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Consistency of Delusion Themes Across First and Subsequent Episodes of Psychosis. 妄想主题在首次和随后的精神病发作中的一致性。
IF 22.5 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-01 DOI: 10.1001/jamapsychiatry.2024.2040
Gil Grunfeld, Ann-Catherine Lemonde, Ian Gold, Vincent Paquin, Srividya N Iyer, Martin Lepage, Ridha Joober, Ashok Malla, Jai L Shah
<p><strong>Importance: </strong>Despite growing interest in the phenomenology of delusions in psychosis, at present little is known about their content and evolution over time, including whether delusion themes are consistent across episodes.</p><p><strong>Objective: </strong>To examine the course of delusions and thematic delusion content across relapse episodes in patients presenting to an early intervention service for psychosis.</p><p><strong>Design, setting, and participants: </strong>This longitudinal, observational study used clinical data systematically collected from January 2003 to March 2018 from a cohort of consenting patients with affective or nonaffective first-episode psychosis, followed up naturalistically for up to 2 years in an early intervention service for psychosis in Montréal, Quebec, Canada. Data included the thematic content and severity of delusions (scores ≥3 using the Scale for the Assessment of Positive Symptoms) and associated psychotic and nonpsychotic symptoms, both across an initial episode and, in the event of remission, a potential relapse. Data were analyzed from September 2021 to February 2023.</p><p><strong>Exposure: </strong>An early intervention service for psychosis, organized around intensive case management and a multidisciplinary team approach, which observed each patient for up to 2 years of care.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was positive symptom relapse and remission, including the presence and content of delusions, which was coded per the Scale for the Assessment of Positive Symptoms and accepted definitions. The main statistical measures included repeated paired-sample t tests and binary logistic regression analyses.</p><p><strong>Results: </strong>Of 636 consenting patients, mean (SD) age was 23.8 (4.75) years; 191 patients were female, 444 were male, and 1 patient was nonbinary. Remission rates were high, and relapse rates were relatively low: 591 individuals had baseline delusions, of which 558 (94.4%) achieved remission. Of these 558 patients, only 182 (32.6%) had a subsequent relapse to a second or later episode of psychosis. Of the 182 patients who did relapse, however, a large proportion (115 [63.2%]) reported threshold-level delusions. Of these 115, 104 patients (90.4%) had thematic delusion content consistent with that reported during the index (first) episode. Those who relapsed with delusions had fewer delusion themes present during subsequent episodes of psychosis compared with the index episode and lower levels of other psychotic and nonpsychotic symptoms.</p><p><strong>Conclusions and relevance: </strong>Specialized early intervention services for psychosis can achieve high rates of sustained remission. However, in this study, the minority of individuals with delusions who later relapsed experienced similar delusion themes during subsequent episodes. These findings raise important considerations for the conceptualization of delusions and have cl
重要性:尽管人们对精神病妄想现象学的兴趣与日俱增,但目前对妄想的内容及其随时间的演变却知之甚少,包括妄想的主题在不同发作期是否一致:目的:研究向精神病早期干预服务机构求诊的患者在复发过程中的妄想过程和妄想主题内容:这项纵向观察性研究使用了 2003 年 1 月至 2018 年 3 月期间系统收集的临床数据,这些数据来自于加拿大魁北克省蒙特利尔市一家精神病早期干预服务机构对自愿接受的情感性或非情感性首发精神病患者进行的长达 2 年的自然随访。数据包括妄想的主题内容和严重程度(使用阳性症状评估量表评分≥3分)以及相关的精神病性和非精神病性症状,既包括首次发作,也包括缓解后的潜在复发。数据分析时间为2021年9月至2023年2月:精神病早期干预服务以强化个案管理和多学科团队方法为基础,对每位患者进行长达两年的护理观察:主要结果是阳性症状的复发和缓解,包括妄想的存在和内容,根据阳性症状评估量表和公认的定义进行编码。主要统计量包括重复配对样本 t 检验和二元逻辑回归分析:在 636 名同意接受治疗的患者中,平均(标清)年龄为 23.8(4.75)岁;191 名女性患者,444 名男性患者,1 名患者为非二元患者。缓解率很高,复发率相对较低:591 人有基线妄想,其中 558 人(94.4%)获得缓解。在这 558 名患者中,只有 182 人(32.6%)随后复发,进入第二次或以后的精神病发作期。然而,在复发的 182 名患者中,有很大一部分(115 人 [63.2%])报告出现了阈值水平的妄想。在这 115 名患者中,有 104 名患者(90.4%)的妄想内容与指数(第一次)发作时的妄想内容一致。妄想复发的患者在随后的精神病发作中出现的妄想主题少于指数发作,其他精神病和非精神病症状的程度也较低:针对精神病的专门早期干预服务可以实现较高的持续缓解率。然而,在这项研究中,少数妄想症患者后来复发了,他们在随后的发作中出现了类似的妄想主题。这些发现对妄想症的概念化提出了重要的思考,并对疾病轨迹和护理具有临床意义。
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引用次数: 0
Social Vulnerability and Prevalence and Treatment for Mental Health and Substance Use Disorders. 社会脆弱性与精神健康和药物使用障碍的流行和治疗。
IF 22.5 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-01 DOI: 10.1001/jamapsychiatry.2024.1870
Robert D Gibbons, Mark Olfson, Loren Saulsberry, Mark J Edlund, Sahar Zangeneh, Natalie Bareis, Lydia Chwastiak, Jason B Gibbons, Ronald C Kessler
<p><strong>Importance: </strong>Community-level social vulnerability (SV) is associated with physical illness and premature mortality. Its association with mental health (MH) and substance use disorders (SUDs) needs further study.</p><p><strong>Objective: </strong>To study associations of SV with clinical diagnoses of MH disorders, SUDs, and related treatments in the US noninstitutionalized population of adults aged 18 years and older.</p><p><strong>Design, setting, and participants: </strong>A survey of adults in a national sample of US households between October 2020 and October 2022. Participants drawn from a multistage, clustered, and stratified area probability sample of US households were included, excluding adults older than 65 years because of the difficulty of differentiating mental disorders from symptoms of dementia. The sample also included adults living in prisons, state psychiatric hospitals, and homeless shelters who were excluded from the sample of US households used in these analyses. Each sample household was sent a letter explaining the study and offering the option to complete the household roster online, by phone, or by email. Of the 12 906 adults selected for clinical interviewing in the household sample, 4674 completed clinical interviews.