Pub Date : 2020-04-14DOI: 10.31031/aics.2020.02.000542
Capareli Fc, Conte Ga, M. Alidoost, J. Mikhail, Hossain Ma
Background: Advanced cholangiocarcinoma is a rare, aggressive tumor. Treatment is limited and very few systemic therapies are available. An effort for new drugs development is in course, which aims higher response rates, prolonged survival and better quality of life. Currently, immune checkpoint inhibitors and tyrosine kinase inhibitors have been used as new approaches after first- or second-line chemotherapy. Case Presentation: A 49-year-old woman, diagnosed in 2013 with an intrahepatic cholangiocarcinoma, underwent surgery (pT2pN1) followed by adjuvant capecitabine and radiotherapy. Disease relapse occurred 9 months later, with a unique hepatic lesion that was treated with gemcitabine and cisplatin following liver ablation by radiofrequency. After 2 years, the identification of metastatic lesions in liver, lymph nodes and bones lead the patient to a re-exposure to gemcitabine and cisplatin, which resulted in partial tumor response, accompanied by limiting myelotoxicity induced by chemotherapy. A combination of fluorouracil, leucovorin and irinotecan was started, but disease progressed after 7 cycles. The patient received regorafenib in a third line setting, which resulted in a substantial metabolic response in all secondary lesions. The patient remains with stable disease for more than 16 months. Conclusion: A surprising prolonged survival with regorafenib was observed. Selecting molecular targets is a promising field in the precision oncology.
{"title":"Prolonged Survival with Regorafenib in Metastatic Cholangiocarcinoma: Case Report","authors":"Capareli Fc, Conte Ga, M. Alidoost, J. Mikhail, Hossain Ma","doi":"10.31031/aics.2020.02.000542","DOIUrl":"https://doi.org/10.31031/aics.2020.02.000542","url":null,"abstract":"Background: Advanced cholangiocarcinoma is a rare, aggressive tumor. Treatment is limited and very few systemic therapies are available. An effort for new drugs development is in course, which aims higher response rates, prolonged survival and better quality of life. Currently, immune checkpoint inhibitors and tyrosine kinase inhibitors have been used as new approaches after first- or second-line chemotherapy. Case Presentation: A 49-year-old woman, diagnosed in 2013 with an intrahepatic cholangiocarcinoma, underwent surgery (pT2pN1) followed by adjuvant capecitabine and radiotherapy. Disease relapse occurred 9 months later, with a unique hepatic lesion that was treated with gemcitabine and cisplatin following liver ablation by radiofrequency. After 2 years, the identification of metastatic lesions in liver, lymph nodes and bones lead the patient to a re-exposure to gemcitabine and cisplatin, which resulted in partial tumor response, accompanied by limiting myelotoxicity induced by chemotherapy. A combination of fluorouracil, leucovorin and irinotecan was started, but disease progressed after 7 cycles. The patient received regorafenib in a third line setting, which resulted in a substantial metabolic response in all secondary lesions. The patient remains with stable disease for more than 16 months. Conclusion: A surprising prolonged survival with regorafenib was observed. Selecting molecular targets is a promising field in the precision oncology.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133437396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-13DOI: 10.31031/aics.2020.02.000540
Yan Leyfman
Fragile X Syndrome is an X-linked recessive mutation in the Fragile X Mental Retardation 1 (FMR1) gene that results in CGG trinucleotide repeats in the 5’ untranslated arm of the FMR1 gene resulting in methylation that silences and/or reduces gene expression. The condition that manifests along a spectrum of symptoms depending on the number of repeats, where a premutation (defined as 55 to 200 CGG repeats) presents with less severe symptoms compared to a full mutation (>200 repeats). The full mutation tends to be more male predominant (85%), while the premutation tends to affect females more who are carrier of this condition [1]. The premutation condition is divided into two subtypesFragile X-associated Primary Ovarian Insufficiency (FXPOI) and Fragile X-associated Tremor/ Ataxia Syndrome (FXTAS) [2]. Although both conditions manifest with psychiatric conditions, they possess unique features on presentation where FXPOI occurs in 20% of female carriers and presents with menopause before the age of 40, while FXTAS occurs in 16% of females and presents with neurological symptoms, including intention tremors, ataxic gait, autonomic dysfunction, neuropathy, and Parkinsonism [3]. Although the psychiatric disorders common to both conditions tend to be depression and/or anxiety, they can also include psychosis and memory and executive function deficits in more advanced cases [4]. Studies have shown that in FXTAS the psychiatric symptoms manifest before the neurological conditions [5]. Studies have also noted an association between the cognitive decline in carriers of this mutation and increased substance abuse that patients fail to acknowledge as abnormal [6,7]. Due to the dearth of Fragile X carrier cases in the literature, there are few observed cases that can document the extent of this condition. Herein, we present a case of female adult carrier who has uniquely displayed the spectrum of systemic manifestations since menarche.
