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Calcification of an intraocular lens designed for sutureless scleral fixation in a patient with band keratopathy 一例带状角膜病患者设计用于无缝线巩膜固定的人工晶状体钙化
Q4 Medicine Pub Date : 2023-08-29 DOI: 10.1097/j.jcro.0000000000000102
Nour Bundogji, Achilleas Filios, V. Hawn, S. Crafoord, L. Werner
Introduction: A case of a calcified Carlevale intraocular lens (IOL), which was explanted or exchanged and underwent laboratory analyses, is reported. Patient and Clinical Findings: A 74-year-old pseudophakic man with a history of type 2 diabetes presented with progressive vision changes 2 years after undergoing vitrectomy and implantation of a Carlevale IOL in the right eye due to previous subluxation of a 3-piece lens. Slitlamp examination was significant for mild band keratopathy and a diffusely opacified Carlevale IOL. Diagnosis, Intervention, and Outcomes: The opacified IOL was explanted and exchanged for an Artisan IOL, with posterior enclavation. Grossly, the explanted IOL exhibited extensive and diffuse deposits/crusts throughout its surface, causing opacification. Scanning electron microscopy coupled with surface analysis confirmed that the deposits/crusts were composed of calcium/phosphate. Conclusions: To the authors' knowledge, this is the first reported case of an opacified Carlevale IOL that underwent laboratory analysis confirming calcification. Alteration in calcium homeostasis that may accompany the diabetic state may represent a contributing factor to the band keratopathy and IOL calcification in this case.
引言:报告了一例钙化的Carlevale人工晶状体(IOL),该人工晶状体被移植或更换并接受了实验室分析。患者和临床发现:一名74岁的有2型糖尿病病史的人工晶状体患者,由于之前的3片晶状体半脱位,在接受玻璃体切除术和右眼Carlevale人工晶状体植入术2年后,出现渐进性视力变化。Slitlamp检查对轻度带状角膜病变和弥漫性混浊的Carlevale IOL具有重要意义。诊断、干预和结果:取出混浊的人工晶状体并更换为Artisan人工晶状体,并进行后包壳。大体上,植入的IOL在整个表面表现出广泛的弥漫性沉积物/结皮,导致混浊。扫描电子显微镜结合表面分析证实,沉积物/结壳由钙/磷酸盐组成。结论:据作者所知,这是第一例经实验室分析证实钙化的不透明Carlevale IOL病例。糖尿病状态下钙稳态的改变可能是带状角膜病变和IOL钙化的一个促成因素。
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引用次数: 0
Small-aperture intraocular lens implantation after multiple penetrating keratoplasties secondary to penetrating ocular trauma 穿透性眼外伤继发的多次穿透性角膜移植术后小孔径人工晶状体植入术
Q4 Medicine Pub Date : 2023-08-18 DOI: 10.1097/j.jcro.0000000000000101
Brandon L. Vander Zee, Tanner J. Ferguson, John P Berdahl, Brent A. Kramer
Introduction: The small-aperture intraocular lens (IOL) is a recently introduced IOL that can provide favorable central visual acuity in patients with irregular corneas. This case describes a patient with multiple prior penetrating keratoplasties secondary to ocular trauma that achieved a favorable outcome with the aforementioned IOL. Patient and Clinical Findings: A 66-year-old man presented with a penetrating corneal injury that was successfully repaired but was eventually complicated by fungal keratitis requiring a therapeutic penetrating keratoplasty (PKP). The patient had a prolonged postoperative course complicated by multiple graft failures and finally stabilized after a third PKP. Through the protracted course, the patient developed a brunescent cataract, and the multiple PKPs resulted in significant irregular astigmatism. Diagnosis, Intervention, and Outcomes: The patient underwent cataract surgery in the affected eye with implantation of a small-aperture IOL 18 months after his initial injury. The patient's uncorrected distance visual acuity was 20/20 at six months post-operatively and he reported excellent quality of vision. Conclusions: This case represents the first use of the small-aperture IOL in a patient with prior PKP since its U.S. Food and Drug Administration approval. The small-aperture IOL can overcome high levels of corneal irregularities and provide favorable visual acuity in complex eyes.
