Pub Date : 2021-08-01DOI: 10.1089/acm.2021.29094.hcr
Holger Cramer
{"title":"We're Still the Blue Journal-Introducing <i>Journal of Integrative and Complementary Medicine</i>.","authors":"Holger Cramer","doi":"10.1089/acm.2021.29094.hcr","DOIUrl":"https://doi.org/10.1089/acm.2021.29094.hcr","url":null,"abstract":"","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 8","pages":"621-622"},"PeriodicalIF":2.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39324227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01Epub Date: 2021-05-04DOI: 10.1089/acm.2020.0500
Michael Francis Norwood, Ali Lakhani, Annick Maujean, Martin Downes, Simone Fullagar, Bonnie L Barber, Elizabeth Kendall
Background: Equine-assisted therapy may promote positive behavior change in young people "at risk." However, it is not always clear what therapeutic content is involved and if a trained therapist is included. The therapeutic effects of the key part of the "therapy," the horse, are not understood. Objectives: To investigate the impact of an equine program without a therapist on attention and behavioral outcomes of young people "at risk." Design: A within subjects pre-post design. A small sample also completed a control period. Setting/location: A small riding center in a rural area of outer Brisbane, Australia. Subjects: Twelve- to 17-year olds (N = 50; 20 girls; mean age 13.88), attending nontraditional flexischool. Intervention: A 5-week program of 2-h long sessions of equine activities that did not include a trained therapist or specific therapeutic content. Outcome measures: Teacher-report measures of externalizing and internalizing behavior were reported before and after the program through the Behavioral Rating Inventory of Executive Function (BRIEF) and the Strength and Difficulties Questionnaire (SDQ). Results: A paired samples t test resulted in the statistically significant reduction of the BRIEF Global Executive Score between pre and post participation in the equine program (mean difference = -5.89), t(36) = -3.377, p = 0.002 and the SDQ Hyperactivity score (mean difference = -0.727), t(43) = -2.244, p = 0.030. Equine activities may reverse a trajectory of worsening problems. This may especially affect symptoms related to attention deficit hyperactivity disorder. Conclusion: Equine programs may offer an alternative method to reduce poor behavior and improve attention in young people. Benefits in attention may occur even without specific therapeutic content or therapist involvement. It is proposed that some of these benefits come directly from the horse and the interactions with the horse; others are contextual.
背景:马辅助疗法可以促进处于危险中的年轻人的积极行为改变。然而,它并不总是清楚涉及什么治疗内容,如果一个训练有素的治疗师被包括在内。“治疗”的关键部分——马的治疗效果尚不清楚。目的:调查一个没有治疗师的马术项目对处于“危险”中的年轻人的注意力和行为结果的影响。设计:一个学科内的前后设计。一个小样本也完成了一个控制期。环境/地点:澳大利亚布里斯班郊区的一个小型骑行中心。受试者:12 - 17岁(N = 50;20个女孩;平均年龄13.88岁),就读非传统弹性学校。干预:为期5周的马活动,每次2小时,不包括训练有素的治疗师或特定的治疗内容。结果测量:通过执行功能行为评定量表(BRIEF)和优势与困难问卷(SDQ),在项目前后报告教师外化和内化行为的测量结果。结果:配对样本t检验结果显示,参与马术项目前后BRIEF全球执行评分(平均差异= -5.89),t(36) = -3.377, p = 0.002, SDQ多动评分(平均差异= -0.727),t(43) = -2.244, p = 0.030,具有统计学意义。马的活动可能会扭转问题恶化的轨迹。这可能特别影响与注意缺陷多动障碍相关的症状。结论:马术项目可能为减少青少年不良行为和提高注意力提供了一种替代方法。即使没有特定的治疗内容或治疗师的参与,注意力方面的益处也可能发生。有人提出,其中一些好处直接来自马以及与马的互动;其他的则是语境因素。
{"title":"The Horse as a Therapist: Effects of an Equine Program Without \"Therapy\" on the Attention and Behavior of Youth Disengaged from Traditional School.","authors":"Michael Francis Norwood, Ali Lakhani, Annick Maujean, Martin Downes, Simone Fullagar, Bonnie L Barber, Elizabeth Kendall","doi":"10.1089/acm.2020.0500","DOIUrl":"https://doi.org/10.1089/acm.2020.0500","url":null,"abstract":"<p><p><b><i>Background:</i></b> Equine-assisted therapy may promote positive behavior change in young people \"at risk.