Iranian Journal of Reproductive Medicine最新文献

The status of depression and anxiety in infertile Turkish couples 土耳其不育夫妇的抑郁和焦虑状况

Iranian Journal of Reproductive Medicine

Pub Date : 2023-08-31 DOI: 10.18502/ijrm.v9i2.104

M. Kazandi, Ozlem Gunday, T. Mermer, Nuray Erturk, E. Ozkınay

Background: Infertility is a major psychosocial crisis as well as being a medical problem. The factors that predict psychosocial consequences of infertility may vary in different gender and different infertile populations. Objective: The primary purpose of this study was to investigate whether Turkish infertile couples had higher levels of depression and anxiety when compared to non-infertile couples. Our secondary aim was to evaluate the relationship between sociodemographic characteristics and levels of depression and anxiety in Turkish infertile couples. Materials and Methods: We designed a descriptive cross sectional study of 248 infertile women and 96 infertile men with no psychiatric disturbance and 51 women and 40 men who have children to evaluate the depression and anxiety levels between infertile couples and fertile couples. A gynecologist evaluated participants for demographic data and then they were visited by a psychologist to perform questionnaire scales which were The Beck Depression Inventory and the State-Trait Anxiety Inventory for the evaluation of the degree of psychopathology. The data were statistically analyzed, with p<0.05 as the level of statistical significance. Results: We observed significant differences between the infertile couples and fertile couples with respect to state and trait anxiety (p<0.0001) while no difference was regarding with depression, both of women and men. Anxiety and depression were observed as independent from gender when infertile women and men were compared (p=0.213). Conclusion: We believed that the psychological management at infertile couples must be individualized with cultural, religious, and class related aspects.

背景：不孕不育是一个主要的社会心理危机，也是一个医学问题。预测不孕心理社会后果的因素在不同性别和不同不孕人群中可能有所不同。目的：本研究的主要目的是调查土耳其不孕夫妇与非不孕夫妇相比是否有更高水平的抑郁和焦虑。我们的第二个目的是评估土耳其不孕夫妇的社会人口学特征与抑郁和焦虑水平之间的关系。材料和方法：我们设计了一项描述性的横断面研究，对248名不孕妇女和96名没有精神障碍的不孕男子以及51名有孩子的妇女和40名有子女的男子进行研究，以评估不孕夫妇和可生育夫妇之间的抑郁和焦虑水平。一名妇科医生评估了参与者的人口统计数据，然后由一名心理学家访问他们，对他们进行问卷调查，即贝克抑郁量表和状态特质焦虑量表，以评估精神病理学的程度。对数据进行统计学分析，统计学显著性水平为p＜0.05。结果：我们观察到不孕夫妇和有生育能力的夫妇在状态和特质焦虑方面存在显著差异（p＜0.0001），而女性和男性在抑郁方面没有差异。在比较不孕妇女和男性时，焦虑和抑郁与性别无关（p=0.0213）。结论：我们认为不孕夫妇的心理管理必须从文化、宗教和阶级相关方面进行个性化。

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引用次数: 45

Vaginal compared oral administration of estradiol in women with thin endometrium: A cross-sectional study 子宫内膜薄的妇女阴道口服雌二醇比较:一项横断面研究

