Pub Date : 2023-12-20DOI: 10.36416/1806-3756/e20230092
Mariana Isadora Ribeiro Vieira1, Mônica Versiani Nunes Pinheiro de Queiroz3, Maria Borges Rabelo de Santana2, Hatilla dos Santos Silva2, Almirane Oliveira2, Camila Alexandrina Viana Figueiredo2, Eduardo Martín Tarazona Santos4, Ryan dos Santos Costa2, Laura Maria de Lima Belizário Facury Lasmar1,2
Objective: To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma. Methods: This was a cross-sectional study, nested within a prospective cohort study of patients with severe asthma. Two outcomes were evaluated: asthma control and bronchodilator reversibility. We extracted DNA from peripheral blood and genotyped three single nucleotide polymorphisms: rs3819024 and rs2275913 in the IL17A gene; and rs3024498 in the IL10 gene. For the association analyses, we performed logistic regression in three genetic models (allelic, additive, and dominant). Results: The rs3024498 C allele in the IL10 gene was associated with failure to achieve asthma control despite regular treatment (p = 0.02). However, the G allele of the IL17A rs3819024 polymorphism was associated with failure to respond to stimulation with a ß2 agonist. The rs2275913 polymorphism of the IL17A gene showed no relationship with asthma control or bronchodilator reversibility. Conclusions: In pediatric patients with severe asthma, the IL10 polymorphism appears to be associated with failure to achieve clinical control, whereas the IL17A polymorphism appears to be associated with a worse bronchodilator response. Knowledge of the involvement of these polymorphisms opens future directions for pharmacogenetic studies and for the implementation of individualized therapeutic management of severe asthma in pediatric patients.
{"title":"The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma","authors":"Mariana Isadora Ribeiro Vieira1, Mônica Versiani Nunes Pinheiro de Queiroz3, Maria Borges Rabelo de Santana2, Hatilla dos Santos Silva2, Almirane Oliveira2, Camila Alexandrina Viana Figueiredo2, Eduardo Martín Tarazona Santos4, Ryan dos Santos Costa2, Laura Maria de Lima Belizário Facury Lasmar1,2","doi":"10.36416/1806-3756/e20230092","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230092","url":null,"abstract":"Objective: To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma. Methods: This was a cross-sectional study, nested within a prospective cohort study of patients with severe asthma. Two outcomes were evaluated: asthma control and bronchodilator reversibility. We extracted DNA from peripheral blood and genotyped three single nucleotide polymorphisms: rs3819024 and rs2275913 in the IL17A gene; and rs3024498 in the IL10 gene. For the association analyses, we performed logistic regression in three genetic models (allelic, additive, and dominant). Results: The rs3024498 C allele in the IL10 gene was associated with failure to achieve asthma control despite regular treatment (p = 0.02). However, the G allele of the IL17A rs3819024 polymorphism was associated with failure to respond to stimulation with a ß2 agonist. The rs2275913 polymorphism of the IL17A gene showed no relationship with asthma control or bronchodilator reversibility. Conclusions: In pediatric patients with severe asthma, the IL10 polymorphism appears to be associated with failure to achieve clinical control, whereas the IL17A polymorphism appears to be associated with a worse bronchodilator response. Knowledge of the involvement of these polymorphisms opens future directions for pharmacogenetic studies and for the implementation of individualized therapeutic management of severe asthma in pediatric patients.","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"59 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139169366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-20DOI: 10.36416/1806-3756/e20230228
Samuel Santos de Freitas1, Ana Paula Zanardo1,2, Rafael Domingos Grando1,2
{"title":"Angioinvasive aspergillosis in a patient with acute myeloid leukemia and influenza B virus infection","authors":"Samuel Santos de Freitas1, Ana Paula Zanardo1,2, Rafael Domingos Grando1,2","doi":"10.36416/1806-3756/e20230228","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230228","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"82 ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139169792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-18DOI: 10.36416/1806-3756/e20220438
Mustafa Engin Sahin1, Seher Satar1, Pınar Ergün1
