Y. Yanagisawa, Tomohiro Kurosu, Yoshiaki Natsume, T. Seino, K. Isama, T. Nishimura, Atsushi Yamashita
In this study, we investigated the perceptions of occupational exposure among pharmacists who prepare anticancer drugs for injection and the exposure control measures taken by individuals and their facilities. Thirty-one hospitals were selected as the target facilities, and 523 pharmacists who were working at the target facilities at the time of questionnaire collection were surveyed. The purpose of this study was to identify the problems that need to be improved not only in each facility, but also in each pharmacist by investigating how to utilize the manuals and guidelines for the preparation of injectable anticancer agents and how each individual pharmacist is implementing the details of their own techniques and procedures. Although all the facilities had prepared their own procedures using common manuals and guidelines, there were some items that were not followed in the procedures. More than half of the pharmacists engaged in the preparation of anticancer drugs performed their work with a sense of anxiety about health hazards and had experience of exposure. In this study, we conducted a survey of the actual conditions of the environment for the preparation of anticancer drugs in medical facilities, as well as a survey of the perceptions of individual pharmacists engaged in the work and their preparation techniques and procedures, to clarify the current problems and future issues. Although it is necessary to use reference materials in accordance with each facility, individual preparation techniques and procedures need to be stan-dardized and mastered to reduce occupational exposure.
{"title":"Survey of the Prevention Practices and the Awareness of Pharmacists in Handling of Mixing of Anticancer Drug Injections in Japanese Regional Core Hospitals","authors":"Y. Yanagisawa, Tomohiro Kurosu, Yoshiaki Natsume, T. Seino, K. Isama, T. Nishimura, Atsushi Yamashita","doi":"10.5649/jjphcs.47.537","DOIUrl":"https://doi.org/10.5649/jjphcs.47.537","url":null,"abstract":"In this study, we investigated the perceptions of occupational exposure among pharmacists who prepare anticancer drugs for injection and the exposure control measures taken by individuals and their facilities. Thirty-one hospitals were selected as the target facilities, and 523 pharmacists who were working at the target facilities at the time of questionnaire collection were surveyed. The purpose of this study was to identify the problems that need to be improved not only in each facility, but also in each pharmacist by investigating how to utilize the manuals and guidelines for the preparation of injectable anticancer agents and how each individual pharmacist is implementing the details of their own techniques and procedures. Although all the facilities had prepared their own procedures using common manuals and guidelines, there were some items that were not followed in the procedures. More than half of the pharmacists engaged in the preparation of anticancer drugs performed their work with a sense of anxiety about health hazards and had experience of exposure. In this study, we conducted a survey of the actual conditions of the environment for the preparation of anticancer drugs in medical facilities, as well as a survey of the perceptions of individual pharmacists engaged in the work and their preparation techniques and procedures, to clarify the current problems and future issues. Although it is necessary to use reference materials in accordance with each facility, individual preparation techniques and procedures need to be stan-dardized and mastered to reduce occupational exposure.","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81078971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Postpartum rubella vaccination is recommended for puerperal women with low rubella antibody titer to prevent congenital rubella syndrome. We have constructed a protocol-based pharmacotherapy management (PBPM) that contributes to the efficiency and safety of rubella vaccination, and we report the results. The ward pharmacist identified a puerperal woman with low rubella antibody titer, provided drug guidance regarding the rubella vaccine to that person, and requested a doctor to prescribe it. When identifying the subjects, it was confirmed whether or not they were inappropriate for vaccination as described in the package insert of the rubella vaccine. The subjects were puerperal women who gave birth at our hospital from April 1, 2017 to March 30, 2020. The vaccination rate (56.7 ％ ) after the introduction of PBPM was not significantly different from that when led by a doctor (60.0 ％ ). The vaccination avoidance rate for those who were unsuitable for rubella vaccination was 71.4 ％ (5/7) before the introduction of PBPM, and 100.0 ％ (9/9) after the introduction of PBPM. Intervening after confirming the package insert is considered to be the work of the pharmacist from the viewpoint of drug management. The introduction of PBPM not only reduces the burden on doctors, but also avoids the health hazards of the rubella vaccine and the inadequate effectiveness of the vaccine, which is considered to be a significant initiative.
