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Predictive Modeling using ARX and ARMAX Models for Glycemic Control in Intensive Care Unit Patients 应用ARX和ARMAX模型对重症监护病房患者血糖控制进行预测建模
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079420
M.Z. Syatirah, M. Fatanah, M.Z. N. Jihan, M.M. Zulfakar, E. Seniz, M. Farhah
Several studies have been venturing into developing a model for controlling blood glucose among diabetes patients. It is because diabetes mellitus is a severe and common chronic disease affecting almost all populations in many countries. This study collected retrospective clinical data from five patients receiving insulin therapy in the ICU of HUSM. The auto-regressive with exogenous (ARX) and auto-regressive moving average with exogenous (ARMAX) model structure techniques were used to generate a model converter that best describes the glucose and insulin relationship of the subject. The simulation of ARX were started from model order (1,1,1) to model order (5,5,10) while, for ARMAX the simulation was started from model order (1,1,1,1) until model order (5,5,5,10). The three best model orders from ARX and ARMAX models were chosen. The best model fits for ARX and ARMAX were compared to identify the best model order in predicting the glucose-insulin system. The finding indicated that the ARX model recorded the best model fit for all patients in the 5th model order. Meanwhile, the ARMAX model recorded patients with different medical backgrounds and produced a different model order. Besides, the ARMAX model was considered the best option for most of the patients in this study due to the highest model fit, time-delay and lowest percentage of peak error. A more extensive data set may be required to ensure the structure of the model precisely describe the glucose-insulin interaction of the patient.Clinical Relevance– This study establishes a prediction model of the glucose-insulin system that can assist clinicians in providing appropriate insulin value and consequently reduce the incidence of hypoglycemia and hyperglycemia.
有几项研究一直在尝试开发一种控制糖尿病患者血糖的模型。这是因为在许多国家,糖尿病是一种影响几乎所有人口的严重和常见的慢性疾病。本研究收集了5例在我院ICU接受胰岛素治疗的患者的回顾性临床资料。采用自回归带外源性(ARX)和自回归带外源性移动平均(ARMAX)模型结构技术生成最能描述受试者葡萄糖和胰岛素关系的模型转换器。ARX的仿真是从模型阶(1,1,1)开始到模型阶(5,5,10),而ARMAX的仿真是从模型阶(1,1,1,1)开始到模型阶(5,5,10)。从ARX和ARMAX型号中选出了三个最佳型号订单。比较了ARX和ARMAX的最佳拟合模型,以确定预测葡萄糖-胰岛素系统的最佳模型顺序。结果表明,ARX模型对所有患者的第5阶模型拟合最好。同时,ARMAX模型记录了不同医学背景的患者,产生了不同的模型顺序。此外,由于ARMAX模型具有最高的模型拟合、时滞和最低的峰值误差百分比,因此在本研究中大多数患者被认为是最佳选择。可能需要更广泛的数据集来确保模型的结构精确地描述患者的葡萄糖-胰岛素相互作用。临床意义-本研究建立了葡萄糖-胰岛素系统的预测模型,可以帮助临床医生提供合适的胰岛素值,从而降低低血糖和高血糖的发生率。
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引用次数: 0
Vector-Quantized Zero-Delay Deep Autoencoders for the Compression of Electrical Stimulation Patterns of Cochlear Implants using STOI 矢量量化零延迟深度自编码器在人工耳蜗电刺激模式压缩中的应用
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079466
Reemt Hinrichs, Felix Ortmann, Jörn Ostermann
Cochlear implants (CIs) are battery-powered, surgically implanted hearing-aids capable of restoring a sense of hearing in people suffering from moderate to profound hearing loss. Wireless transmission of audio from or to signal processors of cochlear implants can be used to improve speech understanding and localization of CI users. Data compression algorithms can be used to conserve battery power in this wireless transmission. However, very low latency is a strict requirement, limiting severly the available source coding algorithms. Previously, instead of coding the audio, coding of the electrical stimulation patterns of CIs was proposed to optimize the trade-off between bit-rate, latency and quality. In this work, a zero-delay deep autoencoder (DAE) for the coding of the electrical stimulation patters of CIs is proposed. Combining for the first time bayesian optimization with numerical approximated gradients of a nondifferential speech intelligibility measure for CIs, the short-time intelligibility measure (STOI), an optimized DAE architecture was found and trained that achieved equal or superior speech understanding at zero delay, outperforming well-known audio codecs. The DAE achieved reference vocoder STOI scores at 13.5 kbit/s compared to 33.6 kbit/s for Opus and 24.5 kbit/s for AMR-WB.
