Pub Date : 2024-06-05DOI: 10.1016/j.neuron.2024.05.007
Alexandra S. Klein, M. Kheirbek
{"title":"From bile acids to melancholia","authors":"Alexandra S. Klein, M. Kheirbek","doi":"10.1016/j.neuron.2024.05.007","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.05.007","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"12 33","pages":"1725-1727"},"PeriodicalIF":16.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-05DOI: 10.1016/j.neuron.2024.04.031
Kali Esancy, Ajay K Dhaka
{"title":"Turning down the body heat: A novel mechanism for TRPV1 antagonist-induced hyperthermia","authors":"Kali Esancy, Ajay K Dhaka","doi":"10.1016/j.neuron.2024.04.031","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.04.031","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"1 10","pages":"1727-1729"},"PeriodicalIF":16.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-05DOI: 10.1016/j.neuron.2024.04.030
Yun Chen, Jason D. Ulrich
{"title":"Seq-ing mechanisms behind types of Alzheimer’s disease","authors":"Yun Chen, Jason D. Ulrich","doi":"10.1016/j.neuron.2024.04.030","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.04.030","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"6 9","pages":"1723-1724"},"PeriodicalIF":16.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.trechm.2024.05.002
Clinton G. L. Veale, David J Clarke
{"title":"Mass spectrometry-based methods for characterizing transient protein–protein interactions","authors":"Clinton G. L. Veale, David J Clarke","doi":"10.1016/j.trechm.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.05.002","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"140 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141406097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.trechm.2024.05.003
Hao Cui, Xiang Chen, F. Lan, Bohang An, Xiao Zhang
{"title":"Photocatalysis as a tool for upcycling of polymers","authors":"Hao Cui, Xiang Chen, F. Lan, Bohang An, Xiao Zhang","doi":"10.1016/j.trechm.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.05.003","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"313 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.trechm.2024.05.004
Matthew Landry, Meera Mehta, Dan Preston, Timothy Su, Clinton Veale, Xiao Zhang
{"title":"Meet our emerging leaders in chemistry – part I","authors":"Matthew Landry, Meera Mehta, Dan Preston, Timothy Su, Clinton Veale, Xiao Zhang","doi":"10.1016/j.trechm.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.05.004","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"51 14","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.trechm.2024.06.002
Jessica Pancholi
{"title":"High five to the future of chemistry!","authors":"Jessica Pancholi","doi":"10.1016/j.trechm.2024.06.002","DOIUrl":"https://doi.org/10.1016/j.trechm.2024.06.002","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"7 16","pages":""},"PeriodicalIF":15.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karen T Feehan, Hannah E. Bridgewater, Jan Stenkiewicz-Witeska, R. D. De Maeyer, John Ferguson, Matthias Mack, Jeremy S Brown, G. Ercoli, Connar M Mawer, Arne N. Akbar, James R W Glanville, Parinaaz Jalali, Olivia V. Bracken, Anna Nicolaou, A. Kendall, Michelle Sugimoto, Derek W. Gilroy
Resolving inflammation is thought to return the affected tissue back to homoeostasis but recent evidence supports a non-linear model of resolution involving a phase of prolonged immune activity. Here we show that within days following resolution of Streptococcus pneumoniae-triggered lung inflammation, there is an influx of antigen specific lymphocytes with a memory and tissue-resident phenotype as well as macrophages bearing alveolar or interstitial phenotype. The transcriptome of these macrophages shows enrichment of genes associated with prostaglandin biosynthesis and genes that drive T cell chemotaxis and differentiation. Therapeutic depletion of post-resolution macrophages, inhibition of prostaglandin E2 (PGE2) synthesis or treatment with an EP4 antagonist, MF498, reduce numbers of lung CD4+/CD44+/CD62L+ and CD4+/CD44+/CD62L-/CD27+ T cells as well as their expression of the α-integrin, CD103. The T cells fail to reappear and reactivate upon secondary challenge for up to six weeks following primary infection. Concomitantly, EP4 antagonism through MF498 causes accumulation of lung macrophages and marked tissue fibrosis. Our study thus shows that PGE2 signalling, predominantly via EP4, plays an important role during the second wave of immune activity following resolution of inflammation. This secondary immune activation drives local tissue-resident T cell development while limiting tissue injury
人们认为炎症的消退会使受影响的组织恢复到平衡状态，但最近的证据支持一种非线性消退模式，该模式涉及一个长期免疫活动的阶段。在这里，我们发现肺炎链球菌引发的肺部炎症消退后几天内，具有记忆和组织驻留表型的抗原特异性淋巴细胞以及具有肺泡或间质表型的巨噬细胞大量涌入。这些巨噬细胞的转录组显示，与前列腺素生物合成相关的基因以及驱动 T 细胞趋化和分化的基因变得丰富。治疗性清除溶解后巨噬细胞、抑制前列腺素 E2 (PGE2)合成或使用 EP4 拮抗剂 MF498 治疗可减少肺部 CD4+/CD44+/CD62L+ 和 CD4+/CD44+/CD62L-/CD27+ T 细胞的数量及其 α 整合素 CD103 的表达。在原发感染后长达六周的时间里，T细胞在二次挑战时不会再出现和再活化。同时，通过 MF498 拮抗 EP4 会导致肺巨噬细胞聚集和明显的组织纤维化。因此，我们的研究表明，PGE2 信号（主要通过 EP4）在炎症消退后的第二波免疫活动中发挥着重要作用。这种二次免疫激活可推动局部组织驻留 T 细胞的发展，同时限制组织损伤。
{"title":"Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia","authors":"Karen T Feehan, Hannah E. Bridgewater, Jan Stenkiewicz-Witeska, R. D. De Maeyer, John Ferguson, Matthias Mack, Jeremy S Brown, G. Ercoli, Connar M Mawer, Arne N. Akbar, James R W Glanville, Parinaaz Jalali, Olivia V. Bracken, Anna Nicolaou, A. Kendall, Michelle Sugimoto, Derek W. Gilroy","doi":"10.1001/jama.294.5.626","DOIUrl":"https://doi.org/10.1001/jama.294.5.626","url":null,"abstract":"Resolving inflammation is thought to return the affected tissue back to homoeostasis but recent evidence supports a non-linear model of resolution involving a phase of prolonged immune activity. Here we show that within days following resolution of Streptococcus pneumoniae-triggered lung inflammation, there is an influx of antigen specific lymphocytes with a memory and tissue-resident phenotype as well as macrophages bearing alveolar or interstitial phenotype. The transcriptome of these macrophages shows enrichment of genes associated with prostaglandin biosynthesis and genes that drive T cell chemotaxis and differentiation. Therapeutic depletion of post-resolution macrophages, inhibition of prostaglandin E2 (PGE2) synthesis or treatment with an EP4 antagonist, MF498, reduce numbers of lung CD4+/CD44+/CD62L+ and CD4+/CD44+/CD62L-/CD27+ T cells as well as their expression of the α-integrin, CD103. The T cells fail to reappear and reactivate upon secondary challenge for up to six weeks following primary infection. Concomitantly, EP4 antagonism through MF498 causes accumulation of lung macrophages and marked tissue fibrosis. Our study thus shows that PGE2 signalling, predominantly via EP4, plays an important role during the second wave of immune activity following resolution of inflammation. This secondary immune activation drives local tissue-resident T cell development while limiting tissue injury","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"63 4","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141114060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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