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Turning Point: A Review of Key Research and Engagement in 2021. 转折点:2021年重点研究与参与回顾。
IF 2.6 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-12-01 Epub Date: 2021-11-25 DOI: 10.1089/acm.2021.0374
Claudia Citkovitz, Lisa Jean Taylor-Swanson, Robert Davis, Richard E Harris, Benjamin Kligler, Jiang-Ti Kong, Lixing Lao, Jun Mao, Ari Ojeda Ocampo Moré, Vitaly Napadow, Lee Hullender Rubin, Rosa Schnyer, Peter D Wayne, Claudia M Witt
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引用次数: 1
Retracted: Music Therapy: A Core Service in Integrative Palliative Care. 撤回:音乐治疗:综合姑息治疗的核心服务。
IF 2.6 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-12-01 Epub Date: 2021-04-27 DOI: 10.1089/acm.2020.0025
Noah Potvin, Molly Hicks, Rebecca Kronk

The Journal of Alternative and Complementary Medicine (JACM) officially withdraws the article entitled, "Music Therapy: A Core Service in Integrative Palliative Care" by Noah Potvin, Molly Hicks, and Rebecca Kronk (epub: 27 April 2021; DOI: https://doi.org/10.1089/acm.2020.0025). The article had been "provisionally accepted" for possible publication in a special issue of JACM, but by the time articles were selected for that issue, the Guest Editors determined it should not be included and the Editor rescinded the provisional acceptance. Regrettably, the acceptance was reversed after the article was processed through normal production processes and was mistakenly released to the Journal's online platform. After the article was posted, the publisher learned that the authors had submitted and published the article elsewhere since the provisional acceptance had been reversed. Because of this, and in keeping with standard peer review practices, JACM must withdraw the article. It is important to note that this was an editorial error and that the authors bear no fault. The publisher of JACM and its editorial team deeply regret this error and sincerely apologize to Dr. Potvin, Dr. Hicks, and Dr. Kronk.

替代和补充医学杂志(JACM)正式撤回题为“音乐治疗:综合姑息治疗的核心服务”的文章,作者Noah Potvin, Molly Hicks和Rebecca Kronk (epub: 2021年4月27日;DOI: https://doi.org/10.1089/acm.2020.0025)。这篇文章已被“暂时接受”,可能在《联合新闻公报》的一期特刊上发表,但当选定该期特刊的文章时,客座编辑决定不应将其列入,编辑取消了临时接受。遗憾的是,该文章在经过正常的制作流程处理后,被错误地发布到《华尔街日报》的在线平台上。文章发表后,出版商了解到,由于临时接受已被撤销,作者已在其他地方提交并发表了文章。因此,为了与标准的同行评审实践保持一致,JACM必须撤回文章。值得注意的是,这是一个编辑错误,作者没有过错。《JACM》的出版商及其编辑团队对这一错误深感遗憾,并真诚地向Potvin博士、Hicks博士和Kronk博士道歉。
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引用次数: 0
Yoga Interventions Used for the Rehabilitation of Stroke, Parkinson's Disease, and Multiple Sclerosis: A Scoping Review of Clinical Research. 瑜伽干预用于中风、帕金森病和多发性硬化症的康复:临床研究的范围综述。
IF 2.3 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-12-01 Epub Date: 2021-06-29 DOI: 10.1089/acm.2021.0003
Zachary Legault, Alizée Znaty, Samantha Smith, Marie-Hélène Boudrias

