Pub Date : 2019-04-25DOI: 10.21886/2308-6424-2019-7-1-67-73
T. Morgoshiia
В статье отмечены основные годы жизни и творчества профессора А.П. Фрумкина. Показано, что с 1926 года в течение 36 лет работал в больнице им. С.П. Боткина (вначале ординатором, а затем зав. урологическим отделением). В 1939 году защитил докторскую диссертацию на тему «Внутривенная пиелография». С 1946 по 1962 года заведовал кафедрой урологии ЦИУ врачей. В годы Великой Отечественной войны был главным урологом Советской Армии. А.П. Фрумкин — автор свыше 150 научных работ, в т. ч. 4 монографий, посвящённых различным вопросам урологии. Анализируется тот факт, что А.П. Фрумкин занимался разработкой методов уретрографии, кишечной пластики мочеточника и мочевого пузыря (интестинальная пластика), хирургического лечения мочеполовых свищей, лечения гнойных процессов в почках. Отмечено, что им внедрён в практику ряд оригинальных урологических операций: резекция шейки мочевого пузыря при раке, верхняя пиелолитотомия, субкапсулярная пиелотомия, операция создания мочевого пузыря при экстрофии и др. А.П. Фрумкин был редактором редотдела «Урология» 2-го изд. Большой медицинской энциклопедии, зам. редактора журнала «Урология», редактором отдела «Урология» «Энциклопедического словаря военной медицины» (1946), редактором 13-го тома «Опыта советской медицины в Великой Отечественной войне 1941—1945 гг.». Отмечено, что с 1949 года А.П. Фрумкин был бессменным председателем Всесоюзного и Московского урологических обществ, почётным членом Шведского королевского медицинского общества, Общества урологов ГДР и Польши. Подчёркнуто, что прогрессивное развитие школы, созданной А.П. Фрумкиным, и диалектическое продолжение его идей в работах его учеников, являются лучшим памятником творческой деятельности учёного.
{"title":"Anatoly Pavlovich Frumkin (1897-1962): сhief urologist of the Soviet Army and outstanding scientist","authors":"T. Morgoshiia","doi":"10.21886/2308-6424-2019-7-1-67-73","DOIUrl":"https://doi.org/10.21886/2308-6424-2019-7-1-67-73","url":null,"abstract":"В статье отмечены основные годы жизни и творчества профессора А.П. Фрумкина. Показано, что с 1926 года в течение 36 лет работал в больнице им. С.П. Боткина (вначале ординатором, а затем зав. урологическим отделением). В 1939 году защитил докторскую диссертацию на тему «Внутривенная пиелография». С 1946 по 1962 года заведовал кафедрой урологии ЦИУ врачей. В годы Великой Отечественной войны был главным урологом Советской Армии. А.П. Фрумкин — автор свыше 150 научных работ, в т. ч. 4 монографий, посвящённых различным вопросам урологии. Анализируется тот факт, что А.П. Фрумкин занимался разработкой методов уретрографии, кишечной пластики мочеточника и мочевого пузыря (интестинальная пластика), хирургического лечения мочеполовых свищей, лечения гнойных процессов в почках. Отмечено, что им внедрён в практику ряд оригинальных урологических операций: резекция шейки мочевого пузыря при раке, верхняя пиелолитотомия, субкапсулярная пиелотомия, операция создания мочевого пузыря при экстрофии и др. А.П. Фрумкин был редактором редотдела «Урология» 2-го изд. Большой медицинской энциклопедии, зам. редактора журнала «Урология», редактором отдела «Урология» «Энциклопедического словаря военной медицины» (1946), редактором 13-го тома «Опыта советской медицины в Великой Отечественной войне 1941—1945 гг.». Отмечено, что с 1949 года А.П. Фрумкин был бессменным председателем Всесоюзного и Московского урологических обществ, почётным членом Шведского королевского медицинского общества, Общества урологов ГДР и Польши. Подчёркнуто, что прогрессивное развитие школы, созданной А.П. Фрумкиным, и диалектическое продолжение его идей в работах его учеников, являются лучшим памятником творческой деятельности учёного.","PeriodicalId":149073,"journal":{"name":"Herald Urology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128067417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-25DOI: 10.21886/2308-6424-2019-7-1-59-66