{"title":"Effect of Protocol-Based Pharmacotherapy Management on Rubella Vaccination in Puerperal Women with Low Rubella Antibody Titer","authors":"Yui Arima, Atsuyoshi Okada, Takeshi Nakamura, Kazuya Ishii, Nobutoshi Otsuka, Masahiko Yamamoto","doi":"10.5649/jjphcs.47.527","DOIUrl":"https://doi.org/10.5649/jjphcs.47.527","url":null,"abstract":"Postpartum rubella vaccination is recommended for puerperal women with low rubella antibody titer to prevent congenital rubella syndrome. We have constructed a protocol-based pharmacotherapy management (PBPM) that contributes to the efficiency and safety of rubella vaccination, and we report the results. The ward pharmacist identified a puerperal woman with low rubella antibody titer, provided drug guidance regarding the rubella vaccine to that person, and requested a doctor to prescribe it. When identifying the subjects, it was confirmed whether or not they were inappropriate for vaccination as described in the package insert of the rubella vaccine. The subjects were puerperal women who gave birth at our hospital from April 1, 2017 to March 30, 2020. The vaccination rate (56.7 ％ ) after the introduction of PBPM was not significantly different from that when led by a doctor (60.0 ％ ). The vaccination avoidance rate for those who were unsuitable for rubella vaccination was 71.4 ％ (5/7) before the introduction of PBPM, and 100.0 ％ (9/9) after the introduction of PBPM. Intervening after confirming the package insert is considered to be the work of the pharmacist from the viewpoint of drug management. The introduction of PBPM not only reduces the burden on doctors, but also avoids the health hazards of the rubella vaccine and the inadequate effectiveness of the vaccine, which is considered to be a significant initiative.","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"309 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89669951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ishida, Y. Shirakura, Shinji Tagawa, Y. Karashima, T. Fujiyoshi, Kaoru Umehara, Chiho Yodogawa, Hiroyuki Watanabe, Toshikazu Tsuji, N. Egashira, T. Nakagawa, I. Ieiri
Pharmacists, as members of the perioperative management team, need to manage patient medication by checking their perioperative medication status to improve medical safety. However, no reports have evaluated the effectiveness of pharmacist interventions on the cancellation rate of surgeries. In this study, we retrospectively evaluated the effect of preoperative drug confirmation by pharmacists at the perioperative support center on the surgery cancellation rate. In addition, questionnaires with other medical staff were conducted to evaluate pharmacist interventions in perioperative patients. Since the initiation of pharmacist interventions in 2014, the surgery cancellation rate was found to have decreased gradually. This reduction is suggested to be the result of the increase in the pharmacist intervention rate in preoperative drug confirmation. Furthermore, preoperative drug confirmation performed by pharmacists at the perioperative support center was highly evaluated by other medical staff. These study findings indicate that preoperative drug confirmation by pharmacists can help to reduce the surgery cancellation rate and improve the medical safety of perioperative patients.
{"title":"Effect of Preoperative Drug Confirmation by Pharmacists on the Surgery Cancellation Rate: A Retrospective Study at the Perioperative Support Center","authors":"S. Ishida, Y. Shirakura, Shinji Tagawa, Y. Karashima, T. Fujiyoshi, Kaoru Umehara, Chiho Yodogawa, Hiroyuki Watanabe, Toshikazu Tsuji, N. Egashira, T. Nakagawa, I. Ieiri","doi":"10.5649/jjphcs.47.569","DOIUrl":"https://doi.org/10.5649/jjphcs.47.569","url":null,"abstract":"Pharmacists, as members of the perioperative management team, need to manage patient medication by checking their perioperative medication status to improve medical safety. However, no reports have evaluated the effectiveness of pharmacist interventions on the cancellation rate of surgeries. In this study, we retrospectively evaluated the effect of preoperative drug confirmation by pharmacists at the perioperative support center on the surgery cancellation rate. In addition, questionnaires with other medical staff were conducted to evaluate pharmacist interventions in perioperative patients. Since the initiation of pharmacist interventions in 2014, the surgery cancellation rate was found to have decreased gradually. This reduction is suggested to be the result of the increase in the pharmacist intervention rate in preoperative drug confirmation. Furthermore, preoperative drug confirmation performed by pharmacists at the perioperative support center was highly evaluated by other medical staff. These study findings indicate that preoperative drug confirmation by pharmacists can help to reduce the surgery cancellation rate and improve the medical safety of perioperative patients.","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90425302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyohei Haruta, Hiroshi Aoi, Kinuko Kimura, Kazuya Okada, C. Mikami, Masaki Murata, Sayo Matsuda, Kana Sado, I. Yoshikawa, Kazuyuki Ikeda
Busulfex ® is a non-aqueous injection of insoluble Busulfan dissolved in the oil-based solvents Polyethylene Glycol 400 (PEG400) and N,N -Dimethylacetamide (DMA). The use of a closed system transfer device (CSTD) is strongly recom-mended for the preparation of all hazardous drugs, and we use a CSTD for the preparation and administration of anticancer drugs at Nara Medical University Hospital. We experienced a case of frequent blockage of the intravenous route when Busulfex ® was administered. In the present study, when the test solution containing PEG400 and DMA mixed in the same ratio as Busulfex ® was syringe aspirated by CSTD, the CSTD was broken and foreign particles were generated within 3 minutes of aspiration. When DMA was syringe aspirated by CSTD, polycarbonate, the material of CSTD, was eluted, and functional abnormality of CSTD was observed 30 minutes after aspiration. Oil-based solvents are used as additives in many anticancer drugs. The suitability of a CSTD for the preparation of anticancer drugs should be deter-mined by considering not only the hazard classification of the anticancer drug, but also the type and ratio of the additives.
