Firouzeh Moeinzadeh, Marjan Mansourian, Mojgan Mortazavi, Shiva Seirafian, Shahrzad Shahidi, Zahra Tasdighi, Sahar Vahdat, Shahram Taheri, Mohammad Hossein Rouhani, Mohammad Saleki, Mostafa Rezaei, Mohammad Hossein Masoudi, Zahra Zamani, Nahid Rafie
Introduction: We intended to explore the prevalence of chronic kidney disease (CKD) and its different stages, as well as CKD associated variables in the adult population in Isfahan province, Iran.
Methods: Adults aged ≥ 18 were recruited in a cross-sectional study from 2017 to 2019. Data including demographics, anthropometrics, and laboratory findings were collected from each subject. The equation of chronic kidney disease- Epidemiology Collaboration (CKD-EPI) was used to estimate glomerular filtration rate (eGFR), and eGFR and UACR values were utilized to determine the stages of CKD.
Results: Data from a total of 3374 subjects was analyzed. The mean age of participants was 49.3 ± 14.09 years and 59.3% were female. The prevalence of CKD was 18.5%. Only 0.25 and 3.5% of the population were in CKD stage 3 and 4, while most of the patients were in CKD stage 2 (7.6%) and stage 1 (7.1%). CKD patients were mostly on refined grains diet and used lesser dairy products compared to healthy participants. Variables including systolic blood pressure (OR = 1.018; P < .001), diastolic blood pressure (OR = 1.005; P < .05), fasting blood sugar (OR = 1.011; P < .001), female sex (OR = 1.319; P < .05), body mass index (OR = 1.030; P < .05), married status (OR = 1.335; P < .05), and smoking (OR = 1.529; P < .05) were significantly associated with increased risk of CKD in the logistic regression analysis.
Conclusion: According to our results, the prevalence of CKD, especially stages 1 and 2, is quite high in central part of Iran. These findings help us to improve the screening for CKD patients and perform larger scale studies to identify the challenges ahead. DOI: 10.52547/ijkd.7201.
{"title":"Chronic Kidney Disease in Isfahan Province, Action Plan for Screening in A Population-based Study.","authors":"Firouzeh Moeinzadeh, Marjan Mansourian, Mojgan Mortazavi, Shiva Seirafian, Shahrzad Shahidi, Zahra Tasdighi, Sahar Vahdat, Shahram Taheri, Mohammad Hossein Rouhani, Mohammad Saleki, Mostafa Rezaei, Mohammad Hossein Masoudi, Zahra Zamani, Nahid Rafie","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>We intended to explore the prevalence of chronic kidney disease (CKD) and its different stages, as well as CKD associated variables in the adult population in Isfahan province, Iran.</p><p><strong>Methods: </strong>Adults aged ≥ 18 were recruited in a cross-sectional study from 2017 to 2019. Data including demographics, anthropometrics, and laboratory findings were collected from each subject. The equation of chronic kidney disease- Epidemiology Collaboration (CKD-EPI) was used to estimate glomerular filtration rate (eGFR), and eGFR and UACR values were utilized to determine the stages of CKD.</p><p><strong>Results: </strong>Data from a total of 3374 subjects was analyzed. The mean age of participants was 49.3 ± 14.09 years and 59.3% were female. The prevalence of CKD was 18.5%. Only 0.25 and 3.5% of the population were in CKD stage 3 and 4, while most of the patients were in CKD stage 2 (7.6%) and stage 1 (7.1%). CKD patients were mostly on refined grains diet and used lesser dairy products compared to healthy participants. Variables including systolic blood pressure (OR = 1.018; P < .001), diastolic blood pressure (OR = 1.005; P < .05), fasting blood sugar (OR = 1.011; P < .001), female sex (OR = 1.319; P < .05), body mass index (OR = 1.030; P < .05), married status (OR = 1.335; P < .05), and smoking (OR = 1.529; P < .05) were significantly associated with increased risk of CKD in the logistic regression analysis.</p><p><strong>Conclusion: </strong>According to our results, the prevalence of CKD, especially stages 1 and 2, is quite high in central part of Iran. These findings help us to improve the screening for CKD patients and perform larger scale studies to identify the challenges ahead. DOI: 10.52547/ijkd.7201.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9112187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Staphylococcus aureus (S. aureus) is one of the most frequent causes of infection around the world. Insertion of intravascular catheter and formation of biofilms by methicillinresistant Staphylococcus aureus (MRSA) have contributed to the increased risk of infection, and morbidity and mortality rates. Biofilms formation on intravascular catheters and other medical devices are of major postoperative concerns because biofilms are often the source of persistent and difficult-to-treat bacterial infections. This study aimed to evaluate different genetic patterns of this bacterium in samples collected from dialysis patients of Nikan hospital.