\" However, it is not always clear what therapeutic content is involved and if a trained therapist is included. The therapeutic effects of the key part of the \"therapy,\" the horse, are not understood. <b><i>Objectives:</i></b> To investigate the impact of an equine program without a therapist on attention and behavioral outcomes of young people \"at risk.\" <b><i>Design:</i></b> A within subjects pre-post design. A small sample also completed a control period. <b><i>Setting/location:</i></b> A small riding center in a rural area of outer Brisbane, Australia. <b><i>Subjects:</i></b> Twelve- to 17-year olds (<i>N</i> = 50; 20 girls; mean age 13.88), attending nontraditional flexischool. <b><i>Intervention:</i></b> A 5-week program of 2-h long sessions of equine activities that did not include a trained therapist or specific therapeutic content. <b><i>Outcome measures:</i></b> Teacher-report measures of externalizing and internalizing behavior were reported before and after the program through the <i>Behavioral Rating Inventory of Executive Function</i> (BRIEF) and the <i>Strength and Difficulties Questionnaire</i> (SDQ). <b><i>Results:</i></b> A paired samples <i>t</i> test resulted in the statistically significant reduction of the <i>BRIEF Global Executive Score</i> between pre and post participation in the equine program (mean difference = -5.89), <i>t</i>(36) = -3.377, <i>p</i> = 0.002 and the <i>SDQ Hyperactivity</i> score (mean difference = -0.727), <i>t</i>(43) = -2.244, <i>p</i> = 0.030. Equine activities may reverse a trajectory of worsening problems. This may especially affect symptoms related to attention deficit hyperactivity disorder. <b><i>Conclusion:</i></b> Equine programs may offer an alternative method to reduce poor behavior and improve attention in young people. Benefits in attention may occur even without specific therapeutic content or therapist involvement. It is proposed that some of these benefits come directly from the horse and the interactions with the horse; others are contextual.</p>","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 8","pages":"678-687"},"PeriodicalIF":2.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38947451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01Epub Date: 2021-08-04DOI: 10.1089/acm.2021.0255
Helene M Langevin
{"title":"Moving the Complementary and Integrative Health Research Field Toward Whole Person Health.","authors":"Helene M Langevin","doi":"10.1089/acm.2021.0255","DOIUrl":"https://doi.org/10.1089/acm.2021.0255","url":null,"abstract":"","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 8","pages":"623-626"},"PeriodicalIF":2.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575059/pdf/acm.2021.0255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39275217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Learning to Fly: Conceptions and Misconceptions, Uses and Misuses of Pilot Studies in Clinical Research.","authors":"Holger Cramer","doi":"10.1089/acm.2021.0197","DOIUrl":"https://doi.org/10.1089/acm.2021.0197","url":null,"abstract":"","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 7","pages":"531-534"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This single-center observational study aimed to assess the inter-rater reliability (IRR) of Kampo medicine pattern diagnosis, which is modularized into three modules for chronic diseases, using 64 participants' information documents. The linearly weighted percentage of agreement and Gwet's agreement coefficient (AC) 2 for the deficiency-excess module, among three specialists, were 85.9% and 0.708, respectively. The unweighted percentage of agreement and Gwet's AC1 were 64.6% and 0.542 for the cold-heat, and 35.9% and 0.254 for the qi-blood-fluid modules, respectively. Our findings suggest that our modularization method may improve the IRR of Kampo medicine pattern diagnosis.
