Injections of hyaluronic acid dermal fillers are minimally invasive cosmetic procedures that in general are considered safe. However, a lot of complications have been reported for the last couple of years. The formation of foreign body granuloma is a rare side effect which usually happens weeks to months after the injection of soft tissue fillers and is one of the most challenging when it comes to management. This study aims to report a case of foreign body granuloma formation after full face treatment with 12 ml of hyaluronic dermal fillers. A short overview of the main factors influencing granuloma formation and a treatment protocol are also presented.
{"title":"Immune system triggers as a factor for the formation of foreign body granuloma after hyaluronic acid fillers treatment.","authors":"Radina Denkova, Iliana Georgieva, Vessel Kantardjiev","doi":"10.56609/jac.v42i2.333","DOIUrl":"https://doi.org/10.56609/jac.v42i2.333","url":null,"abstract":"Injections of hyaluronic acid dermal fillers are minimally invasive cosmetic procedures that in general are considered safe. However, a lot of complications have been reported for the last couple of years. The formation of foreign body granuloma is a rare side effect which usually happens weeks to months after the injection of soft tissue fillers and is one of the most challenging when it comes to management. This study aims to report a case of foreign body granuloma formation after full face treatment with 12 ml of hyaluronic dermal fillers. A short overview of the main factors influencing granuloma formation and a treatment protocol are also presented.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Kolczewski, M. Barwijuk, M. Parafiniuk, A. Kolasa, J. Udała, D. Gączarzewicz, M. Łukaszuk, N. Zerbinati, R. Kuźlik, A. Kordek, D. Branecka-Woźniak, M. Kozłowski, A. Cymbaluk-Płoska
The aim of the study was to evaluate the concentration of collagen and elastin fibers, the number of fibroblasts/fibrocytes and vessels, as well as depth of action in the vaginal wall in a swine model before and after intravaginal 480 kHz bipolar radiofrequency heating created by a 360-degree intravaginal applicator (Berger and Kraft Medical). Three swine’s were treated with a bipolar radiofrequency vaginal probe. Exposure to RF was administered twice, every 4 weeks, and then the vaginas were removed after slaughter, four weeks after the last RF exposure. Histology specimens were obtained from control and exposed areas. Tissue samples were stained by hematoxylin-eosin, orcein, and Mallory trichrome. The concentration of elastin and collagen fibers increased distinctly after a treatment protocol: elastin, on average, was 52.8%, and collagen, on average, was 103.6%. After the treatment protocol, we revealed a significant dispersion of fibroblasts-fibrocytes nuclei for particular animals in segmented areas, with a slightly marked falling trend. A degree of data variability cannot lead to a conclusion concerning the influence of RF heating on several vessels in evaluated areas. The depth of action of the RF heating, measured by collagen concentration, reached up to 1.3 mm of the vaginal wall thickness. Results imply that heating of the vaginal wall, created by radiofrequency, induces neocollagenogenesis and neoelastogenesis, leading to a distinctive rise of collagen and elastin fibers concentration at a depth of up to 1.3 mm of the thickness of the vaginal wall in the animal model.