Iranian Journal of Reproductive Medicine

Pub Date : 2020-08-19 DOI: 10.18502/ijrm.v13i8.7500

R. Davar, Masrooreh Hoseini, Lida Saeed

Background: Endometrial thickness is regarded as an indicator of the receptivity of the endometrium. Patients preparing for frozen embryo transfer need some interventions in case their endometrium is thin. Objective: This study aimed to compare the clinical outcomes of oral administration of estradiol valerate with its vaginal type in women with inappropriate endometrial thickness. Materials and Methods: This cross-sectional study comprised of 79 women (cycles) who had undergone frozen-thawed embryo transfer. On the 13th day of the cycle, vaginal sonography was performed in case the thickness of the endometrium was < 7 mm; in the oral group, the patients continued using oral estradiol valerate tablet. However, in the vaginal group, the participants applied estradiol valerate tablet vaginally. Finally, the chemical and clinical pregnancy rate, also, early miscarriage rate were compared between the two groups. Results: The early miscarriage rate was lower in the vaginal group in comparison with the oral group (p = 0.040). Women in the vaginal group showed a lower rate of chemical pregnancy compared to the oral group, but this difference was not statistically significant (25.0 vs. 34.4%, p = 0.440). The rate of clinical pregnancy in the two groups was not statistically significant, although the vaginal group had a higher pregnancy rate (22.5% vs. 15.6%, p = 0.464), especially in women older than 34 years (37.5% vs. 11.1%, p = 0.355). Conclusion: Vaginal administration of estradiol tablet in women with thin endometrium leads to a lower rate of early miscarriage. Key words: Endometrium, Thickness, Frozen, Embryo transfer, Estradiol valerate.

背景:子宫内膜厚度被认为是子宫内膜容受性的一个指标。准备冷冻胚胎移植的患者需要一些干预措施，以防子宫内膜薄。目的:比较子宫内膜厚度不合适的女性口服戊酸雌二醇与阴道型口服戊酸雌二醇的临床效果。材料和方法:本横断面研究包括79名接受冷冻解冻胚胎移植的妇女(周期)。月经周期第13天，子宫内膜厚度< 7 mm者行阴道超声检查;口服组继续口服戊酸雌二醇片。然而，在阴道组，参与者在阴道使用雌二醇片。比较两组的化学指标、临床妊娠率、早期流产率。结果:阴道组早期流产率低于口服组(p = 0.040)。阴道组的女性化学妊娠率低于口服组，但差异无统计学意义(25.0比34.4%，p = 0.440)。两组临床妊娠率差异无统计学意义，但阴道组妊娠率较高(22.5%比15.6%，p = 0.464)，尤其是34岁以上妇女(37.5%比11.1%，p = 0.355)。结论:子宫内膜薄的妇女经阴道给予雌二醇片可降低早期流产率。关键词:子宫内膜，厚度，冷冻，胚胎移植，雌二醇。

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引用次数: 3

Corrigendum to “Interstitial ectopic pregnancy diagnosis by three-dimensional ultrasound and its laparoscopic management: A case report” [Int J Reprod BioMed 2019; 17: 945-950] “三维超声诊断间质性异位妊娠及腹腔镜治疗1例报告”[J] .生殖生物医学杂志2019;17: 945 - 950)

Iranian Journal of Reproductive Medicine

Pub Date : 2020-03-15 DOI: 10.18502/ijrm.v18i2.6549

F. Ahmadi, F. Pahlavan, F. Ramezanali, F. Akhbari

The publisher has been informed of an error that occurred on page 945 in which the Institute name must be changed to Royan instead of Rayan. On behalf of the author, the publisher wishes to apologize for this error. The online version of the article has been updated on 29 February 2020.

出版商被告知在第945页发生了一个错误，其中研究所的名称必须改为Royan而不是Rayan。出版商谨代表作者对这一错误表示歉意。该文章的在线版本已于2020年2月29日更新。

引用次数: 0

A new strategy and system for the ex vivo ovary perfusion and cryopreservation: An innovation 卵巢体外灌注和冷冻保存新策略和新系统:一项创新

Iranian Journal of Reproductive Medicine

Pub Date : 2017-06-01 DOI: 10.29252/IJRM.15.6.323

Mohamed Shehata Ali Mohamed

Children and young adults, who suffer from cancer, receive gonadotoxic therapy, which destroys their fertile abilities after survival. Ovarian cryopreservation and transplantation provide the promising solution to this problem, where the ovary can be removed before the gonadotoxic therapy and reimplanted after patient's survival, where the ovary is to be cryopreserved during the period of the therapy. However, cryopreservation of the whole ovary is still facing great obstacles, namely the ischemic reperfusion injury and the defective cryopreservation related to the defective ability to universally deliver the cryopreservation/warming solutions through the ovarian vascular bed. Meanwhile, the currently applied technique of ovarian tissue cryopreservation provides limited follicular recovery because many follicles are lost until the development of revascularization post-transplantation. To solve the problems, an innovative system has been developed to insure immediate and universal delivery of the cryopreservation/warming solutions to the graft, in addition to keeping the graft under continuous perfusion before and after cryopreservation, minimizing any chance for microthrombi formation or ischemia-reperfusion. This innovative system can be applied in the following surgical and clinical interventions: 1) Allogeneic ovarian transplantation; 2) Preservation of fertility after systemic chemotherapy or bone marrow transplantation in young females, where the ovaries could be removed before the therapy and exposed to the adequate cryopreservation provided by the system till re-implantation after the patient's survival; 3) The system is also suitable for the corresponding applications on the testicles.