Objectives: The current body of literature was reviewed to compile and describe yoga interventions that have been applied in clinical research and neurologic rehabilitation settings with patients affected by stroke, Parkinson's disease (PD), and multiple sclerosis (MS). Design: Available literature on yoga therapy (YT) was mapped following a five-stage framework to identify key concepts, knowledge gaps, and evidence to inform practice. Publications were identified through Medline, CINAHL, EMBASE, and PsycINFO. Selected studies required subjects with a clinical diagnosis of stroke, PD, and MS to participate in a yoga intervention and have physical, cognitive, and/or psychosocial outcome measures assessed. Results: A total of 50 studies were included in this review. Study characteristics, patient demographics, description of the yoga intervention, reported outcome measures and the main findings were extracted from the studies. Conclusion: Implementing YT in neurorehabilitation can help health care professionals integrate a more holistic approach that addresses the fundamental physical and psychological challenges of living with a chronic and debilitating neurologic disorder. The included studies described yogic interventions consisting of group or individual therapy sessions lasting 60-75 min that were carried out one to three times per week for 8-12 consecutive weeks across all three conditions. All studies described in this scoping review used different yoga protocols confirming the lack of specific interventional parameters available for implementing yoga into the rehabilitation of individuals affected by stroke, PD, or MS.

目的:对现有的文献进行综述,以汇编和描述瑜伽干预在中风、帕金森病(PD)和多发性硬化症(MS)患者的临床研究和神经康复环境中的应用。设计:现有的关于瑜伽疗法(YT)的文献按照五个阶段的框架进行绘制,以确定关键概念、知识差距和证据,为实践提供信息。出版物通过Medline、CINAHL、EMBASE和PsycINFO进行鉴定。选定的研究要求临床诊断为中风、帕金森病和多发性硬化症的受试者参加瑜伽干预,并对身体、认知和/或社会心理结果进行评估。结果:本综述共纳入50项研究。研究特征、患者人口统计、瑜伽干预的描述、报告的结果测量和主要发现都是从研究中提取的。结论:在神经康复中实施YT可以帮助医疗保健专业人员整合更全面的方法,解决慢性衰弱性神经系统疾病患者的基本生理和心理挑战。纳入的研究描述了瑜伽干预,包括持续60-75分钟的团体或个人治疗,每周进行一到三次,连续8-12周,在所有三种情况下。本综述中描述的所有研究都使用了不同的瑜伽方案,证实缺乏特定的干预参数,可用于将瑜伽实施到中风、帕金森病或多发性硬化症患者的康复中。
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引用次数: 0
Herbal Medicines for Treatment of Radiodermatitis: A Systematic Review and Meta-Analysis. 中药治疗放射性皮炎:系统回顾和荟萃分析。
IF 2.6 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-12-01 Epub Date: 2021-08-27 DOI: 10.1089/acm.2021.0166
Ghazaleh Heydarirad, Bahareh Ahadi, Hossein Molavi Vardanjani, Holger Cramer, Hamid Reza Mirzaei, Mehdi Pasalar

Background: There is some evidence in favor of the efficacy of herbal medicine in the treatment of radiodermatitis as a frequent complication among cancer patients. Purpose: The present study aimed to evaluate the effect of herbal medicines on the treatment of radiodermatitis in cancer patients. Study design: Systematic review performed in accordance with the PRISMA guideline. Methods: We searched the electronic databases, Scopus, PubMed, Cochrane Library, Embase, Google Scholar, and ISI Web of Science, through July 2020 for randomized controlled trials (RCTs) that compared herbal compounds against a standard medication or placebo for treatment or prevention of radiodermatitis. Results: A total of 16 RCTs involving 1886 patients with breast, head and neck, or unspecified cancer were included. Risk of bias generally was high. Of those, three RCTs with 562 cancer patients (mainly breast cancer) who used Aloe vera to treat radiodermatitis were included in the meta-analysis. There was a significant level of heterogeneity between the studies (I2 = 95.8). One RCT found positive effects of Aloe vera in reducing the severity of radiodermatitis (standardized mean difference [SMD] = 3.37), whereas another revealed an inverse effect (SMD = -4). Conclusion: At present, there are no herbal compositions that are effective in treating radiodermatitis, with Aloe vera failing to show sufficient efficacy in the meta-analysis.