{"title":"Noninvasive bipolar radiofrequency - vaginal application on swine model","authors":"P. Kolczewski, M. Barwijuk, M. Parafiniuk, A. Kolasa, J. Udała, D. Gączarzewicz, M. Łukaszuk, N. Zerbinati, R. Kuźlik, A. Kordek, D. Branecka-Woźniak, M. Kozłowski, A. Cymbaluk-Płoska","doi":"10.56609/jac.v42i1.340","DOIUrl":"https://doi.org/10.56609/jac.v42i1.340","url":null,"abstract":"The aim of the study was to evaluate the concentration of collagen and elastin fibers, the number of fibroblasts/fibrocytes and vessels, as well as depth of action in the vaginal wall in a swine model before and after intravaginal 480 kHz bipolar radiofrequency heating created by a 360-degree intravaginal applicator (Berger and Kraft Medical). Three swine’s were treated with a bipolar radiofrequency vaginal probe. Exposure to RF was administered twice, every 4 weeks, and then the vaginas were removed after slaughter, four weeks after the last RF exposure. Histology specimens were obtained from control and exposed areas. Tissue samples were stained by hematoxylin-eosin, orcein, and Mallory trichrome. The concentration of elastin and collagen fibers increased distinctly after a treatment protocol: elastin, on average, was 52.8%, and collagen, on average, was 103.6%. After the treatment protocol, we revealed a significant dispersion of fibroblasts-fibrocytes nuclei for particular animals in segmented areas, with a slightly marked falling trend. A degree of data variability cannot lead to a conclusion concerning the influence of RF heating on several vessels in evaluated areas. The depth of action of the RF heating, measured by collagen concentration, reached up to 1.3 mm of the vaginal wall thickness. Results imply that heating of the vaginal wall, created by radiofrequency, induces neocollagenogenesis and neoelastogenesis, leading to a distinctive rise of collagen and elastin fibers concentration at a depth of up to 1.3 mm of the thickness of the vaginal wall in the animal model.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141383503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Botulinum toxin (BoNT), initially approved for strabismus in 1989, has expanded its therapeutic applications into dermatology. This review assesses BoNT’s potential role in treating various dermatological conditions, including Hidradenitis Suppurativa (HS), rosacea, androgenetic alopecia, plaque psoriasis, and primary hyperhidrosis. Studies suggest BoNT’s efficacy in HS, with reductions in inflammation and pain, yet controlled trials are necessary for conclusive evidence. In rosacea, BoNT injections mitigate erythema, but mechanistic understanding remains incomplete. Androgenetic alopecia studies reveal increased hair density following BoNT injections, possibly through dermal papilla modulation and scalp muscle relaxation. BoNT shows promise in plaque psoriasis, likely by mitigating neurogenic inflammation. In primary hyperhidrosis, BoNT significantly reduces sweat production and severity, offering a viable second-line treatment. Despite BoNT’s potential, its use requires caution due to associated risks. Dermatologists must balance on-label and off-label applications for optimal patient outcomes. While existing evidence underscores BoNT’s therapeutic potential, rigorous clinical trials are warranted to establish safety and efficacy definitively. Continued research is imperative to refine BoNT therapy and expand its dermatological applications. This review highlights the need for ongoing investigation and consensus-building to maximize BoNT’s benefits in dermatology.
{"title":"Use of Botulinum Toxin in Dermatology","authors":"Marcelina Kądziela","doi":"10.56609/jac.v42i1.317","DOIUrl":"https://doi.org/10.56609/jac.v42i1.317","url":null,"abstract":"Botulinum toxin (BoNT), initially approved for strabismus in 1989, has expanded its therapeutic applications into dermatology. This review assesses BoNT’s potential role in treating various dermatological conditions, including Hidradenitis Suppurativa (HS), rosacea, androgenetic alopecia, plaque psoriasis, and primary hyperhidrosis. Studies suggest BoNT’s efficacy in HS, with reductions in inflammation and pain, yet controlled trials are necessary for conclusive evidence. In rosacea, BoNT injections mitigate erythema, but mechanistic understanding remains incomplete. Androgenetic alopecia studies reveal increased hair density following BoNT injections, possibly through dermal papilla modulation and scalp muscle relaxation. BoNT shows promise in plaque psoriasis, likely by mitigating neurogenic inflammation. In primary hyperhidrosis, BoNT significantly reduces sweat production and severity, offering a viable second-line treatment. Despite BoNT’s potential, its use requires caution due to associated risks. Dermatologists must balance on-label and off-label applications for optimal patient outcomes. While existing evidence underscores BoNT’s therapeutic potential, rigorous clinical trials are warranted to establish safety and efficacy definitively. Continued research is imperative to refine BoNT therapy and expand its dermatological applications. This review highlights the need for ongoing investigation and consensus-building to maximize BoNT’s benefits in dermatology.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of fillers based on hyaluronic acid in correcting deficits in the upper part of the face, especially in the temporal area, can significantly improve the balance and appearance of the face. Such a procedure, apart from unquestionable aesthetic advantages, carries significant risks, including contour irregularities, vascular occlusion, skin necrosis, hair loss, blindness, stroke, and non-thrombotic pulmonary embolism. To increase the safety and precision of the volumization of the temple area, the technique of administration of the preparation, as well as the product itself, should be carefully selected.
