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Impact of Parents Cancer on Family Communication Models from Adolescents' Perspective 从青少年角度看父母癌症对家庭沟通模式的影响
IF 0.4 4区 医学 Pub Date : 2023-08-18 DOI: 10.32592/ircmj.2023.25.10.2202
Background: Cancer is a common and fatal disease that affects family members, especially adolescents, and causes changes in family communication patterns Objectives: To investigate the impact of parental cancer on family communication patterns from the adolescents' perspective. Methods: The present study was a descriptive correlational study conducted on one hundred adolescents with parents with cancer who were selected by available sampling method. The research instruments were a demographic questionnaire and a revised standard questionnaire of the Ritchie and Fitzpatrick family communication model. The information was analysed using S.P.S.S. version 16 software and descriptive statistics, analysis of variance, and correlation coefficient. Results: The proportion of consensual communication in the family was lowest (3%) and the proportion of laissez-faire communication in the family was highest (58%). The correlation is inverse in the number of children and in the range of treatment level, and a significant direct correlation is observed in the range of family communication pattern and child rank, but in other cases, the correlation coefficient shows no significant communication (p< 0/05). Conclusion: From the adolescents' perspective, most families whose parents have cancer move toward a laissez-faire family. In these families, there is a low level of conversation and harmony, there is little interaction between family members, and usually only a limited number of topics are discussed. Therefore, the importance of family communication during this time, especially with adolescents, should be emphasized through appropriate education of families whose parents have cancer.
背景:癌症是一种常见的致命疾病,会影响家庭成员,尤其是青少年,并导致家庭沟通模式的改变:从青少年的角度研究父母患癌对家庭沟通模式的影响。研究方法本研究是一项描述性相关研究,通过抽样方法选取了 100 名父母患有癌症的青少年作为研究对象。研究工具为人口统计学问卷和里奇与菲茨帕特里克家庭沟通模式修订版标准问卷。使用 S.P.S.S. 16 版软件和描述性统计、方差分析及相关系数对信息进行分析。结果如下家庭中同意沟通的比例最低(3%),而家庭中放任沟通的比例最高(58%)。在儿童人数和治疗水平范围内,相关性呈反比,在家庭沟通模式和儿童等级范围内,观察到显著的直接相关,但在其他情况下,相关系数显示沟通不显著(P< 0/05)。结论从青少年的角度来看,大多数父母患癌的家庭都趋向于自由放任型家庭。在这些家庭中,交谈与和谐的程度很低,家庭成员之间很少互动,通常只讨论有限的几个话题。因此,应通过对父母罹患癌症的家庭进行适当的教育,强调这一时期家庭沟通的重要性,尤其是与青少年的沟通。
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引用次数: 0
Curative Effect of Lateral Transforaminal Endoscopy on the Treatment of Thoracic Disc Herniation 外侧经椎间孔内窥镜治疗胸椎椎间盘突出症的疗效
IF 0.4 4区 医学 Pub Date : 2023-08-18 DOI: 10.32592/ircmj.2023.25.9.2673
Background: The importance of lateral transforaminal endoscopic treatment of thoracic disc herniation lies in the fact that the use of a needle can remove some of the disc contents and cause the disc herniation to disappear. The present study aimed to evaluate the effect of percutaneous endoscopy on the treatment of patients with thoracic disc herniation. Objectives: To investigate the clinical efficacy and feasibility of transforaminal endoscopic discectomy in the treatment of thoracic disc herniation Methods: This retrospective analysis was conducted on patients with thoracic hernias between January 2014 and December 2019. A total of 13 operative cases were selected via census sampling. Lateral endoscopic treatment of thoracic disc herniation was performed on patients, and they were followed up for 6-18 months. All patients were assessed by the visual analog scale Visual Analogue Score (VAS) and Oswestry Disability Index (ODI) before the surgery, as well as one week, three months, and six months after the operation, respectively. Results: The sample included 13 patients with a mean age of 60.3 years. The location of the thoracic disc herniation varied among the patients. The VAS scores before the surgery, as well as one week, three months, and six months after the surgery, were 7±0.8, 3.3±0.6, 2.3±0.8, 1.4±0.3, and 1.3±0.4, respectively, pointing to a significant decrease (P≤0.001). The ODI scores before the surgery, one day after surgery, one week after surgery, three months after surgery, and six months after surgery were 65.2±5.8%, 11.5±5.3%, 8.9±3.3%, 5.3±2.5, and 4.7±3.5, demonstrating a significant decrease (P≤0.001). The score of the Macnab standard, a rating system evaluating the effectiveness of spine surgeries, was also satisfactory. Conclusion: As evidenced by the results of this study, percutaneous endoscopy in the treatment of patients with thoracic disc herniation was able to improve the clinical condition of patients and replace the previous methods of thoracic hernia surgery as an effective, efficient, and safe method.