T. Morgoshiia
{"title":"Prof. S.P. Fedorov — founder of urology in Russia (150th anniversary of the birthday)","authors":"T. Morgoshiia","doi":"10.21886/2308-6424-2019-7-1-59-66","DOIUrl":"https://doi.org/10.21886/2308-6424-2019-7-1-59-66","url":null,"abstract":"","PeriodicalId":149073,"journal":{"name":"Herald Urology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124923065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-25DOI: 10.21886/2308-6424-2019-7-1-46-52
O. Kaplunova
Голубев В.З. создал научную основу для изучения микроангиоархитектоники почек. Принципы, изложенные в его диссертации, предвосхитили появление работ, изучающих юкстамедуллярный кровоток и почечную гемомикроциркуляцию в норме и при патологии При острых сердечно-сосудистых заболеваниях возрастает значение юкстамедуллярного пути кровотока, наблюдается юкстамедуллярное шунтирование. При хронических сердечно-сосудистых заболеваниях вначале усиливается юкстамедуллярное шунтирование, а на поздних стадиях заболевания склероз мозгового вещества почек вызывает редукцию и блок юкстамедуллярного пути кровотока, ухудшается как юкстамедуллярный, так и кортикальный путь кровотока, что приводит к срыву адаптации интраорганного артериального русла почек. Современные сведения о путях почечной гемоциркуляции, подготовленные исследованиями В.З. Голубева, позволяют объяснить механизм развития различных патологических состояний: острой кровопотери, гидронефроза, вазоренальной гипертензии, гломерулонефрита, пиелонефрита, нефроурологических заболеваниях, кардиогенного шока, мочекаменной болезни, кардиоренального синдрома при острой ишемической болезни сердца, артериальной гипертензии, внезапной коронарной смерти и др.
golobev v . h .为研究肾脏微血管造影建立了一个科学基础。他论文中阐述的原则预测了研究黄道和肾脏血流正常的工作，在急性心血管疾病的病理中，黄道心血管通路的重要性上升，出现黄道旁路。慢性心血管疾病一开始会加重心血管旁路，在肾病晚期会导致脑硬化和脑硬化，导致脑血管阻塞和皮质通路恶化，导致对肾内动脉内动脉的适应中断。由v . h .哥卢别夫研究编导的有关肾血循环的最新资料可以解释各种病理的发展机制:急性出血、水解、血管高压、血管炎、肾盂肾炎、肾盂肾炎、肾盂肾炎、心脏病、利尿病、心血管疾病、动脉高压、冠状动脉突然死亡等。
{"title":"Juxtamedullary blood flow pathway","authors":"O. Kaplunova","doi":"10.21886/2308-6424-2019-7-1-46-52","DOIUrl":"https://doi.org/10.21886/2308-6424-2019-7-1-46-52","url":null,"abstract":"Голубев В.З. создал научную основу для изучения микроангиоархитектоники почек. Принципы, изложенные в его диссертации, предвосхитили появление работ, изучающих юкстамедуллярный кровоток и почечную гемомикроциркуляцию в норме и при патологии При острых сердечно-сосудистых заболеваниях возрастает значение юкстамедуллярного пути кровотока, наблюдается юкстамедуллярное шунтирование. При хронических сердечно-сосудистых заболеваниях вначале усиливается юкстамедуллярное шунтирование, а на поздних стадиях заболевания склероз мозгового вещества почек вызывает редукцию и блок юкстамедуллярного пути кровотока, ухудшается как юкстамедуллярный, так и кортикальный путь кровотока, что приводит к срыву адаптации интраорганного артериального русла почек. Современные сведения о путях почечной гемоциркуляции, подготовленные исследованиями В.З. Голубева, позволяют объяснить механизм развития различных патологических состояний: острой кровопотери, гидронефроза, вазоренальной гипертензии, гломерулонефрита, пиелонефрита, нефроурологических заболеваниях, кардиогенного шока, мочекаменной болезни, кардиоренального синдрома при острой ишемической болезни сердца, артериальной гипертензии, внезапной коронарной смерти и др.","PeriodicalId":149073,"journal":{"name":"Herald Urology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127514425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-22DOI: 10.21886/2308-6424-2018-6-4-67-76
V. Medvedev
This lecture describes the preoperative preparation, the course of the operation and the management of patients in the early postoperative period when performing a radical robot-assisted prostatectomy. The material was developed for the purpose of methodological assistance to surgeons in the development of this operational method.
