Jornal de pediatria最新文献_第10页

Psychometric characteristics of the Mini-TEA scale: a screening instrument for autism spectrum disorder in children 迷你tea量表的心理测量特征：儿童自闭症谱系障碍的筛查工具。

IF 2.5 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-09-01 Epub Date: 2025-06-26 DOI: 10.1016/j.jped.2025.05.006

Cassiano Mateus Forcelini , Regina Ampese , Helena Younes de Melo , Camila Pereira Neubauer Pasin , José Renato Donadussi Pádua , Itamara Danelli de Moura , Camila Boschetti Spanholo , Francine Ehrhardt Hoffmann , Júlia Breitenbach Diniz , Laís Cristine Zanella Capponi , Luiza Souza , Maxciel Zortea

Objective

Early diagnosis of autism spectrum disorder (ASD) is advisable to promote better prognosis. The Mini-TEA scale was conceived as a sensitive screening for ASD among children. The authors aimed to confirm the diagnostic accuracy of the scale in a wider population.

Method

279 children from 2.5 to 12 yo were recruited, most of them under evaluation for possible ASD in the APAE of Passo Fundo/RS, as well as children with other diagnoses and normal children. Their parents/relatives answered the 48 binary questions (yes/no) of the Mini-TEA scale, divided into 15 items, which resulted in a score from 0 to 15. After that, the children were evaluated regarding the diagnostic criteria of ASD by experienced raters (gold standard) who had previously submitted to a concordance test and remained unaware of the children’s scores. Sensitivity and specificity Figs. were obtained. Factor analysis and Item Response Theory approaches were used for validity evidence.

Results

115 children were diagnosed with ASD. Scores ≥9 had 98.3 % of sensitivity and 62.2 % of specificity for the diagnosis. Two cases with the typical presentation of Asperger’s syndrome scored lower than 9. The mean time for screening was about 8.5 min. The validation model presented excellent coefficients of factorability. The analysis showed that the total variance of the scores of the scale through the 15 items was explained only by the set of ASD symptoms (unidimensionality).

Conclusion

The Mini-TEA scale is a very sensitive tool to screen for ASD and has high internal consistency for assessing typical autistic symptoms.

目的：早期诊断自闭症谱系障碍（ASD）有助于改善预后。Mini-TEA量表被认为是对儿童自闭症谱系障碍的一种敏感筛查。作者的目的是在更广泛的人群中确认该量表的诊断准确性。方法：招募279名2.5 ~ 12岁的儿童，其中大部分为Passo Fundo/RS APAE中可能存在ASD的儿童，以及其他诊断的儿童和正常儿童。他们的父母/亲戚回答了Mini-TEA量表的48个二元问题（是/否），分为15个项目，得分从0到15。在那之后，孩子们根据ASD的诊断标准由经验丰富的评分者（金标准）进行评估，这些评分者之前已经提交了一个一致性测试，并且不知道孩子们的分数。灵敏度和特异性被获得。效度证据采用因子分析和项目反应理论方法。结果：115例患儿被诊断为ASD。评分≥9分的诊断敏感性为98.3% %，特异性为62.2 %。有两个亚斯伯格综合症典型表现的病例得分低于9分。平均筛选时间约为8.5 min，验证模型具有良好的因子性系数。分析表明，量表15个项目得分的总方差仅由ASD症状集（单维性）来解释。结论：mini-TEA量表是一种非常灵敏的筛查ASD的工具，在评估典型自闭症症状方面具有很高的内在一致性。

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引用次数: 0

A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis 坏死性小肠结肠炎患者血清和粪便钙保护蛋白水平的比较研究。

IF 2.5 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.1016/j.jped.2025.101428

Sara Erol , Cuneyt Tayman , Sabriye Korkut , Ufuk Çakir , Abdullah Kurt , Ismail Koyuncu

Objectives

Necrotizing enterocolitis is a significant cause of morbidity and mortality in premature infants. Various fecal, urinary, and serum biomarkers have all been investigated for their potential in the prediction and early detection of necrotizing enterocolitis. This pilot study aimed to explore the feasibility and clinical utility of measuring serum and fecal calprotectin levels in preterm infants with necrotizing enterocolitis.