</p><p><strong>Main outcomes and measures: </strong>Main outcomes were Structured Clinical Interview for DSM-5 past-year diagnoses of MH disorders and SUDs and responses to survey questions regarding treatment received. The Social Vulnerability Metric (SVM) and the Area Deprivation Index (ADI) were used to determine SV at the residential zip code level.</p><p><strong>Results: </strong>The analysis involved 4674 participants (2904 [62.13%] female and 1770 [37.87%] male; mean [SD] age, 41.51 [13.41] years). Controlling for measured confounders, the SVM was significantly associated with diagnoses of schizophrenia spectrum disorder (SSD; adjusted odds ratio [aOR], 17.22; 95% CI, 3.05-97.29), opioid use disorder (OUD; aOR, 9.47; 95% CI, 2.30-39.02), stimulant use disorder (aOR, 6.60; 95% CI, 2.01-21.67), bipolar I disorder (aOR, 2.39; 95% CI, 1.19-4.80), posttraumatic stress disorder (aOR, 1.63; 95% CI, 1.06-2.50), and any MH disorder (aOR, 1.44; 95% CI, 1.14-1.83), but not major depressive disorder (MDD), generalized anxiety disorder (GAD), or any SUD. Results were similar for the ADI but generally of lower magnitude (SSD aOR, 11.38; 95% CI, 1.61-80.58; OUD aOR, 2.05; 95% CI, 0.30-14.10; stimulant use disorder aOR, 2.18; 95% CI, 0.52-9.18). Among participants with SSDs, SV was associated with reduced MH treatment (aOR, 0.001; 95% CI, 0.00-0.18) and reduced SUD treatment in participants with OUD or stimulant use disorder (aOR, 0.24; 95% CI, 0.02-2.80).</p><p><strong>Conclusions and relevance: </strong>In contrast to previous studies using nonclinical symptom-based survey data, we found no association between SV and GAD or MDD. By contrast, there were associations of SV with prevalence of SSD, s
重要性:社区层面的社会脆弱性(SV)与身体疾病和过早死亡有关。其与心理健康(MH)和药物使用障碍(SUDs)的关系需要进一步研究:研究美国 18 岁及以上非住院成年人群中 SV 与 MH 疾病、SUDs 临床诊断及相关治疗的关系:在 2020 年 10 月至 2022 年 10 月期间对美国全国家庭样本中的成年人进行调查。调查对象来自美国家庭的多级、聚类和分层地区概率样本,但不包括 65 岁以上的成年人,因为很难区分精神障碍和痴呆症状。样本中还包括住在监狱、州立精神病院和无家可归者收容所的成年人,这些人不包括在这些分析所用的美国家庭样本中。每个样本家庭都收到了一封信,信中解释了这项研究,并提供了在线、电话或电子邮件填写家庭名册的选择。在家庭样本中被选中进行临床访谈的 12 906 名成年人中,有 4674 人完成了临床访谈:主要结果为DSM-5结构化临床访谈过去一年的精神障碍和药物滥用诊断,以及对有关所接受治疗的调查问题的回答。社会脆弱性指标(SVM)和地区贫困指数(ADI)用于确定居住地邮编级别的社会脆弱性:分析涉及 4674 名参与者(女性 2904 人 [62.13%] ,男性 1770 人 [37.87%];平均 [SD] 年龄 41.51 [13.41] 岁)。在控制测量的混杂因素后,SVM 与精神分裂症谱系障碍(SSD;调整赔率比 [aOR],17.22;95% CI,3.05-97.29)、阿片类药物使用障碍(OUD;aOR,9.47;95% CI,2.30-39.02)、兴奋剂使用障碍(aOR,6.60;95% CI,2.01-21.67)、双相 I 型障碍(aOR,2.39;95% CI,1.19-4.80)、创伤后应激障碍(aOR,1.63;95% CI,1.06-2.50)和任何 MH 障碍(aOR,1.44;95% CI,1.14-1.83),但不包括重度抑郁障碍(MDD)、广泛性焦虑障碍(GAD)或任何 SUD。ADI 的结果与之相似,但程度普遍较低(SSD aOR,11.38;95% CI,1.61-80.58;OUD aOR,2.05;95% CI,0.30-14.10;兴奋剂使用障碍 aOR,2.18;95% CI,0.52-9.18)。在患有 SSD 的参与者中,SV 与 MH 治疗的减少有关(aOR,0.001;95% CI,0.00-0.18),与 OUD 或兴奋剂使用障碍参与者 SUD 治疗的减少有关(aOR,0.24;95% CI,0.02-2.80):与以往使用非临床症状调查数据进行的研究不同,我们发现 SV 与 GAD 或 MDD 之间没有关联。与此相反,SV 与 SSD、兴奋剂使用障碍和 OUD 的患病率存在关联,且治疗率相应下降。这些结果表明,SVM 可能有助于开发更全面的护理模式,将针对 MH 疾病和 SUD 的医疗和社会护理结合起来。
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引用次数: 0
Suicidal Ideation and Suicide Attempts After Direct or Indirect Psychotherapy: A Systematic Review and Meta-Analysis. 直接或间接心理治疗后的自杀意念和自杀企图:系统回顾与元分析》。
IF 25.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-25 DOI: 10.1001/jamapsychiatry.2024.2854
Wouter van Ballegooijen,Josine Rawee,Christina Palantza,Clara Miguel,Mathias Harrer,Ioana Cristea,Remco de Winter,Renske Gilissen,Merijn Eikelenboom,Aartjan Beekman,Pim Cuijpers
ImportanceSuicidal ideation and suicide attempts are debilitating mental health problems that are often treated with indirect psychotherapy (ie, psychotherapy that focuses on other mental health problems, such as depression or personality disorders). The effects of direct and indirect psychotherapy on suicidal ideation have not yet been examined in a meta-analysis, and several trials have been published since a previous meta-analysis examined the effect size of direct and indirect psychotherapy on suicide attempts.ObjectiveTo investigate the effect sizes of direct and indirect psychotherapy on suicidal ideation and the incidence of suicide attempts.Data SourcesPubMed, Embase, PsycInfo, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials were searched for articles published up until April 1, 2023.Study SelectionRandomized clinical trials of psychotherapy for any mental health problem, delivered in any setting, compared with any control group, and reporting suicidal ideation or suicide attempts were included. Studies measuring suicidal ideation with 1 item were excluded.Data Extraction and SynthesisPRISMA guidelines were followed. Summary data were extracted by 2 independent researchers and pooled using 3-level meta-analyses.Main Outcomes and MeasuresHedges g was pooled for suicidal ideation and relative risk (RR) was pooled for suicide attempts.ResultsOf 15 006 studies identified, 147 comprising 193 comparisons and 11 001 participants were included. Direct and indirect psychotherapy conditions were associated with reduced suicidal ideation (direct: g, -0.39; 95% CI, -0.53 to -0.24; I2, 83.2; indirect: g, -0.30; 95% CI, -0.42 to -0.18; I2, 52.2). Direct and indirect psychotherapy conditions were also associated with reduced suicide attempts (direct: RR, 0.72; 95% CI, 0.62 to 0.84; I2, 40.5; indirect: RR, 0.68; 95% CI, 0.48 to 0.95; I2, 0). Sensitivity analyses largely confirmed these results.Conclusions and RelevanceDirect and indirect interventions had similar effect sizes for reducing suicidal ideation and suicide attempts. Suicide prevention strategies could make greater use of indirect treatments to provide effective interventions for people who would not likely seek treatment for suicidal ideation or self-harm.