{"title":"Case report: temporal hollowness augmentation with PEGylated fillers","authors":"Raquel Fernández de Castro Isalguez","doi":"10.56609/jac.v42i1.332","DOIUrl":"https://doi.org/10.56609/jac.v42i1.332","url":null,"abstract":"The use of fillers based on hyaluronic acid in correcting deficits in the upper part of the face, especially in the temporal area, can significantly improve the balance and appearance of the face. Such a procedure, apart from unquestionable aesthetic advantages, carries significant risks, including contour irregularities, vascular occlusion, skin necrosis, hair loss, blindness, stroke, and non-thrombotic pulmonary embolism. To increase the safety and precision of the volumization of the temple area, the technique of administration of the preparation, as well as the product itself, should be carefully selected.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Tatti, B. Conti, M. Corbeddu, Martina Uda, Giovanni Deriu, Andrea Di Buduo, J. Anedda, L. Pilloni, C. Ferreli, L. Atzori
Climacteric keratoderma is a specific cutaneous disorder often underreported, potentially misdiagnosed, or undervalued. Although the pathogenesis remains undetermined, hormonal changes during menopause heavily affect the trophism and normal cellular function of the epidermis and dermis of the palmoplantar regions. We present the case of a 55-year-old woman referred to the Dermatological Clinic of Cagliari for acquired bilateral palmoplantar hyperkeratosis not responding to common topical treatments. Based on the medical history, clinical appearance of the lesions, and laboratory tests, keratoderma climactericum was diagnosed, as confirmed by histopathological examination. An overlap with allergic contact dermatitis was also detected through patch testing, and its synergic effect contributed to the perpetuation of the dermatosis on the hands. A daily high-potency corticosteroidal topical therapy, combined with a 50% urea-based cream at night, was only partially effective. However, adding estriol-based cream at a concentration of 0.125% led to a significant clinical improvement. Climacteric keratoderma is an acquired condition that deserves further clinical trials to assess topical hormonal treatment protocols, as the current approach is largely empirical.
{"title":"Keratoderma climactericum: an under-reported condition successfully treated with an estriol cream","authors":"A. Tatti, B. Conti, M. Corbeddu, Martina Uda, Giovanni Deriu, Andrea Di Buduo, J. Anedda, L. Pilloni, C. Ferreli, L. Atzori","doi":"10.56609/jac.v42i1.329","DOIUrl":"https://doi.org/10.56609/jac.v42i1.329","url":null,"abstract":"Climacteric keratoderma is a specific cutaneous disorder often underreported, potentially misdiagnosed, or undervalued. Although the pathogenesis remains undetermined, hormonal changes during menopause heavily affect the trophism and normal cellular function of the epidermis and dermis of the palmoplantar regions. We present the case of a 55-year-old woman referred to the Dermatological Clinic of Cagliari for acquired bilateral palmoplantar hyperkeratosis not responding to common topical treatments. Based on the medical history, clinical appearance of the lesions, and laboratory tests, keratoderma climactericum was diagnosed, as confirmed by histopathological examination. An overlap with allergic contact dermatitis was also detected through patch testing, and its synergic effect contributed to the perpetuation of the dermatosis on the hands. A daily high-potency corticosteroidal topical therapy, combined with a 50% urea-based cream at night, was only partially effective. However, adding estriol-based cream at a concentration of 0.125% led to a significant clinical improvement. Climacteric keratoderma is an acquired condition that deserves further clinical trials to assess topical hormonal treatment protocols, as the current approach is largely empirical.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140387237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Z. Kardashova, E. V. Selezneva, N. A. Vasilenko, I. Vasilenko, R. Saggini, P. A. Bacci
In recent years, the demand for non-invasive methodologies in aesthetic medicine for treating localized adiposity, cellulite, and sagging skin has increased significantly, particularly the demand for massage techniques with mechanical vibrations. The aim of the present study is to evaluate the effectiveness of Compressive Microvibration® in reducing the expression of cellulite and improving skin conditions in women of different ages under ultrasound control during 60 days of observation. A prospective, single-center, nonrandomized study enrolled 27 women with mild to moderate gynoid lipodystrophy, aged 40 to 69 years, who have been subject to twelve sessions of Compressive Microvibration® (Endospheres®). A specialized high-resolution digital ultrasound system, the DUB SkinScanner (tpm GmbH, Germany), has been used to visualize the skin. Also, the sample anthropometric parameters have been measured, the body mass index has been calculated, and photographs have been taken. In the patients included in the study, in all age groups, after complete treatment of Endospheres®, a decrease in BM has been noted, with a reduction of the bitrochanteric and hip circumference. An improvement in the morphological topography of the skin in terms of regularization of skin irregularities, leveling of reliefs, reduction of depressions, and increase in skin elasticity and density has also been recorded. After a cycle of therapy on the anterior surface of the abdomen and the thigh anterior and posterior surfaces, the scannograms revealed a decrease in the thickness of the epidermis at various levels, the resolution of the phenomenon of hyperkeratosis, a compaction of the dermis, and an increase in its homogeneity and echogenicity. The effect obtained was still present during a control examination two months after the conclusion of the treatment. The analysis of the dynamics of ultrasound criteria demonstrated the effectiveness of the Compressive Microvibration® in women with mild to moderate gynoid lipodystrophy to improve their skin conditions and maintain the obtained effect for 2 months of observation without unwanted side complications.