小孔径人工晶状体(IOL)是最近引进的一种人工晶状体,可以为不规则角膜患者提供良好的中心视力。本病例描述了一位因眼部外伤而接受多次穿透性角膜移植术的患者,通过上述人工晶状体获得了良好的结果。患者和临床表现:一名66岁的男性患者出现穿透性角膜损伤,成功修复,但最终并发真菌性角膜炎,需要治疗性穿透性角膜移植术(PKP)。患者术后过程延长,并发多次移植物失败,最后在第三次PKP后稳定下来。经过漫长的病程,患者发展为早发性白内障,多个pkp导致明显的不规则散光。诊断、干预和结果:患者在初次受伤18个月后接受了白内障手术,植入了小孔径人工晶状体。术后6个月,患者未矫正距离视力为20/20,视力良好。结论:该病例是自美国食品和药物管理局批准小口径人工晶状体后首次在有PKP的患者中使用。小孔径人工晶状体可以克服高度不规则的角膜,提供良好的视力在复杂的眼睛。
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引用次数: 0
Intraoperative phacoemulsification tip fracture 术中超声乳化尖端骨折
Q4 Medicine Pub Date : 2023-08-18 DOI: 10.1097/j.jcro.0000000000000103
Ameeta Kumar, Diana-Maria Toia, Sharmina Khan
Introduction: Intraoperative instrument fractures pose a serious risk during cataract surgery through the retention of metallic foreign bodies and subsequent injury to intraocular structures. Patient and Clinical Findings: An 83-year-old woman underwent phacoemulsification and insertion of an intraocular lens, during which an intraoperative phacoemulsification tip fracture was encountered during quadrant removal. Diagnosis, Intervention, and Outcome: A thorough examination of the operative field revealed the broken tip fragment in the drape bag, with no intraocular fragments. The surgery was completed with a replacement phacoemulsification probe without issues, and the patient made an uneventful recovery. Conclusions: Early diagnosis and management after instrument breakage are necessary to prevent the retention of metallic foreign bodies.
导言:术中器械骨折是白内障手术中严重的危险因素,其原因是金属异物的滞留和随后对眼内结构的损伤。患者和临床表现:一名83岁的女性接受了超声乳化术和人工晶状体植入术,术中在摘除象限时发现超声乳化术尖端骨折。诊断、干预和结果:手术视野的彻底检查显示,在布袋内发现破碎的尖端碎片,没有眼内碎片。手术完成后,更换了超声乳化术探头,没有任何问题,患者顺利康复。结论:器械破裂后的早期诊断和处理是防止金属异物滞留的必要措施。
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引用次数: 0
Transient band keratopathy associated with epithelial ingrowth treated with antimetabolites 抗代谢物治疗与上皮向内生长相关的短暂性带状角膜病变
Q4 Medicine Pub Date : 2023-07-26 DOI: 10.1097/j.jcro.0000000000000099
Evan Frigoletto, Annahita Amireskandari, T. Mauger
Introduction: To report a case of visually significant band keratopathy associated with ocular inflammation in the setting of epithelial ingrowth, both of which resolved after repeated antimetabolite treatments. Patient and Clinical Findings: A 74-year-old woman with a history of uveitis–glaucoma–hyphema syndrome after complicated cataract surgery presented with epithelial ingrowth in the right eye and diffuse central band keratopathy after posterior chamber intraocular lens (IOL) removal and pars plana vitrectomy and anterior chamber IOL placement. Diagnosis, Intervention, and Outcomes: After multiple intraocular injections of antimetabolites, the epithelial ingrowth and visually significant band keratopathy resolved. Conclusions: Treating the underlying source of inflammation, such as epithelial ingrowth with antimetabolites, was associated with clearance of the band keratopathy without further intervention.