重要性自杀意念和自杀未遂是使人衰弱的心理健康问题,通常采用间接心理疗法(即针对抑郁症或人格障碍等其他心理健康问题的心理疗法)进行治疗。直接和间接心理疗法对自杀意念的影响尚未在一项荟萃分析中进行过研究,而且自从之前的一项荟萃分析研究了直接和间接心理疗法对自杀未遂的影响后,又发表了几项试验。目的 研究直接和间接心理疗法对自杀意念和自杀未遂发生率的影响大小。数据来源检索了PubMed、Embase、PsycInfo、Web of Science、Scopus和Cochrane Central Register of Controlled Trials中截至2023年4月1日发表的文章。研究筛选纳入了针对任何心理健康问题、在任何环境下进行、与任何对照组进行比较、报告有自杀意念或自杀企图的心理治疗随机临床试验。数据提取与综合研究遵循PRISMA指南。由两名独立研究人员提取摘要数据,并采用3级元分析法进行汇总。主要结果和测量方法对自杀意念的Hedges g进行汇总,对自杀未遂的相对风险(RR)进行汇总。结果在确定的15 006项研究中,纳入了147项,包括193项比较和11 001名参与者。直接和间接心理治疗条件与自杀意念的减少有关(直接:g,-0.39;95% CI,-0.53 至 -0.24;I2,83.2;间接:g,-0.30;95% CI,-0.42 至 -0.18;I2,52.2)。直接和间接心理治疗条件也与自杀企图的减少有关(直接:RR,0.72;95% CI,-0.42 至-0.18;I2,52.2):RR,0.72;95% CI,0.62 至 0.84;I2,40.5;间接:RR,0.68;95% CI,0.48 至 0.95;I2,0)。结论与相关性直接和间接干预对减少自杀意念和自杀企图的效果大小相似。自杀预防策略可以更多地利用间接治疗,为那些不可能因自杀意念或自残而寻求治疗的人提供有效的干预。
{"title":"Suicidal Ideation and Suicide Attempts After Direct or Indirect Psychotherapy: A Systematic Review and Meta-Analysis.","authors":"Wouter van Ballegooijen,Josine Rawee,Christina Palantza,Clara Miguel,Mathias Harrer,Ioana Cristea,Remco de Winter,Renske Gilissen,Merijn Eikelenboom,Aartjan Beekman,Pim Cuijpers","doi":"10.1001/jamapsychiatry.2024.2854","DOIUrl":"https://doi.org/10.1001/jamapsychiatry.2024.2854","url":null,"abstract":"ImportanceSuicidal ideation and suicide attempts are debilitating mental health problems that are often treated with indirect psychotherapy (ie, psychotherapy that focuses on other mental health problems, such as depression or personality disorders). The effects of direct and indirect psychotherapy on suicidal ideation have not yet been examined in a meta-analysis, and several trials have been published since a previous meta-analysis examined the effect size of direct and indirect psychotherapy on suicide attempts.ObjectiveTo investigate the effect sizes of direct and indirect psychotherapy on suicidal ideation and the incidence of suicide attempts.Data SourcesPubMed, Embase, PsycInfo, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials were searched for articles published up until April 1, 2023.Study SelectionRandomized clinical trials of psychotherapy for any mental health problem, delivered in any setting, compared with any control group, and reporting suicidal ideation or suicide attempts were included. Studies measuring suicidal ideation with 1 item were excluded.Data Extraction and SynthesisPRISMA guidelines were followed. Summary data were extracted by 2 independent researchers and pooled using 3-level meta-analyses.Main Outcomes and MeasuresHedges g was pooled for suicidal ideation and relative risk (RR) was pooled for suicide attempts.ResultsOf 15 006 studies identified, 147 comprising 193 comparisons and 11 001 participants were included. Direct and indirect psychotherapy conditions were associated with reduced suicidal ideation (direct: g, -0.39; 95% CI, -0.53 to -0.24; I2, 83.2; indirect: g, -0.30; 95% CI, -0.42 to -0.18; I2, 52.2). Direct and indirect psychotherapy conditions were also associated with reduced suicide attempts (direct: RR, 0.72; 95% CI, 0.62 to 0.84; I2, 40.5; indirect: RR, 0.68; 95% CI, 0.48 to 0.95; I2, 0). Sensitivity analyses largely confirmed these results.Conclusions and RelevanceDirect and indirect interventions had similar effect sizes for reducing suicidal ideation and suicide attempts. Suicide prevention strategies could make greater use of indirect treatments to provide effective interventions for people who would not likely seek treatment for suicidal ideation or self-harm.","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":"23 1","pages":""},"PeriodicalIF":25.8,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142321184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actualizing Military Suicide Prevention Through Digital Health Modernization. 通过数字健康现代化实现军队自杀预防。
IF 25.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-25 DOI: 10.1001/jamapsychiatry.2024.2679
Ian H Stanley,Ellen P Embrey,Vikhyat S Bebarta
{"title":"Actualizing Military Suicide Prevention Through Digital Health Modernization.","authors":"Ian H Stanley,Ellen P Embrey,Vikhyat S Bebarta","doi":"10.1001/jamapsychiatry.2024.2679","DOIUrl":"https://doi.org/10.1001/jamapsychiatry.2024.2679","url":null,"abstract":"","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":"8 1","pages":""},"PeriodicalIF":25.8,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142321177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting Suicides Among US Army Soldiers After Leaving Active Service. 预测美军士兵退出现役后的自杀率。
IF 25.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-25 DOI: 10.1001/jamapsychiatry.2024.2744
Chris J Kennedy,Jaclyn C Kearns,Joseph C Geraci,Sarah M Gildea,Irving H Hwang,Andrew J King,Howard Liu,Alex Luedtke,Brian P Marx,Santiago Papini,Maria V Petukhova,Nancy A Sampson,Jordan W Smoller,Charles J Wolock,Nur Hani Zainal,Murray B Stein,Robert J Ursano,James R Wagner,Ronald C Kessler