背景:有一些证据支持草药治疗放射性皮炎作为癌症患者常见并发症的疗效。目的:探讨中药对肿瘤患者放射性皮炎的治疗作用。研究设计:按照PRISMA指南进行系统评价。方法:截至2020年7月,我们检索了电子数据库Scopus、PubMed、Cochrane Library、Embase、Google Scholar和ISI Web of Science,以比较草药化合物与标准药物或安慰剂治疗或预防放射性皮炎的随机对照试验(rct)。结果:共纳入16项随机对照试验,涉及1886例乳腺癌、头颈癌或未指明癌症患者。偏倚风险普遍较高。其中,使用芦荟治疗放射性皮炎的562名癌症患者(主要是乳腺癌患者)的3项随机对照试验被纳入meta分析。两项研究之间存在显著的异质性(I2 = 95.8)。一项随机对照试验发现芦荟在降低放射性皮炎的严重程度方面具有积极作用(标准化平均差[SMD] = 3.37),而另一项随机对照试验显示其具有相反作用(SMD = -4)。结论:目前还没有有效治疗放射性皮炎的草药成分,芦荟在meta分析中也没有显示出足够的疗效。
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引用次数: 3
Association Between Sudarshan Kriya Yoga and Healthy Lifestyle Practices Among Working Adults: A Cross-Sectional Study from Singapore. 苏达山克里亚瑜伽与健康生活方式之间的联系:新加坡的一项横断面研究。
IF 2.6 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-11-01 Epub Date: 2021-07-05 DOI: 10.1089/acm.2021.0035
Robert A Sloan, Divya Kanchibhotla

Objectives: There is a paucity of research on the association between yogic breathing and healthy lifestyle factors in working adults. Also, there is very little information about the frequency of yogic breathing practice and its benefits. The authors investigated the relationship between Sudarshan Kriya Yoga (SKY) frequency and the likelihood of leading a healthier lifestyle among practitioners and nonpractitioners. Design: Cross-sectional investigation on non-SKY and SKY practitioners, SKY was categorized into non-, monthly, weekly, and daily practitioners. Confounding variables included age, gender, ethnicity, marital status, and education level. A multivariate logistic regression model was used to compare practice frequencies with the odds of having a healthier lifestyle. Settings: Community centers, community events, workplaces, and universities throughout Singapore Subjects: Of the 531 working adults (54.8% female), 50.1% had a healthier lifestyle ≥ 4 healthy lifestyle factors). Outcome Measure: Having a healthier lifestyle was defined as having ≥ 4 healthy lifestyle factors out of seven (smoking, alcohol, diet, exercise, sleep, stress, and weight). Results: Multivariate analysis demonstrated that those who practiced SKY ≥ 4 days/week had significantly higher odds of having a healthier lifestyle (odds ratio = 3.62; 95% confidence interval = 2.10-6.23). The p for trend analysis demonstrated that as the frequency of practice increased the likelihood of having a healthier lifestyle also increased ( p < 0.001). Conclusion: The practice of yogic breathing may promote a healthier lifestyle in working adults. Further experimental and longitudinal investigations are warranted.

目的:在工作的成年人中,瑜伽呼吸与健康生活方式因素之间的关系研究很少。此外,关于瑜伽呼吸练习的频率及其益处的信息也很少。作者调查了练苏达山克里亚瑜伽(SKY)的人和不练苏达山克里亚瑜伽的人之间的关系。设计:对非SKY和SKY从业人员进行横断面调查,SKY分为非、每月、每周和每日从业人员。混杂变量包括年龄、性别、种族、婚姻状况和教育水平。多变量逻辑回归模型用于比较练习频率与拥有更健康生活方式的几率。研究对象:531名有工作的成年人(54.8%为女性)中,50.1%的人有更健康的生活方式(≥4种健康生活方式因素)。结果测量:拥有更健康的生活方式定义为在7个健康生活方式因素(吸烟、饮酒、饮食、运动、睡眠、压力和体重)中拥有≥4个。结果:多因素分析表明,那些每周练习SKY≥4天的人拥有更健康生活方式的几率显著更高(优势比= 3.62;95%置信区间= 2.10-6.23)。趋势分析的p表明,随着练习频率的增加,拥有更健康生活方式的可能性也在增加(p结论:练习瑜伽呼吸可以促进在职成年人更健康的生活方式。进一步的实验和纵向研究是必要的。
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引用次数: 0
Efficacy and Safety of a Standardized Soy and Hop Extract on Menopausal Symptoms: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 标准化大豆和啤酒花提取物对更年期症状的疗效和安全性:为期 12 周的多中心、随机、双盲、安慰剂对照临床试验。
IF 2.6 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-11-01 Epub Date: 2021-08-16 DOI: 10.1089/acm.2021.0027
Hye In Kim, Min Kyoung Kim, Inha Lee, Jisun Yun, Eui Hyeok Kim, Seok Kyo Seo