患有癌症的儿童和年轻人接受了促性腺毒素治疗，这破坏了他们生存后的生育能力。卵巢冷冻保存和移植为这一问题提供了有希望的解决方案，卵巢可以在促性腺毒素治疗前切除，在患者存活后重新植入，在治疗期间卵巢将被冷冻保存。然而，整个卵巢的低温保存仍然面临着很大的障碍，即缺血再灌注损伤和低温保存的缺陷，这与通过卵巢血管床普遍递送低温保存/加热溶液的能力不足有关。同时，目前应用的卵巢组织冷冻保存技术对卵泡的恢复有限，因为许多卵泡在移植后血管重建发展之前就已经丢失。为了解决这些问题，一种创新的系统已经被开发出来，以确保快速和普遍地将冷冻保存/加热溶液输送到移植物中，除了在冷冻保存前后保持移植物持续灌注，最大限度地减少微血栓形成或缺血再灌注的机会。该创新系统可应用于以下手术和临床干预:1)异基因卵巢移植;2)年轻女性全身化疗或骨髓移植后保留生育能力，在治疗前切除卵巢，暴露于系统提供的充分低温保存，直至患者存活后再植入;3)该系统也适用于睾丸的相应应用。

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引用次数: 2

The etiologies of DNA abnormalities in male infertility: An assessment and review 男性不育症DNA异常的病因:评估和回顾

Iranian Journal of Reproductive Medicine

Pub Date : 2017-06-01 DOI: 10.29252/IJRM.15.6.331

S. Pourmasumi, P. Sabeti, T. Rahiminia, E. Mangoli, N. Tabibnejad, A. Talebi

The sperm DNA damage may occur in testis, genital ducts, and also after ejaculation. Mechanisms altering chromatin remodeling are abortive apoptosis and oxidative stress resulting from reactive oxygen species. Three classifications of intratesticular, post-testicular, and external factors have been correlated with increased levels of human sperm DNA damage which can affect the potential of fertility. Lifestyle, environment, medical, and iatrogenic factors might be considered to cause dysmetabolism to make distracting interactions and endocrine disrupting compounds. As a result, these may induce chromatin/DNA alteration in germ cells, which may be transmitted across generations with phenotypic consequences. Alcohol consumption may not increase the rate of sperm residual histones and protamine deficiency; however, it causes an increase in the percentage of spermatozoa with DNA fragmentation and apoptosis. In a medical problem as spinal cord injury, poor semen parameters and sperm DNA damage were reported. Infection induces reactive oxygen species production, decreases the total antioxidant capacity and sperm DNA fragmentation or antigen production that lead to sperm dysfunctions and DNA fragmentation. While reactive oxygen species generation increases with age, oxidative stress may be responsible for the age-dependent sperm DNA damage. The exposing of reproductive organs in older men to oxidative stress for a long time may produce more DNA-damaged spermatozoa than youngers. Examining the sperm chromatin quality in testicular cancer and Hodgkin’s lymphoma patients prior to chemotherapy demonstrated the high incidence of DNA damage and low compaction in spermatozoa at the time of the diagnosis. In chemotherapy cycle with genotoxic agents in cancer patients, an increase in sperm DNA damage was shown after treatment. In overall, those factors occurring during the prenatal or the adult life alter the distribution of proteins associated with sperm chromatin induce changes in germ cells which can be detected in infertile patients.