背景:侧经椎间孔内窥镜治疗胸椎椎间盘突出症的重要性在于,使用一根针可以取出部分椎间盘内容物,使椎间盘突出消失。本研究旨在评估经皮内窥镜对治疗胸椎间盘突出症患者的效果。研究目的研究经椎间孔内窥镜椎间盘切除术治疗胸椎间盘突出症的临床疗效和可行性:对2014年1月至2019年12月期间的胸椎疝患者进行回顾性分析。通过普查抽样共选取了13例手术病例。对患者进行了胸椎椎间盘突出症的侧内窥镜治疗,并随访6-18个月。所有患者术前、术后一周、三个月和六个月分别接受视觉模拟量表视觉模拟评分(VAS)和Oswestry残疾指数(ODI)评估。研究结果样本包括 13 名患者,平均年龄为 60.3 岁。患者胸椎椎间盘突出的位置各不相同。术前、术后一周、三个月和六个月的 VAS 评分分别为 7±0.8、3.3±0.6、2.3±0.8、1.4±0.3 和 1.3±0.4,显著下降(P≤0.001)。术前、术后1天、术后1周、术后3个月和术后6个月的ODI评分分别为65.2±5.8%、11.5±5.3%、8.9±3.3%、5.3±2.5和4.7±3.5,均有明显下降(P≤0.001)。评估脊柱手术有效性的评分系统 Macnab 标准的得分也令人满意。结论本研究结果表明,经皮内窥镜治疗胸椎椎间盘突出症患者能够改善患者的临床状况,取代以往的胸椎疝手术方法,是一种有效、高效、安全的方法。
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引用次数: 0
Clinical Profile and Quality of Life in Patients with Resistant to Treatment Vitiligo Lesions in Iran: Vitiligo Patients need Medico-psycho-social Assistance 伊朗难治性白癜风患者的临床概况和生活质量:白癜风患者需要医疗-心理-社会援助
IF 0.4 4区 医学 Pub Date : 2023-08-14 DOI: 10.32592/ircmj.2023.25.9.2626
Background: Vitiligo is a common chronic disease associated with physical effects, psychological impacts, and impaired quality of life (QoL). Lesions in acral areas are resistant to treatments. Since these areas are exposed and visible, they have a profound effect on patients' self-confidence. Despite the high prevalence of these conditions, information in this field, especially for Iranian patients, is scarce. Objectives: To study the clinical profile of patients with vitiligo lesions in the acral areas, assess the burden of QoL impairment, and investigate the association between patient's characteristics and their QoL outcomes Methods: A total of 84 patients with non-segmental vitiligo who had involvement in resistant treatment areas were recruited in this study. Clinical characteristics and disease outcomes, with a special emphasis on the quality of life (QoL), were investigated using the Dermatology Life Quality Index (DLQI) questionnaire. Furthermore, the extent of the disease was calculated by utilizing the Vitiligo Area Scoring Index (VASI). Descriptive and comparative analyses were conducted using SPSS software (version 29). Results: The most common comorbidity observed among the patients was various types of immune diseases. The mean total score of DLQI was 8.1, indicating a moderate effect of the disease on the patient's life since the score falls within the range of 6-10. The Kruskal-Wallis non-parametric test illustrated a significant difference in QoL among different age groups (P=0.020). The results indicated a positive, direct, and significant relationship between the extent of the disease and DLQI (r=0.269,;P=0.013). Nonetheless, the relationship between the engagement of the genital area in married patients and difficulties in sexual relations was not found to be statistically significant at α=0.05. Conclusion: The involvement of end-extremities based on existing studies is a frequent occurrence in vitiligo. These affected areas hold considerable significance in terms of the patient's quality of life (QoL) due to their prominent visibility and resistance to available treatments. Considering the high prevalence of psychological consequences, diversity in skin phototypes, and social acceptance, regional studies are necessary for more efficient and responsive medical management integrated with psychosocial assistance.