Objective: One of the common limitations after COVID-19 pneumonia is the decrease in exercise capacity. The identification of the factors affecting exercise capacity and the assessment of patients at risk are important for determining treatment strategy. This study was conducted to determine the predictors of decreased exercise capacity in long post-COVID-19 patients. Methods: We investigated the association of exercise capacity as measured by the incremental shuttle walk test (ISWT) with age, sex, spirometric variables, respiratory and peripheral muscle strength, quality of life, fatigue, hospital anxiety depression scale, chest X-ray involvement, and hospitalization. The patients were divided into three groups: outpatients, inpatients, and ICU patients. Regression analysis was used to determine which parameters were significant predictors of exercise capacity. Results: Of the 181 patients included in the study, 56 (31%) were female. The mean ISWT in percentage of predicted values (ISWT%pred) was 43.20% in the whole sample, whereas that was 52.89%, 43.71%, and 32.21% in the outpatient, inpatient, and ICU patient groups, respectively. Linear regression analysis showed that predictors of decreased ISWT%pred were sex (ß = 8.089; p = 0.002), mMRC scale score (ß = -7.004; p = 0.001), FVC%pred (ß = 0.151; p = 0.003), and handgrip strength (ß = 0.261; p = 0.030). Conclusions: In long post-COVID-19 patients, sex, perception of dyspnea, restrictive pattern in respiratory function, and decrease in peripheral muscle strength are predictors of reduced exercise capacity that persists three months after COVID-19. In this context, we suggest that pulmonary rehabilitation might be an important therapy for patients after COVID-19.
目的：COVID-19 肺炎后常见的限制之一是运动能力下降。确定影响运动能力的因素和评估高危患者对于确定治疗策略非常重要。本研究旨在确定 COVID-19 后长期患者运动能力下降的预测因素。方法我们调查了通过增量穿梭步行测试（ISWT）测量的运动能力与年龄、性别、肺活量测量变量、呼吸和外周肌力、生活质量、疲劳、医院焦虑抑郁量表、胸部 X 光检查参与度和住院时间的关系。患者被分为三组：门诊患者、住院患者和重症监护室患者。采用回归分析确定哪些参数可显著预测运动能力。研究结果在参与研究的 181 名患者中，有 56 名女性（占 31%）。整个样本的平均 ISWT 占预测值的百分比（ISWT%pred）为 43.20%，而门诊病人组、住院病人组和重症监护病房病人组分别为 52.89%、43.71% 和 32.21%。线性回归分析显示，性别（ß = 8.089; p = 0.002）、mMRC 量表评分（ß = -7.004; p = 0.001）、FVC%pred（ß = 0.151; p = 0.003）和手握力（ß = 0.261; p = 0.030）是预测 ISWT%pred 下降的因素。结论在 COVID-19 后的长期患者中，性别、呼吸困难感、呼吸功能限制模式和外周肌力下降是 COVID-19 三个月后运动能力持续下降的预测因素。在这种情况下，我们认为肺康复可能是 COVID-19 患者的一种重要治疗方法。
{"title":"Predictors of reduced incremental shuttle walk test performance in patients with long post-COVID-19","authors":"Mustafa Engin Sahin1, Seher Satar1, Pınar Ergün1","doi":"10.36416/1806-3756/e20220438","DOIUrl":"https://doi.org/10.36416/1806-3756/e20220438","url":null,"abstract":"Objective: One of the common limitations after COVID-19 pneumonia is the decrease in exercise capacity. The identification of the factors affecting exercise capacity and the assessment of patients at risk are important for determining treatment strategy. This study was conducted to determine the predictors of decreased exercise capacity in long post-COVID-19 patients. Methods: We investigated the association of exercise capacity as measured by the incremental shuttle walk test (ISWT) with age, sex, spirometric variables, respiratory and peripheral muscle strength, quality of life, fatigue, hospital anxiety depression scale, chest X-ray involvement, and hospitalization. The patients were divided into three groups: outpatients, inpatients, and ICU patients. Regression analysis was used to determine which parameters were significant predictors of exercise capacity. Results: Of the 181 patients included in the study, 56 (31%) were female. The mean ISWT in percentage of predicted values (ISWT%pred) was 43.20% in the whole sample, whereas that was 52.89%, 43.71%, and 32.21% in the outpatient, inpatient, and ICU patient groups, respectively. Linear regression analysis showed that predictors of decreased ISWT%pred were sex (ß = 8.089; p = 0.002), mMRC scale score (ß = -7.004; p = 0.001), FVC%pred (ß = 0.151; p = 0.003), and handgrip strength (ß = 0.261; p = 0.030). Conclusions: In long post-COVID-19 patients, sex, perception of dyspnea, restrictive pattern in respiratory function, and decrease in peripheral muscle strength are predictors of reduced exercise capacity that persists three months after COVID-19. In this context, we suggest that pulmonary rehabilitation might be an important therapy for patients after COVID-19.","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"233 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139173275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13DOI: 10.36416/1806-3756/e20230300
