A. Yılgor, G. Ozaydin Yavuz, I. H. Yavuz, C. Boyvadoglu, P. Korkmaz, H. S. Inaloz
Isotretinoin, a first-generation nonaromatic retinoid, leads to numerous diseases including eye disorders and neurological, gastrointestinal, psychiatric, metabolic, connective tissue, and musculoskeletal diseases. The aim of this study was to investigate the effects of isotretinoin on peripheral nerve functions. The study included 30 patients that were started on isotretinoin due to nodulocystic acne. A thorough neurological and general examination was performed for each patient by a neurologist both at the beginning and end of the study. Laboratory investigations including complete blood count (CBC), serum biochemical analysis, vitamin B12 levels, thyroid function tests, and urine tests were performed to identify the other factors that may affect the functions of peripheral nerves. A neurophysiological examination was performed using an electroneuromyography (EMG) device. The 30 patients comprised 7 (23.3%) men and 23 (76.7%) women, with a mean age of 21.9±3.56 years. No serious side effect occurred in any patient. No motor or sensory values suggestive of neuropathy were observed in any patient. However, significant differences were found between the pre-and post-treatment sensory and motor values of some nerves. Although it did not cause peripheral polyneuropathy, isotretinoin resulted in alterations in the latency, amplitude, and velocity values of peripheral nerves.
{"title":"Isotretinoin-Induced Peripheral Neuropathy: An Enigma","authors":"A. Yılgor, G. Ozaydin Yavuz, I. H. Yavuz, C. Boyvadoglu, P. Korkmaz, H. S. Inaloz","doi":"10.56609/jac.v41i2.301","DOIUrl":"https://doi.org/10.56609/jac.v41i2.301","url":null,"abstract":"Isotretinoin, a first-generation nonaromatic retinoid, leads to numerous diseases including eye disorders and neurological, gastrointestinal, psychiatric, metabolic, connective tissue, and musculoskeletal diseases. The aim of this study was to investigate the effects of isotretinoin on peripheral nerve functions. The study included 30 patients that were started on isotretinoin due to nodulocystic acne. A thorough neurological and general examination was performed for each patient by a neurologist both at the beginning and end of the study. Laboratory investigations including complete blood count (CBC), serum biochemical analysis, vitamin B12 levels, thyroid function tests, and urine tests were performed to identify the other factors that may affect the functions of peripheral nerves. A neurophysiological examination was performed using an electroneuromyography (EMG) device. The 30 patients comprised 7 (23.3%) men and 23 (76.7%) women, with a mean age of 21.9±3.56 years. No serious side effect occurred in any patient. No motor or sensory values suggestive of neuropathy were observed in any patient. However, significant differences were found between the pre-and post-treatment sensory and motor values of some nerves. Although it did not cause peripheral polyneuropathy, isotretinoin resulted in alterations in the latency, amplitude, and velocity values of peripheral nerves.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":"352 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135153733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Of the several dermal fillers developed in recent decades, hyaluronic acid fillers have become the material of choice. They are safe, long-lasting, non-immunogenic, available to most patients, and can be removed with hyaluronidase. Unfortunately, early and delayed complications can also occur after HA filler injection. Below, we present the case of a 42-year-old patient who had complications after the aesthetic procedure using hyaluronic acid dermal fillers in the past. Surprisingly, the treatment performed with hyaluronic acid cross-linked with another cross-linking agent was without complications. The affected places were the chin and malar area. In 2021, after performing augmentation with hyaluronic acid in the chin area, a patient developed swelling, which subsided after using hyaluronidase (Hylase Dessau 300 I.E.) and corticosteroids. The patient repeated the procedure in 2022, where she was administered 2 ml of hyaluronic acid in July 2022. About 3 weeks after injection, oedema and nodules appeared at the injection site in the zygomatic/malar area; after using Prednisone, the changes subsided. In September 2022, 3 ml of PEG-cross-linked hyaluronic acid was successfully performed with no side effects. In the described case, an important role was played by the ability of the hyaluronic acid hydrogel to modulate human immunological functions, which was associated with a very low risk of immune-related side effects and accompanying cellulitic processes.