Methods

This prospective pilot study included preterm infants born at < 32 weeks’ gestation with a birth weight of ≤ 1500 g, consisting of patients diagnosed with necrotizing enterocolitis stage II or III and a randomly selected control group without necrotizing enterocolitis. The relationship between serum and fecal calprotectin concentrations and necrotizing enterocolitis severity, need for surgical intervention, and mortality was systematically analyzed.

Results

A total of 39 necrotizing enterocolitis patients (25 with stage II, 14 with stage III) and 20 randomly selected preterm infants were included as the control group. Serum and fecal calprotectin levels were significantly higher in necrotizing enterocolitis stage III and in infants who required surgery or died (p < 0.05), indicating their potential to predict disease severity and poor outcomes.

Conclusions

This pilot study suggests that dual assessment of serum and fecal calprotectin may provide insight into necrotizing enterocolitis severity and outcomes. Larger studies are needed to validate these findings and determine clinical applicability.

Trial Registration

This study was registered with the ClinicalTrials.gov database under the registration number NCT06693154 on November 15, 2024.

目的：坏死性小肠结肠炎是早产儿发病和死亡的重要原因。各种粪便、尿液和血清生物标志物都被研究用于预测和早期发现坏死性小肠结肠炎的潜力。本初步研究旨在探讨测定坏死性小肠结肠炎早产儿血清和粪便钙保护蛋白水平的可行性和临床应用。方法：本前瞻性先导研究纳入妊娠< 32周，出生体重≤1500 g的早产儿，包括诊断为坏死性小肠结肠炎II期或III期的患者和随机选择无坏死性小肠结肠炎的对照组。系统分析血清和粪便钙保护蛋白浓度与坏死性小肠结肠炎严重程度、手术干预需求和死亡率的关系。结果：共纳入坏死性小肠结肠炎患者39例（II期25例，III期14例），随机抽取早产儿20例作为对照组。在坏死性小肠结肠炎III期和需要手术或死亡的婴儿中，血清和粪便钙保护蛋白水平显著升高（p ）。结论：这项初步研究表明，血清和粪便钙保护蛋白的双重评估可能有助于了解坏死性小肠结肠炎的严重程度和结局。需要更大规模的研究来验证这些发现并确定临床适用性。试验注册：本研究于2024年11月15日在ClinicalTrials.gov数据库注册，注册号为NCT06693154。

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引用次数: 0

Serum hsa-miR-21 expression and its clinical value in pediatric patients with fulminant myocarditis 小儿暴发性心肌炎患者血清hsa-miR-21表达及其临床价值

IF 2.5 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.1016/j.jped.2025.04.007

Wenwen Wang, Jingmin Sun, Jing Li

Objective

Fulminant myocarditis (FM) is a distinct and rare form of myocarditis. This study probed hsa-miR-21 expression in FM pediatric patients and its clinical value.

Methods

This study enrolled 88 FM pediatric patients and 90 healthy children (normal controls), with serum sample hsa-miR-21 levels measured by RT-qPCR. FM children were categorized into the good and poor prognosis groups. Correlations of hsa-miR-21 expression with myocardial injury markers [cardiac troponin I (cTnI), creatine kinase isoenzyme (CK-MB)], and independent risk factors and predictive value of hsa-miR-21 expression for FM patients’ poor prognoses were analyzed by Pearson’s, logistic regression, and receiver operating characteristic (ROC) curve analyses.

Results

Serum hsa-miR-21 levels were elevated in FM children relative to the healthy controls and linked with poor prognoses. hsa-miR-21 levels positively correlated with myoglobin (MYO), B-type natriuretic peptide (BNP), cTnI, and CK-MB levels. Elevated hsa-miR-21, CK-MB, left ventricular ejection fraction, C-reactive protein, lactate dehydrogenase, and lactate were independent risk factors for FM children’s poor prognoses. Serum hsa-miR-21 levels yielded an area under the ROC curve of 0.790 in predicting FM pediatric patients’ poor prognoses (58.1 % sensitivity, 87.7 % specificity), with positive and negative predictive values of 74.07 % and 81.97 %, respectively, demonstrating that hsa-miR-21 aided in predicting FM pediatric patients’ poor prognoses to some extent.