简介:报告一例视觉上显著的带状角膜病变与上皮向内生长的眼部炎症相关,这两种情况在反复的抗代谢物治疗后消退。患者和临床表现:一名74岁的女性,在复杂的白内障手术后出现了葡萄膜炎-青光眼-前房积血综合征,在后房型人工晶状体(IOL)摘除和玻璃体切割及前房型人工晶状体植入术后出现了右眼上皮细胞向内生长和弥漫性中央带角膜病变。诊断、干预和结果:多次眼内注射抗代谢物后,上皮向内生长和视觉上显著的带状角膜病变得到缓解。结论:用抗代谢物治疗炎症的潜在来源,如上皮向内生长,与带状角膜病变的清除有关,无需进一步干预。
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引用次数: 0
Explantation of a light-adjustable intraocular lens: case report with laboratorial analyses 可调光人工晶状体植入术一例报告及实验室分析
Q4 Medicine Pub Date : 2023-07-21 DOI: 10.1097/j.jcro.0000000000000100
V. Hawn, Nour Bundogji, Ruth Sahler, M. Mifflin, B. Monson, N. Mamalis, L. Werner
Introduction: A case in which a light-adjustable lens (LAL) underwent explantation and extensive laboratory analyses is reported. Patient and Clinical Findings: A 61-year-old man underwent uneventful cataract surgery with in-the-bag implantation of a first-generation LAL in the right eye. Examination on the second postoperative day revealed limbus-to-limbus corneal edema, moderate anterior chamber cells, and a mid-dilated, minimally responsive pupil, suggesting toxic anterior segment syndrome (TASS). Diagnosis, Intervention, and Outcomes: Endothelial keratoplasty was performed 2 months after LAL implantation. The patient reported noncompliance with required UV-protective eyewear, and an attempted light adjustment confirmed macromer reserve depletion, likely secondary to ambient UV contamination. Gross and microscopic examinations of the explanted LAL showed a decentered round elevation on the optic. The light transmittance (%T) curve was normal, with 95.9%T on average in the visible spectrum. Optical coherence tomography revealed irregular curvatures of the anterior and posterior optic surfaces. Wavefront analysis displayed aberrations and large power variations, which corresponded to decreased focus and contrast through the optic. Conclusions: To the authors' knowledge, this is the first reported case of LAL implantation complicated by TASS, leading to a prolonged clinical course and nonadherence to proprietary UV-protective spectacles. Extensive laboratory analyses of the explanted LAL demonstrated findings that can be expected with uncontrolled polymerization of the LAL.
引言:报道了一例可调光晶状体(LAL)进行移植和广泛的实验室分析的病例。患者和临床发现:一名61岁的男子接受了平静的白内障手术,在右眼植入了第一代左心耳。术后第二天的检查显示角膜缘至角膜缘水肿,前房细胞中等,瞳孔中等扩张,反应最低,提示中毒性眼前节综合征(TASS)。诊断、干预和结果:左心耳植入术后2个月进行内皮角膜移植术。患者报告不符合所需的紫外线防护眼镜,并尝试调整光线,证实大分子单体储备耗尽,可能是环境紫外线污染所致。移植左心耳的大体和显微镜检查显示,视神经上有一个偏心的圆形隆起。透光率(%T)曲线是正常的,在可见光谱中平均为95.9%T。光学相干断层扫描显示前部和后部光学表面的曲率不规则。波前分析显示像差和大的功率变化,这与通过光学器件的聚焦和对比度降低相对应。结论:据作者所知,这是第一例报道的左心耳植入术并发TASS的病例,导致临床病程延长,且不佩戴专有的紫外线防护眼镜。对移植LAL的广泛实验室分析表明,LAL的不受控制的聚合可以得到预期的结果。
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引用次数: 1
Sealing of clear corneal incisions with autologous blood 自体血液封闭角膜切口
Q4 Medicine Pub Date : 2023-07-01 DOI: 10.1097/j.jcro.0000000000000098
Harshul Tak
The author describes a novel technique of using autologous blood as a sealant to seal clear corneal phacoemulsification incisions, which leak even after stromal hydration at the end of phacoemulsification surgery. Using a 26-gauge, half-inch straight needle, mounted on an empty 2-mL syringe, limbal blood vessels near the leaking incisions are nicked so that mild blood oozes out. Once some blood is collected, this blood is spread over the incision by the property of surface tension using the 26-gauge needle tip and kept there for 20 to 40 seconds. By capillary action, it also seals the microleaks in the incision tunnel and forms a clot at the incision entry.
作者描述了一种新颖的技术,使用自体血液作为密封剂来密封透明的角膜超声乳化术切口,即使在超声乳化术结束时基质水化后也会泄漏。使用一根26号半英寸的直针,安装在一个2毫升的空注射器上,在泄漏切口附近的唇缘血管上划上缺口,使温和的血液渗出。一旦收集到一些血液,这些血液就会通过26号针头的表面张力分布在切口上,并在那里保持20到40秒。通过毛细血管的作用,它还封闭了切口隧道内的微渗漏,并在切口入口处形成血块。
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引用次数: 0
Early pigment dispersion and raised intraocular pressure after uneventful central-hole implantable collamer lens surgery 中心孔可植入人工晶状体手术后早期色素分散和眼压升高
Q4 Medicine Pub Date : 2023-05-23 DOI: 10.1097/j.jcro.0000000000000096
Sanjay Chaudhary, Hema Mehra, Shanu Kumar Mittal, A. Pandey
Introduction: With ever-increasing cases of myopia worldwide, there has been a quantum jump in the number of refractive procedures. 3 cases who had an uncomplicated implantable collamer lens (ICL) surgery in both eyes, but had a new complication, are presented here. This is not yet described in the literature to the authors' knowledge. Patient and Clinical Findings: 2 weeks after uneventful bilateral ICL surgery, the patients presented with slight blurring of vision in 1 eye only. On examination, there was excessive pigment dispersion in the anterior chamber both in front of and behind the ICL. They also had raised intraocular pressure (IOP) a few days later, possibly due to blockage of the trabecular meshwork by iris pigments. Diagnosis, Intervention, and Outcomes: All the patients were managed conservatively on anti-inflammatory and IOP-lowering eyedrops. The dispersed pigments decreased with normalization of IOP after 2 to 4 weeks of conservative management with no blurring of vision. However, the pupil remained slightly dilated and irregular in all these cases. Conclusions: The excessive pigment dispersion seen after ICL surgery is not commonly encountered after ICL surgery and can be managed conservatively.