ImportanceThe suicide rate of military servicemembers increases sharply after returning to civilian life. Identifying high-risk servicemembers before they leave service could help target preventive interventions.ObjectiveTo develop a model based on administrative data for regular US Army soldiers that can predict suicides 1 to 120 months after leaving active service.Design, Setting, and ParticipantsIn this prognostic study, a consolidated administrative database was created for all regular US Army soldiers who left service from 2010 through 2019. Machine learning models were trained to predict suicides over the next 1 to 120 months in a random 70% training sample. Validation was implemented in the remaining 30%. Data were analyzed from March 2023 through March 2024.Main outcome and measuresThe outcome was suicide in the National Death Index. Predictors came from administrative records available before leaving service on sociodemographics, Army career characteristics, psychopathologic risk factors, indicators of physical health, social networks and supports, and stressors.ResultsOf the 800 579 soldiers in the cohort (84.9% male; median [IQR] age at discharge, 26 [23-33] years), 2084 suicides had occurred as of December 31, 2019 (51.6 per 100 000 person-years). A lasso model assuming consistent slopes over time discriminated as well over all but the shortest risk horizons as more complex stacked generalization ensemble machine learning models. Test sample area under the receiver operating characteristic curve ranged from 0.87 (SE = 0.06) for suicides in the first month after leaving service to 0.72 (SE = 0.003) for suicides over 120 months. The 10% of soldiers with highest predicted risk accounted for between 30.7% (SE = 1.8) and 46.6% (SE = 6.6) of all suicides across horizons. Calibration was for the most part better for the lasso model than the super learner model (both estimated over 120-month horizons.) Net benefit of a model-informed prevention strategy was positive compared with intervene-with-all or intervene-with-none strategies over a range of plausible intervention thresholds. Sociodemographics, Army career characteristics, and psychopathologic risk factors were the most important classes of predictors.Conclusions and relevanceThese results demonstrated that a model based on administrative variables available at the time of leaving active Army service can predict suicides with meaningful accuracy over the subsequent decade. However, final determination of cost-effectiveness would require information beyond the scope of this report about intervention content, costs, and effects over relevant horizons in relation to the monetary value placed on preventing suicides.
重要性军人回归平民生活后自杀率急剧上升。设计、设置和参与者在这项预后研究中,我们为 2010 年至 2019 年期间退役的所有正规美国陆军士兵创建了一个综合行政数据库。在70%的随机训练样本中,对机器学习模型进行了训练,以预测未来1至120个月内的自杀事件。在其余 30% 的样本中进行验证。主要结果和测量指标结果是国家死亡指数中的自杀。预测因素来自退役前的行政记录,包括社会人口统计学、军队职业特征、精神病理学风险因素、身体健康状况指标、社会网络和支持以及压力因素。结果在队列中的 800 579 名士兵(84.9% 为男性;退役时的中位数 [IQR] 年龄为 26 [23-33] 岁)中,截至 2019 年 12 月 31 日发生了 2084 起自杀事件(每 10 万人年 51.6 起)。假设斜率随时间变化一致的套索模型与更复杂的堆叠泛化集合机器学习模型相比,在除最短风险范围外的所有风险范围内都具有良好的判别能力。接受者操作特征曲线下的测试样本面积从退役后第一个月内自杀的 0.87(SE = 0.06)到 120 个月内自杀的 0.72(SE = 0.003)不等。预测风险最高的 10%的士兵占整个范围内所有自杀人数的 30.7%(SE = 1.8)到 46.6%(SE = 6.6)。与 "全部干预 "或 "不干预 "策略相比,在一系列合理的干预阈值范围内,以模型为依据的预防策略的净收益为正。社会人口学、军队职业特征和精神病理学风险因素是最重要的几类预测因素。这些结果表明,基于离开现役军队时可用的管理变量的模型可以准确预测随后十年的自杀事件。然而,最终确定成本效益需要本报告范围之外的信息,即干预内容、成本和相关时间段内的效果与预防自杀的货币价值之间的关系。
{"title":"Predicting Suicides Among US Army Soldiers After Leaving Active Service.","authors":"Chris J Kennedy,Jaclyn C Kearns,Joseph C Geraci,Sarah M Gildea,Irving H Hwang,Andrew J King,Howard Liu,Alex Luedtke,Brian P Marx,Santiago Papini,Maria V Petukhova,Nancy A Sampson,Jordan W Smoller,Charles J Wolock,Nur Hani Zainal,Murray B Stein,Robert J Ursano,James R Wagner,Ronald C Kessler","doi":"10.1001/jamapsychiatry.2024.2744","DOIUrl":"https://doi.org/10.1001/jamapsychiatry.2024.2744","url":null,"abstract":"ImportanceThe suicide rate of military servicemembers increases sharply after returning to civilian life. Identifying high-risk servicemembers before they leave service could help target preventive interventions.ObjectiveTo develop a model based on administrative data for regular US Army soldiers that can predict suicides 1 to 120 months after leaving active service.Design, Setting, and ParticipantsIn this prognostic study, a consolidated administrative database was created for all regular US Army soldiers who left service from 2010 through 2019. Machine learning models were trained to predict suicides over the next 1 to 120 months in a random 70% training sample. Validation was implemented in the