人工耳蜗(CIs)是一种通过手术植入的电池供电的助听器,能够帮助患有中度到重度听力损失的人恢复听力。通过人工耳蜗信号处理器之间的音频无线传输,可以提高人工耳蜗用户的语音理解和定位能力。在这种无线传输中,可以使用数据压缩算法来节省电池电量。然而,非常低的延迟是一个严格的要求,严重限制了可用的源编码算法。以前,为了优化比特率、延迟和质量之间的权衡,提出了对ci的电刺激模式进行编码,而不是对音频进行编码。在这项工作中,提出了一个零延迟深度自编码器(DAE)编码的电刺激模式的ci。首次将贝叶斯优化与CIs的非差分语音可理解度度量(短时可理解度度量(STOI))的数值近似梯度相结合,发现并训练了一个优化的DAE架构,该架构在零延迟下实现了同等或更好的语音理解,优于知名的音频编解码器。DAE实现了参考声码器STOI分数为13.5 kbit/s,而Opus为33.6 kbit/s, AMR-WB为24.5 kbit/s。
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引用次数: 1
A FastDTW Based Lightweight Limb Motion Function Assessment Method 基于FastDTW的轻量级肢体运动功能评估方法
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079373
Guorui Xu, S. Mahmoud, Akshay Kumar, Qiang Fang
Stroke is a severe cerebrovascular disease caused by the disruption of blood supply to the brain. To provide Inhome rehabilitation, it is essential to solve the problem of high rehabilitation cost and improve the rehabilitation efficacy. The training quality assessment is the core part of an in-home based training system as it provides important feedback which can be used by both the doctors and the patients. Furthermore, patients can conduct training in a comfortable, familiar environment. In this paper, a fast-training motion quality evaluation algorithm is proposed for the motion data captured by an accelerometer-based sensor network. The experiment results show that the evaluation result from the proposed system is within a satisfactory error range compared with that obtained by using the commercial X-sens system. The presented fast and efficient quantitative assessment method could be used for implementing a networked regional in-home rehabilitation system covering multiple users. Clinical Relevance– A fast and efficient upper limb assessment framework is proposed to support the development of a massive telerehabilitation system. Clinical Relevance – A fast and efficient upper limb assessment framework is proposed to support the development of a massive telerehabilitation system.
中风是一种严重的脑血管疾病,由大脑血液供应中断引起。提供居家康复,解决康复费用高的问题,提高康复效果是必不可少的。培训质量评估是家庭培训系统的核心部分,它为医生和患者提供了重要的反馈信息。此外,患者可以在舒适、熟悉的环境中进行训练。针对基于加速度计的传感器网络捕获的运动数据,提出了一种快速训练运动质量评价算法。实验结果表明,与商用X-sens系统的评价结果相比,该系统的评价结果在满意的误差范围内。所提出的快速有效的定量评估方法可用于实现覆盖多用户的网络化区域家庭康复系统。临床相关性-提出了一个快速有效的上肢评估框架,以支持大规模远程康复系统的发展。临床相关性-提出了一个快速有效的上肢评估框架,以支持大规模远程康复系统的发展。
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引用次数: 0
Convolution Neural Network Performance in Recognising EEG Signals of Dyslexic Children 卷积神经网络在难语儿童脑电信号识别中的应用
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079531
W. Mansor, A. Z. Ahmad Zainuddin, M. F. Mohd Hanafi
Dyslexia diagnosis in children could not be performed in the absence of a specialist. This issue can be overcome with the use of advanced technology. Using convolution neural networks (CNN), the automatic classification of dyslexia from electroencephalogram (EEG) can be achieved. The role of the CNN and EEG in distinguishing dyslexia in children has not been explored. This study reveals the performance of CNN in recognising EEG signals of dyslexic and normal children using raw signals. The recorded EEG signals were passed through Short-Time Fourier Transform Analysis to transform the signals into images, which were then served as the input of the CNN. It was found that the CNN could recognise the EEG signals of dyslexic children with an accuracy of 80.9% and 72.1% using training and testing data, respectively.