引言:随着全球近视病例的不断增加,屈光手术的数量出现了巨大的飞跃。本文报告了3例双眼均接受了简单的植入式collamer lens(ICL)手术,但出现了新的并发症。据作者所知,文献中尚未对此进行描述。患者和临床发现:在平静的双侧ICL手术后2周,患者仅1眼出现轻微视力模糊。检查时,ICL前后前房色素分散过多。几天后,他们的眼压也升高了,可能是因为虹膜色素堵塞了小梁网。诊断、干预和结果:所有患者均采用抗炎和降眼压滴眼液进行保守治疗。在没有视力模糊的情况下,经过2-4周的保守治疗后,分散的色素随着IOP的正常化而减少。然而,在所有这些病例中,瞳孔仍然轻微扩张和不规则。结论:ICL术后色素过度分散不常见,可以保守治疗。
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引用次数: 0
Netarsudil-associated reticular epithelial corneal edema after phacoemulsification 白内障超声乳化术后Netarsudil相关性网状上皮性角膜水肿
Q4 Medicine Pub Date : 2023-04-20 DOI: 10.1097/j.jcro.0000000000000097
Cooper D. Rodgers, Ankit Shah, C. R. Blake
Introduction: To the authors' knowledge, this is the first reported case of netarsudil-associated reticular corneal edema noted shortly after phacoemulsification with intraocular lens (IOL) implantation. Patient and Clinical Findings: A 68-year-old woman with a history of chronic angle-closure glaucoma with a long-term history of tolerance to netarsudil presented with “honeycomb” epitheliopathy shortly after phacoemulsification with IOL implantation. Diagnosis, Intervention, and Outcomes: Netarsudil was discontinued, and the patient's reticular corneal edema resolved shortly thereafter. Conclusions: Reticular corneal epitheliopathy can be seen in patients being treated with netarsudil after phacoemulsification with IOL implantation. Fortunately, this condition resolves shortly after the drug is discontinued.
简介:据作者所知,这是首例在人工晶状体(IOL)植入术后不久发生奈沙地尔相关网状角膜水肿的报道。患者和临床表现:一名68岁女性,有慢性闭角型青光眼病史,长期耐受性奈沙地尔,在超声乳化术合并人工晶状体植入术后不久出现“蜂窝状”上皮病变。诊断、干预和结果:停用奈沙地尔后,患者网状角膜水肿很快消失。结论:超声乳化术合并人工晶状体植入术后应用奈沙地尔可出现网状角膜上皮病变。幸运的是,这种情况在停药后不久就会消失。
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引用次数: 1
Use of primary and piggyback toric intraocular lenses for treatment of high myopic astigmatism 原发和背负式环形人工晶状体治疗高度近视散光
Q4 Medicine Pub Date : 2023-03-20 DOI: 10.1097/j.jcro.0000000000000093
Andrew C. Thomson, Kathryn E McAnnis, B. Ambati
Introduction: High myopic astigmatism often presents a challenge for cataract surgeons. Procedures such as limbal relaxation incisions may also be impossible in the setting of an extensive refractive surgical history. Patient and Clinical Findings: A 61-year-old woman for cataract surgery with a history of automated lamellar keratoplasty, 4-incision radial keratotomy, and arcuate incisions in the left eye. Astigmatism was 8.00 diopters (D) by manifest refraction, and on optical biometry, corneal topography, and auto keratometry, astigmatism was 9.01 D, 7.52 D, and 8.25 D, respectively. Diagnosis, Intervention, and Outcomes: A primary in-the-bag toric intraocular lens (IOL) and piggyback toric IOL with reverse optic capture were used. A surgically induced astigmatism of 6.59 D, magnitude of error of −1.41 D, angle of error 5.6 degrees, and correction index of 0.82 were achieved. Owing to limited potential improvement with IOL rotation, additional enhancement with photorefractive keratectomy (PRK) of −0.61 −1.78 × 69 degrees was performed to achieve desired results and high patient satisfaction. Preoperative corrected distance visual acuity was 20/50, and the uncorrected visual acuity achieved after cataract surgery and PRK enhancement was 20/25. Conclusions: The use of double toric IOLs for treating high astigmatism in patients with prior keratorefractive surgery is reported.