Methods: In this descriptive cross-sectional study 30 samples from the removed catheters of patients suspected to have S. aureus infection and admitted to the dialysis ward of Nikan hospital were collected and phenotypic evaluations were done to confirm the type of the infectious species. Evaluation of antibiotic resistance of bacterial samples using Kirby-Bauer method was done. Biofilm production of the samples was assessed by the 96-plate microtiter method. The existence of two genes hla and hlb were evaluated using Multiplex PCR.
Results: The biofilm production test showed that 60% of the samples were able to produce strong biofilms. Multiplex PCR results revealed that both hla and hlb genes were expressed in 93% of the samples, while, hlb gene alone was expressed in 53% of cases.
Conclusion: The results of this study provide significant insight into the virulence gene makeup of catheter-colonizing S. aureus strains, and will assist in developing a more targeted treatment approach for persistent S. aureus biofilm contamination of medical devices. DOI: 10.52547/ijkd.7146.
{"title":"Virulence Factors of Staphylococcus Aureus Hemolysin HLA and HLB Isolated from Catheters of Dialysis Patients Referred to Nikan Hospital in Tehran During the Spring and Summer of 2021.","authors":"Mehrdad Jafari Fesharaki, Sara Alipanahi, Nazila Arbabsoleimani, Fatemeh Pourrezagholi, Zeinab Piravar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Staphylococcus aureus (S. aureus) is one of the most frequent causes of infection around the world. Insertion of intravascular catheter and formation of biofilms by methicillinresistant Staphylococcus aureus (MRSA) have contributed to the increased risk of infection, and morbidity and mortality rates. Biofilms formation on intravascular catheters and other medical devices are of major postoperative concerns because biofilms are often the source of persistent and difficult-to-treat bacterial infections. This study aimed to evaluate different genetic patterns of this bacterium in samples collected from dialysis patients of Nikan hospital.</p><p><strong>Methods: </strong>In this descriptive cross-sectional study 30 samples from the removed catheters of patients suspected to have S. aureus infection and admitted to the dialysis ward of Nikan hospital were collected and phenotypic evaluations were done to confirm the type of the infectious species. Evaluation of antibiotic resistance of bacterial samples using Kirby-Bauer method was done. Biofilm production of the samples was assessed by the 96-plate microtiter method. The existence of two genes hla and hlb were evaluated using Multiplex PCR.</p><p><strong>Results: </strong>The biofilm production test showed that 60% of the samples were able to produce strong biofilms. Multiplex PCR results revealed that both hla and hlb genes were expressed in 93% of the samples, while, hlb gene alone was expressed in 53% of cases.</p><p><strong>Conclusion: </strong>The results of this study provide significant insight into the virulence gene makeup of catheter-colonizing S. aureus strains, and will assist in developing a more targeted treatment approach for persistent S. aureus biofilm contamination of medical devices. DOI: 10.52547/ijkd.7146.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9112189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The newest Kidney Disease Improving Global Outcomes (KDIGO) guideline recommendations were investigated mainly for the care of adult kidney transplant recipients, but no guideline exists for the management of pediatric transplant recipients. This review provides update recommendations in the management of pediatric kidney transplantation. Four electronic databases, PubMed, EMBASE, Google Scholar, and Web of Science were searched systematically for the last two decades, using Mesh terms in English language. The Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach was used for grading the quality of the overall evidence and the strength of recommendations for each outcome across the studies. The overall quality of evidence categorized as high (A), moderate (B), low (C), or poor (D). The strength of a recommendation was determined as level 1 (recommended) or level 2 (suggested). The ungraded statements were determined on the basis of common sense to provide general advice. Of the 317 citations which were screened for the evidence review, 62 were included in data extraction. The included studies were randomized controlled trials, prospective cohorts and cross-sectional, descriptive, and review studies. Of the 115 statements, 56 (48.6%) were graded 1 (we recommend), 34 (29.5%) were graded 2 (we suggest), and 25 (21.7%) were ungraded statements. Altogether, only 22 (19.1%) of recommendations reached the "A" or "B" levels of quality of evidence. The pediatric kidney transplant recipients are different from adult recipients regarding the primary kidney diseases, surgical techniques, drug metabolism, adherence to medications, growth and neurocognitive development and immunization needs prior to transplantation. DOI: 10.52547/ijkd.7179.