背景:白癜风是一种常见的慢性疾病,与身体影响、心理影响和生活质量(QoL)受损有关。痤疮部位的皮损对治疗具有抗药性。由于这些部位暴露在外,清晰可见,因此对患者的自信心产生了深远的影响。尽管这些病症的发病率很高,但这方面的信息却很少,尤其是针对伊朗患者的信息。研究目的研究尖锐湿疣部位白癜风皮损患者的临床概况,评估其 QoL 损伤的负担,并调查患者特征与其 QoL 结果之间的关联 方法:研究尖锐湿疣部位白癜风皮损患者的临床概况,评估其 QoL 损伤的负担,并调查患者特征与其 QoL 结果之间的关联:本研究共招募了84名累及抗药性治疗区的非节段性白癜风患者。研究人员使用皮肤科生活质量指数(DLQI)问卷调查了患者的临床特征和疾病预后,特别强调了生活质量(QoL)。此外,还利用白癜风面积评分指数(VASI)计算了疾病的范围。使用 SPSS 软件(29 版)进行了描述性分析和比较分析。结果患者中最常见的合并症是各种类型的免疫性疾病。DLQI 的平均总分为 8.1,表明疾病对患者生活的影响适中,因为得分在 6-10 分之间。Kruskal-Wallis 非参数检验表明,不同年龄组的患者在生活质量方面存在显著差异(P=0.020)。结果表明,疾病程度与 DLQI 之间存在正向、直接和显著的关系(r=0.269,;P=0.013)。然而,在α=0.05时,已婚患者生殖器部位的参与度与性关系困难之间的关系没有统计学意义。结论根据现有研究,白癜风患者的四肢末端经常受累。这些受累部位由于其明显的可见性和对现有治疗方法的耐受性,对患者的生活质量(QoL)具有相当重要的意义。考虑到心理后果的高发病率、皮肤光型的多样性以及社会的接受程度,有必要开展区域性研究,以便更有效、更有针对性地进行医疗管理,并将社会心理援助结合起来。
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引用次数: 0
Impact of Telehealth on Pregnant Women's Self-care, Self-efficacy, and Satisfaction during the COVID-19 Pandemic: A Quasi-experimental Study 在 COVID-19 大流行期间,远程保健对孕妇自我护理、自我效能和满意度的影响:准实验研究
IF 0.4 4区 医学 Pub Date : 2023-08-12 DOI: 10.32592/ircmj.2023.25.10.2982
Background: Pregnant women need correct information and skills for effective self-care and improved self-efficacy during pregnancy. Maternal training will raise women's awareness of pregnancy and childbirth, leading to higher self-efficacy. Objectives: The present study aimed to assess the impact of telehealth on pregnant women's self-care, self-efficacy, and satisfaction during the COVID-19 pandemic. Methods: This quasi-experimental study involved low-risk pregnant women selected from prenatal public clinics in Ahvaz, Iran. Eligible pregnant women (n=150) were assigned to three groups: WhatsApp training (n=50), phone call training (n=50), and control (n=50). Women in the three groups received four face-to-face prenatal care sessions based on the content recommended by the Iranian Ministry of Health. In addition to these four face-to-face sessions, four more virtual training sessions were held for the WhatsApp and phone call groups. Results: Raising the awareness of pregnant women through telephone counseling was found to not only increase their self-efficacy, self-care, and satisfaction but also reduce the need for in-person visits during the COVID-19 pandemic. Furthermore, a moderate positive correlation was observed between self-efficacy and self-care scores; moreover, they have a relatively negative weak correlation with face-to-face visits. Conclusion: The results of this study suggested that most pregnant women were satisfied with telehealth during the COVID-19 pandemic, and thanks to this type of care provision, their self-efficacy and self-care levels were high. Reduced face-to-face visits during the pandemic are the main advantage of telehealth.