Conclusion

Serum hsa-miR-21 was up-regulated in FM pediatric patients, and positively correlated with MYO, BNP, cTnI, and CK-MB. hsa-miR-21 expression was an independent risk factor for FM pediatric patients' poor prognosis, and predicted prognoses to some extent; however, the diagnostic accuracy was limited.

目的：暴发性心肌炎（FM）是一种独特而罕见的心肌炎。本研究探讨hsa-miR-21在小儿FM患者中的表达及其临床价值。方法：本研究纳入88例FM患儿和90例健康儿童（正常对照），采用RT-qPCR检测血清样本hsa-miR-21水平。将FM患儿分为预后良好组和预后不良组。通过Pearson’s、logistic回归和受试者工作特征（ROC）曲线分析，分析hsa-miR-21表达与心肌损伤标志物[心肌肌钙蛋白I （cTnI）、肌酸激酶同工酶（CK-MB）]、独立危险因素以及hsa-miR-21表达对FM患者不良预后的预测价值的相关性。结果：与健康对照组相比，FM儿童血清hsa-miR-21水平升高，并与预后不良有关。hsa-miR-21水平与肌红蛋白（MYO）、b型利钠肽（BNP）、cTnI和CK-MB水平呈正相关。hsa-miR-21、CK-MB、左室射血分数、c反应蛋白、乳酸脱氢酶和乳酸水平升高是FM患儿预后不良的独立危险因素。血清hsa-miR-21水平预测FM患儿不良预后的ROC曲线下面积为0.790（敏感性为58.1% %，特异性为87.7 %），阳性预测值为74.07 %，阴性预测值为81.97 %，说明hsa-miR-21在一定程度上有助于预测FM患儿不良预后。结论：小儿FM患者血清hsa-miR-21表达上调，且与MYO、BNP、cTnI、CK-MB呈正相关。hsa-miR-21的表达是小儿FM患者预后不良的独立危险因素，并在一定程度上预测预后；然而，诊断的准确性是有限的。

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引用次数: 0

Sleep and breathing in children with cerebral palsy: it’s complicated….!* 脑瘫儿童的睡眠和呼吸：这很复杂....！

IF 2.5 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.1016/j.jped.2025.101434

David Gozal

引用次数: 0

Use of simulation in the evaluation of airway clearance devices 在气道间隙装置评估中的模拟应用。

IF 2.5 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.1016/j.jped.2025.101435

Maria Lucia S. Hristonof , Marina C. Amantéa , Fernando J. Lazzaretti , Marina M. Bernardes , Luiza F. Xavier , Sergio Luis Amantéa

引用次数: 0

The expression of ferroptosis-related proteins GPX4 and PTGS2 in colonic tissues of pediatric Crohn’s disease 铁中毒相关蛋白GPX4和PTGS2在儿童克罗恩病结肠组织中的表达

IF 2.5 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-09-01 Epub Date: 2025-08-18 DOI: 10.1016/j.jped.2025.101431

Shuanghong Zhang , Chunzhi Kang , Xiaoxiao He , Hui Huang , Qian Xiao

Objective

To investigate the expression of ferroptosis-related proteins GPX4 and PTGS2 in pediatric Crohn’s disease (CD).

Methods

Pediatric CD colonic tissues by colonoscopy biopsy were selected as the subjects. The Pediatric Crohn’s Disease Activity Index (PCDAI) was used to assess the disease activity of CD. Immunohistochemistry was used to detect the expression of GPX4 and PTGS2.