{"title":"Ultrasonographic Picture Of The Skin And Subcutaneous Tissue In The Treatment Of Cellulite Using The Compressive Microvibration®","authors":"Z. Z. Kardashova, E. V. Selezneva, N. A. Vasilenko, I. Vasilenko, R. Saggini, P. A. Bacci","doi":"10.56609/jac.v42i1.326","DOIUrl":"https://doi.org/10.56609/jac.v42i1.326","url":null,"abstract":"In recent years, the demand for non-invasive methodologies in aesthetic medicine for treating localized adiposity, cellulite, and sagging skin has increased significantly, particularly the demand for massage techniques with mechanical vibrations. The aim of the present study is to evaluate the effectiveness of Compressive Microvibration® in reducing the expression of cellulite and improving skin conditions in women of different ages under ultrasound control during 60 days of observation. A prospective, single-center, nonrandomized study enrolled 27 women with mild to moderate gynoid lipodystrophy, aged 40 to 69 years, who have been subject to twelve sessions of Compressive Microvibration® (Endospheres®). A specialized high-resolution digital ultrasound system, the DUB SkinScanner (tpm GmbH, Germany), has been used to visualize the skin. Also, the sample anthropometric parameters have been measured, the body mass index has been calculated, and photographs have been taken. In the patients included in the study, in all age groups, after complete treatment of Endospheres®, a decrease in BM has been noted, with a reduction of the bitrochanteric and hip circumference. An improvement in the morphological topography of the skin in terms of regularization of skin irregularities, leveling of reliefs, reduction of depressions, and increase in skin elasticity and density has also been recorded. After a cycle of therapy on the anterior surface of the abdomen and the thigh anterior and posterior surfaces, the scannograms revealed a decrease in the thickness of the epidermis at various levels, the resolution of the phenomenon of hyperkeratosis, a compaction of the dermis, and an increase in its homogeneity and echogenicity. The effect obtained was still present during a control examination two months after the conclusion of the treatment. The analysis of the dynamics of ultrasound criteria demonstrated the effectiveness of the Compressive Microvibration® in women with mild to moderate gynoid lipodystrophy to improve their skin conditions and maintain the obtained effect for 2 months of observation without unwanted side complications.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140245567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The integrity of blood vessels is critical to vascular homeostasis, whose disruption is involved in atherosclerosis (AS), causing stroke and myocardial infarction. Therefore, detecting early AS is essential to avoid severe complications. An arteriograph is the best device for detecting early AS by measuring the rigidity of the blood vessels. To date, there are no safe and effective treatments to clean the blood vessels from lipid accumulation and calcium deposition, which are involved in the onset of AS. For this purpose, we have developed a 4-weeks non-pharmacological protocol, consisting of intravenous laser blood irradiation, injections of glutathione and carnosine, and oral supplementation with phosphatidylcholine, aimed at patients with risk factors for early AS. We observed a significant amelioration of lipids parameters and PWVao, an indicator of the existence of asymptomatic AS, confirming the efficacy of our protocol. Besides, all other health issues must be improved.