儿童阅读障碍的诊断不能在没有专家的情况下进行。这个问题可以通过使用先进技术来解决。利用卷积神经网络(CNN)可以实现从脑电图(EEG)中对阅读障碍的自动分类。CNN和EEG在鉴别儿童阅读障碍中的作用尚未被探讨。本研究揭示了CNN在使用原始信号识别诵读困难儿童和正常儿童脑电图信号中的表现。将记录的脑电图信号进行短时傅里叶变换分析,将信号转化为图像,作为CNN的输入。使用训练数据和测试数据发现,CNN对失读症儿童脑电图信号的识别准确率分别为80.9%和72.1%。
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引用次数: 0
Structural, Electrical and Raman Characterization of AgNP-coated Porous Silicon SERS Substrate for Detection of Dengue NS1 Protein agnp包覆多孔硅SERS基底检测登革热NS1蛋白的结构、电学和拉曼表征
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079329
N. F. Ismail, K. Y. Lee, L. N. Ismail, A. F. Abdul Rahim, N. S. Mohamad Hadis, A. Radzol
Surface Enhanced Raman Spectroscopy (SERS) is a specific and sensitive analytic technique suitable for detection of low concentration analyte. However, the performance of SERS is highly dependent on the type of SERS substrate used. In this study, solid base SERS substrates are fabricated for detection of low concentration dengue non-structural protein 1 (NS1) in saliva. Using an n-type phosphorous dopant, microstructural porous silicon (PSi) was fabricated using direct current electrochemical method. The PSi was deposited with different sizes of silver nanoparticles (AgNP) to increase the strength of electromagnetic field on the PSi surface. Here, the structural, electrical and Raman characterization of the fabricated AgNP coated PSi are presented. FESEM images show the cross-shaped surface structure of the substrate. The I-V curve reveals that the 75nm-AgNP samples produce better electrical conductivity property than the others. It is also observed that etching longer than a threshold reduces the conductivity performance of the substrate substantially, due to increase in the surface porosity. From Raman spectrum, the silicon peak at 520cm-1 shows a decreasing trend in intensity for samples with 30 min of etching. Interestingly, this observation complements that reported in our previous paper, where etching time of more than 28 min is found not suitable for producing uniform structure of PSi. The consistency between the structural, conductivity and Raman intensity can be used as indicators in developing good SERS substrate for non-invasive detection of low concentration dengue NS1 protein in saliva.