Ana Paula Zanardo1,2, Vicente Bohrer Brentano2, Rafael Domingos Grando1,2, Rafael Ramos Rambo1,2, Felipe Teixeira Hertz2, Luís Carlos Anflor Júnior2,3, Jônatas Fávero Prietto dos Santos1,2, Gabriela Schneider Galvão1,2, Cristiano Feijó Andrade4,5
{"title":"Detection of subsolid nodules on chest CT scans during the COVID-19 pandemic","authors":"Ana Paula Zanardo1,2, Vicente Bohrer Brentano2, Rafael Domingos Grando1,2, Rafael Ramos Rambo1,2, Felipe Teixeira Hertz2, Luís Carlos Anflor Júnior2,3, Jônatas Fávero Prietto dos Santos1,2, Gabriela Schneider Galvão1,2, Cristiano Feijó Andrade4,5","doi":"10.36416/1806-3756/e20230300","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230300","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"25 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139005135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-06DOI: 10.36416/1806-3756/e20230369
Alvar Agusti1, Claus F. Vogelmeier2
{"title":"GOLD 2024: a brief overview of key changes","authors":"Alvar Agusti1, Claus F. Vogelmeier2","doi":"10.36416/1806-3756/e20230369","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230369","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"4 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138597205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-06DOI: 10.36416/1806-3756/e20230360
Parameswaran Nair1
{"title":"Eosinophils and therapeutic responses to steroids and biologics in COPD: a complex relationship","authors":"Parameswaran Nair1","doi":"10.36416/1806-3756/e20230360","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230360","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"64 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138595486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-05DOI: 10.36416/1806-3756/e20230371
Ricardo Gassmann Figueiredo1,2, Cecilia María Patino,2,3, Juliana Carvalho Ferreira 2,4
{"title":"Crafting a research protocol: a stepwise comprehensive approach","authors":"Ricardo Gassmann Figueiredo1,2, Cecilia María Patino,2,3, Juliana Carvalho Ferreira 2,4","doi":"10.36416/1806-3756/e20230371","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230371","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"56 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138598323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-28DOI: 10.36416/1806-3756/e20230269
Denise Rossato Silva1, Ana Paula Santos2,3, Dina Visca4,5, Sidney Bombarda6, Margareth Maria Pretti Dalcolmo7, Tatiana Galvão8, Silvana Spíndola de Miranda9, Ana Alice Amaral Ibiapina Parente10, Marcelo Fouad Rabahi11, Roberta Karla Barbosa de Sales12, Giovanni Battista Migliori13, Fernanda Carvalho de Queiroz Mello2
ABSTRACT Historically, all efforts against tuberculosis were focused on rapid diagnosis and effective treatment to break the chain of transmission of Mycobacterium tuberculosis. However, in the last few years, more and more evidence has been found on the dramatic consequences of the condition defined as post-tuberculosis lung disease (PTLD). Approximately one third of patients surviving pulmonary tuberculosis face considerable ongoing morbidities, including respiratory impairment, psychosocial challenges, and reduced health-related quality of life after treatment completion. Given the important global and local burden of tuberculosis, as well as the estimated burden of PTLD, the development of a consensus document by a Brazilian scientific society-Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)-was considered urgent for the prevention and management of this condition in order to allocate resources to and within tuberculosis services appropriately and serve as a guide for health care professionals. A team of eleven pulmonologists and one methodologist was created by the SBPT to review the current evidence on PTLD and develop recommendations adapted to the Brazilian context. The expert panel selected the topics on the basis of current evidence and international guidelines. During the first phase, three panel members drafted the recommendations, which were divided into three sections: definition and prevalence of PTLD, assessment of PTLD, and management of PTLD. In the second phase, all panel members reviewed, discussed, and revised the recommendations until a consensus was reached. The document was formally approved by the SBPT in a special session organized during the 2023 SBPT Annual Conference.