血管的完整性对血管平衡至关重要，而血管平衡的破坏会导致动脉粥样硬化（AS），引起中风和心肌梗死。因此，早期发现动脉粥样硬化对避免严重并发症至关重要。动脉造影仪是通过测量血管硬度来检测早期 AS 的最佳设备。迄今为止，还没有安全有效的治疗方法来清除血管中的脂质堆积和钙质沉积，而这正是强直性脊柱炎发病的原因。为此，我们针对有早期强直性脊柱炎危险因素的患者，制定了为期 4 周的非药物治疗方案，包括静脉激光血液照射、注射谷胱甘肽和肌肽以及口服磷脂酰胆碱补充剂。我们观察到血脂参数和脉搏波速度（无症状强直性脊柱炎的指标）明显改善，这证实了我们方案的有效性。此外，还必须改善所有其他健康问题。
{"title":"Cleaning of the blood vessels","authors":"D. Kaliterna, Q. Zhu, I. Bizic","doi":"10.56609/jac.v42i1.322","DOIUrl":"https://doi.org/10.56609/jac.v42i1.322","url":null,"abstract":" The integrity of blood vessels is critical to vascular homeostasis, whose disruption is involved in atherosclerosis (AS), causing stroke and myocardial infarction. Therefore, detecting early AS is essential to avoid severe complications. An arteriograph is the best device for detecting early AS by measuring the rigidity of the blood vessels. To date, there are no safe and effective treatments to clean the blood vessels from lipid accumulation and calcium deposition, which are involved in the onset of AS. For this purpose, we have developed a 4-weeks non-pharmacological protocol, consisting of intravenous laser blood irradiation, injections of glutathione and carnosine, and oral supplementation with phosphatidylcholine, aimed at patients with risk factors for early AS. We observed a significant amelioration of lipids parameters and PWVao, an indicator of the existence of asymptomatic AS, confirming the efficacy of our protocol. Besides, all other health issues must be improved.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":"3 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140430696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Facial volume deficits, providing long-term facial aesthetic enhancement outcomes for the signs of aging and/or facial contouring. Numerous hyaluronic acid (HA) fillers seem to have similar characteristics, although their properties regarding rheology, viscoelasticity, heat resistance are different in many ways. The resistance heat degradation is important when hyaluronic acid fillers and energy-based devices are going to be used sequentially. Our objective was to determine the characteristics of HA gels in terms of heat resistance. Degradation of the gels was measured as a change of surface area of the sample. Five types of HA fillers, chosen from most common products on the market for temporary correction of congenital and acquired soft tissue deficits of the face via intradermal or subcutaneous injection: 20mg/ml HA-BDDE, 20mg/ml HA-BDDE, 20mg/ml HA-BDDE, 25 mg/ml HA-BDDE, 28mg/ml HA-PEG were tested in this study. Even though the three dermal fillers contained the same concentration of HA and were cross-linked with the same cross-linking agent, they were produced by different manufacturers using different technologies developed by individual companies. We tested in vitro resistance to heat degradation using Celltibator GT (Medikan Co., LTD, Seoul, Rep. of Korea) and Autoclave (Medotti 22L PRO, Poland). All of the HA fillers samples (0,3 ml) were placed on the petri dishes and put into the autoclave for 10 minutes (temp. 72,4°C). Three of the gels samples (20mg/ml HA-BDDE, 25mg/ml HA-BDDE, 28mg/ml HA-PEG) each 0,3ml were placed into Celltibator for 10 min, temp. 55,2°C degree, centrifugation: 30 RPM. Centrifugation was used to imitate the behaviour of the fillers under the conditions of forces acting on it in the tissue (stress under the influence of facial expressions, exercises, etc.). The temperatures used during this test correspond with commonly used heat-based devices, such as radio-frequency devices (about 45°C), infrared (about 55-65°C) and HiFU (about 70-75°C). Before and after each test pictures of the samples were taken. Heat degradation of the HA samples was measured by comparing (before and after) the changes of the surface area of samples on the petri dishes (on the graph paper). The 28-mg/ml HA-PEG gel filler demonstrated greater resistance to heat versus the 20- mg/ml and 25-mg/ml BDDE gel fillers. The 28-mg/ml HA-PEG, demonstrated in both test (celltibator with/without rotation and autoclave) greater resistance to heat in terms of deformation / thermal degradation and change of surface area. Selection of dermal filler with the right rheological properties is a key factor in achieving a natural-looking long-lasting desired aesthetic outcome. Hyaluronic acid fillers combined with energy-based devices are frequently used sequentially during the same session, however, in some cases it might cause thermal damage of HA. Caution is advised in using IR over recently injected filler (selection of dermal fillers is crucial in this case).