remaining 30%. Data were analyzed from March 2023 through March 2024.Main outcome and measuresThe outcome was suicide in the National Death Index. Predictors came from administrative records available before leaving service on sociodemographics, Army career characteristics, psychopathologic risk factors, indicators of physical health, social networks and supports, and stressors.ResultsOf the 800 579 soldiers in the cohort (84.9% male; median [IQR] age at discharge, 26 [23-33] years), 2084 suicides had occurred as of December 31, 2019 (51.6 per 100 000 person-years). A lasso model assuming consistent slopes over time discriminated as well over all but the shortest risk horizons as more complex stacked generalization ensemble machine learning models. Test sample area under the receiver operating characteristic curve ranged from 0.87 (SE = 0.06) for suicides in the first month after leaving service to 0.72 (SE = 0.003) for suicides over 120 months. The 10% of soldiers with highest predicted risk accounted for between 30.7% (SE = 1.8) and 46.6% (SE = 6.6) of all suicides across horizons. Calibration was for the most part better for the lasso model than the super learner model (both estimated over 120-month horizons.) Net benefit of a model-informed prevention strategy was positive compared with intervene-with-all or intervene-with-none strategies over a range of plausible intervention thresholds. Sociodemographics, Army career characteristics, and psychopathologic risk factors were the most important classes of predictors.Conclusions and relevanceThese results demonstrated that a model based on administrative variables available at the time of leaving active Army service can predict suicides with meaningful accuracy over the subsequent decade. However, final determination of cost-effectiveness would require information beyond the scope of this report about intervention content, costs, and effects over relevant horizons in relation to the monetary value placed on preventing suicides.","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":"33 1","pages":""},"PeriodicalIF":25.8,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suicidality Calls to a National Helpline After a Terror Attack and War. 恐怖袭击和战争后全国求助热线接到的自杀电话。
IF 25.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-18 DOI: 10.1001/jamapsychiatry.2024.2034
Joy Benatov,Liat Itzhaky,Shiri Daniels,Gil Zalsman
ImportanceChanges in suicide rates after a nationwide trauma may be different from changes in psychiatric symptoms or general distress after such events. However, very few studies have examined short-term suicide-related reactions after such an event.ObjectiveTo evaluate the short-term outcome of the events in Israel on October 7, 2023, a large-scale terror attack and unfolding war, on changes in suicidality as reflected in percentages of suicide-related calls in relation to all calls to a national mental health first aid helpline, the Israeli Association for Emotional First Aid (ERAN).Design, Setting and ParticipantsThe data included all interactions via the various ERAN helpline services between January 1, 2022, and December 31, 2023.ExposuresThe October 7, 2023, terror attack on Israel.Mean Outcomes and MeasuresChanges in the numbers of overall calls and suicide-related calls to the ERAN helpline using an interrupted time-series analysis.ResultsA total of 602 323 calls were received by the ERAN helpline. The number of calls reflecting psychological distress in the 3 months before October 7, 2023, was 67 555 compared with 89 445 calls in the 3 months after. Analysis indicated that overall calls increased significantly on October 7 (β = 2089.16; 95% CI, 1918.97-2259.35). In addition, the daily trajectory of all calls changed significantly after October 7 (β = -22.77; 95% CI, -33.37 to -12.16), such that there was a decrease in the number of calls per day (β = -11.34; SE = 1.213; t = -9.35; P < .001). The number of suicide-related calls in the 3 months before October 7 was 1887, whereas 1663 suicide-related calls were registered in the 3 months after. Analysis showed that there were no changes in the daily number of suicide-related calls from before October 7 (β = -0.001; 95% CI, -0.005 to 0.03) or on October 7 (β = -0.22; 95% CI, -3.69 to 3.25). Therefore, the percentage of suicide-related calls decreased significantly on October 7 (β = -1.42; 95% CI, -1.92 to -0.92) and gradually increased in the following period (β = 0.016; 95% CI, 0.006-0.026).Conclusions and RelevanceThe findings of this cohort study suggest that although short-term emotional distress increased after national trauma, the percentage of suicide-related calls decreased. These results support previous studies suggesting that suicidality is not one of the immediate reactions to such traumas.