{"title":"Fragile X Syndrome: A Rare Case of a Female Carrier Exhibiting the Phenotypic Spectrum of Disease Features","authors":"Yan Leyfman","doi":"10.31031/aics.2020.02.000540","DOIUrl":"https://doi.org/10.31031/aics.2020.02.000540","url":null,"abstract":"Fragile X Syndrome is an X-linked recessive mutation in the Fragile X Mental Retardation 1 (FMR1) gene that results in CGG trinucleotide repeats in the 5’ untranslated arm of the FMR1 gene resulting in methylation that silences and/or reduces gene expression. The condition that manifests along a spectrum of symptoms depending on the number of repeats, where a premutation (defined as 55 to 200 CGG repeats) presents with less severe symptoms compared to a full mutation (>200 repeats). The full mutation tends to be more male predominant (85%), while the premutation tends to affect females more who are carrier of this condition [1]. The premutation condition is divided into two subtypesFragile X-associated Primary Ovarian Insufficiency (FXPOI) and Fragile X-associated Tremor/ Ataxia Syndrome (FXTAS) [2]. Although both conditions manifest with psychiatric conditions, they possess unique features on presentation where FXPOI occurs in 20% of female carriers and presents with menopause before the age of 40, while FXTAS occurs in 16% of females and presents with neurological symptoms, including intention tremors, ataxic gait, autonomic dysfunction, neuropathy, and Parkinsonism [3]. Although the psychiatric disorders common to both conditions tend to be depression and/or anxiety, they can also include psychosis and memory and executive function deficits in more advanced cases [4]. Studies have shown that in FXTAS the psychiatric symptoms manifest before the neurological conditions [5]. Studies have also noted an association between the cognitive decline in carriers of this mutation and increased substance abuse that patients fail to acknowledge as abnormal [6,7]. Due to the dearth of Fragile X carrier cases in the literature, there are few observed cases that can document the extent of this condition. Herein, we present a case of female adult carrier who has uniquely displayed the spectrum of systemic manifestations since menarche.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123463544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-07DOI: 10.31031/aics.2020.02.000536
C. Blaine
Extracranial internal carotid artery stenosis poses a high risk of recurrent stroke or transient ischemic attack (TIA) after a TIA or minor stroke. Secondary prevention with carotid endarterectomy for high-grade stenosis between 70-99% has been well documented with large scale randomized controlled trials in both Europe and North America. The benefit of intermediate grade stenosis (50-69%) stenosis is not as clear and the present-day standard treatment guidelines do not favor surgery or best medical treatment. When the surgery trials were published in early 1990s, the medical therapy was not as clear or as aggressive. Over the past 20+ years, multimodality medical therapy has been strongly recommended in all stroke guidelines and significantly improved results of secondary prevention of 80-90% is achievable. This review will try to analyze the available data to provide the best treatment recommendation for patients with symptomatic extracranial internal carotid stenosis of 50-69%.