{"title":"Robot-assisted laparoscopic radical prostatectomy","authors":"V. Medvedev","doi":"10.21886/2308-6424-2018-6-4-67-76","DOIUrl":"https://doi.org/10.21886/2308-6424-2018-6-4-67-76","url":null,"abstract":"This lecture describes the preoperative preparation, the course of the operation and the management of patients in the early postoperative period when performing a radical robot-assisted prostatectomy. The material was developed for the purpose of methodological assistance to surgeons in the development of this operational method.","PeriodicalId":149073,"journal":{"name":"Herald Urology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114169568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-15DOI: 10.21886/2308-6424-2017-6-2-54-61
S. Shkodkin, Y. Idashkin, S. A. Fironov, V. V. Fentisov, A. Udovenko
Introduction.Generally recognized critical moments in kidney resection are the time of ischemia and the adequacy of hemostasis. Until now, one of the main contraindications to nephron-sparing treatment is the inability to provide hemostasis in middle-segment tumors, especially when they are intrarenal.Purpose of research.To evaluate the effectiveness of open resection of the kidney.Materials and methods.For the period 2005 to 2018 us made 152 open partial nephrectomy (OPN) for renal cell carcinoma. The algorithm OPN included extra peritoneal lumbotome access in the IX intercostal space with resection of the X rib resection under conditions of warm ischemia for compression of the blood vessel, in 92.8% of cases completed the clamping of segmental or aberrant arteries. Resection was performed, retreating from the tumor 0.5-1 cm within the unchanged renal parenchyma.Results.The mean age of patients was 55.4±16.2 years; male/female ratio was 52.6/47.4%; right-sided/ left-sided tumor localization was 42.1/57.9%, respectively. The duration of the operation was 109.6±56.7 min, the time of partial ischemia was 15.1±8.3 min, the volume of blood loss was 258±93 ml the Discharge along the drains lasted for 4-12 hours after the operation and averaged 35.7±22.1 ml. Patients were activated after 24 hours, when the urethral catheter was removed, in 59 (38.8%) cases, bladder drainage was not performed. Average postoperative hospital stay was 10.1±4.2 per day.Conclusion.The technique of open resection of the kidney with a margin from the border of the visible tumor and visual control of the surgical edge provides good oncological results, does not require the «Express» histology and is an alternative to nephrectomy in patients with high risk of complications, calculated on morphometric scales.Disclosure: The study did not have sponsorship. The authors declare no conflict of interest.