{"title":"Inter-Rater Reliability of Kampo Diagnosis for Chronic Diseases.","authors":"Ayako Maeda-Minami, Tetsuhiro Yoshino, Yuko Horiba, Tomonori Nakamura, Kenji Watanabe","doi":"10.1089/acm.2020.0298","DOIUrl":"https://doi.org/10.1089/acm.2020.0298","url":null,"abstract":"<p><p>This single-center observational study aimed to assess the inter-rater reliability (IRR) of Kampo medicine pattern diagnosis, which is modularized into three modules for chronic diseases, using 64 participants' information documents. The linearly weighted percentage of agreement and Gwet's agreement coefficient (AC) 2 for the deficiency-excess module, among three specialists, were 85.9% and 0.708, respectively. The unweighted percentage of agreement and Gwet's AC1 were 64.6% and 0.542 for the cold-heat, and 35.9% and 0.254 for the <i>qi</i>-blood-fluid modules, respectively. Our findings suggest that our modularization method may improve the IRR of Kampo medicine pattern diagnosis.</p>","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 7","pages":"613-616"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38800001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Acupuncture, widely used in Chinese society, has been studied as an adjunct treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). The purpose of this study is to investigate the effectiveness of combined acupuncture and hyperbaric oxygen therapy (HBOT) with conventional steroid therapy for ISSNHL. Methods: This retrospective chart review enrolled 154 patients who met the ISSNHL criteria and were categorized into three groups according to the different treatment regimens. Among these patients, 43 underwent steroid therapy only (S) group, 74 received steroid and HBOT (S-H) group, and the remaining 37 were treated with combined acupuncture-HBOT in addition to steroid therapy (S-H-A) group. The outcome was determined by comparing the differences in pure-tone thresholds and absolute hearing gains after treatment calculated at each audiometric octave frequency or grouped frequencies of audiograms. Hearing recoveries classified into three grades: complete, partial, and poor were also analyzed and compared among different treatment groups. Results: All subjects presented with initial severe hearing loss with averaged hearing thresholds >70 dB. The S-H-A group exhibited good hearing improvement outcomes at each audiometric octave frequency and grouped frequencies of audiograms, with greater hearing gain and had more favorable outcomes in hearing recovery grades compared with the S group and the S-H group. Conclusions: The results obtained in this study revealed a preliminary finding of ISSNHL patients benefiting from combined acupuncture, HBOT, and conventional steroid therapy. Acupuncture is a safe and nonpharmacologic treatment option and can be considered as an initial treatment strategy in such a clinical scenario.
目的:研究针刺作为特发性突发性感音神经性听力损失(ISSNHL)的辅助治疗方法。本研究旨在探讨针刺高压氧联合常规类固醇治疗ISSNHL的疗效。方法:本回顾性研究纳入154例符合ISSNHL标准的患者,根据不同的治疗方案分为三组。其中单纯类固醇(S)组43例,类固醇+ HBOT (S- h)组74例,针刺+ HBOT +类固醇(S- h - a)组37例。结果是通过比较纯音阈值和治疗后的绝对听力增益的差异来确定的,这些差异是在听力图的每个听力八度频率或分组频率上计算的。听力恢复分为完全、部分和较差三个等级,并在不同治疗组之间进行分析和比较。结果:所有受试者均表现为初始重度听力损失,平均听力阈值>70 dB。与S组和S- h组相比,S- h - a组在每个听力图八度频和听力图分组频率上均表现出良好的听力改善结果,听力增益更大,听力恢复等级结果更有利。结论:本研究初步发现,ISSNHL患者受益于针灸、HBOT和常规类固醇联合治疗。针灸是一种安全的非药物治疗选择,可以被认为是这种临床情况下的初始治疗策略。
{"title":"Combined Acupuncture-Hyperbaric Oxygen-Steroids Therapy for Idiopathic Sudden Sensorineural Hearing Loss: A Retrospective Observational Study.","authors":"Che-Jui Lee, Hsin-Chien Chen, Cheng-Ping Shih, Yuan-Yung Lin, Chao-Yin Kuo, Shao-Cheng Liu","doi":"10.1089/acm.2020.0330","DOIUrl":"https://doi.org/10.1089/acm.2020.0330","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> Acupuncture, widely used in Chinese society, has been studied as an adjunct treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). The purpose of this study is to investigate the effectiveness of combined acupuncture and hyperbaric oxygen therapy (HBOT) with conventional steroid therapy for ISSNHL. <b><i>Methods:</i></b> This retrospective chart review enrolled 154 patients who met the ISSNHL criteria and were categorized into three groups according to the different treatment regimens. Among these patients, 43 underwent steroid therapy only (S) group, 74 received steroid and HBOT (S-H) group, and the remaining 37 were treated with combined acupuncture-HBOT in addition to steroid therapy (S-H-A) group. The outcome was determined by comparing the differences in pure-tone thresholds and absolute hearing gains after treatment calculated at each audiometric octave frequency or grouped frequencies of audiograms. Hearing recoveries classified into three grades: complete, partial, and poor were also analyzed and compared among different treatment groups. <b><i>Results:</i></b> All subjects presented with initial severe hearing loss with averaged hearing thresholds >70 dB. The S-H-A group exhibited good hearing improvement outcomes at each audiometric octave frequency and grouped frequencies of audiograms, with greater hearing gain and had more favorable outcomes in hearing recovery grades compared with the S group and the S-H group. <b><i>Conclusions:</i></b> The results obtained in this study revealed a preliminary finding of ISSNHL patients benefiting from combined acupuncture, HBOT, and conventional steroid therapy. Acupuncture is a safe and nonpharmacologic treatment option and can be considered as an initial treatment strategy in such a clinical scenario.</p>","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 7","pages":"588-595"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38956566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01Epub Date: 2021-05-06DOI: 10.1089/acm.2020.0539
