JHEP Reports最新文献

{"title":"Characteristics and long-term mortality of individuals with MASLD, MetALD, and ALD, and the utility of SAFE score","authors":"","doi":"10.1016/j.jhepr.2024.101127","DOIUrl":"10.1016/j.jhepr.2024.101127","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><p>The new nomenclature of steatotic liver disease (SLD) was recently launched with sub-classifications of metabolic dysfunction-associated SLD (MASLD), MASLD with increased alcohol intake (MetALD), and alcohol-related liver disease (ALD). Herein, we aimed to evaluate the characteristics and long-term outcomes associated with these subgroups and the utility of non-invasive biomarkers.</p></div><div><h3>Methods</h3><p>Using NHANES III (the third National Health and Nutrition Examination Survey) and linked mortality data, all adult participants with available ultrasonographic liver steatosis status were included. Those with viral hepatitis, incomplete data on alcohol consumption, cardiometabolic risk, and missing data that hindered Steatosis-associated Fibrosis Estimator (SAFE) score calculation were excluded. The characteristics of those without SLD (no steatosis on ultrasound), MASLD, MetALD, and ALD were compared. Overall survival (OS) was determined and SAFE score strata were applied to SLD subgroups.</p></div><div><h3>Results</h3><p>A total of 9,939 participants were eligible; 64% had no SLD, while 30%, 2.3%, and 1% had MASLD, MetALD, and ALD, respectively. A higher proportion of men, as well as active smokers, was observed in the MetALD and ALD groups compared to the MASLD group. Diabetes was more prevalent in the MASLD group than in the MetALD and ALD groups. The ALD subgroup had significantly lower OS than the MASLD group (<em>p</em> = 0.004), but the MetALD did not (<em>p</em> = 0.165). SAFE score strata meaningfully differentiated OS of all SLD subgroups.</p></div><div><h3>Conclusions</h3><p>MASLD accounted for the largest proportion of SLD. MetALD shared the characteristics of both MASLD and ALD. The ALD subgroup had a significantly lower OS than the MASLD subgroup but there was no difference between MetALD and MASLD. The SAFE score can be used to stratify long-term outcomes in all SLD subgroups.</p></div><div><h3>Impact and implications:</h3><p>“Steatotic liver disease (SLD)” is a recently introduced term covering three subgroups: MASLD (metabolic dysfunction-associated SLD), MetALD (MASLD with increased alcohol intake), and ALD (alcohol-related liver disease). We explored the characteristics and outcomes of these subgroups among the US population. We found that MASLD was far more common than MetALD and ALD, but all subgroups shared cardiometabolic risk factors. The ALD subgroup has the worst survival, pointing to the synergistic effect of alcohol and metabolic dysfunction. In addition, the SAFE (Steatosis-associated Fibrosis Estimator) score might be a useful non-invasive test to stratify long-term risk in all three SLD subgroups.</p></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 10","pages":"Article 101127"},"PeriodicalIF":9.5,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924001319/pdfft?md5=70fb5f648622f96dd3f315e9fc75d05b&pid=1-s2.0-S2589555924001319-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Transplant oncology – Current indications and strategies to advance the field’ [JHEP Reports 6 (2024) 100965]","authors":"Felix J. Krendl ,&nbsp;Ruben Bellotti ,&nbsp;Gonzalo Sapisochin ,&nbsp;Benedikt Schaefer ,&nbsp;Herbert Tilg ,&nbsp;Stefan Scheidl ,&nbsp;Christian Margreiter ,&nbsp;Stefan Schneeberger ,&nbsp;Rupert Oberhuber ,&nbsp;Manuel Maglione","doi":"10.1016/j.jhepr.2024.101071","DOIUrl":"10.1016/j.jhepr.2024.101071","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101071"},"PeriodicalIF":9.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924000752/pdfft?md5=09622a9759fd88794907654dfb975933&pid=1-s2.0-S2589555924000752-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board page","authors":"","doi":"10.1016/S2589-5559(24)00142-3","DOIUrl":"https://doi.org/10.1016/S2589-5559(24)00142-3","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101138"},"PeriodicalIF":9.