表面增强拉曼光谱(SERS)是一种特异、灵敏的分析技术,适用于低浓度分析物的检测。然而,SERS的性能高度依赖于所使用的SERS衬底的类型。本研究制备了固体基SERS底物,用于检测唾液中低浓度登革热非结构蛋白1 (NS1)。以n型磷掺杂剂为原料,采用直流电化学法制备了微结构多孔硅。在PSi表面沉积不同尺寸的银纳米粒子(AgNP),以增加PSi表面的电磁场强度。本文介绍了制备的AgNP包覆PSi的结构、电学和拉曼特性。FESEM图像显示了基板的十字形表面结构。I-V曲线显示,75nm-AgNP样品的导电性能优于其他样品。还观察到,由于表面孔隙率的增加,蚀刻时间超过阈值会大大降低衬底的导电性。从拉曼光谱上看,在520cm-1处的硅峰强度在蚀刻30min后呈下降趋势。有趣的是,这一观察结果补充了我们在之前的论文中报道的,其中发现超过28分钟的蚀刻时间不适合产生均匀结构的PSi。结构、电导率和拉曼强度之间的一致性可作为开发良好的SERS底物的指标,用于唾液中低浓度登革热NS1蛋白的无创检测。
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引用次数: 0
Bicubic Interpolation and Gradient-based Edge Detection with Skeletonization Segmentation (Bicubic-GES) on MR Optic Nerve Images for Examining NMOSD 基于双三次插值和梯度边缘检测的MR视神经图像骨架分割(Bicubic- ges)检测NMOSD
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079643
Yang Feng, L. Chow, S. S. Tiang, N. Ramli, Nadia Muhammad Gowdh, L. Tan, Suhailah Abdullah
The post-processing of optic nerve Magnetic Resonance (MR) images is very challenging due to their small size and the surrounding cerebrospinal fluid (CSF). This study proposed a new segmentation method called gradient-based edge detection with skeletonization (GES), which is specifically designed to segment the optic nerve acquired with T1-weighted magnetization-prepared 180° radio-frequency pulses and rapid gradient-echo (MPRAGE) without fat saturation (FATSAT). GES identifies the edges of the optic nerve based on the largest gradient changes of signal intensity from one region (optic nerve) to another region (CSF). The proposed GES method performed better than the well-known level set method (LSM) with higher Dice similarity coefficient (DSC) of 0.80 - 0.85 compared to 0.61 – 0.77 using LSM. Bicubic interpolation with a factor of 8 was applied before the segmentation process to increase the spatial resolution of the optic nerve. Five datasets of NMOSD patients, clinically diagnosed optic neuritis, were used in this study. The bicubic-GES processed optic nerve images were used for the area and volume measurements on the intraorbital portion of both left and right optic nerves. The measurement results were used to study the effect of Neuromyelitis Optica Spectrum Disorder (NMOSD) on the optic nerve The NMOSD causes optic neuritis and demyelination in the optic nerve. This study found that the affected optic nerve has a smaller volume than the normal contralateral optic nerve. Clinical Relevance — This study provides an additional tool to confirm the diagnosis of optic neuritis in NMOSD patients through the volume measurement on bicubic-GES processed optic nerve MR images.
视神经磁共振(MR)图像由于其体积小且周围有脑脊液(CSF),因此后处理非常具有挑战性。本研究提出了一种新的分割方法,称为基于梯度的边缘检测与骨架化(GES),该方法专门用于分割由t1加权磁化制备的180°射频脉冲和无脂肪饱和(FATSAT)快速梯度回波(MPRAGE)获得的视神经。GES根据信号强度从一个区域(视神经)到另一个区域(脑脊液)的最大梯度变化来识别视神经边缘。该方法的骰子相似系数(DSC)为0.80 ~ 0.85,高于LSM方法的0.61 ~ 0.77。在分割前采用因子为8的双三次插值,提高视神经的空间分辨率。本研究使用了临床诊断为视神经炎的NMOSD患者的5个数据集。利用双立方- ges处理后的视神经图像测量左右视神经眶内部分的面积和体积。测量结果用于研究视神经脊髓炎视谱障碍(NMOSD)对视神经的影响,NMOSD引起视神经炎和视神经脱髓鞘。本研究发现,受影响的视神经体积小于正常对侧视神经。临床意义:本研究提供了一种额外的工具,通过测量立方- ges处理视神经MR图像的体积来确认NMOSD患者视神经炎的诊断。
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引用次数: 0
Inefficacy Prediction of Alpha Up-Regulation Neurofeedback Training Using Eyes-Open Resting State Wavelet Features and Machine Learning 基于闭眼静息状态小波特征和机器学习的α上调神经反馈训练无效预测
Pub Date : 2022-12-07 DOI: 10.1109/IECBES54088.2022.10079591
Hannan N. Riaz, H. Nisar, K. Yeap
Neurofeedback Training (NFT) is an effective way for the participants to self-regulate the Electroencephalography (EEG) activity based on real-time feedback. This procedure has been proven to improve the neurological disorders in mentally ill patients and the psychological behavior of healthy individuals. Despite the considerable success of neurofeedback techniques, it is observed that some subjects fail to learn how to control their brain activities during neurofeedback training. This study is aimed to investigate the EEG learning process in alpha neurofeedback as an early-stage predictor of learners and non-learners in terms of the enhancement of alpha-band activities. 25 healthy participants have been trained using alpha upregulations. 8 of them were unable to regulate their alpha band within each session. Hence in this work resting state eyes-open EEG is used to predict the learning performance of the NFT participants. Using machine learning. A comparison of three machine learning algorithms; LDA, SVM, and GBM is performed to predict the non-learners based on the absolute alpha power and its Daubechies (level-4) wavelet decompositions eyes-open resting state EEG signals.