{"title":"Clinical Review: Best Medical Therapy Superior to Carotid Endarterectomy in Secondary Stroke Prevention in Symptomatic Extracranial Internal Carotid Artery Stenosis of 50-69%","authors":"C. Blaine","doi":"10.31031/aics.2020.02.000536","DOIUrl":"https://doi.org/10.31031/aics.2020.02.000536","url":null,"abstract":"Extracranial internal carotid artery stenosis poses a high risk of recurrent stroke or transient ischemic attack (TIA) after a TIA or minor stroke. Secondary prevention with carotid endarterectomy for high-grade stenosis between 70-99% has been well documented with large scale randomized controlled trials in both Europe and North America. The benefit of intermediate grade stenosis (50-69%) stenosis is not as clear and the present-day standard treatment guidelines do not favor surgery or best medical treatment. When the surgery trials were published in early 1990s, the medical therapy was not as clear or as aggressive. Over the past 20+ years, multimodality medical therapy has been strongly recommended in all stroke guidelines and significantly improved results of secondary prevention of 80-90% is achievable. This review will try to analyze the available data to provide the best treatment recommendation for patients with symptomatic extracranial internal carotid stenosis of 50-69%.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129862990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-05DOI: 10.31031/aics.2019.02.000535
M. Alidoost
Background: Abdominal compartment syndrome (ACS) occurs in critically sick patients and is defined as intra-abdominal pressure (IAP) over 20mmHg accompanied by new-onset organ dysfunction [1]. ACS necessitates emergent therapy to decrease abdominal pressures-whether it be via surgical means, or in the case of our patient, paracentesis [1]. Case presentation: A 60-year-old male with a medical history of coronary artery disease status post coronary artery bypass graft and hypertension presented to the Emergency Department (ED) with shortness of breath of 2 days duration preceded by three weeks of increasing abdominal pain and lower extremity edema. He was found to have large ascites and extensive lymphadenopathy on computed tomography (CT) of the abdomen and pelvis. He went for emergent paracentesis and 13,500mL of chyle was removed from the peritoneum. He was eventually diagnosed with non-Hodgkin’s lymphoma (NHL) and started on chemotherapy. Unfortunately, he expired four months later due to a cardiac arrest at home. Conclusion: Although ACS caused trauma and/or bleeding, severe liver cirrhosis, ileus, fluid also IAP described a complication of chylous Here, we report the first case of ACS caused by chylous ascites in the setting of newly diagnosed NHL
{"title":"A Rare Cause of Abdominal Compartment Syndrome: Chylous Ascites in non-Hodgkin’s Lymphoma","authors":"M. Alidoost","doi":"10.31031/aics.2019.02.000535","DOIUrl":"https://doi.org/10.31031/aics.2019.02.000535","url":null,"abstract":"Background: Abdominal compartment syndrome (ACS) occurs in critically sick patients and is defined as intra-abdominal pressure (IAP) over 20mmHg accompanied by new-onset organ dysfunction [1]. ACS necessitates emergent therapy to decrease abdominal pressures-whether it be via surgical means, or in the case of our patient, paracentesis [1]. Case presentation: A 60-year-old male with a medical history of coronary artery disease status post coronary artery bypass graft and hypertension presented to the Emergency Department (ED) with shortness of breath of 2 days duration preceded by three weeks of increasing abdominal pain and lower extremity edema. He was found to have large ascites and extensive lymphadenopathy on computed tomography (CT) of the abdomen and pelvis. He went for emergent paracentesis and 13,500mL of chyle was removed from the peritoneum. He was eventually diagnosed with non-Hodgkin’s lymphoma (NHL) and started on chemotherapy. Unfortunately, he expired four months later due to a cardiac arrest at home. Conclusion: Although ACS caused trauma and/or bleeding, severe liver cirrhosis, ileus, fluid also IAP described a complication of chylous Here, we report the first case of ACS caused by chylous ascites in the setting of newly diagnosed NHL","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130825978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-19DOI: 10.31031/aics.2019.02.000534
Leah Fecik
We report an unusual termination of external jugular vein on the right side of the neck during routine dissection in a 72- year -old female cadaver in which the right external jugular vein drains directly into the cephalic vein, running in front of the medial 1/3 of the clavicle. Detailed knowledge of anatomical variations in this part of the human body is so vital in intervention radiology, intravenous infusion, and surgical procedures involving the head and neck region.