精子DNA损伤可能发生在睾丸、生殖道，也可能发生在射精后。改变染色质重塑的机制是由活性氧引起的凋亡流产和氧化应激。三种类型的睾丸内、睾丸后和外部因素与人类精子DNA损伤水平的增加有关，这可能影响生育的潜力。生活方式、环境、医学和医源性因素均可引起代谢障碍，产生分散注意力的相互作用和内分泌干扰化合物。因此，这些可能会诱导生殖细胞的染色质/DNA改变，这可能会通过表型后果跨代传播。饮酒可能不会增加精子残留组蛋白和鱼精蛋白缺乏率;然而，它会导致精子DNA断裂和细胞凋亡的比例增加。在脊髓损伤等医学问题中，有精液参数差和精子DNA损伤的报道。感染诱导活性氧产生，降低总抗氧化能力和精子DNA断裂或抗原产生，导致精子功能障碍和DNA断裂。虽然活性氧的产生随着年龄的增长而增加，但氧化应激可能是造成年龄依赖性精子DNA损伤的原因。老年男性的生殖器官长期暴露于氧化应激下，可能比年轻人产生更多dna受损的精子。在化疗前检查睾丸癌和霍奇金淋巴瘤患者的精子染色质质量表明，在诊断时，DNA损伤的发生率高，精子压实度低。在基因毒性药物化疗周期中，癌症患者治疗后精子DNA损伤增加。总的来说，在产前或成年期发生的这些因素改变了与精子染色质相关的蛋白质的分布，导致了生殖细胞的变化，这些变化可以在不育患者中检测到。

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引用次数: 33

Frequency of anti-Chlamydia trachomatis antibodies in infertile women referred to Al-Zahra hospital in Tabriz 转诊到大不里士Al-Zahra医院的不孕妇女中沙眼衣原体抗体的频率

Iranian Journal of Reproductive Medicine

Pub Date : 2017-01-01 DOI: 10.29252/IJRM.15.1.17

M. Sattari, M. Rad, A. Ghasemzadeh, Zahra Mohammadoghli Reihan

Background: Infertility is one of the major issues in society and its incidence is estimated to be almost 10-15%.. Chlamydia is an important cause of sexually transmitted diseases leading to infertility.Objective: This study was designed to determine the frequency of anti-Chlamydia trachomatis (anti-C. trachomatis) antibodies in infertile women at Alzahra hospital, Tabriz, Iran.Materials and Methods: In this cross-sectional study, the blood samples were collected randomly from 184 infertile women (case group) and 100 pregnant women (control group).the frequency of specific IgG and IgM anti-Chlamydia trachomatis antibodies were evaluated using ELISA.Results: The frequency of anti-C. trachomatis IgG in pregnant and infertile women was 18% and 35.88%, respectively. The frequency of anti- C. trachomatis IgM in pregnant and infertile women was 2% and 5.44%.Our results showed the significant high rate of anti-Chlamydia trachomatis IgG (p=0.035), IgM (p=0.004) (p 0.05).Conclusion: According to the high frequency of antibody anti-C. trachomatis among infertile women in competition to the control group, evaluation and treatment of Chlamydia infections is necessary in these patients.

背景:不孕症是社会的主要问题之一，其发病率估计约为10-15%。衣原体是导致不孕症的性传播疾病的重要原因。目的:测定沙眼衣原体抗(c。伊朗大不里士Alzahra医院不孕妇女沙眼原体抗体。材料与方法:本横断面研究随机抽取184例不孕症妇女(病例组)和100例孕妇(对照组)的血液样本。ELISA法检测沙眼衣原体IgG和IgM特异性抗体出现频率。结果:抗c。孕妇沙眼IgG阳性率为18%，不孕症为35.88%。妊娠和不育妇女抗沙眼衣原体IgM检出率分别为2%和5.44%。结果显示抗沙眼衣原体IgG (p=0.035)、IgM (p=0.004)阳性率显著高于对照组(p 0.05)。结论:根据抗- c抗体的高频率。在与对照组竞争的不孕症妇女中，衣原体感染的评估和治疗是必要的。