{"title":"KIDNEY OPEN RESECTION IN RENAL CELL CARCINOMA","authors":"S. Shkodkin, Y. Idashkin, S. A. Fironov, V. V. Fentisov, A. Udovenko","doi":"10.21886/2308-6424-2017-6-2-54-61","DOIUrl":"https://doi.org/10.21886/2308-6424-2017-6-2-54-61","url":null,"abstract":"Introduction.Generally recognized critical moments in kidney resection are the time of ischemia and the adequacy of hemostasis. Until now, one of the main contraindications to nephron-sparing treatment is the inability to provide hemostasis in middle-segment tumors, especially when they are intrarenal.Purpose of research.To evaluate the effectiveness of open resection of the kidney.Materials and methods.For the period 2005 to 2018 us made 152 open partial nephrectomy (OPN) for renal cell carcinoma. The algorithm OPN included extra peritoneal lumbotome access in the IX intercostal space with resection of the X rib resection under conditions of warm ischemia for compression of the blood vessel, in 92.8% of cases completed the clamping of segmental or aberrant arteries. Resection was performed, retreating from the tumor 0.5-1 cm within the unchanged renal parenchyma.Results.The mean age of patients was 55.4±16.2 years; male/female ratio was 52.6/47.4%; right-sided/ left-sided tumor localization was 42.1/57.9%, respectively. The duration of the operation was 109.6±56.7 min, the time of partial ischemia was 15.1±8.3 min, the volume of blood loss was 258±93 ml the Discharge along the drains lasted for 4-12 hours after the operation and averaged 35.7±22.1 ml. Patients were activated after 24 hours, when the urethral catheter was removed, in 59 (38.8%) cases, bladder drainage was not performed. Average postoperative hospital stay was 10.1±4.2 per day.Conclusion.The technique of open resection of the kidney with a margin from the border of the visible tumor and visual control of the surgical edge provides good oncological results, does not require the «Express» histology and is an alternative to nephrectomy in patients with high risk of complications, calculated on morphometric scales.Disclosure: The study did not have sponsorship. The authors declare no conflict of interest.","PeriodicalId":149073,"journal":{"name":"Herald Urology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124349962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-15DOI: 10.21886/2308-6424-2017-6-2-44-53
E. Chernogubova
Introduction.Chronic prostatitis is the most common and difficult to diagnose androurologic disease. However, the etiology, pathogenesis and pathophysiology of chronic abacterial prostatitis are not well understood.Objective.Analysis of the role of the body’s proteolytic systems in inflammatory processes in the prostate, detection of markers of inflammation in the blood, prostate secretion in various forms of chronic abacterial prostatitis / chronic pelvic pain syndrome (CAP/CPPS).Materials and methods.The study included 52 patients with inflammatory (CAP/CPPS IIIA) and 46 patients with non - inflammatory (CAP/CPPS IIIB) forms of chronic abacterial prostatitis. We determined the activity of kallikrein, level of prekallikrein, inhibitory activity α1-proteinase inhibitor and α2- macroglobulin, total arginine-esterase activity, activity of leukocyte elastase and elastase-like activity in the blood serum and the prostate secret.Results.Disturbance of metabolic processes of inflammation development in chronic abacterial prostatitis occurs against the background of imbalance of the proteinase inhibitors system, uncontrolled enhancement of proteolytic processes in the prostate in conditions of weakening of natural resistance of the organism is the most significant factor in the development of CAP/CPPS.Conclusions.The analysis of the activity of proteolytic processes in the blood and prostate secretion can serve as an additional diagnostic criterion for chronic abacterial prostatitis/chronic pelvic pain syndrome.Disclosure: TInformation about sponsorship. The publication was prepared within the framework of the implementation of the State Task of the SSC RAS for 2018. The state registration of the project № 01201363192. The author declares no conflict of interest.