{"title":"Safety and aesthetic outcomes of using fillers with different cross-linking agents. A case report.","authors":"S. Menkes","doi":"10.56609/jac.v41i2.297","DOIUrl":"https://doi.org/10.56609/jac.v41i2.297","url":null,"abstract":"Of the several dermal fillers developed in recent decades, hyaluronic acid fillers have become the material of choice. They are safe, long-lasting, non-immunogenic, available to most patients, and can be removed with hyaluronidase. Unfortunately, early and delayed complications can also occur after HA filler injection. Below, we present the case of a 42-year-old patient who had complications after the aesthetic procedure using hyaluronic acid dermal fillers in the past. Surprisingly, the treatment performed with hyaluronic acid cross-linked with another cross-linking agent was without complications. The affected places were the chin and malar area. In 2021, after performing augmentation with hyaluronic acid in the chin area, a patient developed swelling, which subsided after using hyaluronidase (Hylase Dessau 300 I.E.) and corticosteroids. The patient repeated the procedure in 2022, where she was administered 2 ml of hyaluronic acid in July 2022. About 3 weeks after injection, oedema and nodules appeared at the injection site in the zygomatic/malar area; after using Prednisone, the changes subsided. In September 2022, 3 ml of PEG-cross-linked hyaluronic acid was successfully performed with no side effects. In the described case, an important role was played by the ability of the hyaluronic acid hydrogel to modulate human immunological functions, which was associated with a very low risk of immune-related side effects and accompanying cellulitic processes.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48903597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since the late 1990s, when the first commercially available hyaluronic acid-based tissue filler appeared, HA fillers have become the “product of choice” of soft tissue augmentation due to their favourable safety profile and minimally invasive nature of the treatment. Recent years have increased the popularity of HA fillers among doctors and patients and the number of available HA fillers and indications for aesthetic treatments. Due to the greater availability, and growing awareness among patients, HA filler treatments have become one of the most frequently performed cosmetic procedures worldwide. For several decades, we have been observing the development and progress of improving fillers to increase the safety and effectiveness of performed treatments.
{"title":"Overview of hyaluronic acid and its development as dermal fillers gel","authors":"N. Elmahdawi","doi":"10.56609/jac.v41i2.294","DOIUrl":"https://doi.org/10.56609/jac.v41i2.294","url":null,"abstract":"Since the late 1990s, when the first commercially available hyaluronic acid-based tissue filler appeared, HA fillers have become the “product of choice” of soft tissue augmentation due to their favourable safety profile and minimally invasive nature of the treatment. Recent years have increased the popularity of HA fillers among doctors and patients and the number of available HA fillers and indications for aesthetic treatments. Due to the greater availability, and growing awareness among patients, HA filler treatments have become one of the most frequently performed cosmetic procedures worldwide. For several decades, we have been observing the development and progress of improving fillers to increase the safety and effectiveness of performed treatments.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41695615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Group D vitamins are a family of micronutrients essential for the health of numerous organs and systems. The family members come from different sources. In particular, UV irradiation forms ergocalciferol (vitamin D2) in some plants, predominantly in fungi. Differently, cholecalciferol (vitamin D3) is synthesised in the skin of animals by UV irradiation of 7-dehydrocholesterol. Consequently, humans synthesise vitamin D3 and introduce the same vitamin to foods of animal origin and vitamin D2 to foods of plant origin. The pre-hormonal forms, cholecalciferol and ergo cholecalciferol are converted to active compounds via a 2-step enzymatic dihydroxylation in the liver and kidney to synthesise the active form of vitamin D, calcitriol. It has recently been demonstrated that the skin possesses the hydroxylases responsible for activating vitamin D directly in the keratinocytes. We have previously demonstrated the effectiveness of vitamin D3 combined with silver nanoparticles in wound healing in vitro. The aim of the present work was to establish whether vitamin D2 could have a similar effect to vitamin D3. Therefore, we used the same combination of vitamin D+ silver nanoparticles by substituting vitamin D3 for vitamin D2. We demonstrated that the effect of vitamin D2 on wound repair is very similar to that of vitamin D3. Indeed vitamin D2 induces an even stronger effect suggesting the possible future use of the combination of vitamin D2 + silver nanoparticles for the repair of skin damage, not only repair of wounds, but also atopic dermatitis, irritative pathologies such as diaper area dermatitis, actinic dermatitis, minor burns, folliculitis, and other skin wounds such as umbilical stump care. Possible applications were discussed.