{"title":"External Jugular Vein Terminates in Cephalic Vein, an Anatomical Variation During Neck Dissection & its Clinical Impact","authors":"Leah Fecik","doi":"10.31031/aics.2019.02.000534","DOIUrl":"https://doi.org/10.31031/aics.2019.02.000534","url":null,"abstract":"We report an unusual termination of external jugular vein on the right side of the neck during routine dissection in a 72- year -old female cadaver in which the right external jugular vein drains directly into the cephalic vein, running in front of the medial 1/3 of the clavicle. Detailed knowledge of anatomical variations in this part of the human body is so vital in intervention radiology, intravenous infusion, and surgical procedures involving the head and neck region.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131835833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-17DOI: 10.31031/AICS.2019.02.000532
Yevtushenko, S. Kramarov
Encephalites have a wide range of etiological factors. The measles virus is relatively rare during large-scale vaccination. However, during the outbreak, its role increases, and it should be considered in the differential diagnosis of encephalitis. A major measles outbreak continues in Ukraine during 2017 and up to now, with over 100,000 patients and dozens dead. Encephalitis is the most serious complication of measles virus infection [1].
{"title":"Two Kind of Measles-Related Encephalitis in Pediatric Patients: A Case Report","authors":"Yevtushenko, S. Kramarov","doi":"10.31031/AICS.2019.02.000532","DOIUrl":"https://doi.org/10.31031/AICS.2019.02.000532","url":null,"abstract":"Encephalites have a wide range of etiological factors. The measles virus is relatively rare during large-scale vaccination. However, during the outbreak, its role increases, and it should be considered in the differential diagnosis of encephalitis. A major measles outbreak continues in Ukraine during 2017 and up to now, with over 100,000 patients and dozens dead. Encephalitis is the most serious complication of measles virus infection [1].","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129873319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-19DOI: 10.31031/AICS.2019.02.000530
H. Peng, T. Pau, T. Lim, Y. Eichel, N. Patel
Low-grade appendiceal mucinous neoplasm is a rare entity that commonly presents with appendicitis-like symptoms. Cecal volvulus is a rare complication of this disease, but often requires urgent surgical intervention due to high ischemia rate. Here, we present a case of cecal volvulus caused by appendiceal mucinous neoplasm which represents an uncommon clinical finding of a rare entity.
{"title":"Low-Grade Appendiceal Mucinous Neoplasm Presenting as a Volvulus of the Cecum: A Rare Presentation of a Rare Disease","authors":"H. Peng, T. Pau, T. Lim, Y. Eichel, N. Patel","doi":"10.31031/AICS.2019.02.000530","DOIUrl":"https://doi.org/10.31031/AICS.2019.02.000530","url":null,"abstract":"Low-grade appendiceal mucinous neoplasm is a rare entity that commonly presents with appendicitis-like symptoms. Cecal volvulus is a rare complication of this disease, but often requires urgent surgical intervention due to high ischemia rate. Here, we present a case of cecal volvulus caused by appendiceal mucinous neoplasm which represents an uncommon clinical finding of a rare entity.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"39 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129527788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-20DOI: 10.31031/AICS.2019.02.000527
J MichaelAnjello
Ethics plays a major role in upholding Human Dignity in any field of research and development. Case studies are not exceptional to it. Most of the researchers follow the Belmont Report on guiding principles in Research Ethics with reference to Justice, Beneficence and Autonomy. Ethics Committees were established Internationally (IRB) and every country in every field of human welfare have their own ethical committees. Most of us will be familiar with Medical Ethics Committees or Clinical Ethics Committees and their functions.
