Chung-Feng Huang, Manar Hijaze Awad, M. Gal-Tanamy, Ming-Lung Yu
Hepatitis C virus (HCV) is one of the major etiologies of hepatocellular carcinoma with approximately 30% of HCC being due to HCV infection worldwide. HCV eradication by antivirals greatly reduces the risk of HCC; nevertheless, HCC remains to occur in CHC patients who have achieved a sustained virological response (SVR). The proportion of post-SVR HCC among newly diagnosed HCC patients is increasing in the DAA era and might be due to preexisting inflammatory and fibrotic liver background, immune dysregulation between host and virus interaction, as well as host epigenetic scar, genetic predispositions and alternations. By means of applying surrogate markers and adopting risk stratification, HCC surveillance should be consistently performed in high-risk populations. In this review, we discuss the possible molecular mechanism, risk factors and surveillance strategy for HCC development after HCV eradication.
{"title":"Unmet needs in the post-DAA era: the risk and molecular mechanisms of hepatocellular carcinoma after HCV eradication.","authors":"Chung-Feng Huang, Manar Hijaze Awad, M. Gal-Tanamy, Ming-Lung Yu","doi":"10.3350/cmh.2024.0155","DOIUrl":"https://doi.org/10.3350/cmh.2024.0155","url":null,"abstract":"Hepatitis C virus (HCV) is one of the major etiologies of hepatocellular carcinoma with approximately 30% of HCC being due to HCV infection worldwide. HCV eradication by antivirals greatly reduces the risk of HCC; nevertheless, HCC remains to occur in CHC patients who have achieved a sustained virological response (SVR). The proportion of post-SVR HCC among newly diagnosed HCC patients is increasing in the DAA era and might be due to preexisting inflammatory and fibrotic liver background, immune dysregulation between host and virus interaction, as well as host epigenetic scar, genetic predispositions and alternations. By means of applying surrogate markers and adopting risk stratification, HCC surveillance should be consistently performed in high-risk populations. In this review, we discuss the possible molecular mechanism, risk factors and surveillance strategy for HCC development after HCV eradication.","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"31 8","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140651958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.1038/s41467-024-47902-4
Weiyue Zhou, Yang Yang, Guiqiu Zheng, K. Woller, Peter W. Stahle, A. M. Minor, Michael P Short
{"title":"Author Correction: Proton irradiation-decelerated intergranular corrosion of Ni-Cr alloys in molten salt.","authors":"Weiyue Zhou, Yang Yang, Guiqiu Zheng, K. Woller, Peter W. Stahle, A. M. Minor, Michael P Short","doi":"10.1038/s41467-024-47902-4","DOIUrl":"https://doi.org/10.1038/s41467-024-47902-4","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"59 18","pages":"3500"},"PeriodicalIF":16.6,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.1038/s41467-024-47977-z
P. Vensaus, Yunchang Liang, J. Ansermet, Galo J. A. A. Soler-Illia, M. Lingenfelder
{"title":"Author Correction: Enhancement of electrocatalysis through magnetic field effects on mass transport.","authors":"P. Vensaus, Yunchang Liang, J. Ansermet, Galo J. A. A. Soler-Illia, M. Lingenfelder","doi":"10.1038/s41467-024-47977-z","DOIUrl":"https://doi.org/10.1038/s41467-024-47977-z","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"52 12","pages":"3501"},"PeriodicalIF":16.6,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.1038/s41467-024-47946-6
S. Hadži, Zala Živič, Matic Kovačič, Uroš Zavrtanik, Sarah Haesaerts, Daniel Charlier, J. Plavec, Alexander N Volkov, Jurij Lah, Remy Loris
{"title":"Author Correction: Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae.","authors":"S. Hadži, Zala Živič, Matic Kovačič, Uroš Zavrtanik, Sarah Haesaerts, Daniel Charlier, J. Plavec, Alexander N Volkov, Jurij Lah, Remy Loris","doi":"10.1038/s41467-024-47946-6","DOIUrl":"https://doi.org/10.1038/s41467-024-47946-6","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"86 6","pages":"3484"},"PeriodicalIF":16.6,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.1001/jamacardio.2024.0684
Kristen K Patton, Clyde W. Yancy
{"title":"Atrial Fibrillation Ablation in Heart Failure-More Data Are Needed.","authors":"Kristen K Patton, Clyde W. Yancy","doi":"10.1001/jamacardio.2024.0684","DOIUrl":"https://doi.org/10.1001/jamacardio.2024.0684","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"66 37","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.1001/jamacardio.2024.0615
Ahmed Sayed, Dmitry Abramov, G. Fonarow, M. Mamas, O. Kobo, Javed Butler, M. Fudim
This cohort study evaluates recent reversals in declines in cardiovascular mortality and whether they vary across sociodemographic categories.
这项队列研究评估了近期心血管死亡率下降的逆转情况，以及不同社会人口类别的心血管死亡率是否存在差异。
{"title":"Reversals in the Decline of Heart Failure Mortality in the US, 1999 to 2021.","authors":"Ahmed Sayed, Dmitry Abramov, G. Fonarow, M. Mamas, O. Kobo, Javed Butler, M. Fudim","doi":"10.1001/jamacardio.2024.0615","DOIUrl":"https://doi.org/10.1001/jamacardio.2024.0615","url":null,"abstract":"\u0000 This cohort study evaluates recent reversals in declines in cardiovascular mortality and whether they vary across sociodemographic categories.\u0000","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"59 7","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.1001/jamacardio.2024.0689
S. Balaji, J. Rychik, Jeremy P Moore
This Viewpoint discusses the impact of sinus node dysfunction and escape junctional rhythm associated with the Fontan procedure on patient outcomes.
本视点讨论了与丰坦手术相关的窦房结功能障碍和交界性逸搏对患者预后的影响。
{"title":"Fontan Junctional Rhythm-Innocent Bystander or Silent Killer?","authors":"S. Balaji, J. Rychik, Jeremy P Moore","doi":"10.1001/jamacardio.2024.0689","DOIUrl":"https://doi.org/10.1001/jamacardio.2024.0689","url":null,"abstract":"\u0000 This Viewpoint discusses the impact of sinus node dysfunction and escape junctional rhythm associated with the Fontan procedure on patient outcomes.\u0000","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"33 22","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-22DOI: 10.1038/s41467-024-47535-7
Jinxin Phaedo Chen, Constantin Diekmann, Honggui Wu, Chong Chen, Giulia Della Chiara, E. Berrino, Konstantinos L. Georgiadis, Britta A. M. Bouwman, Mohit Virdi, L. Harbers, S. Bellomo, Caterina Marchiò, M. Bienko, Nicola Crosetto
{"title":"Author Correction: scCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells","authors":"Jinxin Phaedo Chen, Constantin Diekmann, Honggui Wu, Chong Chen, Giulia Della Chiara, E. Berrino, Konstantinos L. Georgiadis, Britta A. M. Bouwman, Mohit Virdi, L. Harbers, S. Bellomo, Caterina Marchiò, M. Bienko, Nicola Crosetto","doi":"10.1038/s41467-024-47535-7","DOIUrl":"https://doi.org/10.1038/s41467-024-47535-7","url":null,"abstract":"","PeriodicalId":14,"journal":{"name":"ACS Combinatorial Science","volume":"25 13","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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