Objectives: Soy and hop extracts have been investigated as alternatives for hormone replacement therapy. However, their combined efficacy is not known. We investigated the efficacy and safety of a combined soy and hop extract on postmenopausal symptoms. Design: Double-blinded, randomized controlled trial. Settings/Location: Gynecological outpatient clinic of tertiary hospital. Subjects: Seventy-eight women with moderate or severe menopausal symptoms assessed as modified Kupperman Menopoausal Index (KMI) scores >20. Interventions: They received either a combined soy and hop extract (n = 38) or placebo (n = 40). Outcome measures: Menopausal symptoms were evaluated through self-reporting of modified Kupperman Menopausal Index (KMI) scores at baseline and after 6 and 12 weeks. We assessed serum levels of bone metabolism biomarkers, ultrasonographic parameters, hormone profiles, compliance, and safety. Results: After 12 weeks of the treatment, treatment group scores decreased by 20.61 points compared with 14.80 points in the placebo group (p < 0.05). Fatigue, paresthesia, arthralgia, and myalgia, palpitation and vaginal dryness significantly improved more in the treatment group compared with the placebo group after 12 weeks (p < 0.05). Urine N-telopeptide in participants ≥50 years in the treatment group showed a reduced increase. Endometrial thickness and hormonal profiles did not show significant changes in either group. No serious adverse events were reported. Conclusion: The results suggest that 190 mg of combined soy and hop extract is safe and effective for improvement of menopausal symptoms. CRIS No.: KCT0006019.

目的:大豆和啤酒花提取物已被研究作为激素替代疗法的替代品。然而,它们的综合疗效尚不清楚。我们研究了大豆和啤酒花提取物对绝经后症状的疗效和安全性。设计:双盲随机对照试验。设置/地点:三级医院妇科门诊。研究对象: 78 名患有中度更年期症状的妇女:78名患有中度或重度更年期症状的女性,评估标准为改良库珀曼更年期指数(KMI)评分大于20分。干预措施她们接受大豆和啤酒花提取物联合疗法(38 人)或安慰剂(40 人)。结果测量:更年期症状通过基线时以及 6 周和 12 周后的改良库珀曼更年期指数 (KMI) 评分自我报告进行评估。我们评估了血清中的骨代谢生物标志物水平、超声参数、激素概况、依从性和安全性。结果显示治疗 12 周后,治疗组得分降低了 20.61 分,而安慰剂组得分降低了 14.80 分(P P 结论:治疗组得分降低了 20.61 分,而安慰剂组得分降低了 14.80 分:结果表明,190 毫克大豆和啤酒花提取物联合疗法对改善更年期症状安全有效。CRIS 编号:KCT0006019。
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引用次数: 2
Beyond the Standard of Care: An Exploratory Qualitative Study of an Implemented Integrative Therapeutic Care Program in a Brazilian Pediatric Oncology Unit. 超越标准护理:一项在巴西儿科肿瘤科实施的综合治疗护理计划的探索性定性研究。
IF 2.6 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-11-01 Epub Date: 2021-10-20 DOI: 10.1089/acm.2021.0058
Marc Tröndle, Wiebke Stritter, Vicente Odone, Karina Peron, Ricardo Ghelman, Georg Seifert