Jürgen Barth, Claudia Canella, Manuela Oehler, Claudia M Witt
Objective: We evaluated digital consultations at a University Hospital in Switzerland within an integrative medicine outpatient setting. Patients' and treatment providers' (physicians and therapists) evaluated digital conversation-based consultations as well as the digital delivery of practical exercises. Methods: Digital consultations between March 15, 2020 and April 30, 2020 were identified. Between June and July 2020, patients and treatment providers completed online questionnaires addressing challenges and advantages of their digital consultations. Both groups documented their satisfaction and working alliance (Working Alliance Inventory). In addition, semistructured qualitative interviews with treatment providers were conducted. Findings: A total of 82 online surveys (response rate 47%) about the digital consultations were available for analyses, with 60 patients correctly identifying at least one treatment provider, and 9 interviews were performed. Patients and treatment providers overall evaluated the new setting of digital consultation as feasible and an efficient consultation format. Interestingly, the working alliance was rated as good. Technical problems were mentioned as the main challenge and the delivery of practical exercises in digital consultations was seen more challenging than having digital conversation-based consultations. Conclusion: Digital consultations were established with overall positive evaluations and with a good working alliance between patients and providers. For the delivery of practical exercises it might be required to develop more innovative digital settings to overcome shortcomings of the digital format. Hybrid settings that combine the best of both settings could be a good option for future in postpandemic times.
{"title":"Digital Consultations During COVID-19: A Multiperspective Mixed-Methods Study in an Integrative Medicine Setting in Switzerland.","authors":"Jürgen Barth, Claudia Canella, Manuela Oehler, Claudia M Witt","doi":"10.1089/acm.2020.0539","DOIUrl":"https://doi.org/10.1089/acm.2020.0539","url":null,"abstract":"<p><p><b><i>Objective:</i></b> We evaluated digital consultations at a University Hospital in Switzerland within an integrative medicine outpatient setting. Patients' and treatment providers' (physicians and therapists) evaluated digital conversation-based consultations as well as the digital delivery of practical exercises. <b><i>Methods:</i></b> Digital consultations between March 15, 2020 and April 30, 2020 were identified. Between June and July 2020, patients and treatment providers completed online questionnaires addressing challenges and advantages of their digital consultations. Both groups documented their satisfaction and working alliance (Working Alliance Inventory). In addition, semistructured qualitative interviews with treatment providers were conducted. <b><i>Findings:</i></b> A total of 82 online surveys (response rate 47%) about the digital consultations were available for analyses, with 60 patients correctly identifying at least one treatment provider, and 9 interviews were performed. Patients and treatment providers overall evaluated the new setting of digital consultation as feasible and an efficient consultation format. Interestingly, the working alliance was rated as good. Technical problems were mentioned as the main challenge and the delivery of practical exercises in digital consultations was seen more challenging than having digital conversation-based consultations. <b><i>Conclusion:</i></b> Digital consultations were established with overall positive evaluations and with a good working alliance between patients and providers. For the delivery of practical exercises it might be required to develop more innovative digital settings to overcome shortcomings of the digital format. Hybrid settings that combine the best of both settings could be a good option for future in postpandemic times.</p>","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 7","pages":"569-578"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38959412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01Epub Date: 2021-06-15DOI: 10.1089/acm.2020.0529
Heidi Williams, Dianne Bloxsome, Sara Bayes, Carol Chungfeng Wang
{"title":"The Efficacy and Safety of Acupoint Stimulation for Fetal Malpresentation/Malposition During Pregnancy, Labor, or Birth: A Scoping Review.","authors":"Heidi Williams, Dianne Bloxsome, Sara Bayes, Carol Chungfeng Wang","doi":"10.1089/acm.2020.0529","DOIUrl":"10.1089/acm.2020.0529","url":null,"abstract":"","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 7","pages":"617-619"},"PeriodicalIF":2.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39233178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01Epub Date: 2021-04-27DOI: 10.1089/acm.2020.0040