背景:孕妇需要正确的信息和技能,以便在怀孕期间进行有效的自我保健和提高自我效能。孕产妇培训将提高妇女对怀孕和分娩的认识,从而增强自我效能感。研究目的本研究旨在评估 COVID-19 大流行期间远程保健对孕妇自我保健、自我效能和满意度的影响。研究方法这项准实验研究从伊朗阿瓦士的产前公共诊所中挑选了低风险孕妇参与。符合条件的孕妇(n=150)被分配到三个小组:WhatsApp培训组(人数=50)、电话培训组(人数=50)和对照组(人数=50)。根据伊朗卫生部推荐的内容,三组妇女接受了四次面对面的产前护理培训。除这四次面对面培训外,WhatsApp 组和电话组还进行了四次虚拟培训。结果研究发现,通过电话咨询提高孕妇的意识不仅能增强她们的自我效能感、自我保健意识和满意度,还能减少 COVID-19 大流行期间亲自到医院就诊的需求。此外,还观察到自我效能和自我护理得分之间存在中度正相关;而且,它们与面访之间存在相对较弱的负相关。结论这项研究的结果表明,在 COVID-19 大流行期间,大多数孕妇对远程保健感到满意,而且由于提供了这种保健服务,她们的自我效能感和自我保健水平都很高。在大流行期间减少面诊是远程保健的主要优势。
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引用次数: 0
Research on the Transitional Care Model-based Health Management Protocol for Patients after Sleeve Gastrectomy 基于过渡护理模式的袖状胃切除术后患者健康管理方案研究
IF 0.4 4区 医学 Pub Date : 2023-08-05 DOI: 10.32592/ircmj.2023.25.10.2807
Background: Postoperative care after sleeve gastrectomy is critical to a successful outcome because of the increasing popularity of the procedure in the treatment of obesity and related conditions. Objectives: The purpose of this study was to evaluate the effectiveness of a health intervention plan for sleeve gastrectomy patients based on the Transitional Care Model (TCM). Methods: This study was conducted from January 2021 to January 2022 at Mudanjiang Hospital. The study included a total of 72 patients who underwent sleeve gastric volume reduction. Patients were randomly divided into an intervention group (36 cases) and a control group (36 cases). The intervention group received care based on a health intervention plan, while the control group received routine care. Various assessments were performed on the first day of hospitalization and three months after surgery, such as questionnaires on general information, physical activity, eating behavior, quality of life, and adherence to implementation. Results: After the intervention, the intervention group showed significant improvements in total duration of physical activity, moderate-intensity activity, restrained eating, emotional eating, physical pain, mental health, and social functioning (p<0.05). However, there were no significant differences between groups in activity intensity, walking, external diet, physical functioning, physical role, general health, or vitality (p>0.05). Adherence to the health management protocol was significantly higher in the intervention group (p<0.05). Conclusion: The health intervention plan based on the transitional care model improves physical activity, eating behaviors, quality of life, and compliance in sleeve gastrectomy patients.
背景:袖带胃切除术在治疗肥胖症及相关疾病方面越来越受欢迎,因此术后护理对手术的成功至关重要。 研究目的本研究旨在评估基于过渡护理模式(TCM)的袖状胃切除术患者健康干预计划的有效性。 研究方法本研究于 2021 年 1 月至 2022 年 1 月在牡丹江医院进行。研究共纳入 72 例袖状胃切除术患者。患者被随机分为干预组(36 例)和对照组(36 例)。干预组接受基于健康干预计划的护理,而对照组则接受常规护理。在住院第一天和术后三个月进行了各种评估,如关于一般信息、体力活动、饮食行为、生活质量和执行情况的调查问卷。 结果显示干预后,干预组在体力活动总时长、中等强度活动、节制饮食、情绪化饮食、身体疼痛、心理健康和社会功能方面均有显著改善(P0.05)。干预组对健康管理方案的坚持率明显更高(P<0.05)。 结论基于过渡护理模式的健康干预计划可改善袖状胃切除术患者的体力活动、饮食行为、生活质量和依从性。
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引用次数: 0
Lessons from Flood Disaster Management of Khuzestan Province, Iran, Based on the Experiences of Policymakers: A Qualitative Study 基于决策者经验的伊朗胡齐斯坦省洪水灾害管理教训:定性研究
IF 0.4 4区 医学 Pub Date : 2023-08-05 DOI: 10.32592/ircmj.2023.25.10.2199
Background: Floods are among the most destructive crises in various countries, including Iran, and are considered a national issue. To reduce flood damages, the flood management process must be regularly reviewed and its problems be identified. Objectives: Therefore, the present study aimed to focus on flood management in April 2019 in Khuzestan province, Iran, to investigate the flood disaster management in Iran based on the experiences of policymakers, identify problems, improve the process of flood disaster management, and reduce damage in the future. Methods: This study was designed based on qualitative content analysis. Data was collected using one-on-one, semi-structured interviews with open-ended questions. According to the targeted sampling method, six policymakers related to the Khuzestan flood disaster management in April 2019 were selected as interviewees. Interviews continued until data saturation. Results: After data analysis, three main themes were identified, namely 1) actions before the flood disaster, such as provision of infrastructure and public awareness, 2) actions during the flood disaster, such as flood disaster level assessment and coordination of actions, and 3) actions after the flood disaster, such as damage assessment. It should be mentioned that each theme included sub-themes and categories. Conclusion: Increased effectiveness of disaster management requires integration and centralization of disaster management and coordination between organizations involved in the disaster at all stages of disaster management, including before, during, and after the disaster. It is also necessary to pay attention to research and successful models and implement preparedness programs along with disaster drills to prevent disaster damage. Engagement of the participation of people should be considered as well.