{"title":"Agaric extract and colloidal silver promote skin health and wound repair","authors":"G. Ruggiero, S. Cataldi, M. Mandarano, E. Albi","doi":"10.56609/jac.v41i2.291","DOIUrl":"https://doi.org/10.56609/jac.v41i2.291","url":null,"abstract":"Group D vitamins are a family of micronutrients essential for the health of numerous organs and systems. The family members come from different sources. In particular, UV irradiation forms ergocalciferol (vitamin D2) in some plants, predominantly in fungi. Differently, cholecalciferol (vitamin D3) is synthesised in the skin of animals by UV irradiation of 7-dehydrocholesterol. Consequently, humans synthesise vitamin D3 and introduce the same vitamin to foods of animal origin and vitamin D2 to foods of plant origin. The pre-hormonal forms, cholecalciferol and ergo cholecalciferol are converted to active compounds via a 2-step enzymatic dihydroxylation in the liver and kidney to synthesise the active form of vitamin D, calcitriol. It has recently been demonstrated that the skin possesses the hydroxylases responsible for activating vitamin D directly in the keratinocytes. We have previously demonstrated the effectiveness of vitamin D3 combined with silver nanoparticles in wound healing in vitro. The aim of the present work was to establish whether vitamin D2 could have a similar effect to vitamin D3. Therefore, we used the same combination of vitamin D+ silver nanoparticles by substituting vitamin D3 for vitamin D2. We demonstrated that the effect of vitamin D2 on wound repair is very similar to that of vitamin D3. Indeed vitamin D2 induces an even stronger effect suggesting the possible future use of the combination of vitamin D2 + silver nanoparticles for the repair of skin damage, not only repair of wounds, but also atopic dermatitis, irritative pathologies such as diaper area dermatitis, actinic dermatitis, minor burns, folliculitis, and other skin wounds such as umbilical stump care. Possible applications were discussed.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48385360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Diffidenti, S. Vannuccini, G. Cavalletti, P. L. Rossi, E. Caradonna, P. Bacci
Society is characterised by a substantial increase in overweight and obesity, with progressive diseases such as diabetes, lipolymphedema and lipoedema. Many experiences have demonstrated the sensitivity of the subcutaneous adipose tissue utilising non-invasive mechanical treatments. This study aims to study the sensitivity of the subcutaneous adipose layer of the abdomen using compressive microvibration treatments with spheres of variable density. Thirty patients were followed between the period from 10th January to the 30th May 2022. Fifteen patients were treated with twelve compressive microvibration sessions with variable density spheres, and the other fifteen with the same treatment associated with a nutritional purification program. All patients were studied with clinical/instrumental examinations and evaluations in compliance with ethical and deontological standards. All patients showed improvements in the single treatment and the treatment associated with the nutritional program. The reduction of subcutaneous adipose tissue observed with the treatment of compressive microvibration with spheres of variable density indicates a direct stimulation of the biochemical and biophysical structures that regulate the cellular biology of adipose tissue, with metabolic action induced by the vibrations.
