Pub Date : 2022-05-12DOI: 10.1001/jamaoncol.2022.0316
A. Barrio, G. Montagna, M. Morrow
{"title":"Is Regional Nodal Radiotherapy Necessary for Patients With cN1 and ypN0 Breast Cancer After Neoadjuvant Chemotherapy?-Reply.","authors":"A. Barrio, G. Montagna, M. Morrow","doi":"10.1001/jamaoncol.2022.0316","DOIUrl":"https://doi.org/10.1001/jamaoncol.2022.0316","url":null,"abstract":"","PeriodicalId":14850,"journal":{"name":"JAMA Oncology","volume":" ","pages":""},"PeriodicalIF":28.4,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41638844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-05DOI: 10.1001/jamaoncol.2022.0880
C. Weinstock, Anup K Amatya, J. Beaver
{"title":"Analysis of Association of Radiation Therapy With Risk of Adverse Events in Patients Receiving Immunotherapy Using Pooled Trial Data Matched by Propensity Score-Reply.","authors":"C. Weinstock, Anup K Amatya, J. Beaver","doi":"10.1001/jamaoncol.2022.0880","DOIUrl":"https://doi.org/10.1001/jamaoncol.2022.0880","url":null,"abstract":"","PeriodicalId":14850,"journal":{"name":"JAMA Oncology","volume":" ","pages":""},"PeriodicalIF":28.4,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47028866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-05DOI: 10.1001/jamaoncol.2022.0877
T. Nopsopon, M. Y. Wu, D. Sardana
{"title":"Analysis of Association of Radiation Therapy With Risk of Adverse Events in Patients Receiving Immunotherapy Using Pooled Trial Data Matched by Propensity Score.","authors":"T. Nopsopon, M. Y. Wu, D. Sardana","doi":"10.1001/jamaoncol.2022.0877","DOIUrl":"https://doi.org/10.1001/jamaoncol.2022.0877","url":null,"abstract":"","PeriodicalId":14850,"journal":{"name":"JAMA Oncology","volume":" ","pages":""},"PeriodicalIF":28.4,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45716059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-05DOI: 10.1001/jamaoncol.2022.0863
G. Calip, N. Meropol, D. Weinberg
{"title":"Colorectal Cancer Incidence Among Adults Younger Than 50 Years-Understanding Findings From Observational Studies of Lower Gastrointestinal Endoscopy.","authors":"G. Calip, N. Meropol, D. Weinberg","doi":"10.1001/jamaoncol.2022.0863","DOIUrl":"https://doi.org/10.1001/jamaoncol.2022.0863","url":null,"abstract":"","PeriodicalId":14850,"journal":{"name":"JAMA Oncology","volume":" ","pages":""},"PeriodicalIF":28.4,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46838039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-05DOI: 10.1001/jamaoncol.2022.0503
M. Qiu, Yang Zhang, Ye Guo, W. Guo, Weiqi Nian, W. Liao, Zhongyuan Xu, Wenxue Zhang, Hongzhe Zhao, Xiaoli Wei, L. Xue, W. Tang, Yunteng Wu, G. Ren, Ling Wang, Jingle Xi, Yongshuai Jin, Hu Li, Chaohong Hu, R. Xu
Key Points Question What is the safety and antitumor activity of MRG003 in patients with advanced solid tumors? Findings In this phase 1 clinical trial of 61 patients with advanced or metastatic solid tumors, treatment with MRG003 exhibited manageable safety and showed encouraging antitumor activity in squamous cell carcinomas of the head and neck and nasopharyngeal carcinoma, with a confirmed objective response rates of 40% and 44%, respectively. Meaning The study findings suggest the safety of treatment with MRG003 and an acceptable tolerance in most patients with epidermal growth factor receptor–expressing solid tumors, as well as encouraging antitumor activity in patients with squamous cell carcinomas of the head and neck and nasopharyngeal carcinoma.
{"title":"Evaluation of Safety of Treatment With Anti–Epidermal Growth Factor Receptor Antibody Drug Conjugate MRG003 in Patients With Advanced Solid Tumors","authors":"M. Qiu, Yang Zhang, Ye Guo, W. Guo, Weiqi Nian, W. Liao, Zhongyuan Xu, Wenxue Zhang, Hongzhe Zhao, Xiaoli Wei, L. Xue, W. Tang, Yunteng Wu, G. Ren, Ling Wang, Jingle Xi, Yongshuai Jin, Hu Li, Chaohong Hu, R. Xu","doi":"10.1001/jamaoncol.2022.0503","DOIUrl":"https://doi.org/10.1001/jamaoncol.2022.0503","url":null,"abstract":"Key Points Question What is the safety and antitumor activity of MRG003 in patients with advanced solid tumors? Findings In this phase 1 clinical trial of 61 patients with advanced or metastatic solid tumors, treatment with MRG003 exhibited manageable safety and showed encouraging antitumor activity in squamous cell carcinomas of the head and neck and nasopharyngeal carcinoma, with a confirmed objective response rates of 40% and 44%, respectively. Meaning The study findings suggest the safety of treatment with MRG003 and an acceptable tolerance in most patients with epidermal growth factor receptor–expressing solid tumors, as well as encouraging antitumor activity in patients with squamous cell carcinomas of the head and neck and nasopharyngeal carcinoma.","PeriodicalId":14850,"journal":{"name":"JAMA Oncology","volume":"8 1","pages":"1042 - 1046"},"PeriodicalIF":28.4,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47275871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-05DOI: 10.1001/jamaoncol.2022.0500
Ricardo J. Bello, G. Chang, N. Massarweh
{"title":"Colorectal Cancer Screening in the US-Still Putting the Cart Before the Horse?","authors":"Ricardo J. Bello, G. Chang, N. Massarweh","doi":"10.1001/jamaoncol.2022.0500","DOIUrl":"https://doi.org/10.1001/jamaoncol.2022.0500","url":null,"abstract":"","PeriodicalId":14850,"journal":{"name":"JAMA Oncology","volume":" ","pages":""},"PeriodicalIF":28.4,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43048173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-28DOI: 10.1001/jamaoncol.2022.0874
C. Cao, C. Friedenreich, L. Yang
{"title":"Concerns Remain Regarding the Association of Sitting Time and Physical Activity With Cancer Survivorship-Reply.","authors":"C. Cao, C. Friedenreich, L. Yang","doi":"10.1001/jamaoncol.2022.0874","DOIUrl":"https://doi.org/10.1001/jamaoncol.2022.0874","url":null,"abstract":"","PeriodicalId":14850,"journal":{"name":"JAMA Oncology","volume":" ","pages":""},"PeriodicalIF":28.4,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41938829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-28DOI: 10.1001/jamaoncol.2022.0871
T. Goto
{"title":"Concerns Remain Regarding the Association of Sitting Time and Physical Activity With Cancer Survivorship.","authors":"T. Goto","doi":"10.1001/jamaoncol.2022.0871","DOIUrl":"https://doi.org/10.1001/jamaoncol.2022.0871","url":null,"abstract":"","PeriodicalId":14850,"journal":{"name":"JAMA Oncology","volume":" ","pages":""},"PeriodicalIF":28.4,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44292750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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