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引用次数: 5

Effect of body weight on serum homocysteine level in patients with polycystic ovarian syndrome: A case control study 体重对多囊卵巢综合征患者血清同型半胱氨酸水平的影响:一项病例对照研究

Iranian Journal of Reproductive Medicine

Pub Date : 2016-02-01 DOI: 10.29252/IJRM.14.2.81

Ali I. Al- Gareeb, Wafaa Salah Abd Al- Amieer, Hayder M. Alkuraishy, Thabat J. Al- Mayahi

Background: Polycystic ovarian syndrome (PCOS) represent one of the common endocrine disorders which influence around 8% of reproductive women whom usually suffering from obesity and increase cardiovascular risk. Serum homocysteine levels are associated with bad impact on endothelial functions and considered as an independent risk factor for cardiovascular disease. Objective: The aim was to study the level of plasma homocysteine in obese and non-obese Iraqi patients with PCOS. Materials and Methods: This study was carried out on 207 women. Of theme, 101 women with PCOS and 106 PCOS- free women served as controls. Blood sample was taken from each participant on the 2nd day of menstruation morning after an overnight fasting. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone and androstenedione were measured. Moreover, total lipid profile and plasma homocysteine levels were measured in both groups. Results: Sixty percent of PCOS women were overweight or obese and 56% of them had a waist circumference >88cm. Moreover plasma homocysteine concentrations were found to be higher in patients with PCOS (11.5±5.41μmol/L) as compared with control (8.10±1.89 μmol/L) (p<0.002). Furthermore the homocysteine concentrations were 13.19±5.97 μmol/L and 9.38±2.99 μmol/L in both obese and normal-weight PCOS women respectively which was significantly higher than obese (p<0.002) and normal-weight (p<0.004) control women. Conclusion: Increase in body weight is not an independent risk factor to increase plasma homocysteine levels in PCOS women.

背景:多囊卵巢综合征(PCOS)是一种常见的内分泌疾病，影响约8%的育龄妇女，她们通常患有肥胖并增加心血管风险。血清同型半胱氨酸水平与内皮功能的不良影响相关，被认为是心血管疾病的独立危险因素。目的:研究肥胖和非肥胖伊拉克多囊卵巢综合征患者血浆同型半胱氨酸水平。材料与方法:研究对象为207名女性。101名多囊卵巢综合征妇女和106名无多囊卵巢综合征妇女作为对照组。在禁食一夜后，每位参与者在月经的第2天早上采集血液样本。测定血清促卵泡激素(FSH)、促黄体生成素(LH)、游离睾酮和雄烯二酮水平。此外，测量两组患者的总脂质谱和血浆同型半胱氨酸水平。结果:60%的PCOS女性体重超重或肥胖，56%的PCOS女性腰围为808cm。PCOS患者血浆同型半胱氨酸浓度(11.5±5.41μmol/L)高于对照组(8.10±1.89 μmol/L) (p<0.002)。肥胖和正常体重PCOS女性的同型半胱氨酸浓度分别为13.19±5.97 μmol/L和9.38±2.99 μmol/L，显著高于肥胖(p<0.002)和正常体重(p<0.004)对照组。结论:体重增加不是PCOS患者血浆同型半胱氨酸水平升高的独立危险因素。

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引用次数: 12

Effects of aqueous extract from Asparagus officinalis L. roots on hypothalamic-pituitary-gonadal axis hormone levels and the number of ovarian follicles in adult rats 芦笋根水提物对成年大鼠下丘脑-垂体-性腺轴激素水平及卵巢卵泡数量的影响

Iranian Journal of Reproductive Medicine

Pub Date : 2016-02-01 DOI: 10.29252/IJRM.14.2.75

hojatollah karimi jashni, Hossein Kargar Jahromi, Ali Ghorbani Ranjbary, Zahra Kargar Jahromi, zahra Khabbaz Kherameh