Introduction: This article examines the feedback of health care providers within the implementation of an integrative care project in a clinic for pediatric oncology in São Paulo, Brazil. Since 2017, the project has implemented external anthroposophic therapies in the activities of daily nursing. The objective is to evaluate how the project evolved and what impact it had on the daily operation of the hospital. A special focus emphasizes the perspective of study nurses. Materials and Methods: Twelve qualitative semistructured interviews were conducted. Audio files were transcribed, translated to German, and underwent a MAXQDA software-assisted analysis. Using a thematic approach, coherent cross-case topics were defined. Results: Three main topics emerged from analysis of the data. (1) The implementation and its effects on daily patient care demonstrated positive outcomes in patients and were well accepted with minimal changes in daily activities. (2) The perspective of study nurses showed a large motivation due to beneficial and stress-relieving effects of the application and a growing patient-health care provider relationship. (3) Problems and aspirations for improvement were the lack of time and the urge to make the project grow in the future. Conclusion: Not only patients but also health care providers seem to benefit from integrative methods. They have the potential to improve the working atmosphere and to strengthen relations between patients, caregivers, and family members. General feedback was positive and acceptance in the team arose over time when beneficial effects became visible.

简介:本文研究了在巴西圣保罗一家儿科肿瘤学诊所实施综合护理项目期间卫生保健提供者的反馈。自2017年起,项目在日常护理活动中实施外部人智疗法。目的是评估该项目的发展情况及其对医院日常运营的影响。特别强调学习护士的视角。材料与方法:进行了12次定性半结构化访谈。音频文件被转录,翻译成德语,并进行MAXQDA软件辅助分析。使用主题方法,定义了连贯的跨案例主题。结果:从数据分析中产生了三个主要主题。(1)该方案的实施及其对患者日常护理的影响在患者中显示出积极的结果,并且在日常活动变化最小的情况下被患者所接受。(2)由于应用的有益和缓解压力的效果以及日益增长的患者-医疗保健提供者关系,研究护士的观点显示出很大的动机。(3)问题和改进的愿望是缺乏时间和迫切需要使项目在未来成长。结论:综合治疗方法不仅对患者有益,对医护人员也有益。它们有可能改善工作氛围,加强患者、护理人员和家庭成员之间的关系。总体反馈是积极的,当有益的效果变得明显时,团队中的接受度会随着时间的推移而提高。
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引用次数: 3
Heavy Metals in Indian Traditional Systems of Medicine: A Systematic Scoping Review and Recommendations for Integrative Medicine Practice. 印度传统医学系统中的重金属:一个系统的范围审查和综合医学实践的建议。
IF 2.3 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-11-01 Epub Date: 2021-06-17 DOI: 10.1089/acm.2021.0083
Sanchari Mukhopadhyay, Shalu Elizabeth Abraham, Bharath Holla, Kishore Kr Ramakrishna, Kamala Lakshmi Gopalakrishna, Akhila Soman, Umesh C Chikkanna, Muchukunte Mukunda Srinivas Bharath, Hemant Bhargav, Shivarama Varambally, Bangalore Nanjundaiah Gangadhar

Introduction: Ayurveda and Siddha are two important components of the traditional Indian medicine (TIM). The regulatory mechanisms have been insufficient, and heavy metal toxicity with TIM preparations continues to be a public health nuisance, putting integrated medicine practice in jeopardy. The current study was undertaken to review the potential health hazards of the heavy metal content in the TIM and formulate patient-safety recommendations for integrative medical practice. Materials and Methods: Systematic MEDLINE searches were performed using a combination of relevant MeSH terms and keywords, and case report/series of Ayurveda or Siddha-induced heavy metal toxicity, published in the previous two decades, were included. Risk of bias was assessed with the tool by Murad et al. Results: A total of 220 cases (51 case reports and 14 case series) were found (lead, n = 156; arsenic, n = 11; mercury, n = 47; thallium, n = 1; gold, n = 1; combination of heavy metals, n = 4) after screening for the inclusion and exclusion criteria. Among them, 169 (76.8%) had a low risk of bias, 113 (out of 135 [83.7%] analyzed) contained higher-than-permissible heavy metal content in the drug samples, and the majority showed elevated biological levels of the heavy metals in the body. Conclusion: The heavy metals in TIM are often the result of adulteration or improper manufacturing and prescribing practices, despite national and international guidelines recommending quality standards and protocols for preparing and dispensing TIM. We thus propose multipronged approaches and provide recommendations at various levels, including individual, institutional, national policy decisions essential to establish patient safety of TIM.