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924001423/pdfft?md5=634b2073d61f5fd7c79d6cc4a42825c8&pid=1-s2.0-S2589555924001423-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “O-GlcNAc transferase acts as a critical nutritional node for the control of liver homeostasis” [JHEP Reports 6 [2024] 100878]","authors":"Paula Ortega-Prieto ,&nbsp;Lucia Parlati ,&nbsp;Fadila Benhamed ,&nbsp;Marion Regnier ,&nbsp;Isadora Cavalcante ,&nbsp;Mélanie Montabord ,&nbsp;Rachel Onifarasoaniaina ,&nbsp;Maryline Favier ,&nbsp;Natasa Pavlovic ,&nbsp;Julie Magusto ,&nbsp;Michèle Cauzac ,&nbsp;Patrick Pagesy ,&nbsp;Jérémie Gautheron ,&nbsp;Chantal Desdouets ,&nbsp;Sandra Guilmeau ,&nbsp;Tarik Issad ,&nbsp;Catherine Postic","doi":"10.1016/j.jhepr.2024.101076","DOIUrl":"10.1016/j.jhepr.2024.101076","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101076"},"PeriodicalIF":9.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924000806/pdfft?md5=0045d808b5e263b29936145ecfae7375&pid=1-s2.0-S2589555924000806-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141027829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: “Endoscopic duodenal mucosal resurfacing improves glycaemic and hepatic indices in type 2 diabetes: 6-month multicentre results” [JHEP Reports 5 (2019) 101041]","authors":"Annieke C.G. van Baar ,&nbsp;Ulrich Beuers ,&nbsp;Kari Wong ,&nbsp;Rehan Haidry ,&nbsp;Guido Costamagna ,&nbsp;Alia Hadefi ,&nbsp;Jacques Deviere ,&nbsp;Soumitra S. Ghosh ,&nbsp;Juan Carlos Lopez-Talavera ,&nbsp;Leonardo Rodriguez ,&nbsp;Manoel P. Galvao Neto ,&nbsp;Arun Sanyal ,&nbsp;Jacques J.G.H.M. Bergman","doi":"10.1016/j.jhepr.2024.101041","DOIUrl":"https://doi.org/10.1016/j.jhepr.2024.101041","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101041"},"PeriodicalIF":9.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924000429/pdfft?md5=5ba742f04071f41423d96a68de5b55ef&pid=1-s2.0-S2589555924000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to ‘B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation’ (JHEP Reports 5 [2023] 100903)","authors":"Yao Tang ,&nbsp;Zhijie Xu ,&nbsp;Fuyuan Xu ,&nbsp;Juan Ye ,&nbsp;Jianxu Chen ,&nbsp;Jianzhong He ,&nbsp;Yingchun Chen ,&nbsp;Chunhui Qi ,&nbsp;Hongbin Huang ,&nbsp;Ruiyang Liu ,&nbsp;Hong Shan ,&nbsp;Fei Xiao","doi":"10.1016/j.jhepr.2024.101042","DOIUrl":"10.1016/j.jhepr.2024.101042","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101042"},"PeriodicalIF":9.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924000430/pdfft?md5=70ff5988a97c553668489d2a7395bffc&pid=1-s2.0-S2589555924000430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140283520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCR6+CD69+ CD8+ T cells in ascites are associated with disease severity in patients with cirrhosis","authors":"Christian Niehaus ,&nbsp;Sebastian Klein ,&nbsp;Benedikt Strunz ,&nbsp;Erich Freyer ,&nbsp;Benjamin Maasoumy ,&nbsp;Heiner Wedemeyer ,&nbsp;Niklas K. Björkström ,&nbsp;Anke R.M. Kraft ,&nbsp;Markus Cornberg","doi":"10.1016/j.jhepr.2024.101074","DOIUrl":"10.1016/j.jhepr.2024.101074","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><p>Patients with advanced cirrhosis often develop hepatic decompensation, which is accompanied by systemic inflammation and may eventually lead to acute-on-chronic liver failure. One important cause of systemic hyperinflammation is a dysregulated overshooting immune response in ascites in the abdominal cavity. In this study, we analyzed the role of CD8⁺ T cells in the ascites immune compartment.</p></div><div><h3>Methods</h3><p>Peripheral blood and ascites fluid were collected from 50 patients with decompensated cirrhosis. Phenotype and functional responses of CD8⁺ T cells were analyzed, and obtained data were compared with each other as well as with healthy controls and patients with compensated cirrhosis.