David M Steinhorn, Jana Din, Patrick J Macmillan
{"title":"Integrative Palliative Care: Transpersonal Medicine for the Dying.","authors":"David M Steinhorn, Jana Din, Patrick J Macmillan","doi":"10.1089/acm.2020.0040","DOIUrl":"https://doi.org/10.1089/acm.2020.0040","url":null,"abstract":"","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 7","pages":"535-537"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38911296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Chinese herbal medicine (CHM) is quite popular in Asia. The purpose of this study is to investigate the benefits of decreasing the risk of cirrhosis in patients with non-alcoholic fatty liver disease (NAFLD) by using CHM. Design: We performed a 1:3 propensity score-matched cohort study to analyze patients with NAFLD diagnosed between January 1, 1997 and December 31, 2011 through the Taiwanese National Health Insurance Research Database. Patients who received CHM therapy from the initial date of diagnosis of NAFLD to December 31, 2011 were included in the CHM group. Patients who were not treated with CHM during the same interval were categorized in the non-CHM group. Cox regression model was used to adjust for sex, age, comorbidities, and drug use. Hazard ratios were also compared between the two groups. Results: A total of 13,072 patients were identified after 1:3 propensity score matching. The patients had similar basic characteristics. A lower cumulative incidence of cirrhosis was found in the CHM cohort (log-rank test, p < 0.0001). Finally, 176 patients in the CHM cohort (4.66 per 1000 person-years) and 582 patients in the non-CHM cohort (7.92 per 1000 person-years) developed cirrhosis (adjusted hazard ratios 0.63, 95% confidence interval 0.53-0.75). The effect of CHM to lower cirrhosis incidence was independent of sex, drug use, and comorbidities, including diabetes mellitus, hypertension, and cardiovascular diseases. Patients older than 40 years of age and without comorbidities such as chronic obstructive pulmonary disease, hyperlipidemia, alcoholism, tobacco use, or obesity also benefited from CHM. Conclusions: Our study is the first large-scale investigation in Taiwan that shows the association between patients with NAFLD and cirrhosis prevention after CHM intervention. The results may be useful for treatment and for decision making for patients and clinical doctors. Further restricted trials are needed to support our findings.
{"title":"Chinese Herbal Medicine Decreases Incidence of Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease in Taiwan: A Propensity Score-Matched Cohort Study.","authors":"Chia-Yu Huang, Mei-Yao Wu, Hsiang-Chi Wang, Yuan-Ching Liao, Sio-Ian Tou, Hung-Rong Yen","doi":"10.1089/acm.2020.0494","DOIUrl":"https://doi.org/10.1089/acm.2020.0494","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Chinese herbal medicine (CHM) is quite popular in Asia. The purpose of this study is to investigate the benefits of decreasing the risk of cirrhosis in patients with non-alcoholic fatty liver disease (NAFLD) by using CHM. <b><i>Design:</i></b> We performed a 1:3 propensity score-matched cohort study to analyze patients with NAFLD diagnosed between January 1, 1997 and December 31, 2011 through the Taiwanese National Health Insurance Research Database. Patients who received CHM therapy from the initial date of diagnosis of NAFLD to December 31, 2011 were included in the CHM group. Patients who were not treated with CHM during the same interval were categorized in the non-CHM group. Cox regression model was used to adjust for sex, age, comorbidities, and drug use. Hazard ratios were also compared between the two groups. <b><i>Results:</i></b> A total of 13,072 patients were identified after 1:3 propensity score matching. The patients had similar basic characteristics. A lower cumulative incidence of cirrhosis was found in the CHM cohort (log-rank test, <i>p</i> < 0.0001). Finally, 176 patients in the CHM cohort (4.66 per 1000 person-years) and 582 patients in the non-CHM cohort (7.92 per 1000 person-years) developed cirrhosis (adjusted hazard ratios 0.63, 95% confidence interval 0.53-0.75). The effect of CHM to lower cirrhosis incidence was independent of sex, drug use, and comorbidities, including diabetes mellitus, hypertension, and cardiovascular diseases. Patients older than 40 years of age and without comorbidities such as chronic obstructive pulmonary disease, hyperlipidemia, alcoholism, tobacco use, or obesity also benefited from CHM. <b><i>Conclusions:</i></b> Our study is the first large-scale investigation in Taiwan that shows the association between patients with NAFLD and cirrhosis prevention after CHM intervention. The results may be useful for treatment and for decision making for patients and clinical doctors. Further restricted trials are needed to support our findings.</p>","PeriodicalId":14944,"journal":{"name":"Journal of alternative and complementary medicine","volume":"27 7","pages":"596-605"},"PeriodicalIF":2.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38920027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}