Background: Asparagus is a plant with high nutritional, pharmaceutical, and industrial values. Objective: The present study aimed to evaluate the effect of aqueous extract of asparagus roots on the hypothalamic-pituitary-gonadal axis hormones and oogenesis in female rats. Materials and Methods: In this experimental study, 40 adult female Wistar rats were divided into five groups, which consist 8 rats. Groups included control, sham and three experimental groups receiving different doses (100, 200, 400 mg/kg/bw) of aqueous extract of asparagus roots. All dosages were administered orally for 28 days. Blood samples were taken from rats to evaluate serum levels of Gonadotropin releasing hormone (GnRH), follicular stimulating hormone (FSH), Luteinal hormone (LH), estrogen, and progesterone hormones. The ovaries were removed, weighted, sectioned, and studied by light microscope. Results: Dose-dependent aqueous extract of asparagus roots significantly increased serum levels of GnRH, FSH, LH, estrogen, and progestin hormones compared to control and sham groups. Increase in number of ovarian follicles and corpus luteum in groups treated with asparagus root extract was also observed (p<0.05). Conclusion: Asparagus roots extract stimulates secretion of hypothalamic- pituitary- gonadal axis hormones. This also positively affects oogenesis in female rats.

背景:芦笋是一种具有高营养、药用和工业价值的植物。目的:研究芦笋根水提液对雌性大鼠下丘脑-垂体-性腺轴激素及卵子生成的影响。材料与方法:将40只成年雌性Wistar大鼠分为5组，每组8只。各组分为对照组、假手术组和3个实验组，分别给予不同剂量(100、200、400 mg/kg/bw)的芦笋根水提液。所有剂量均口服28天。取大鼠血样，评估血清促性腺激素释放激素(GnRH)、卵泡刺激素(FSH)、黄体激素(LH)、雌激素和孕酮激素水平。取卵巢，称重，切片，光镜下观察。结果:与对照组和假手术组相比，芦笋根水提物的剂量依赖性显著提高血清GnRH、FSH、LH、雌激素和黄体酮水平。芦笋根提取物各组卵巢卵泡和黄体数量均显著增加(p<0.05)。结论:芦笋提取物刺激下丘脑-垂体-性腺轴激素的分泌。这对雌性大鼠的卵子生成也有积极影响。

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引用次数: 17

The effects of vitamin D supplementation on maternal and neonatal outcome: A randomized clinical trial. 补充维生素 D 对产妇和新生儿预后的影响：随机临床试验。

Iranian Journal of Reproductive Medicine

Pub Date : 2015-11-01

Mahdieh Mojibian, Sedigheh Soheilykhah, Mohammad Ali Fallah Zadeh, Maryam Jannati Moghadam

Background: Vitamin D supplementation during pregnancy has been supposed to defend against adverse gestational outcomes.

Objective: This randomized clinical trial study was conducted to assess the effects of 50,000 IU of vitamin D every two weeks supplementation on the incidence of gestational diabetes (GDM), gestational hypertension, preeclampsia and preterm labor, vitamin D status at term and neonatal outcomes contrasted with pregnant women that received 400 IU vitamin D daily.

Materials and methods: 500 women with gestational age 12-16 weeks and serum 25 hydroxy vitamin D (25 (OH) D ) less than 30 ng/ml randomly categorized in two groups. Group A received 400 IU vitamin D daily and group B 50,000 IU vitamin D every 2 weeks orally until delivery. Maternal and Neonatal outcomes were assessed in two groups.

Results: The incidence of GDM in group B was significantly lower than group A (6.7% versus 13.4%) and odds ratio (95% Confidence interval) was 0.46 (0.24-0.87) (P=0.01). The mean ± SD level of 25 (OH) D at the time of delivery in mothers in group B was significantly higher than A (37.9 ± 19.8 versus 27.2 ± 18.8 ng/ml, respectively) (P=0.001). There were no differences in the incidence of preeclampsia, gestational hypertension, preterm labor, and low birth weight between two groups. The mean level of 25 (OH) D in cord blood of group B was significantly higher than group A (37.9 ± 18 versus 29.7 ± 19ng/ml, respectively). Anthropometric measures between neonates were not significantly different.

Conclusion: Our study showed 50,000 IU vitamin D every 2 weeks decreased the incidence of GDM.