阿育吠陀和悉达是传统印度医学(TIM)的两个重要组成部分。监管机制不足,TIM制剂的重金属毒性仍然是一种公共卫生危害,使综合医学实践处于危险之中。目前进行的研究是为了审查TIM中重金属含量的潜在健康危害,并为综合医疗实践制定患者安全建议。材料和方法:使用相关的MeSH术语和关键词组合进行系统的MEDLINE搜索,并纳入了过去20年发表的阿育吠陀或悉达陀引起的重金属中毒的病例报告/系列。Murad等人使用该工具评估偏倚风险。结果:共发现病例220例,其中报告病例51例,系列病例14例(lead, n = 156;砷,n = 11;水星,n = 47;铊,n = 1;金,n = 1;组合重金属,n = 4)筛选后确定纳入和排除标准。其中169份(76.8%)偏倚风险较低,135份(83.7%)中有113份药物样品重金属含量超标,多数显示体内重金属生物学水平升高。结论:TIM中的重金属通常是掺假或不当生产和处方操作的结果,尽管国家和国际指南推荐了TIM的制备和配药的质量标准和方案。因此,我们提出了多管齐下的方法,并在各个层面提供建议,包括个人、机构和国家的政策决定,这对建立TIM的患者安全至关重要。
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引用次数: 0
The Relationships Between Reduced Alcohol Use and Decreased Burnout Following Mindfulness-Based Resilience Training in Law Enforcement Officers. 执法人员正念复原力训练后减少酒精使用与减少倦怠之间的关系
IF 2.6 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-11-01 Epub Date: 2021-09-13 DOI: 10.1089/acm.2021.0052
Kristoffer Rehder, Ashley Eddy, Josh Kaplan, Aaron Bergman, Michael Christopher

Objective: This study is a secondary analysis of data collected in an earlier clinical trial of mindfulness-based resilience training (MBRT) (ClinicalTrials.gov registration number 02521454), where the MBRT condition demonstrated a significant reduction in self-reported burnout and trend-level reductions in alcohol use in law enforcement officers (LEOs). Given that MBRT is not designed to be a substance use intervention and does not contain explicit substance-related content, this study sought to clarify these findings by exploring whether improved burnout mediates reduced alcohol use. Method: Participants (n = 61) were sworn LEOs (89% male, 85% White, 8% Hispanic/Latinx) recruited from departments in a large urban metro area of the northwestern United States, and were randomized to either MBRT (n = 31) or no intervention control group (n = 30) during the trial. Results: MBRT group assignment predicted reduced burnout (b = 0.43, standard error [SE] = 0.14, p = 0.004), which subsequently predicted reduced alcohol use (b = 1.69, SE = 0.81, p = 0.045). Results suggest that reduced alcohol use was indirectly related to a reduction in burnout post-MBRT. Conclusion: Given that MBRT does not explicitly address substance use, these findings were interpreted to suggest that officers in the training acquired a new set of coping skills to deal with the operational and organizational stressors of police work.