Results

30 CD cases were collected, with an average age of 12.36±2.65 years, including 9 in the mild activity phase, 8 in the moderate activity phase, and 13 in the severe activity phase. The positive expression rate of GPX4 in CD colonic tissues was lower than that in normal colonic tissues (p = 0.02); PTGS2 in CD colonic tissues was higher than that in normal colonic tissues (p = 0.004). Based on the average optical density (AOD) values of the positive reactants, the relative expression levels of GPX4 in CD colonic tissues were lower than those in normal colonic tissues (p = 0.02); PTGS2 in CD colonic tissues were higher than those in normal colonic tissues (p = 0.000). The staining scores of GPX4 decreased with increasing CD disease activity (p < 0.001); PTGS2 increased with increasing CD disease activity (p < 0.001). GPX4 was negatively correlated with CD disease activity (r = −0.326); PTGS2 was positively correlated with CD disease activity (r = 0.299).

Conclusion

GPX4 and PTGS2 may be involved in the process of ferroptosis in CD intestinal epithelial cells and are correlated with the severity of pediatric CD.

目的：探讨铁中毒相关蛋白GPX4和PTGS2在儿童克罗恩病（CD）中的表达。方法：选择经结肠镜活检的儿童CD结肠组织作为研究对象。采用儿童克罗恩病活跃性指数（PCDAI）评估CD的疾病活跃性。采用免疫组化检测GPX4和PTGS2的表达。结果：共收集CD病例30例，平均年龄12.36±2.65岁，其中轻度活动期9例，中度活动期8例，重度活动期13例。GPX4在CD结肠组织中的阳性表达率低于正常结肠组织（p = 0.02）；PTGS2在CD结肠组织中的表达高于正常结肠组织（p = 0.004）。从阳性反应物的平均光密度（AOD）值来看，GPX4在CD结肠组织中的相对表达量低于正常结肠组织（p = 0.02）；PTGS2在CD结肠组织中的表达高于正常结肠组织（p = 0.000）。结论：GPX4和PTGS2可能参与了CD肠上皮细胞铁凋亡的过程，并与儿童CD的严重程度相关。

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引用次数: 0

Parental predictors of childhood vaccination adherence in border areas of Southern Vietnam: a first look at minority communities 越南南部边境地区儿童疫苗接种依从性的父母预测因素：首先看少数民族社区。

IF 2.8 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI: 10.1016/j.jped.2025.04.005

An Dai Tran , Charuai Suwanbamrung , Muhammad Haroon Stanikzai , Nirachon Chutipattana , Shamarina Shohaimin , Patthanasak Khammaneechan , Le Minh Luan , Tran Phu Dien , Truong Thanh Nam , Phan Thanh Tung , Cua Ngoc Le

Objectives

Suboptimal timeliness and coverage of childhood vaccination programs undermined their effectiveness in achieving population-level immunity. This issue is particularly concerning among minority populations, where disparities in vaccination adherence persist. To address this gap, the study assessed the extent of parental adherence to age-appropriate childhood vaccination and its predictors among the minority children under five years of age.

Methods

This cross-sectional study was conducted in three districts of Dong Thap Province, Vietnam, and neighboring Cambodia. A total of 449 ethnic minority parents with children under five years old participated. Data were gathered through face-to-face household interviews using a structured questionnaire, complemented by direct observation of the children’s vaccination cards to verify adherence. Binary logistic regression was used to identify predictors of vaccination adherence.

Results

The adherence rate to childhood vaccination among children in the minority population was 18.9 %. Parental adherence was significantly higher for children under one year of age (aOR = 2.54, 95 % CI: 1.29–5.03) and for firstborn children (aOR = 3.48, 95 % CI: 1.36–9.92). Within the Health Belief Model framework, greater perceived barriers were associated with lower adherence (aOR = 0.32, 95 % CI: 0.21–0.49), while higher parental self-efficacy was linked to increased adherence (aOR = 1.84, 95 % CI: 1.11–3.11).

Conclusion

This study revealed a low parental adherence rate (18.9 %) to childhood vaccination. A child’s age, birth order, perceived barriers, and parental self-efficacy influenced adherence. These findings emphasize the need to incorporate these factors into targeted policies and interventions for improving immunization rates in minority populations and comparable settings.