背景:洪水是包括伊朗在内的各国最具破坏性的危机之一,被视为国家问题。为了减少洪水造成的损失,必须定期审查洪水管理程序并找出其中存在的问题。 目标:因此,本研究旨在关注伊朗胡齐斯坦省 2019 年 4 月的洪水管理情况,根据决策者的经验调查伊朗的洪水灾害管理情况,找出问题,改进洪水灾害管理过程,减少未来的损失。 研究方法:本研究采用定性内容分析法。采用一对一、半结构化访谈和开放式问题的方式收集数据。根据有针对性的抽样方法,选取了六位与 2019 年 4 月胡齐斯坦省洪水灾害管理相关的政策制定者作为受访者。访谈一直持续到数据饱和为止。 结果:经过数据分析,确定了三大主题,即:1)洪水灾害前的行动,如提供基础设施和提高公众意识;2)洪水灾害期间的行动,如洪水灾害等级评估和行动协调;3)洪水灾害后的行动,如损失评估。值得一提的是,每个主题都包括子主题和类别。 结论要提高灾害管理的有效性,就必须在灾害管理的各个阶段(包括灾前、灾中和灾后)实现灾害管理的一体化和集中化,以及参与灾害管理的各组织之间的协调。还必须重视研究和成功模式,在实施备灾计划的同时开展灾害演习,以防止灾害造成损失。还应该考虑让人们参与进来。
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引用次数: 0
Application of ALCOCK Tube Ultrasound-guided Internal Pudendal Nerve Block in Postoperative Anal Analgesia ALCOCK 管超声引导下的耻骨内神经阻滞在术后肛门镇痛中的应用
IF 0.4 4区 医学 Pub Date : 2023-08-05 DOI: 10.32592/ircmj.2023.25.8.2675
Background: While surgery is the most effective treatment for anorectal diseases, traditional anesthesia methods are increasingly regarded not suitable for the clinical needs of anorectal patients. Although pudendal nerve block can play a good analgesic role in the anal region, the traditional pudendal nerve block is performed under blind probing, which is inaccurate in positioning, has poor anesthesia effect, and causes many complications. Objectives: At present, ultrasound-guided pudendal nerve block for analgesia has emerged in clinical practice. Therefore, the present study aimed to investigate the analgesic effect of ALCOCK tube ultrasound-guided internal pudendal nerve block in anal surgery. Methods: A prospective study was conducted. A total of 134 patients who underwent anal surgery in Hangzhou Lin'an District First People's Hospital from May, 2021 to July, 2022 were divided into three categories according to mixed hemorrhoids, anal fistula, and anal fissure and randomly divided into control and experimental groups. The two groups were treated with corresponding surgical treatment, and the experimental group was treated with bilateral pudendal nerve block under the guidance of ALCOCK tube ultrasound at the end of the operation. The operation time, blood loss, initial postoperative pain time, and visual analogue scale, postoperative pain score at each time point, incidence of complications, and patient satisfaction were recorded and analyzed. Results: The operation time of the experimental group was significantly longer than that of the control group, the bleeding volume of anal fistula in the experimental group was more than the control group, the first pain time of anal fistula in the experimental group was higher than that of the control group. The first pain score of anal fistula in the experimental group was lower than that of the control group. Follow-up showed that the pain scores of anal fistula and anal fissure groups were inconsistent 48 h after surgery. The total incidence of adverse reactions was lower, and the patient satisfaction was higher in the experimental group than in the control group. Conclusion: The application of internal pudendal nerve block under the guidance of ALCOCK tube ultrasound in anal surgery has a good analgesic effect and high patient satisfaction, which is worthy of promotion.