重要性全国性创伤后自杀率的变化可能不同于此类事件后精神症状或一般痛苦的变化。目标评估 2023 年 10 月 7 日在以色列发生的大规模恐怖袭击和正在进行的战争事件对自杀率变化的短期影响,自杀相关电话占全国心理健康急救求助热线以色列情感急救协会(ERAN)所有电话的百分比反映了自杀率的变化。设计、环境和参与者数据包括2022年1月1日至2023年12月31日期间通过ERAN求助热线各种服务进行的所有互动。暴露2023年10月7日对以色列的恐怖袭击。平均结果和测量采用间断时间序列分析法对ERAN求助热线的总来电数量和自杀相关来电数量进行分析。在 2023 年 10 月 7 日之前的 3 个月中,反映心理困扰的电话数量为 67 555 个,而在之后的 3 个月中则为 89 445 个。分析表明,10 月 7 日当天的总来电数明显增加(β = 2089.16;95% CI,1918.97-2259.35)。此外,在 10 月 7 日之后,所有呼叫的日轨迹发生了显著变化(β = -22.77; 95% CI, -33.37 to -12.16),每天的呼叫数量有所减少(β = -11.34; SE = 1.213; t = -9.35; P < .001)。在 10 月 7 日之前的 3 个月中,与自杀有关的电话数量为 1887 个,而在 10 月 7 日之后的 3 个月中,与自杀有关的电话数量为 1663 个。分析表明,与 10 月 7 日之前(β = -0.001;95% CI,-0.005 至 0.03)或 10 月 7 日当天(β = -0.22;95% CI,-3.69 至 3.25)相比,每天的自杀相关电话数量没有变化。因此,自杀相关电话的百分比在 10 月 7 日显著下降(β = -1.42; 95% CI, -1.92 to -0.92),并在接下来的时间里逐渐上升(β = 0.016; 95% CI, 0.006-0.026)。这些结果支持了之前的研究,即自杀并不是此类创伤的直接反应之一。
{"title":"Suicidality Calls to a National Helpline After a Terror Attack and War.","authors":"Joy Benatov,Liat Itzhaky,Shiri Daniels,Gil Zalsman","doi":"10.1001/jamapsychiatry.2024.2034","DOIUrl":"https://doi.org/10.1001/jamapsychiatry.2024.2034","url":null,"abstract":"ImportanceChanges in suicide rates after a nationwide trauma may be different from changes in psychiatric symptoms or general distress after such events. However, very few studies have examined short-term suicide-related reactions after such an event.ObjectiveTo evaluate the short-term outcome of the events in Israel on October 7, 2023, a large-scale terror attack and unfolding war, on changes in suicidality as reflected in percentages of suicide-related calls in relation to all calls to a national mental health first aid helpline, the Israeli Association for Emotional First Aid (ERAN).Design, Setting and ParticipantsThe data included all interactions via the various ERAN helpline services between January 1, 2022, and December 31, 2023.ExposuresThe October 7, 2023, terror attack on Israel.Mean Outcomes and MeasuresChanges in the numbers of overall calls and suicide-related calls to the ERAN helpline using an interrupted time-series analysis.ResultsA total of 602 323 calls were received by the ERAN helpline. The number of calls reflecting psychological distress in the 3 months before October 7, 2023, was 67 555 compared with 89 445 calls in the 3 months after. Analysis indicated that overall calls increased significantly on October 7 (β = 2089.16; 95% CI, 1918.97-2259.35). In addition, the daily trajectory of all calls changed significantly after October 7 (β = -22.77; 95% CI, -33.37 to -12.16), such that there was a decrease in the number of calls per day (β = -11.34; SE = 1.213; t = -9.35; P < .001). The number of suicide-related calls in the 3 months before October 7 was 1887, whereas 1663 suicide-related calls were registered in the 3 months after. Analysis showed that there were no changes in the daily number of suicide-related calls from before October 7 (β = -0.001; 95% CI, -0.005 to 0.03) or on October 7 (β = -0.22; 95% CI, -3.69 to 3.25). Therefore, the percentage of suicide-related calls decreased significantly on October 7 (β = -1.42; 95% CI, -1.92 to -0.92) and gradually increased in the following period (β = 0.016; 95% CI, 0.006-0.026).Conclusions and RelevanceThe findings of this cohort study suggest that although short-term emotional distress increased after national trauma, the percentage of suicide-related calls decreased. These results support previous studies suggesting that suicidality is not one of the immediate reactions to such traumas.","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":"7 1","pages":""},"PeriodicalIF":25.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Outcomes of Continuation and Maintenance Electroconvulsive Therapy 持续和维持电休克疗法的临床效果
IF 25.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-18 DOI: 10.1001/jamapsychiatry.2024.2360
Anders Jørgensen, Frederikke Hoerdam Gronemann, Maarten P. Rozing, Martin B. Jørgensen, Merete Osler
ImportanceLarge-scale evidence for the efficacy of continuation and maintenance electroconvulsive therapy (c/mECT) is lacking.ObjectiveTo provide an exhaustive and naturalistic insight into the real-world outcomes and the cost-effectiveness of c/mECT in a large dataset.Design, Setting, and ParticipantsThis cohort study included all patients in the Danish National Patient Registry who initiated treatment with ECT from 2003 through 2022. The data were analyzed from October 2023 to February 2024.ExposuresECT. An algorithm to identify c/mECTs in the dataset was developed: (&amp;gt;3 treatments with ≥7 and &amp;lt;90 days between adjacent treatments, occurring within a time frame of 180 days [cECT] or more [mECT] after an acute [aECT] series).Main Outcomes and MeasuresThe association of c/mECT with subsequent 6- to 12-month risk of hospitalization or suicidal behavior using Cox proportional hazard regression with multiple adjustments and aECT only as a reference, propensity score matching, and self-controlled case series analysis using a Poisson regression model. A cost-effectiveness analysis based on hospitalization and ECT expenses was made.ResultsA total of 19 944 individuals were treated with ECT (12 157 women [61%], 7787 men [39%]; median [IQR] age, 55 [41-70] years). Of these, 1533 individuals (7.7%) received c/mECT at any time point (1017 [5.1%] cECT only and 516 [2.6%] mECT). Compared with patients receiving aECT only, c/mECT patients more frequently experienced schizophrenia (odds ratio [OR], 2.14; 95% CI, 1.86-2.46) and schizoaffective disorder (OR, 2.42; 95% CI, 1.90-3.09) and less frequently unipolar depression (OR, 0.56; 95% CI, 0.51-0.62). In all models, c/mECT was associated with a lower rate of hospitalization after finishing aECT (eg, 6-month adjusted hazard ratio, 0.68; 95% CI, 0.60-0.78 [Cox regression]; 6-month incidence rate ratio, 0.51; 95% CI, 0.41-0.62 [Poisson regression]). There was no significant difference in the risk of suicidal behavior. Compared with the periods before the end of aECT, c/mECT was associated with a substantial reduction in total treatment costs.Conclusions and RelevanceIn a nationwide and naturalistic setting, c/mECT after aECT was infrequently used but associated with a lower risk of readmission than aECT alone. The totality of the evidence indicates that c/mECT should be considered more often to prevent relapse after successful aECT in patients whose condition does not respond sufficiently to other interventions.