{"title":"MARKERS OF INFLAMMATION IN DIFFERENT FORMS OF CHRONIC ABACTERIAL PROSTATITIS","authors":"E. Chernogubova","doi":"10.21886/2308-6424-2017-6-2-44-53","DOIUrl":"https://doi.org/10.21886/2308-6424-2017-6-2-44-53","url":null,"abstract":"Introduction.Chronic prostatitis is the most common and difficult to diagnose androurologic disease. However, the etiology, pathogenesis and pathophysiology of chronic abacterial prostatitis are not well understood.Objective.Analysis of the role of the body’s proteolytic systems in inflammatory processes in the prostate, detection of markers of inflammation in the blood, prostate secretion in various forms of chronic abacterial prostatitis / chronic pelvic pain syndrome (CAP/CPPS).Materials and methods.The study included 52 patients with inflammatory (CAP/CPPS IIIA) and 46 patients with non - inflammatory (CAP/CPPS IIIB) forms of chronic abacterial prostatitis. We determined the activity of kallikrein, level of prekallikrein, inhibitory activity α1-proteinase inhibitor and α2- macroglobulin, total arginine-esterase activity, activity of leukocyte elastase and elastase-like activity in the blood serum and the prostate secret.Results.Disturbance of metabolic processes of inflammation development in chronic abacterial prostatitis occurs against the background of imbalance of the proteinase inhibitors system, uncontrolled enhancement of proteolytic processes in the prostate in conditions of weakening of natural resistance of the organism is the most significant factor in the development of CAP/CPPS.Conclusions.The analysis of the activity of proteolytic processes in the blood and prostate secretion can serve as an additional diagnostic criterion for chronic abacterial prostatitis/chronic pelvic pain syndrome.Disclosure: TInformation about sponsorship. The publication was prepared within the framework of the implementation of the State Task of the SSC RAS for 2018. The state registration of the project № 01201363192. The author declares no conflict of interest.","PeriodicalId":149073,"journal":{"name":"Herald Urology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121278935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-15DOI: 10.21886/2308-6424-2018-6-2-62-68
T. Morgoshiia
The article notes that James Israel and Max Nitze have successfully developed European medicine for more than 30 years of their scientific and practical activities, enriching it with both experimental and large clinical experience. Their scientific achievements greatly contributed to the development of modern clinical urology throughout the world. Based on an analysis of the results of more than 1000 nephrectomy operations for tuberculosis, Izrael made a conclusion about the effectiveness of surgical treatment of this disease. In addition to kidney surgery, J. Israel developed questions of rhinoplasty. He participated in the International Congress of Physicians in Moscow (1897), where he reported on 191 kidney operations. He was an honorary member of the German Society of Surgeons, the Berlin Society of Urology, President of the International Congress of Urology (Paris, 1908). The main merit of M. Nitze is the invention of a cystoscope, in which for the first time an electric light source for illuminating the bladder was located at the end of a tool inserted into the bladder. The invention of the cystoscope contributed to the development of urology as an independent clinical discipline and marked the beginning of endoscopic studies of various organs and body cavities. It is analyzed the fact that the history of medicine gives rich material not only to understanding evolution, but also to the possibility to foresee its further development. The current state of clinical urology is determined by the progress of basic research in biology, physics, biochemistry, bacteriology, immunology, pharmacology. At the same time, it was noted that the personality of the scientist-physician, his observation, the non-standard view, the ability to see the opening perspectives, to bring up worthy students, to create a scientific and clinical school of urologists, is of utmost importance, at the same time, to the full compliance of the great German urologists J Israel and M. Nitze.Disclosure: The study did not have sponsorship. The author declares no conflict of interest.
{"title":"MEMORIES OF PROFESSORS OF D. IZRAEL (1848–1926) AND M. NITTS (1848–1906) (TO THE 170 ANNIVERSARY SINCE BIRTH)","authors":"T. Morgoshiia","doi":"10.21886/2308-6424-2018-6-2-62-68","DOIUrl":"https://doi.org/10.21886/2308-6424-2018-6-2-62-68","url":null,"abstract":"The article notes that James Israel and Max Nitze have successfully developed European medicine for more than 30 years of their scientific and practical activities, enriching it with both experimental and large clinical experience. Their scientific achievements greatly contributed to the development of modern clinical urology throughout the world. Based on an analysis of the results of more than 1000 nephrectomy operations for tuberculosis, Izrael made a conclusion about the effectiveness of surgical treatment of this disease. In addition to kidney surgery, J. Israel developed