背景:手术是治疗肛肠疾病最有效的方法,但传统的麻醉方法越来越被认为不适合肛肠患者的临床需要。虽然阴部神经阻滞能在肛门区域发挥良好的镇痛作用,但传统的阴部神经阻滞是在盲探的情况下进行的,定位不准确,麻醉效果差,并发症多。 研究目的目前,临床上出现了超声引导下的阴部神经阻滞镇痛。因此,本研究旨在探讨 ALCOCK 管超声引导下的阴茎内神经阻滞在肛门手术中的镇痛效果。 研究方法采用前瞻性研究方法。将 2021 年 5 月至 2022 年 7 月在杭州市临安区第一人民医院接受肛肠手术的 134 例患者按照混合痔、肛瘘、肛裂分为三类,随机分为对照组和实验组。两组均采用相应的手术治疗,实验组手术结束后在ALCOCK管超声引导下行双侧阴部神经阻滞治疗。记录并分析手术时间、失血量、术后初始疼痛时间以及各时间点的视觉模拟量表、术后疼痛评分、并发症发生率和患者满意度。 结果实验组手术时间明显长于对照组,实验组肛瘘出血量多于对照组,实验组肛瘘首次疼痛时间高于对照组。实验组肛瘘首次疼痛评分低于对照组。随访显示,肛瘘组和肛裂组术后 48 h 的疼痛评分不一致。实验组不良反应总发生率低于对照组,患者满意度高于对照组。 结论在ALCOCK管超声引导下应用阴茎内神经阻滞治疗肛肠手术,镇痛效果好,患者满意度高,值得推广。
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引用次数: 0
Efficacy and Safety of Immediate Latissimus Dorsi Breast Reconstruction after Breast Cancer Surgery 乳腺癌术后即刻背阔肌乳房再造的有效性和安全性
IF 0.4 4区 医学 Pub Date : 2023-08-02 DOI: 10.32592/ircmj.2023.25.8.2817
Background: Most traditional breast reconstruction surgeries require the removal of the patient's own tissue or the use of artificial implants for reconstruction. The improvement of the efficiency and safety of breast reconstruction surgery assumes critical importance for the rehabilitation of breast cancer patients. Immediate latissimus dorsi breast reconstruction surgery, which utilizes the patient's own tissue to perform immediate reconstruction, can address this issue in a targeted manner, avoiding the cumbersome and complex nature of multiple surgeries. Objectives: To analyze the efficacy and safety of immediate latissimus dorsi breast reconstruction (BR) after breast cancer surgery. Methods: A total of 91 female patients with breast cancer diagnosed and treated by breast surgery in our hospital from August 2017 to July 2021 were retrospectively analyzed. The patients were assigned to the prosthetic implant group (n=39) and latissimus dorsi group (n=52) according to the method of immediate postoperative BR. The difference in curative effect can be analyzed by comparing the operation time, intraoperative bleeding, postoperative drainage time, and aesthetic evaluation of BR. The safety of postoperative BR was analyzed by comparing the postoperative complications, local recurrence rate, distant metastasis rate of breast cancer, and rehabilitation rate. Results: There was no dramatic difference in intraoperative bleeding, postoperative drainage time, and rehabilitation rate between the latissimus dorsi and prosthetic implantation groups (P>0.05). Nonetheless, there was a significant difference in operation time, aesthetic evaluation of BR, postoperative complications, local recurrence rate, and distant metastasis rate of breast cancer in the latissimus dorsi group than the prosthetic implant group(P<0.05). In general, the latissimus dorsi group exhibited better therapeutic effects. Conclusion: Immediate latissimus dorsi BR dramatically affects postoperative breast repair of breast cancer patients and is safer than prosthesis implantation. As an evaluation of their safety and effectiveness, it is necessary to provide patients with more stable and reliable medical outcomes to ensure their surgical safety.