重要性目前尚缺乏有关持续和维持电休克疗法(c/mECT)疗效的大规模证据。目的通过一个大型数据集,对 c/mECT 的实际疗效和成本效益进行详尽的自然分析。数据分析时间为 2023 年 10 月至 2024 年 2 月。开发了一种算法来识别数据集中的c/mECTs:(相邻治疗之间相隔≥7和&amp;lt;90天的3次治疗,在急性[aECT]系列治疗后180天[cECT]或更长时间[mECT]内发生)。主要结果和测量采用经多重调整的 Cox 比例危险回归、仅以 aECT 为参照、倾向得分匹配以及使用泊松回归模型的自控病例系列分析,得出 c/mECT 与随后 6 至 12 个月的住院或自杀行为风险之间的关系。结果 共有 19 944 人接受了 ECT 治疗(女性 12 157 人 [61%],男性 7 787 人 [39%];中位数 [IQR] 年龄 55 [41-70] 岁)。其中,1533 人(7.7%)在任何时间点接受了 c/mECT 治疗(1017 人 [5.1%] 仅接受了 cECT,516 人 [2.6%] 接受了 mECT)。与仅接受 aECT 的患者相比,c/mECT 患者更常出现精神分裂症(几率比 [OR],2.14;95% CI,1.86-2.46)和分裂情感障碍(OR,2.42;95% CI,1.90-3.09),而单相抑郁症(OR,0.56;95% CI,0.51-0.62)则较少出现。在所有模型中,c/mECT 与完成 aECT 后较低的住院率相关(例如,6 个月调整后危险比为 0.68;95% CI 为 0.60-0.78 [Cox回归];6 个月发病率比为 0.51;95% CI 为 0.41-0.62 [泊松回归])。自杀行为的风险没有明显差异。结论与意义在全国范围内的自然环境中,aECT 后使用 c/mECT 的情况并不常见,但与单独使用 aECT 相比,c/mECT 的再入院风险更低。所有证据表明,对于病情对其他干预措施反应不佳的患者,应更多地考虑使用 c/mECT 来预防 aECT 成功后的复发。
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引用次数: 0
Are Psychiatric Nosologies Limiting the Success of Clinical Prediction Models? 精神病学命名是否限制了临床预测模型的成功?
IF 25.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-18 DOI: 10.1001/jamapsychiatry.2024.2662
Isabelle Scott,Barnaby Nelson
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引用次数: 0
Patient Self-Guided Interventions to Reduce Sedative Use and Improve Sleep: The YAWNS NB Randomized Clinical Trial. 减少镇静剂使用和改善睡眠的患者自我指导干预:YAWNS NB 随机临床试验。
IF 25.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-18 DOI: 10.1001/jamapsychiatry.2024.2731
David M Gardner,Justin P Turner,Sandra Magalhaes,Malgorzata Rajda,Andrea L Murphy
ImportanceDirect-to-patient interventions enabling transitions from long-term benzodiazepine receptor agonist (BZRA) use to cognitive behavioral therapy for insomnia (CBTI) by older adults has the potential to reduce BZRA use and related harms while improving sleep outcomes without requiring prearranged clinician involvement.ObjectiveTo compare 2 direct-to-patient behavior change interventions with treatment as usual (TAU) on BZRA use, sleep, and other health outcomes, and uptake of CBTI techniques.Design, Setting, and ParticipantsThe Your Answers When Needing Sleep in New Brunswick (YAWNS NB) study was a 3-arm, pragmatic, open-label, minimum-contact, randomized clinical trial. The study began November 2020 and ended June 2022. Participants were randomly allocated to 1 of 3 groups, including 2 different mailed behavior change interventions or no intervention (TAU). Participants were from communities across the province of New Brunswick, Canada, and included adults 65 years and older living independently with long-term use of BZRAs and current or past insomnia.InterventionsThe Sleepwell package (YAWNS-1) consisted of a cover letter and 2 booklets ("How to Stop Sleeping Pills" and "How to Get Your Sleep Back"). The other package (YAWNS-2) included updated versions of the 2 booklets ("You May Be at Risk" and "How to Get a Good Night's Sleep Without Medication") used in the Eliminating Medications Through Patient Ownership of End Results (EMPOWER) study.Main Outcomes and MeasuresBZRA use at 6 months was the primary measure. Secondary measures included CBTI use, sleep, insomnia, daytime sleepiness, safety, anxiety, frailty, and quality of life.ResultsA total of 1295 individuals expressed interest in the study, and 565 (43.6%) completed a baseline assessment. Participants had a mean (SD) age of 72.1 (5.7) years, a mean (SD) BZRA use duration of 11.4 (9.1) years, and 362 (64.1%) were female. Discontinuations and dose reductions of 25% or greater were highest with YAWNS-1 (50 of 191 [26.2%]; 39 of 191 [20.4%]; total, 46.6%) compared with YAWNS-2 (38 of 187 [20.3%]; 27 of 187 [14.4%]; total, 34.8%, P = .02) and TAU (14 of 187 [7.5%]; 24 of 187 [12.8%]; total, 20.3%, P < .001). YAWNS-1 also demonstrated better uptake of CBTI techniques and sleep outcomes compared with YAWNS-2 (new CBTI techniques: 3.1 vs 2.4; P =.03; sleep efficiency change: 4.1% vs -1.7%; P =.001) and reduced insomnia severity and daytime sleepiness compared with TAU (insomnia severity index change: -2.0 vs 0.3; P <.001; Epworth Sleepiness Scale change: -0.8 vs 0.3; P =.001).Conclusions and RelevanceResults of the YAWNS NB randomized clinical trial show that, as a simple, scalable, direct-to-patient intervention, YAWNS-1 substantially reduced BZRA use and improved sleep outcomes. It could be implemented to transform insomnia care for older adults at the population level.Trial RegistrationClinicalTrials.gov Identifier: NCT04406103.