最新的肾脏疾病改善全球结局(KDIGO)指南建议主要针对成人肾移植受者的护理进行了调查,但没有针对儿童肾移植受者的管理指南。这篇综述提供了儿科肾移植治疗的最新建议。在过去的二十年里,我们系统地检索了四个电子数据库,PubMed, EMBASE, Google Scholar和Web of Science,使用英语的Mesh术语。推荐评估、发展和评价分级(GRADE)方法用于对整个研究中每个结果的总体证据质量和推荐强度进行分级。证据的总体质量分为高(A)、中等(B)、低(C)或差(D)。推荐的强度分为1级(推荐)或2级(建议)。未分级陈述是根据常识确定的,目的是提供一般性意见。在为证据审查筛选的317条引文中,有62条被纳入数据提取。纳入的研究包括随机对照试验、前瞻性队列和横断面、描述性和回顾性研究。在115个语句中,56个(48.6%)为1级(我们推荐),34个(29.5%)为2级(我们建议),25个(21.7%)为未分级语句。总的来说,只有22条(19.1%)的建议达到了“A”或“B”级别的证据质量。儿童肾移植受者在原发肾脏疾病、手术技术、药物代谢、药物依从性、生长和神经认知发育以及移植前的免疫需求等方面与成人肾移植受者不同。DOI: 10.52547 / ijkd.7179。
{"title":"Revisiting the Management of Pediatric Kidney Transplants, \u0000A Multicenter Analysis","authors":"Farahnak Assadi, Nakysa Hooman, Abdolhassan Seyedzadeh, Anoush Azarfar, Elaheh Malakan Rad, Behnaz Bazargani, Arash Abasi, Mastaneh Moghtaderi, Afshin Safaeiasl, Nasrin Esfandiar, Ali Derakhsan, Hamidreza Badeli, Alireza Eskandarifar, Mojgan Mazaheri, Fatemeh Ghane Sharbaf","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The newest Kidney Disease Improving Global Outcomes (KDIGO) guideline recommendations were investigated mainly for the care of adult kidney transplant recipients, but no guideline exists for the management of pediatric transplant recipients. This review provides update recommendations in the management of pediatric kidney transplantation. Four electronic databases, PubMed, EMBASE, Google Scholar, and Web of Science were searched systematically for the last two decades, using Mesh terms in English language. The Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach was used for grading the quality of the overall evidence and the strength of recommendations for each outcome across the studies. The overall quality of evidence categorized as high (A), moderate (B), low (C), or poor (D). The strength of a recommendation was determined as level 1 (recommended) or level 2 (suggested). The ungraded statements were determined on the basis of common sense to provide general advice. Of the 317 citations which were screened for the evidence review, 62 were included in data extraction. The included studies were randomized controlled trials, prospective cohorts and cross-sectional, descriptive, and review studies. Of the 115 statements, 56 (48.6%) were graded 1 (we recommend), 34 (29.5%) were graded 2 (we suggest), and 25 (21.7%) were ungraded statements. Altogether, only 22 (19.1%) of recommendations reached the \"A\" or \"B\" levels of quality of evidence. The pediatric kidney transplant recipients are different from adult recipients regarding the primary kidney diseases, surgical techniques, drug metabolism, adherence to medications, growth and neurocognitive development and immunization needs prior to transplantation. DOI: 10.52547/ijkd.7179.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9117134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}