背景:传统的乳房再造手术大多需要切除患者自身组织或使用人工植入物进行再造。提高乳房再造手术的效率和安全性对乳腺癌患者的康复至关重要。即刻背阔肌乳房重建手术利用患者自身组织进行即刻重建,可以有针对性地解决这一问题,避免多次手术的繁琐和复杂。 研究目的分析乳腺癌术后即刻背阔肌乳房再造术(BR)的有效性和安全性。 方法回顾性分析2017年8月至2021年7月在我院经乳腺外科诊治的乳腺癌女性患者共91例。根据术后即刻BR的方法将患者分为假体植入组(n=39)和背阔肌组(n=52)。通过比较手术时间、术中出血量、术后引流时间和 BR 的美学评价,分析治疗效果的差异。通过比较术后并发症、局部复发率、乳腺癌远处转移率和康复率,分析术后 BR 的安全性。 结果显示背阔肌植入组和假体植入组在术中出血量、术后引流时间和康复率方面没有显著差异(P>0.05)。然而,背阔肌组与假体植入组在手术时间、BR美学评价、术后并发症、乳腺癌局部复发率和远处转移率方面均有显著差异(P<0.05)。总体而言,背阔肌组的治疗效果更好。 结论即刻背阔肌BR对乳腺癌患者的术后乳房修复效果显著,且比假体植入更安全。作为对其安全性和有效性的评估,有必要为患者提供更稳定可靠的医疗结果,以确保其手术安全。
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引用次数: 0
In Silico and Experimental Outcomes of the Expression of miR508-5p and miR-635 in Tumor Tissues of Patients with Breast Cancer 乳腺癌患者肿瘤组织中 miR508-5p 和 miR-635 表达的硅学和实验结果
IF 0.4 4区 医学 Pub Date : 2023-07-30 DOI: 10.32592/ircmj.2023.25.8.2505
Fatemeh Zeinali Sehrig, Mohammad Zaefizadeh, C. Ahmadizadeh, M. Alivand, S. Ghorbian
Background: Breast cancer (BC) is a malignant tumor that occurs in the epithelial tissue of the breast gland and has become the most common malignancy in women. Various studies have reported the effect of epigenetic changes, including DNA methylation and microRNAs, on breast carcinogenesis. microRNAs play an important role in the post-transcriptional regulation of genes and are important regulators of oncogenic pathways. Studying microRNAs in BC facilitates the development of targeted therapies and early detection of this cancer. Objectives: This study aimed to evaluate the expression level of miR-508-5p and miR-635 in BC tumor tissues compared to healthy marginal tissues. Methods: In silico analysis confirmed microarray datasets (GSE40525, GSE44124 and GSE45666) downloaded from the GEO database. The analysis was defined using the Affy packages in R software to screen remarkably dysregulated miRNAs attended by utilized to predict the potential biological processes and molecular pathways of miR-508-5p and miR-635. Experimental statistical significance of differences in miRNA relative expression results was analyzed by pair-wise fixed reallocation randomization test as a statistical model included in the REST (relative expression software tool). Results: GEO microarray data set, similar to qPCR results, showed that miR-508-5p was downregulated in the sample group by a mean factor of 0.327 (S.E.M range is 0.031-2.000). Moreover, miR-635 was upregulated in the sample group by a mean factor of 2.361 (S.E.M range is 0.250-16.000). Conclusion: miR-508-5p was downregulated, while miR-635 was upregulated in BC tissues. They may be proposed as diagnostic and therapeutic biomarkers for patients with BC.