{"title":"Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease","authors":"Denise Rossato Silva1, Ana Paula Santos2,3, Dina Visca4,5, Sidney Bombarda6, Margareth Maria Pretti Dalcolmo7, Tatiana Galvão8, Silvana Spíndola de Miranda9, Ana Alice Amaral Ibiapina Parente10, Marcelo Fouad Rabahi11, Roberta Karla Barbosa de Sales12, Giovanni Battista Migliori13, Fernanda Carvalho de Queiroz Mello2","doi":"10.36416/1806-3756/e20230269","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230269","url":null,"abstract":"ABSTRACT Historically, all efforts against tuberculosis were focused on rapid diagnosis and effective treatment to break the chain of transmission of Mycobacterium tuberculosis. However, in the last few years, more and more evidence has been found on the dramatic consequences of the condition defined as post-tuberculosis lung disease (PTLD). Approximately one third of patients surviving pulmonary tuberculosis face considerable ongoing morbidities, including respiratory impairment, psychosocial challenges, and reduced health-related quality of life after treatment completion. Given the important global and local burden of tuberculosis, as well as the estimated burden of PTLD, the development of a consensus document by a Brazilian scientific society-Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)-was considered urgent for the prevention and management of this condition in order to allocate resources to and within tuberculosis services appropriately and serve as a guide for health care professionals. A team of eleven pulmonologists and one methodologist was created by the SBPT to review the current evidence on PTLD and develop recommendations adapted to the Brazilian context. The expert panel selected the topics on the basis of current evidence and international guidelines. During the first phase, three panel members drafted the recommendations, which were divided into three sections: definition and prevalence of PTLD, assessment of PTLD, and management of PTLD. In the second phase, all panel members reviewed, discussed, and revised the recommendations until a consensus was reached. The document was formally approved by the SBPT in a special session organized during the 2023 SBPT Annual Conference.","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139215615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-27DOI: 10.36416/1806-3756/e20230317
Glauco Cabral Marinho Plens1, Guilherme das Posses Bridi1, Ellen Caroline Toledo do Nascimento2, Rodrigo Caruso Chate3, Bruno Guedes Baldi1, Fábio Eiji Arimura1, Ronaldo Adib Kairalla1,3
IgG4-related
IgG4 相关
{"title":"Nephrobronchial fistula: a diagnostic challenge in a patient with IgG4-related disease","authors":"Glauco Cabral Marinho Plens1, Guilherme das Posses Bridi1, Ellen Caroline Toledo do Nascimento2, Rodrigo Caruso Chate3, Bruno Guedes Baldi1, Fábio Eiji Arimura1, Ronaldo Adib Kairalla1,3","doi":"10.36416/1806-3756/e20230317","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230317","url":null,"abstract":"IgG4-related","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"46 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139230338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-21DOI: 10.36416/1806-3756/e20230340
Edson Marchiori1, Bruno Hochhegger2, Gláucia Zanetti1
{"title":"Paraseptal emphysema","authors":"Edson Marchiori1, Bruno Hochhegger2, Gláucia Zanetti1","doi":"10.36416/1806-3756/e20230340","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230340","url":null,"abstract":"","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"57 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139251543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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