目的：儿童疫苗接种计划的及时性和覆盖率不理想，破坏了其在实现人口水平免疫方面的有效性。这一问题在少数民族人群中尤其令人关切，因为他们在坚持接种疫苗方面仍然存在差异。为了解决这一差距，该研究评估了父母遵守适龄儿童疫苗接种的程度及其在五岁以下少数民族儿童中的预测因素。方法：横断面研究在越南同塔省的三个地区和邻近的柬埔寨进行。共有449名有5岁以下子女的少数民族家长参与了调查。通过使用结构化问卷进行面对面的家庭访谈收集数据，并通过直接观察儿童的疫苗接种卡来验证依从性。二元逻辑回归用于确定疫苗接种依从性的预测因子。结果：少数民族儿童儿童疫苗接种率为18.9 %。1岁以下儿童（aOR = 2.54,95 % CI: 1.29-5.03）和头胎儿童（aOR = 3.48,95 % CI: 1.36-9.92）的父母依从性显著较高。在健康信念模型框架内，更大的感知障碍与更低的依从性相关（aOR = 0.32,95 % CI: 0.21-0.49），而更高的父母自我效能与更高的依从性相关（aOR = 1.84,95 % CI: 1.11-3.11）。结论：本研究显示儿童接种疫苗的家长依从率较低（18.9 %）。儿童年龄、出生顺序、感知障碍和父母自我效能影响依从性。这些发现强调需要将这些因素纳入有针对性的政策和干预措施中，以提高少数群体和类似环境中的免疫接种率。

{"title":"Parental predictors of childhood vaccination adherence in border areas of Southern Vietnam: a first look at minority communities","authors":"An Dai Tran , Charuai Suwanbamrung , Muhammad Haroon Stanikzai , Nirachon Chutipattana , Shamarina Shohaimin , Patthanasak Khammaneechan , Le Minh Luan , Tran Phu Dien , Truong Thanh Nam , Phan Thanh Tung , Cua Ngoc Le","doi":"10.1016/j.jped.2025.04.005","DOIUrl":"10.1016/j.jped.2025.04.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Suboptimal timeliness and coverage of childhood vaccination programs undermined their effectiveness in achieving population-level immunity. This issue is particularly concerning among minority populations, where disparities in vaccination adherence persist. To address this gap, the study assessed the extent of parental adherence to age-appropriate childhood vaccination and its predictors among the minority children under five years of age.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted in three districts of Dong Thap Province, Vietnam, and neighboring Cambodia. A total of 449 ethnic minority parents with children under five years old participated. Data were gathered through face-to-face household interviews using a structured questionnaire, complemented by direct observation of the children’s vaccination cards to verify adherence. Binary logistic regression was used to identify predictors of vaccination adherence.</div></div><div><h3>Results</h3><div>The adherence rate to childhood vaccination among children in the minority population was 18.9 %. Parental adherence was significantly higher for children under one year of age (aOR = 2.54, 95 % CI: 1.29–5.03) and for firstborn children (aOR = 3.48, 95 % CI: 1.36–9.92). Within the Health Belief Model framework, greater perceived barriers were associated with lower adherence (aOR = 0.32, 95 % CI: 0.21–0.49), while higher parental self-efficacy was linked to increased adherence (aOR = 1.84, 95 % CI: 1.11–3.11).</div></div><div><h3>Conclusion</h3><div>This study revealed a low parental adherence rate (18.9 %) to childhood vaccination. A child’s age, birth order, perceived barriers, and parental self-efficacy influenced adherence. These findings emphasize the need to incorporate these factors into targeted policies and interventions for improving immunization rates in minority populations and comparable settings.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"101 4","pages":"Pages 642-650"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exclusive breastfeeding modifies the association between maternal education and child development: a cross-sectional study nested in a cohort 纯母乳喂养改变了母亲教育和儿童发展之间的关系：一项嵌套在队列中的横断面研究。

IF 2.8 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-07-01 Epub Date: 2025-04-07 DOI: 10.1016/j.jped.2025.02.004

Luiza Alves Ford , Gabriela Buccini , Amanda Castelo Saragosa , Isadora de Araújo Martins , Janaína Matos Moreira , Stela Maris Aguiar Lemos , Claudia Regina Lindgren Alves , Vivian Mara Gonçalves de Oliveira Azevedo

Objective

Low maternal education is a risk factor for early childhood development (ECD), while exclusive breastfeeding (EBF) is a protective factor. This study examined the association between maternal education and ECD outcomes such as cognitive, language, and motor domains and whether EBF modifies this association in Brazil.