questions of rhinoplasty. He participated in the International Congress of Physicians in Moscow (1897), where he reported on 191 kidney operations. He was an honorary member of the German Society of Surgeons, the Berlin Society of Urology, President of the International Congress of Urology (Paris, 1908). The main merit of M. Nitze is the invention of a cystoscope, in which for the first time an electric light source for illuminating the bladder was located at the end of a tool inserted into the bladder. The invention of the cystoscope contributed to the development of urology as an independent clinical discipline and marked the beginning of endoscopic studies of various organs and body cavities. It is analyzed the fact that the history of medicine gives rich material not only to understanding evolution, but also to the possibility to foresee its further development. The current state of clinical urology is determined by the progress of basic research in biology, physics, biochemistry, bacteriology, immunology, pharmacology. At the same time, it was noted that the personality of the scientist-physician, his observation, the non-standard view, the ability to see the opening perspectives, to bring up worthy students, to create a scientific and clinical school of urologists, is of utmost importance, at the same time, to the full compliance of the great German urologists J Israel and M. Nitze.Disclosure: The study did not have sponsorship. The author declares no conflict of interest.","PeriodicalId":149073,"journal":{"name":"Herald Urology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114879338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-15DOI: 10.21886/2308-6424-2018-6-2-5-12
O. Bratchikov, M. Pokrovskiy, V. Elagin, D. A. Kostina
This article contains the results of research of the endothelial dysfunction arising during the modeling of thermal local asphyxia of kidney and possibilities of their correction by distant ischemic and pharmacological preconditioning. The modeling of thermal local asphyxia of kidney is characterized by the disturbance of microcirculation and expression of eNOS in the kidney tissue. The usage of distant ischemic preconditioning and phosphodiesterase inhibitors type 5 sildenafil and tadalafil leads to pronounced correction of microcirculation dysfunction and activity of eNOS. During the modeling of thermal local asphyxia of kidney against endothelium dysfunction caused by ADMA-like L-NAME induced deficiency of nitric oxide more pronounced dysfunction of microcirculation and activity of eNOS are observed. The usage of distant ischemic and pharmacological preconditioning with the help of phosphodiesterase inhibitors type 5 in this type of pathology led to pronounced correction of microcirculation dysfunction and activity of eNOS. The injection of glibenclamide blocker of ATP – dependent K+ channels during the correction of the disturbance caused by the modeling of thermal local asphyxia of kidney with the help of distant ischemic and pharmacological preconditioning leads to the decrease of its efficiency.Disclosure: The study did not have sponsorship. The authors have declared no conflicts of interest.
{"title":"THE CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH THE HELP OF DISTANT ISCHEMIC AND PHARMACOLOGICAL PRECONDITIONING WITH THERMAL LOCAL ASPHYXIA OF KIDNEY","authors":"O. Bratchikov, M. Pokrovskiy, V. Elagin, D. A. Kostina","doi":"10.21886/2308-6424-2018-6-2-5-12","DOIUrl":"https://doi.org/10.21886/2308-6424-2018-6-2-5-12","url":null,"abstract":"This article contains the results of research of the endothelial dysfunction arising during the modeling of thermal local asphyxia of kidney and possibilities of their correction by distant ischemic and pharmacological preconditioning. The modeling of thermal local asphyxia of kidney is characterized by the disturbance of microcirculation and expression of eNOS in the kidney tissue. The usage of distant ischemic preconditioning and phosphodiesterase inhibitors type 5 sildenafil and tadalafil leads to pronounced correction of microcirculation dysfunction and activity of eNOS. During the modeling of thermal local asphyxia of kidney against endothelium dysfunction caused by ADMA-like L-NAME induced deficiency of nitric oxide more pronounced dysfunction of microcirculation and activity of eNOS are observed. The usage of distant ischemic and pharmacological preconditioning with the help of phosphodiesterase inhibitors type 5 in this type of pathology led to pronounced correction of microcirculation dysfunction and activity of eNOS. The injection of glibenclamide blocker of ATP – dependent K+ channels during the correction of the disturbance caused by the modeling of thermal local asphyxia of kidney with the help of distant ischemic and pharmacological preconditioning leads to the decrease of its efficiency.Disclosure: The study did not have sponsorship. The authors have declared no conflicts of interest.","PeriodicalId":149073,"journal":{"name":"Herald Urology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131082091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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