神经反馈训练(NFT)是一种基于实时反馈的参与者自我调节脑电图活动的有效方法。这一过程已被证明可以改善精神疾病患者的神经障碍和健康个体的心理行为。尽管神经反馈技术取得了相当大的成功,但观察到一些受试者在神经反馈训练中未能学会如何控制他们的大脑活动。本研究旨在探讨脑电图学习过程作为学习者和非学习者在α波段活动增强方面的早期预测因子。25名健康的参与者接受了α上调的训练。其中8人无法在每次疗程中调节α波段。因此,本研究采用静息状态睁眼脑电图预测NFT参与者的学习表现。使用机器学习。三种机器学习算法的比较;基于绝对alpha功率及其Daubechies (level-4)小波分解睁眼静息状态脑电图信号,采用LDA、SVM和GBM对非学习者进行预测。
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引用次数: 0
Enhancing Deep Learning-based 3-lead ECG Classification with Heartbeat Counting and Demographic Data Integration 基于心跳计数和人口统计数据集成的深度学习增强三导联心电分类
Pub Date : 2022-08-15 DOI: 10.1109/IECBES54088.2022.10079267
Khiem H. Le, Hieu Pham, Thao Nguyen, Tu Nguyen, Cuong D. Do
An increasing number of people are being diagnosed with cardiovascular diseases (CVDs), the leading cause of death globally. The gold standard for identifying these heart problems is via electrocardiogram (ECG). The standard 12-lead ECG is widely used in clinical practice and most of the current research. However, using fewer leads can make ECG more pervasive as it can be integrated with portable or wearable devices. This article introduces two novel techniques to improve the performance of the current deep learning system for 3-lead ECG classification, making it comparable with models that are trained using standard 12-lead ECG. Specifically, we propose a multi-task learning scheme in the form of the number of heartbeats regression and an effective mechanism to integrate patient demographic data into the system. With these two advancements, we got classification performance in terms of F1 scores of 0.9796 and 0.8140 on two large-scale ECG datasets, i.e., Chapman and CPSC2018, respectively, which surpassed current state-of-the-art ECG classification methods, even those trained on 12-lead data. Our source code is available at github.com/lhkhiem28/LightX3ECG.
越来越多的人被诊断患有心血管疾病,这是全球死亡的主要原因。鉴别这些心脏问题的黄金标准是通过心电图(ECG)。标准的12导联心电图广泛应用于临床实践和目前的大多数研究。然而,使用更少的引线可以使ECG更加普及,因为它可以与便携式或可穿戴设备集成。本文介绍了两种新技术,以提高目前用于3导联ECG分类的深度学习系统的性能,使其与使用标准12导联ECG训练的模型相媲美。具体而言,我们提出了一种以心跳次数回归形式的多任务学习方案,并提出了一种将患者人口统计数据整合到系统中的有效机制。通过这两项进步,我们在Chapman和CPSC2018两个大型心电数据集上分别获得了0.9796和0.8140的F1分数的分类性能,超过了目前最先进的心电分类方法,即使是在12导联数据上训练的方法。我们的源代码可从github.com/lhkhiem28/LightX3ECG获得。
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引用次数: 2
期刊
2022 IEEE-EMBS Conference on Biomedical Engineering and Sciences (IECBES)
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