Methods

This cross-sectional study analyzed data from a non-probabilistic sample of 12-month-old infants born during the COVID-19. Moderation analyses using the Mann-Whitney test examined the effect of EBF at 6 months (effect modifier) on the relationship between Bayley-III cognitive, language, and motor scores as well as Bayley Global Score (BGS) (outcomes) and maternal education (independent variable). The effect size (r) from the sensitivity analysis of the effect modifier was estimated.

Results

A total of 269 full-term infants were evaluated. Higher maternal education was associated with better cognitive, language, and BGS (p < 0.00). EBF was associated with higher cognitive (p < 0.01), language (p < 0.02), and BGS (p < 0.00). EBF modified the effect of low maternal education (<10 years; and 10–12 years) on cognitive score and BGS. Among mothers with >10 years of education, a large effect size of EBF was observed on the BGS (r = 0.51), and a medium effect size was noted in the cognitive domain (r = 0.38).

Conclusion

Higher maternal education is associated with better scores on Bayley-III domains, and EBF can modify the effect of lower maternal education on ECD in Brazil. This is the first study to identify EBF as a mechanism to protect ECD in adverse conditions such as low maternal education.

目的：母亲受教育程度低是儿童早期发育（ECD）的危险因素，而纯母乳喂养（EBF）是保护因素。本研究考察了母亲教育与ECD结果（如认知、语言和运动领域）之间的关系，以及EBF是否改变了巴西的这种关系。方法：本横断面研究分析了COVID-19期间出生的12个月大婴儿的非概率样本数据。使用Mann-Whitney检验的适度分析检验了6个月时EBF（效果调节剂）对Bayley- iii认知、语言和运动评分以及Bayley全局评分（BGS）（结果）和母亲教育（自变量）之间关系的影响。从效应调节剂的敏感性分析中估计效应量(r)。结果：共对269例足月儿进行了评估。较高的母亲教育程度与更好的认知、语言和BGS相关（p ），10年教育，EBF对BGS有较大的效应量（r = 0.51），认知领域有中等效应量（r = 0.38）。结论：较高的母亲教育程度与较高的Bayley-III域得分相关，EBF可以修正巴西较低的母亲教育程度对ECD的影响。这是首次确定EBF是在不利条件下（如产妇教育程度低）保护ECD的机制。

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引用次数: 0

Factors associated with developmental delay in late preterm infants: the BRISA cohort 晚期早产儿发育迟缓的相关因素：BRISA队列

IF 2.8 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1016/j.jped.2025.04.002

Paulo Ricardo Higassiaraguti Rocha , Gabriela Pap da Silva , Otávio Augusto Gratão , Marco Antonio Barbieri , Viviane Cunha Cardoso , Maria da Conceição Pereira Saraiva , Heloisa Bettiol

Objective

To investigate the association of sociodemographic characteristics, gestational factors, and birth outcomes with developmental delay from the second year of life in late preterm (LPT) infants.

Method

This study included 327 LPT infants from a cohort started in 2010. Developmental performance was assessed using the Bayley-III screening test. The covariates were obtained with questionnaires and from the maternity records. Hierarchical multiple logistic regression was used for analysis.

Results

Smoking during pregnancy was associated with fine motor and cognitive delays (OR = 2.27, 95 %CI 1.05–4.93 and OR = 2.22, 95 %CI 1.05–4.68, respectively). Living without a partner (OR = 2.98, 95 %CI 1.36–6.52) and intrauterine growth restriction of the child (OR = 2.63, 95 %CI 1.32–5.24) were associated with fine motor delay and neonatal intensive care unit admission with cognitive delay (OR = 2.11, 95 %CI 1.01–4.44).

