技术可以提高治疗方案的有效性。临床试验注册号:NCT06777095(回顾性注册)。
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引用次数: 0
An assessment of pelvic binder placement on patients referred to the Irish national centre for pelvic and acetabular fractures. 评估盆腔粘合剂放置的病人转介到爱尔兰国家中心骨盆和髋臼骨折。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-08 DOI: 10.1007/s11845-025-04262-2
C Timon, C Kilkenny, K O'Sullivan, A Bracken, J Fournier, B O'Daly
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引用次数: 0
Nursing home research in Ireland before and after the pandemic. 大流行前后爱尔兰养老院的研究。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-08 DOI: 10.1007/s11845-025-04251-5
Patrick Doyle, Sinéad McHugh, Desmond O'Neill
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引用次数: 0
Can teachers hear clearly? Investigating speech intelligibility and noise sensitivity in the classroom. 老师听得清楚吗?调查课堂上的语音清晰度和噪音敏感性。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-08 DOI: 10.1007/s11845-025-04257-z
Belde Culhaoglu, Tugce Gul Caglar, Seyra Erbek
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引用次数: 0
Therapeutic impact of electrical stimulation versus intramuscular electrical stimulation via dry needling on tibialis anterior muscle on reducing spasticity in stroke survivors: a randomized controlled trial. 电刺激与干针刺胫骨前肌肌内电刺激对减少中风幸存者痉挛的治疗影响:一项随机对照试验。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-08 DOI: 10.1007/s11845-025-04261-3
Ranim Al Amin, Rami L Abbas, Ahmed S Ali, Ibtissam M Saab, Salma AlKhatib, Ahmed M El Melhat
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引用次数: 0
A novel upper-extremity-based performance test for sarcopenia: reliability and clinical utility of the elbow performance test. 一种基于肌肉减少症的上肢性能测试:肘部性能测试的可靠性和临床应用。
IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-07 DOI: 10.1007/s11845-025-04263-1
Taha Yasin Yildirim, Eser Kalaoglu, Tugba Aydin, Kemal Sitki Türker, Ilhan Karacan
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Irish Journal of Medical Science
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