背景:乳腺癌(BC)是发生在乳腺上皮组织的恶性肿瘤,已成为女性最常见的恶性肿瘤。microRNAs在基因转录后调控中发挥着重要作用,是致癌通路的重要调节因子。研究 BC 中的 microRNAs 有助于开发靶向疗法和早期检测这种癌症。 研究目的本研究旨在评估与健康边缘组织相比,miR-508-5p 和 miR-635 在 BC 肿瘤组织中的表达水平。 方法从 GEO 数据库下载微阵列数据集(GSE40525、GSE44124 和 GSE45666),并对其进行硅分析确认。使用 R 软件中的 Affy 软件包进行分析,筛选出明显失调的 miRNAs,并利用这些 miRNA 预测 miR-508-5p 和 miR-635 的潜在生物学过程和分子通路。miRNA 相对表达结果差异的实验统计意义是通过 REST(相对表达软件工具)中包含的统计模型--成对固定再分配随机化检验来分析的。 结果与 qPCR 结果相似,GEO 微阵列数据集显示,样本组中 miR-508-5p 的平均下调因子为 0.327(S.E.M 范围为 0.031-2.000)。此外,样本组中 miR-635 的平均上调因子为 2.361(S.E.M 范围为 0.250-16.000)。 结论:在 BC 组织中,miR-508-5p 下调,而 miR-635 上调。它们可作为诊断和治疗 BC 患者的生物标记物。
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引用次数: 0
Designing a Model to Predict the Mortality in Multiple Trauma Patients due to Traffic Accidents 设计一个模型来预测交通事故导致的多发性创伤患者的死亡率
IF 0.4 4区 医学 Pub Date : 2023-07-30 DOI: 10.32592/ircmj.2023.25.10.2299
Background: It is of prime importance to manage trauma patients in the early hours and use easy trauma severity scoring systems to make decisions and evaluate patient prognosis. Objectives: The present study aimed to design a predictive model of the mortality of multi-trauma patients due to traffic accidents. Methods: This cross-sectional analytical study was performed on 600 patients who suffered from multi-trauma caused by traffic accidents from December 2019 to September 2021. Collected data included age, sex, vital signs, trauma mechanism, involved vehicle in the accident, accident location, and hospital outcome. Results: In this study, 600 multi-trauma cases caused by traffic accidents were evaluated. Among the significant variables included in the regression model, age, Mean Arterial Pressure (MAP), Glasgow Coma Scale (GCS), AVPU (Alert, Verbal response, Pain response, Unresponsive), and vehicle versus fixed objects (in Vehicle 2) in the presence of other variables in the model, significantly predicted patient outcomes. Therefore, with the other variables being constant, one unit increase in the age variable increases the probability of death by 1.04 times, one unit increase in the score of the two variables of MAP and GCS, and also the transfer of trauma mechanism from the fixed object to the vehicle reduces death by 0.92, 0.62, and 0.10 times, respectively. In the AVPU variable, the transition from Alert to Verbal, the transition from Verbal to Pain, and the transition from Pain to Unresponsive increases the probability of death by 32, 104, and 567, respectively. Conclusion: In this study, AVPU, age, MAP, primary GCS, and trauma mechanism due to hitting a vehicle with a fixed object had significantly the highest predictive power of hospital mortality in patients with multiple trauma due to traffic accidents, respectively. It is suggested that further studies be performed to replace the AVPU variable with GCS in the newly designed formulas for calculating the severity of trauma to simplify these scores.
背景:最重要的是在早期对创伤患者进行管理,并使用简便的创伤严重程度评分系统来做出决定和评估患者的预后。研究目的本研究旨在设计一个预测交通事故导致的多发性创伤患者死亡率的模型。方法:本横断面分析研究的对象是 2019 年 12 月至 2021 年 9 月期间因交通事故造成的 600 名多发性创伤患者。收集的数据包括年龄、性别、生命体征、创伤机制、事故车辆、事故地点和住院结果。研究结果本研究评估了 600 例因交通事故造成的多发创伤病例。在回归模型中包含的重要变量中,年龄、平均动脉压(MAP)、格拉斯哥昏迷量表(GCS)、AVPU(警觉、语言反应、疼痛反应、无反应)以及车辆与固定物体(在车辆 2 中)在模型中存在其他变量的情况下,可显著预测患者的预后。因此,在其他变量不变的情况下,年龄变量每增加一个单位,死亡概率就会增加 1.04 倍,MAP 和 GCS 两个变量的得分每增加一个单位,以及将创伤机制从固定物体转移到车辆上,死亡概率就会分别降低 0.92 倍、0.62 倍和 0.10 倍。在 AVPU 变量中,从 "警觉 "到 "言语"、从 "言语 "到 "疼痛 "以及从 "疼痛 "到 "无反应 "分别会使死亡概率增加 32、104 和 567 倍。结论在本研究中,AVPU、年龄、MAP、主要 GCS 和因固定物体撞车导致的创伤机制分别对交通事故导致的多发创伤患者的住院死亡率具有显著的最高预测能力。建议开展进一步研究,在新设计的创伤严重程度计算公式中用 GCS 取代 AVPU 变量,以简化这些评分。
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引用次数: 0
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Iranian Red Crescent Medical Journal
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