引言:高度近视散光通常是白内障外科医生面临的挑战。在有大量屈光手术史的情况下,角膜缘松弛切口等手术也可能是不可能的。患者和临床发现:一名接受白内障手术的61岁女性,有自动板层角膜移植术、4切口放射状角膜切开术和左眼弧形切口病史。通过明显折射,散光为8.00屈光度(D),在光学生物测量、角膜地形图和自动角膜测量中,散光分别为9.01D、7.52D和8.25D。诊断、干预和结果:使用原发性囊内复曲面人工晶状体(IOL)和带反向光学捕获的背负式复曲面IOL。手术诱导的散光为6.59 D,误差幅度为-1.41 D,误差角度为5.6度,矫正指数为0.82。由于IOL旋转的潜在改善有限,因此进行了−0.61−1.78×69度的屈光性角膜切削术(PRK)的额外增强,以达到预期的效果和高患者满意度。术前矫正远视力为20/50,白内障手术和PRK增强后的裸眼视力为20/25。结论:双复曲面人工晶状体用于治疗既往屈光性角膜手术患者的高度散光。
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引用次数: 0
Postoperative discoloration of a multifocal hydrophobic acrylic lens: case report with laboratory analyses 多焦疏水丙烯酸晶状体术后变色:病例报告及实验室分析
Q4 Medicine Pub Date : 2023-03-16 DOI: 10.1097/j.jcro.0000000000000094
Nour Bundogji, V. Hawn, J. Micheletti, Ruth Sahler, L. Werner
Introduction: A case of discoloration of a multifocal hydrophobic acrylic intraocular lens (IOL), which was explanted and exchanged as well as underwent laboratory analysis, is reported. Patient and Clinical Findings: The patient presented with a corrected distance visual acuity of 20/50 and glare in the right eye 8 years after implantation. Slitlamp examination revealed a nasally decentered IOL with a whitish-brownish haze throughout. Diagnosis, Intervention, and Outcomes: The discolored IOL (ZMB00) was explanted and exchanged for a 3-piece IOL (sulcus fixation). Grossly, the explanted IOL showed a whitish discoloration of the optic only after hydration, corresponding to a yellowish-brownish discoloration observed under light microscopy. Back light scattering revealed bulk scatter throughout the optic. Light transmittance (%T) showed a slight progressive decrease starting at 500 nm when compared with %T in the directions for use (DFUs). Although modulation transfer function analysis demonstrated similar values to the control lens, the contrast of U.S. Air Force targets appeared slightly decreased. Conclusions: To the authors' knowledge, this is the first reported case of a discolored ZMB00 IOL that underwent explantation and laboratory assessment. Although current analyses did not reveal the etiology of the discoloration, surgeons should be aware of this possible occurrence with this lens design and carefully assess signs and symptoms before explantation.
引言:报道了一例多焦点疏水性丙烯酸人工晶状体(IOL)变色的病例,该人工晶状体被取出、更换并接受了实验室分析。患者和临床发现:患者在植入后8年出现20/50的矫正远视敏度和右眼眩光。Slitlamp检查显示一个鼻腔偏心的IOL,全身有一片白色褐色的薄雾。诊断、干预和结果:取出变色IOL(ZMB00)并更换为3片IOL(沟固定)。大体上,移植的IOL仅在水合作用后才显示出视神经的白色变色,对应于在光学显微镜下观察到的黄棕色变色。背光散射显示了整个光学器件的整体散射。与使用方向(DFU)上的%T相比,从500nm开始,透光率(%T)显示出轻微的逐渐降低。尽管调制传递函数分析显示出与控制镜头相似的值,但美国空军目标的对比度似乎略有下降。结论:据作者所知,这是第一例经过移植和实验室评估的变色ZMB00人工晶状体病例。尽管目前的分析没有揭示变色的病因,但外科医生应该意识到这种晶状体设计可能会发生这种情况,并在移植前仔细评估体征和症状。
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引用次数: 0
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