{"title":"Breakage and Elution of CSTD by Oil-based Solvents in Injection Drugs","authors":"Kyohei Haruta, Hiroshi Aoi, Kinuko Kimura, Kazuya Okada, C. Mikami, Masaki Murata, Sayo Matsuda, Kana Sado, I. Yoshikawa, Kazuyuki Ikeda","doi":"10.5649/jjphcs.47.590","DOIUrl":"https://doi.org/10.5649/jjphcs.47.590","url":null,"abstract":"Busulfex ® is a non-aqueous injection of insoluble Busulfan dissolved in the oil-based solvents Polyethylene Glycol 400 (PEG400) and N,N -Dimethylacetamide (DMA). The use of a closed system transfer device (CSTD) is strongly recom-mended for the preparation of all hazardous drugs, and we use a CSTD for the preparation and administration of anticancer drugs at Nara Medical University Hospital. We experienced a case of frequent blockage of the intravenous route when Busulfex ® was administered. In the present study, when the test solution containing PEG400 and DMA mixed in the same ratio as Busulfex ® was syringe aspirated by CSTD, the CSTD was broken and foreign particles were generated within 3 minutes of aspiration. When DMA was syringe aspirated by CSTD, polycarbonate, the material of CSTD, was eluted, and functional abnormality of CSTD was observed 30 minutes after aspiration. Oil-based solvents are used as additives in many anticancer drugs. The suitability of a CSTD for the preparation of anticancer drugs should be deter-mined by considering not only the hazard classification of the anticancer drug, but also the type and ratio of the additives.","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80994563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Kawazoe, Sayo Suzuki, Yui Hiraga, Yuta Yokoyama, A. Jibiki, Hiroki Iwata, Noriko Kobayashi, Kazuko Fujimoto, Hideo Nakada, T. Aomori, K. Yamaura, Tomonori Nakamura
{"title":"Can Rubric-based Performance Evaluation Measure Students’ Performance Levels in Pharmacy Practice Experiences?: Based on the Revised Model Core Curriculum for Pharmaceutical Education","authors":"H. Kawazoe, Sayo Suzuki, Yui Hiraga, Yuta Yokoyama, A. Jibiki, Hiroki Iwata, Noriko Kobayashi, Kazuko Fujimoto, Hideo Nakada, T. Aomori, K. Yamaura, Tomonori Nakamura","doi":"10.5649/jjphcs.47.513","DOIUrl":"https://doi.org/10.5649/jjphcs.47.513","url":null,"abstract":"","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74635684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiho Andou, M. Toyoda, H. Jinnai, Mizuki Ishii, Keiichi Matsumoto
{"title":"Consideration of the Effects of COVID-19 on Adjuvant Chemotherapy for Patients with Resected Colorectal Cancer","authors":"Shiho Andou, M. Toyoda, H. Jinnai, Mizuki Ishii, Keiichi Matsumoto","doi":"10.5649/jjphcs.47.490","DOIUrl":"https://doi.org/10.5649/jjphcs.47.490","url":null,"abstract":"","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79870514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tsuyoshi Hayashi, T. Tachi, Y. Noguchi, M. Sugioka, S. Aoyama, Kazuhide Tanaka, M. Yasuda, C. Goto, Koji Yamada, T. Mizui, H. Teramachi
{"title":"Assessing the Risk Minimization Activity in Risk Management Plans for Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2)","authors":"Tsuyoshi Hayashi, T. Tachi, Y. Noguchi, M. Sugioka, S. Aoyama, Kazuhide Tanaka, M. Yasuda, C. Goto, Koji Yamada, T. Mizui, H. Teramachi","doi":"10.5649/jjphcs.47.464","DOIUrl":"https://doi.org/10.5649/jjphcs.47.464","url":null,"abstract":"","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88746931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utility of the Family Pharmacist System:","authors":"Ryo Iketani, K. Konomura","doi":"10.5649/jjphcs.47.453","DOIUrl":"https://doi.org/10.5649/jjphcs.47.453","url":null,"abstract":"","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79779089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mayumi Yamada, Y. Takafuji, Kana Iwahashi, A. Yamatani
{"title":"Questionnaire Study Aimed at Disseminating Child-Resistant Packaging and Enlightening Consumers as a Measure to Prevent Accidental Ingestion of Medicines","authors":"Mayumi Yamada, Y. Takafuji, Kana Iwahashi, A. Yamatani","doi":"10.5649/jjphcs.47.505","DOIUrl":"https://doi.org/10.5649/jjphcs.47.505","url":null,"abstract":"","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"178 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80678398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nakaba Okamura, H. Koike, C. Yokoyama, Misako Shimura, Misako Tomata, Daisuke Furukawa, Yukiko Sahashi, R. Kubota
{"title":"How the Characteristics of Cubixx® Solutions Work in Recent Pharmaceutical Market Trends in Japan","authors":"Nakaba Okamura, H. Koike, C. Yokoyama, Misako Shimura, Misako Tomata, Daisuke Furukawa, Yukiko Sahashi, R. Kubota","doi":"10.5649/jjphcs.47.477","DOIUrl":"https://doi.org/10.5649/jjphcs.47.477","url":null,"abstract":"","PeriodicalId":14574,"journal":{"name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","volume":"6 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90814957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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