目的:本研究是对早期基于正念的恢复力训练(MBRT)临床试验(ClinicalTrials.gov注册号02521454)收集的数据进行二次分析,其中MBRT条件显示执法人员(LEOs)自我报告的倦怠和酒精使用的趋势水平显著降低。鉴于MBRT不是设计为物质使用干预,也不包含明确的物质相关内容,本研究试图通过探索改善倦怠是否介导减少酒精使用来澄清这些发现。方法:参与者(n = 61)是从美国西北部大城市都会区的部门招募的宣誓leo(89%男性,85%白人,8%西班牙裔/拉丁裔),在试验期间随机分为MBRT组(n = 31)或无干预对照组(n = 30)。结果:MBRT组分配预测倦怠减少(b = 0.43,标准误差[SE] = 0.14, p = 0.004),随后预测酒精使用减少(b = 1.69, SE = 0.81, p = 0.045)。结果表明,酒精使用的减少与mbrt后职业倦怠的减少间接相关。结论:鉴于MBRT没有明确地解决药物使用问题,这些发现被解释为在培训中获得了一套新的应对技能,以处理警察工作中的操作和组织压力源。
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引用次数: 1
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review. 优化健康成人认知能力的膳食补充剂成分:系统综述。
IF 2.6 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-11-01 Epub Date: 2021-08-09 DOI: 10.1089/acm.2021.0135
Cindy Crawford, Courtney Boyd, Patricia A Deuster

Background: Dietary supplements promoted for brain health and enhanced cognitive performance are widely available. Claims made for these products are directed not only to the elderly wishing to prevent or mitigate cognitive decline, but also young healthy populations looking to boost their cognitive performance. It is unclear whether these claims made on product bottles and through advertising match the science. Objectives: To explore the evidence on the efficacy and safety of single dietary supplement ingredients frequently marketed with claims of enhanced cognitive performance among healthy adults. Design: A systematic review. Results: Nine of 54 dietary supplement ingredients identified through a scoping review met the eligibility criteria with at least 3 published studies identified per ingredient, yielding 69 unique publications. Ingredients evaluated included Bacopa monnieri, choline, creatine, omega-3 fatty acids, Ginkgo biloba, ginseng, Rhodiola rosea, tyrosine, and valerian root, all in supplement form and compared with a placebo, at various serving sizes and durations of use. Conclusions: The low level of certainty in the state of the science, coupled with not always knowing what is in a dietary supplement product, make weighing risks and benefits difficult; these data hinder the ability to develop recommendations about using such ingredients for consumers interested in boosting their cognitive performance. Whereas certain trends regarding promising serving sizes or duration for use, are pointed to in this synthesis, when combined, studies are inconsistent and imprecise, and many are methodologically flawed. Potential solutions to address research gaps are offered, for future research next steps, which is needed to strengthen the evidence and inform decisions.

背景:促进大脑健康和增强认知能力的膳食补充剂是广泛可用的。这些产品的宣传不仅针对希望预防或减轻认知能力下降的老年人,也针对希望提高认知能力的年轻健康人群。目前还不清楚这些产品瓶子上和广告上的说法是否符合科学。目的:探讨单一膳食补充剂成分的有效性和安全性的证据,这些成分经常在市场上声称能提高健康成年人的认知能力。设计:系统回顾。结果:通过范围审查确定的54种膳食补充剂成分中有9种符合资格标准,每种成分至少有3项已发表的研究,产生69种独特的出版物。评估的成分包括假马齿苋、胆碱、肌酸、欧米伽-3脂肪酸、银杏叶、人参、红景天、酪氨酸和缬草根,所有成分都以补充剂的形式存在,并在不同的服用量和使用时间下与安慰剂进行比较。结论:科学水平的低确定性,加上并不总是知道膳食补充剂产品中含有什么,使得权衡风险和收益变得困难;这些数据阻碍了对有意提高认知能力的消费者提出使用这些成分的建议的能力。虽然在这一综合中指出了有关有希望的服用量或使用时间的某些趋势,但当结合起来时,研究是不一致和不精确的,而且许多研究在方法上存在缺陷。为未来研究的下一步提供了解决研究差距的潜在解决方案,这是加强证据和为决策提供信息所必需的。
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引用次数: 6
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Journal of alternative and complementary medicine
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