{"title":"Lung cancer screening: an urgent necessity.","authors":"Gustavo Faibischew Prado, Thiago Lins Fagundes de Sousa, Isabele Alves Chirichela","doi":"10.36416/1806-3756/e20250344","DOIUrl":"10.36416/1806-3756/e20250344","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250344"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.36416/1806-3756/e20250229
Lorenzo Carriera, Roberto Lipsi, Angelo Coppola
{"title":"Red flags for thoracic endometriosis.","authors":"Lorenzo Carriera, Roberto Lipsi, Angelo Coppola","doi":"10.36416/1806-3756/e20250229","DOIUrl":"10.36416/1806-3756/e20250229","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250229"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.36416/1806-3756/e20250318
Rafael Futoshi Mizutani, Ubiratan de Paula Santos
{"title":"Household air pollution: another threat to Indigenous people in Brazil.","authors":"Rafael Futoshi Mizutani, Ubiratan de Paula Santos","doi":"10.36416/1806-3756/e20250318","DOIUrl":"10.36416/1806-3756/e20250318","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250318"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.36416/1806-3756/e20250211
Simone Duarte Damato, Alessandro Severo Alves de Melo, Edson Marchiori
{"title":"Accidental chest penetration of a glass foreign body.","authors":"Simone Duarte Damato, Alessandro Severo Alves de Melo, Edson Marchiori","doi":"10.36416/1806-3756/e20250211","DOIUrl":"10.36416/1806-3756/e20250211","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250211"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27eCollection Date: 2025-01-01DOI: 10.36416/1806-3756/e20250125
Isadora Salles, Jamile Garcia de Oliveira, Alexandra Brito de Souza, Silvia Cohn, Renata Spener-Gomes, Solange Dourado de Andrade, Valeria Saraceni, Solange Cesar Cavalcante, Jeff Weiser, Makaita Gombe, Violet Chihota, Gavin Churchyard, Richard E Chaisson, Marcelo Cordeiro-Santos, Betina Durovni
Objective: In July of 2021, the Brazilian National Ministry of Health integrated three months of once-weekly isoniazid plus rifapentine (3HP) into the National Guidelines for Tuberculosis Control as a first-line tuberculosis preventive therapy (TPT) option for people living with HIV (PLHIV) and tuberculosis household contacts (HHCs). As part of the Unitaid-sponsored Increasing Market and Public Health Outcomes through Scaling up Affordable Access Models of Short Course Preventive Therapy for TB project to implement short-course TPT, we evaluated 3HP uptake, completion, and tolerability among PLHIV and pediatric HHCs in Brazil.
Methods: We conducted a multicenter single-arm pragmatic project to roll out 3HP for PLHIV and HHCs in the 2- to 14-year age bracket in the cities of Rio de Janeiro and Manaus, Brazil. Participants were identified, treated, and monitored in accordance with Brazilian national tuberculosis guidelines. De-identified patient-level data on treatment initiation, adverse events, and completion were collected and analyzed.
Results: From October of 2021 to March of 2023, 380 PLHIV (77.6% of whom were male; median age, 40 years [IQR, 31-51]) and 74 HHCs (54.1% of whom were male; median age, 8.6 years [IQR, 5.1-11.8]) were enrolled in the study. Treatment completion rates were 83.7% among PLHIV and 82.4% among HHCs. Completion rates were higher in Rio de Janeiro than in Manaus (PLHIV: 86.0% vs. 79.6%; HHCs: 85.2% vs. 80.9%), although completion of 10 doses was similar (PLHIV: 86.4% vs. 86.1%). Adverse event-related discontinuation was low (PLHIV: 2.4%; HHCs: 2.7%). One person living with HIV developed active tuberculosis during treatment. At six months of follow-up, 99.6% of the PLHIV remained free of tuberculosis.
Conclusions: The 3HP regimen was successfully introduced, had high treatment completion rates, and was well tolerated. Widespread use of 3HP for TPT may accelerate tuberculosis elimination in Brazil.