背景：怀孕期间补充维生素 D孕期补充维生素 D 被认为可以预防不良妊娠结局：本随机临床试验研究旨在评估每两周补充 50,000 IU 维生素 D 对妊娠糖尿病 (GDM)、妊娠高血压、子痫前期和早产的发生率、临产时维生素 D 状态以及新生儿预后的影响，并与每天服用 400 IU 维生素 D 的孕妇进行对比。A 组每天服用 400 IU 维生素 D，B 组每两周口服 50,000 IU 维生素 D，直至分娩。对两组产妇和新生儿的预后进行评估：结果：B 组的 GDM 发生率明显低于 A 组（6.7% 对 13.4%），几率比（95% 置信区间）为 0.46（0.24-0.87）（P=0.01）。B 组产妇分娩时 25 (OH) D 的平均值（± SD）水平明显高于 A 组（分别为 37.9 ± 19.8 和 27.2 ± 18.8 ng/ml）（P=0.001）。子痫前期、妊娠高血压、早产和低出生体重的发生率在两组之间没有差异。B 组脐带血中 25 (OH) D 的平均水平明显高于 A 组（分别为 37.9 ± 18 和 29.7 ± 19ng/ml）。新生儿之间的人体测量没有明显差异：我们的研究表明，每两周服用 50,000 IU 维生素 D 可降低 GDM 的发病率。

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引用次数: 0

Evaluation of sperm retrieval rate with bilateral testicular sperm extraction in infertile patients with azoospermia. 评估无精子症不育患者双侧睾丸取精术的取精率。

Iranian Journal of Reproductive Medicine

Pub Date : 2015-11-01

Mohammad Reza Moein, Mahmoud Reza Moein, Jalal Ghasemzadeh, Soheila Pourmasoumi

Background: About 10% to 15% of infertile men have azoospermia, which could be obstructive or non-obstructive. Diagnostic biopsy from the testis and recently testicular sperm extraction (TESE) are the most precise investigations in these patients. Testicular biopsy can be done unilaterally or bilaterally. The worth of unilateral or bilateral testicular biopsy in men with azoospermia is controversial.

Objective: To evaluate the necessity of bilateral diagnostic biopsy from the testis in new era of diagnosis and treatment of male infertility.

Materials and methods: In this retrospective study, we reviewed the results of testis biopsy in 419 azoospermic men, referred to Yazd Research and Clinical Center for Infertility from 2009-2013. Patients with known obstructive azoospermia were excluded from the study.

Results: In totally, 254 infertile men (60.6%) were underwent unilateral TESE, which in 175 patients (88.4%) sperm were extracted from their testes successfully. Bilateral testis biopsy was done in 165 patients (39.4%) which in 37 patients (22.4%), sperm were found in their testes tissues.

Conclusion: Due to the low probability of positive bilateral TESE results especially when we can't found sperm in the first side, we recommend that physicians re-evaluate the risk and benefit of this procedure in era of newer and more precise technique of sperm retrieval like micro TESE.

背景：约 10%至 15%的不育男性患有无精子症，可能是梗阻性或非梗阻性的。睾丸诊断性活检和最近的睾丸取精术（TESE）是这些患者最精确的检查方法。睾丸活检可以单侧或双侧进行。对于无精子症男性进行单侧或双侧睾丸活检的价值还存在争议：评估在诊断和治疗男性不育症的新时代进行双侧睾丸活检的必要性：在这项回顾性研究中，我们回顾了2009-2013年期间转诊至亚兹德不孕不育研究与临床中心的419名无精症男性的睾丸活检结果。研究排除了已知患有梗阻性无精子症的患者：共有 254 名不育男性（60.6%）接受了单侧 TESE，其中 175 名患者（88.4%）成功从睾丸中提取了精子。165 名患者（39.4%）接受了双侧睾丸活检，其中 37 名患者（22.4%）的睾丸组织中发现了精子：由于双侧 TESE 阳性结果的概率较低，尤其是当我们在第一侧睾丸中未发现精子时，我们建议医生重新评估该手术的风险和益处，因为现在有了更新、更精确的取精技术，如显微 TESE。

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引用次数: 0