{"title":"Heat Influence on Different Hyaluronic Acid Fillers","authors":"P. Kubik, W. Gruszczyński","doi":"10.56609/jac.v41i2.305","DOIUrl":"https://doi.org/10.56609/jac.v41i2.305","url":null,"abstract":"Facial volume deficits, providing long-term facial aesthetic enhancement outcomes for the signs of aging and/or facial contouring. Numerous hyaluronic acid (HA) fillers seem to have similar characteristics, although their properties regarding rheology, viscoelasticity, heat resistance are different in many ways. The resistance heat degradation is important when hyaluronic acid fillers and energy-based devices are going to be used sequentially. Our objective was to determine the characteristics of HA gels in terms of heat resistance. Degradation of the gels was measured as a change of surface area of the sample. Five types of HA fillers, chosen from most common products on the market for temporary correction of congenital and acquired soft tissue deficits of the face via intradermal or subcutaneous injection: 20mg/ml HA-BDDE, 20mg/ml HA-BDDE, 20mg/ml HA-BDDE, 25 mg/ml HA-BDDE, 28mg/ml HA-PEG were tested in this study. Even though the three dermal fillers contained the same concentration of HA and were cross-linked with the same cross-linking agent, they were produced by different manufacturers using different technologies developed by individual companies. We tested in vitro resistance to heat degradation using Celltibator GT (Medikan Co., LTD, Seoul, Rep. of Korea) and Autoclave (Medotti 22L PRO, Poland). All of the HA fillers samples (0,3 ml) were placed on the petri dishes and put into the autoclave for 10 minutes (temp. 72,4°C). Three of the gels samples (20mg/ml HA-BDDE, 25mg/ml HA-BDDE, 28mg/ml HA-PEG) each 0,3ml were placed into Celltibator for 10 min, temp. 55,2°C degree, centrifugation: 30 RPM. Centrifugation was used to imitate the behaviour of the fillers under the conditions of forces acting on it in the tissue (stress under the influence of facial expressions, exercises, etc.). The temperatures used during this test correspond with commonly used heat-based devices, such as radio-frequency devices (about 45°C), infrared (about 55-65°C) and HiFU (about 70-75°C). Before and after each test pictures of the samples were taken. Heat degradation of the HA samples was measured by comparing (before and after) the changes of the surface area of samples on the petri dishes (on the graph paper). The 28-mg/ml HA-PEG gel filler demonstrated greater resistance to heat versus the 20- mg/ml and 25-mg/ml BDDE gel fillers. The 28-mg/ml HA-PEG, demonstrated in both test (celltibator with/without rotation and autoclave) greater resistance to heat in terms of deformation / thermal degradation and change of surface area. Selection of dermal filler with the right rheological properties is a key factor in achieving a natural-looking long-lasting desired aesthetic outcome. Hyaluronic acid fillers combined with energy-based devices are frequently used sequentially during the same session, however, in some cases it might cause thermal damage of HA. Caution is advised in using IR over recently injected filler (selection of dermal fillers is crucial in this case).","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":"6 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135390923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our nose is a very important and sometimes an essential element of facial beauty. The nose, located in the centre of the face, should be in harmony with the other features of the face. Rhinoplasty is one of the most frequently performed aesthetic operations today. Below, we present the case of a 29-year-old patient with a complication after surgical rhinoplasty. The patient underwent surgical rhinoplasty twice - the first time (2011) with terrible results and the second time (2017) only with gentle improvements. Twelve years after the first surgery, the patient was still looking for a way to improve the outcome of her nose; we proposed the treatment plan with the use of novel PEG-cross-linked hyaluronic acid to improve the appearance of the nose area, with significant visual effect and no side effects.
{"title":"PEGylated hyaluronic acid as tissue expander on a surgical compromised nose. A case study","authors":"Diego Araya Bruna","doi":"10.56609/jac.v41i2.303","DOIUrl":"https://doi.org/10.56609/jac.v41i2.303","url":null,"abstract":"Our nose is a very important and sometimes an essential element of facial beauty. The nose, located in the centre of the face, should be in harmony with the other features of the face. Rhinoplasty is one of the most frequently performed aesthetic operations today. Below, we present the case of a 29-year-old patient with a complication after surgical rhinoplasty. The patient underwent surgical rhinoplasty twice - the first time (2011) with terrible results and the second time (2017) only with gentle improvements. Twelve years after the first surgery, the patient was still looking for a way to improve the outcome of her nose; we proposed the treatment plan with the use of novel PEG-cross-linked hyaluronic acid to improve the appearance of the nose area, with significant visual effect and no side effects.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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