重要性直接对患者进行干预,使老年人从长期使用苯二氮卓受体激动剂(BZRA)过渡到失眠认知行为疗法(CBTI),有可能减少 BZRA 的使用和相关危害,同时改善睡眠效果,而无需事先安排临床医生参与。设计、设置和参与者新不伦瑞克睡眠需求时您的答案(YAWNS NB)研究是一项三臂、务实、开放标签、最小接触、随机临床试验。研究于 2020 年 11 月开始,2022 年 6 月结束。参与者被随机分配到 3 组中的 1 组,包括 2 种不同的邮寄行为改变干预措施或无干预措施(TAU)。参与者来自加拿大新不伦瑞克省的各个社区,包括65岁及以上独立生活、长期服用BZRAs、目前或过去曾失眠的成年人。干预措施睡眠健康套餐(YAWNS-1)包括一封封面信和两本小册子(《如何停止服用安眠药》和《如何恢复睡眠》)。另一种套餐(YAWNS-2)包括 "通过患者自主决定最终结果来消除药物"(EMPOWER)研究中使用的两本小册子(《您可能面临风险》和《如何在不服药的情况下获得良好睡眠》)的更新版本。次要测量指标包括 CBTI 使用情况、睡眠、失眠、白天嗜睡、安全、焦虑、虚弱和生活质量。结果共有 1295 人表示有兴趣参与研究,其中 565 人(43.6%)完成了基线评估。参与者的平均(标清)年龄为 72.1 (5.7)岁,平均(标清)服用 BZRA 的时间为 11.4 (9.1)年,其中 362 人(64.1%)为女性。YAWNS-1(191 例中有 50 例 [26.2%];191 例中有 39 例 [20.4%];总计 46.6%)与 YAWNS-2 (187 例中有 38 例 [20.3%];187 例中有 27 例 [14.4%];总计 34.8%,P = .02)和 TAU(187 例中有 14 例 [7.5%];187 例中有 24 例 [12.8%];总计 20.3%,P < .001)相比,停药和剂量减少 25% 或更多的比例最高。与 YAWNS-2 相比,YAWNS-1 还显示出更好的 CBTI 技术接受率和睡眠效果(新 CBTI 技术:3.1 vs 2.4;新 CBTI 技术:3.1 vs 2.4;新 CBTI 技术:3.1 vs 2.4):3.1 vs 2.4;P =.03;睡眠效率变化:结论和相关性YAWNS NB 随机临床试验的结果表明,作为一种简单、可扩展、直接面向患者的干预措施,YAWNS-1 大幅减少了 BZRA 的使用并改善了睡眠效果。该干预措施的实施可在人群层面改变对老年人的失眠护理:NCT04406103。
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引用次数: 0
Prioritization of Psychopathological Symptoms and Clinical Characterization in Psychiatric Diagnoses 精神病诊断中精神病理症状和临床特征的优先排序
IF 25.8 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-11 DOI: 10.1001/jamapsychiatry.2024.2652
Stefan Leucht, Jim van Os, Markus Jäger, John M. Davis
ImportancePsychiatry mainly deals with conditions that are mediated by brain function but are not directly attributable to specific brain abnormalities. Given the lack of concrete biological markers, such as laboratory tests or imaging results, the development of diagnostic systems is difficult.ObservationsThis narrative review evaluated 9 diagnostic approaches. The validity of the DSM and the International Classification of Disorders (ICD) is limited. The Research Domain Criteria is a research framework, not a diagnostic system. The clinical utility of the quantitatively derived, dimensional Hierarchical Taxonomy of Psychopathology is questionable. The Psychodynamic Diagnostic Manual Version 2 follows psychoanalytic theory and focuses on personality. Unlike the personality assessments in ICD-11 or DSM-5’s alternative model, based on pathological extremes of the big 5 traits (extraversion, agreeableness, openness, conscientiousness, and neuroticism), it lacks foundation in empirical evidence. Network analytic approaches are intriguing, but their complexity makes them difficult to implement. Staging would be easier if individually predictive biological markers were available. The problem with all these new approaches is that they abstract patient experiences into higher-order constructs, potentially obscuring individual symptoms so much that they no longer reflect patients’ actual problems.Conclusions and RelevanceICD and DSM diagnoses can be questioned, but the reality of psychopathological symptoms, such as hallucinations, depression, anxiety, compulsions, and the suffering stemming from them, cannot. Therefore, it may be advisable to primarily describe patients according to the psychopathological symptoms they present, and any resulting personal syndromes, embedded in a framework of contextual clinical characterization including personality assessment and staging. The DSM and ICD are necessary for reimbursement, but they should be simplified and merged. A primarily psychopathological symptoms–based, clinical characterization approach would be multidimensional and clinically useful, because it would lead to problem-oriented treatment and support transdiagnostic research. It should be based on a universally used instrument to assess psychopathology and structured clinical characterization.
重要性精神病学主要研究由大脑功能介导但并非直接归因于特定大脑异常的病症。由于缺乏具体的生物标记,如实验室检测或成像结果,因此诊断系统的开发十分困难。DSM 和《国际疾病分类》(ICD)的有效性有限。研究领域标准是一个研究框架,而非诊断系统。定量得出的精神病理学分层分类法的临床实用性值得怀疑。心理动力学诊断手册第二版》遵循精神分析理论,侧重于人格。与 ICD-11 中的人格评估或 DSM-5 的替代模型(基于五大特质(外向性、合意性、开放性、自觉性和神经质)的病态极端)不同,它缺乏实证依据。网络分析方法令人感兴趣,但其复杂性使其难以实施。如果有可以单独预测的生物标志物,分期会更容易。所有这些新方法的问题在于,它们将患者的经历抽象为更高阶的建构,有可能使个体症状变得模糊不清,以至于它们不再反映患者的实际问题。结论与相关性精神疾病和 DSM 诊断可以被质疑,但幻觉、抑郁、焦虑、强迫等精神病理症状的真实性以及由此产生的痛苦却不能被质疑。因此,也许应该主要根据患者表现出的精神病理症状以及由此产生的个人综合征来描述患者,并将其嵌入包括人格评估和分期在内的临床特征描述框架中。DSM 和 ICD 是报销所必需的,但应加以简化和合并。主要以精神病理症状为基础的临床特征描述方法将是多维的和临床有用的,因为它将导致以问题为导向的治疗并支持跨诊断研究。这种方法应以普遍使用的精神病理学评估工具和结构化临床特征描述为基础。
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引用次数: 0
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JAMA Psychiatry
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