</p></div><div><h3>Results</h3><p>High-dimensional flow cytometry revealed that CD8⁺ T cells are abundant in the ascites of patients with cirrhosis and exhibit a chronically activated bystander phenotype with innate-like functions. Indeed, we identified distinct CXCR6⁺CD69⁺ clusters of late effector memory CD8⁺ T cells that were rarely found in blood and correlated with clinical parameters of disease severity. Moreover, this CD8⁺ T-cell population was hyperresponsive to innate cytokines and exhibited cytokine-mediated bystander activation. Interestingly, the Janus kinase (JAK) inhibitor tofacitinib was able to effectively block bystander-activated CXCR6⁺CD69⁺ CD8⁺ T cells and significantly suppress effector molecule production.</p></div><div><h3>Conclusions</h3><p>The results indicate that CXCR6⁺CD69⁺ CD8⁺ T cells in ascites are associated with disease severity and may contribute to inflammation in patients with decompensated cirrhosis, suggesting that targeted inhibition of this immune cell subset may be a viable therapeutic option.</p></div><div><h3>Impact and Implications</h3><p>Patients with advanced cirrhosis often develop hepatic decompensation, which is accompanied by systemic inflammation and eventually leads to acute-on-chronic liver failure. One important cause of systemic hyperinflammation is a dysregulated overshooting immune response in ascites in the abdominal cavity. In this study, we demonstrate that CXCR6⁺CD69⁺ CD8⁺ T cells are abundant in the ascites of patients with cirrhosis, exhibit a chronically activated bystander phenotype, and correlate with clinical parameters of disease severity. Moreover, we show that the Janus kinase (JAK) inhibitor tofacitinib can effectively block these bystander-activated CXCR6⁺CD69⁺ CD8⁺ T cells, suggesting that targeted inhibition of this immune cell subset may be a potential therapeutic strategy.</p></div><div><h3>Clinical trial number</h3><p>Prospective registry: INFEKTA (DRKS00010664).</p></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101074"},"PeriodicalIF":8.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924000788/pdfft?md5=214eb9bc97e0176e3ecc27623e229962&pid=1-s2.0-S2589555924000788-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Predicting post-resection recurrence by integrating imaging-based surrogates of distinct vascular patterns of hepatocellular carcinoma’ (JHEP Reports 5 [2023] 100806)","authors":"Xiang-Pan Meng ,&nbsp;Tian-Yu Tang ,&nbsp;Yongping Zhou ,&nbsp;Cong Xia ,&nbsp;Tianyi Xia ,&nbsp;Yibing Shi ,&nbsp;Xueying Long ,&nbsp;Yun Liang ,&nbsp;Wenbo Xiao ,&nbsp;Yuan-Cheng Wang ,&nbsp;Xiangming Fang ,&nbsp;Shenghong Ju","doi":"10.1016/j.jhepr.2024.101059","DOIUrl":"10.1016/j.jhepr.2024.101059","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101059"},"PeriodicalIF":9.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924000600/pdfft?md5=253814cdd3f48c4423bb92186d9466cb&pid=1-s2.0-S2589555924000600-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140275062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Opinion paper on the diagnosis and treatment of progressive familial intrahepatic cholestasis” [JHEP Reports 6 (2024) 100949]","authors":"Patrick McKiernan ,&nbsp;Jesus Quintero Bernabeu ,&nbsp;Muriel Girard ,&nbsp;Giuseppe Indolfi ,&nbsp;Eberhard Lurz ,&nbsp;Palak Trivedi","doi":"10.1016/j.jhepr.2024.101058","DOIUrl":"10.1016/j.jhepr.2024.101058","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101058"},"PeriodicalIF":9.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924000594/pdfft?md5=6078312bb3017debc82330560409a34a&pid=1-s2.0-S2589555924000594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140278446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum Regarding Previously Published Articles","authors":"","doi":"10.1016/j.jhepr.2024.101096","DOIUrl":"https://doi.org/10.1016/j.jhepr.2024.101096","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"6 6","pages":"Article 101096"},"PeriodicalIF":9.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589555924001009/pdfft?md5=83a794258a0d23fdd9c710d1e69ac758&pid=1-s2.0-S2589555924001009-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}