{"title":"Ethics of Case Studies Based on Human Dignity","authors":"J MichaelAnjello","doi":"10.31031/AICS.2019.02.000527","DOIUrl":"https://doi.org/10.31031/AICS.2019.02.000527","url":null,"abstract":"Ethics plays a major role in upholding Human Dignity in any field of research and development. Case studies are not exceptional to it. Most of the researchers follow the Belmont Report on guiding principles in Research Ethics with reference to Justice, Beneficence and Autonomy. Ethics Committees were established Internationally (IRB) and every country in every field of human welfare have their own ethical committees. Most of us will be familiar with Medical Ethics Committees or Clinical Ethics Committees and their functions.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116914549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-25DOI: 10.31031/aics.2019.02.000526
H. Akelma, F. Salık, M. Bıçak, İbrahim Andan, Esra Aktiz Bıçak, A. Yıldırım
Combination of and Usg-Guided Low-Dose Abstract Brachial plexus blockade is commonly used in upper extremity surgery because it causes a good effective intraoperative cooperation anesthesia and analgesia. When performed under USG guidance, it has high success and low complication rate. Since multiple extremity burns are present and difficult airway patients have increased blood supply in the extremities and provide long-term analgesia in burn wound healing, regional anesthesia is a good choice. In anesthesia approach, regional anesthesia technique is a good alternative to general anesthesia especially in patients with large burns accompanied by facial and neck burns. In this case, we aimed to present a case of spinal anesthesia in addition to successful low-dose bilateral infraclavicular block with USG in a patient with multiple limb burns and a difficult airway suspicion.
{"title":"Combination of Spinal Anesthesia and Usg- Guided Low-Dose Bilateral Infraclavicular Block in a Patient with Difficult Airway: A Rare Case Report","authors":"H. Akelma, F. Salık, M. Bıçak, İbrahim Andan, Esra Aktiz Bıçak, A. Yıldırım","doi":"10.31031/aics.2019.02.000526","DOIUrl":"https://doi.org/10.31031/aics.2019.02.000526","url":null,"abstract":"Combination of and Usg-Guided Low-Dose Abstract Brachial plexus blockade is commonly used in upper extremity surgery because it causes a good effective intraoperative cooperation anesthesia and analgesia. When performed under USG guidance, it has high success and low complication rate. Since multiple extremity burns are present and difficult airway patients have increased blood supply in the extremities and provide long-term analgesia in burn wound healing, regional anesthesia is a good choice. In anesthesia approach, regional anesthesia technique is a good alternative to general anesthesia especially in patients with large burns accompanied by facial and neck burns. In this case, we aimed to present a case of spinal anesthesia in addition to successful low-dose bilateral infraclavicular block with USG in a patient with multiple limb burns and a difficult airway suspicion.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127289985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-25DOI: 10.31031/aics.2019.01.000525
Jui-Ann Hsu, Tzu-Hsin Lee
This case report presented the orthodontic treatment for an 18-year-old female patient who has Class I malocclusion with bilateral missing maxillary lateral incisors, proclined lower incisors and slight convex profile. According to the profile of the patient, the space analysis of dentition and the color and shape of canine, these above factors favored canine substitution and lower first premolar extraction as our treatment plan. The anterior teeth esthetics was achieved by orthodontic space closure and rehabilitated by composite resin build-up. The patient was satisfied with the treatment outcome.
{"title":"Orthodontic Treatment for Congenitally Missing Maxillary Lateral Incisors with Canine Substitution: A Case Report","authors":"Jui-Ann Hsu, Tzu-Hsin Lee","doi":"10.31031/aics.2019.01.000525","DOIUrl":"https://doi.org/10.31031/aics.2019.01.000525","url":null,"abstract":"This case report presented the orthodontic treatment for an 18-year-old female patient who has Class I malocclusion with bilateral missing maxillary lateral incisors, proclined lower incisors and slight convex profile. According to the profile of the patient, the space analysis of dentition and the color and shape of canine, these above factors favored canine substitution and lower first premolar extraction as our treatment plan. The anterior teeth esthetics was achieved by orthodontic space closure and rehabilitated by composite resin build-up. The patient was satisfied with the treatment outcome.","PeriodicalId":148950,"journal":{"name":"Advancements in Case Studies","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130250833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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