Conclusions

These factors must be considered when implementing strategies for the diagnosis of possible developmental delays and when designing interventions for LPT children.

目的：探讨晚早产儿（LPT） 2岁起发育迟缓与社会人口学特征、妊娠因素和出生结局的关系。方法：本研究从2010年开始的队列中纳入327例LPT婴儿。采用Bayley-III筛选试验评估发育表现。协变量通过问卷调查和产妇记录获得。采用层次多元逻辑回归进行分析。结果：怀孕期间吸烟与精细运动和认知延迟相关（OR = 2.27,95 %CI 1.05-4.93, OR = 2.22,95 %CI 1.05-4.68）。生活没有一个伙伴(或 = 2.98,95 %可信区间1.36 - -6.52),宫内生长受限的孩子(或 = 2.63 95 %可信区间1.32 - -5.24)与动作有关延迟和新生儿重症监护室承认与认知延迟(或 = 2.11 95 %可信区间1.01 - -4.44)。结论：在实施可能的发育迟缓诊断策略和设计LPT儿童干预措施时，必须考虑这些因素。

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引用次数: 0

Mental health issues in adolescent mothers and young adult mothers: the Brazilian context 青少年母亲和年轻成年母亲的心理健康问题：巴西情况。

IF 2.8 4区医学 Q1 PEDIATRICS

Jornal de pediatria

Pub Date : 2025-07-01 Epub Date: 2025-05-27 DOI: 10.1016/j.jped.2025.03.011

Amanda Ferreira de Carvalho , Daniela Dal Forno Kinalski Guaranha , Bruna Marmett , Júlia Mathias Reis , Carmem Lisiane Escouto de Souza , Bruna Silveira da Rosa , Tiago Chagas Dalcin , Sérgio Luis Amantea

Objective

To analyze anxiety and depression levels in adolescent and young adult mothers.

Methods

This multicenter cross-sectional study was conducted across Brazil’s five regions. A non-probabilistic sample of 1177 adolescent (10–19 years) and young adult (20–29 years) mothers was selected proportionally based on regional live birth rates. Data collection (August 2022–May 2023) involved a structured questionnaire assessing mental health (DASS-21), family support, and quality of life. Statistical analyses were performed using RStudio©, with p-values < 0.05 considered significant. The study was approved by the Research Ethics Committee (CAAE: 55465822.0.2003.5086).

Results

Depression or anxiety was reported by 22.7 % of both adolescent and young adult mothers, with 7.55 % and 7.07 % diagnosed during pregnancy, respectively. Among affected adolescents, 66.67 % did not seek follow-up care, primarily due to limited healthcare access (29.55 %). Adolescent mothers showed a higher prevalence of depression (p < 0.001), anxiety (p < 0.001), and stress (p = 0.027) postpartum. Depression was associated with a lack of emotional support from the child’s father (p = 0.096), insufficient family caregiving support (p = 0.014), and low perceived quality of life.

Conclusion

Adolescent mothers exhibit greater vulnerability to mental disorders, emphasizing the need for targeted psychological and social support during the perinatal period.

目的：分析青少年和青年母亲的焦虑和抑郁水平。方法：这项多中心横断面研究在巴西的五个地区进行。根据地区活产率按比例选择了1177名青少年（10-19岁）和年轻成人（20-29岁）母亲的非概率样本。数据收集（2022年8月至2023年5月）包括一份评估心理健康（DASS-21）、家庭支持和生活质量的结构化问卷。采用RStudio©进行统计学分析，p值< 0.05为差异有统计学意义。本研究已获得研究伦理委员会批准（CAAE: 55465822.0.2003.5086）。结果：22.7% %的青春期和年轻成年母亲报告抑郁或焦虑，其中7.55% %和7.07 %分别在怀孕期间被诊断。在受影响的青少年中，66.67 %没有寻求后续护理，主要是由于有限的医疗保健机会（29.55 %）。结论：青少年母亲更容易出现精神障碍，强调在围产期需要有针对性的心理和社会支持。

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引用次数: 0