目的：2021年7月，巴西国家卫生部将为期3个月、每周一次的异烟肼加利福喷丁（3HP）纳入国家结核病控制指南，作为艾滋病毒感染者（PLHIV）和结核病家庭接触者（hhc）的一线结核病预防治疗（TPT）选择。作为unitaid赞助的通过扩大可负担的短期结核病预防治疗模式来增加市场和公共卫生结果的一部分，我们评估了巴西PLHIV和儿科hhc患者3HP的吸收、完成和耐受性。方法：我们在巴西里约热内卢和马瑙斯市开展了一项多中心单臂实用项目，在2至14岁年龄组的PLHIV和hhc人群中推广3HP。根据巴西国家结核病指南对参与者进行了识别、治疗和监测。收集和分析关于治疗开始、不良事件和完成的未识别患者水平的数据。结果：从2021年10月至2023年3月，共有380例PLHIV患者（77.6%为男性，中位年龄40岁[IQR， 31-51]）和74例hhc患者（54.1%为男性，中位年龄8.6岁[IQR， 5.1-11.8]）纳入研究。治疗完成率分别为83.7%和82.4%。里约热内卢的完成率高于马瑙斯（PLHIV: 86.0% vs. 79.6%; HHCs: 85.2% vs. 80.9%），尽管10剂的完成率相似（PLHIV: 86.4% vs. 86.1%）。不良事件相关的停药率很低（PLHIV: 2.4%; hhc: 2.7%）。1名艾滋病毒感染者在治疗期间发展为活动性结核病。在6个月的随访中，99.6%的hiv感染者仍然没有结核。结论：3HP方案成功引入，治疗完成率高，耐受性好。在巴西，广泛使用3HP进行破伤风三联疗法可能会加速结核病的消除。
{"title":"Treatment completion and challenges in rolling out 12-dose weekly rifapentine plus isoniazid to prevent tuberculosis among people living with HIV and pediatric household contacts in Brazil.","authors":"Isadora Salles, Jamile Garcia de Oliveira, Alexandra Brito de Souza, Silvia Cohn, Renata Spener-Gomes, Solange Dourado de Andrade, Valeria Saraceni, Solange Cesar Cavalcante, Jeff Weiser, Makaita Gombe, Violet Chihota, Gavin Churchyard, Richard E Chaisson, Marcelo Cordeiro-Santos, Betina Durovni","doi":"10.36416/1806-3756/e20250125","DOIUrl":"10.36416/1806-3756/e20250125","url":null,"abstract":"<p><strong>Objective: </strong>In July of 2021, the Brazilian National Ministry of Health integrated three months of once-weekly isoniazid plus rifapentine (3HP) into the National Guidelines for Tuberculosis Control as a first-line tuberculosis preventive therapy (TPT) option for people living with HIV (PLHIV) and tuberculosis household contacts (HHCs). As part of the Unitaid-sponsored Increasing Market and Public Health Outcomes through Scaling up Affordable Access Models of Short Course Preventive Therapy for TB project to implement short-course TPT, we evaluated 3HP uptake, completion, and tolerability among PLHIV and pediatric HHCs in Brazil.</p><p><strong>Methods: </strong>We conducted a multicenter single-arm pragmatic project to roll out 3HP for PLHIV and HHCs in the 2- to 14-year age bracket in the cities of Rio de Janeiro and Manaus, Brazil. Participants were identified, treated, and monitored in accordance with Brazilian national tuberculosis guidelines. De-identified patient-level data on treatment initiation, adverse events, and completion were collected and analyzed.</p><p><strong>Results: </strong>From October of 2021 to March of 2023, 380 PLHIV (77.6% of whom were male; median age, 40 years [IQR, 31-51]) and 74 HHCs (54.1% of whom were male; median age, 8.6 years [IQR, 5.1-11.8]) were enrolled in the study. Treatment completion rates were 83.7% among PLHIV and 82.4% among HHCs. Completion rates were higher in Rio de Janeiro than in Manaus (PLHIV: 86.0% vs. 79.6%; HHCs: 85.2% vs. 80.9%), although completion of 10 doses was similar (PLHIV: 86.4% vs. 86.1%). Adverse event-related discontinuation was low (PLHIV: 2.4%; HHCs: 2.7%). One person living with HIV developed active tuberculosis during treatment. At six months of follow-up, 99.6% of the PLHIV remained free of tuberculosis.</p><p><strong>Conclusions: </strong>The 3HP regimen was successfully introduced, had high treatment completion rates, and was well tolerated. Widespread use of 3HP for TPT may accelerate tuberculosis elimination in Brazil.</p>","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250125"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.36416/1806-3756/e20250207
Bianca Fidelix Espindula, Iunis Suzuki, Altair da Silva Costa Junior, Priscila Mina Falsarella, Rodrigo Gobbo Garcia
{"title":"Bronchoscopy and interventional radiology: a strategic alliance in thoracic disease management.","authors":"Bianca Fidelix Espindula, Iunis Suzuki, Altair da Silva Costa Junior, Priscila Mina Falsarella, Rodrigo Gobbo Garcia","doi":"10.36416/1806-3756/e20250207","DOIUrl":"10.36416/1806-3756/e20250207","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250207"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.36416/1806-3756/e20250348
Maria Paula de Carli Hanel, Júlia Giffoni Krey, Laissa Harumi Furukawa, Marcos Brum, Frederico Friedrich, Leonardo Araújo Pinto
{"title":"Inhalation therapy: current and emerging devices in pediatrics.","authors":"Maria Paula de Carli Hanel, Júlia Giffoni Krey, Laissa Harumi Furukawa, Marcos Brum, Frederico Friedrich, Leonardo Araújo Pinto","doi":"10.36416/1806-3756/e20250348","DOIUrl":"10.36416/1806-3756/e20250348","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250348"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.36416/1806-3756/e20250278
Edson Marchiori, Bruno Hochhegger, Gláucia Zanetti
{"title":"Intrapulmonary lymph nodes.","authors":"Edson Marchiori, Bruno Hochhegger, Gláucia Zanetti","doi":"10.36416/1806-3756/e20250278","DOIUrl":"10.36416/1806-3756/e20250278","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250278"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.36416/1806-3756/e20250163
Irlanda Alvarado-Amador, Mario Arturo Flores-Valadez, Laura Gochicoa-Rangel
{"title":"Technical aspects and interpretation of oscillometry.","authors":"Irlanda Alvarado-Amador, Mario Arturo Flores-Valadez, Laura Gochicoa-Rangel","doi":"10.36416/1806-3756/e20250163","DOIUrl":"10.36416/1806-3756/e20250163","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250163"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.36416/1806-3756/e20250329
Ana Paula Santos, Fernanda Carvalho Queiroz Mello
{"title":"Lateral flow urine lipoarabinomannan assay for tuberculosis diagnosis in people living with HIV: a step in the right direction, but we need more.","authors":"Ana Paula Santos, Fernanda Carvalho Queiroz Mello","doi":"10.36416/1806-3756/e20250329","DOIUrl":"10.36416/1806-3756/e20250329","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"51 4","pages":"e20250329"},"PeriodicalIF":3.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号