{"title":"Fat tissue reduction by depurative diet and compressive microvibration with spheres of variable density","authors":"B. Diffidenti, S. Vannuccini, G. Cavalletti, P. L. Rossi, E. Caradonna, P. Bacci","doi":"10.56609/jac.v41i2.290","DOIUrl":"https://doi.org/10.56609/jac.v41i2.290","url":null,"abstract":"Society is characterised by a substantial increase in overweight and obesity, with progressive diseases such as diabetes, lipolymphedema and lipoedema. Many experiences have demonstrated the sensitivity of the subcutaneous adipose tissue utilising non-invasive mechanical treatments. This study aims to study the sensitivity of the subcutaneous adipose layer of the abdomen using compressive microvibration treatments with spheres of variable density. Thirty patients were followed between the period from 10th January to the 30th May 2022. Fifteen patients were treated with twelve compressive microvibration sessions with variable density spheres, and the other fifteen with the same treatment associated with a nutritional purification program. All patients were studied with clinical/instrumental examinations and evaluations in compliance with ethical and deontological standards. All patients showed improvements in the single treatment and the treatment associated with the nutritional program. The reduction of subcutaneous adipose tissue observed with the treatment of compressive microvibration with spheres of variable density indicates a direct stimulation of the biochemical and biophysical structures that regulate the cellular biology of adipose tissue, with metabolic action induced by the vibrations.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43231158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Melfa, A. Gennai, G. Carfagna, B. Bovani, D. Piccolo, M. Colli, M. Baldessin, D. Siragusa
Increased interest in regenerative medicine in the last few years was registered. In parallel, a progressive increase in injectable calcium hydroxylapatite (CaHA) applications has been observed due to its applications in skin rejuvenation. This study combined micro fragmented fatty tissue (FAT) grafting with the CAHA filler procedure to observe the biological effect on FAT. Each sample of micro fragmented adipose tissue harvested using the guided Superficial Enhanced Fluid Fat Injection (guided SEFFI) technique were collected from 5 patients. The 5 samples were divided into aliquots to create two different experimental conditions: FAT and FAT combined with CaHA (FAT + R). Afterwards, the cellularity of mesenchymal phenotype and the in vitro differentiation capacity in mesenchymal lineages were assessed in both experimental conditions, FAT and FAT+R. Despite low cellularity observed for FAT+R compared to FAT, isolated cells could grow and expand in culture in both experimental conditions, thus proving their proliferative ability. Cells were proved to differentiate towards mesenchymal lineages, expressing mesenchymal markers by flow cytometry analysis. Combining emulsified harvested tissue prepared with guided SEFFI technique with CaHA products can be exploited to counteract the loss of volume and skin ageing of the human face and body. This approach to regenerative aesthetic treatment is a promising treatment for facial antiaging therapy.
{"title":"Characterization of Adipose-Derived Mesenchymal Stem Cells from tissue harvested with the guided SEFFI technique and co-cultured with calcium hydroxyapatite","authors":"F. Melfa, A. Gennai, G. Carfagna, B. Bovani, D. Piccolo, M. Colli, M. Baldessin, D. Siragusa","doi":"10.56609/jac.v41i2.288","DOIUrl":"https://doi.org/10.56609/jac.v41i2.288","url":null,"abstract":"Increased interest in regenerative medicine in the last few years was registered. In parallel, a progressive increase in injectable calcium hydroxylapatite (CaHA) applications has been observed due to its applications in skin rejuvenation. This study combined micro fragmented fatty tissue (FAT) grafting with the CAHA filler procedure to observe the biological effect on FAT. Each sample of micro fragmented adipose tissue harvested using the guided Superficial Enhanced Fluid Fat Injection (guided SEFFI) technique were collected from 5 patients. The 5 samples were divided into aliquots to create two different experimental conditions: FAT and FAT combined with CaHA (FAT + R). Afterwards, the cellularity of mesenchymal phenotype and the in vitro differentiation capacity in mesenchymal lineages were assessed in both experimental conditions, FAT and FAT+R. Despite low cellularity observed for FAT+R compared to FAT, isolated cells could grow and expand in culture in both experimental conditions, thus proving their proliferative ability. Cells were proved to differentiate towards mesenchymal lineages, expressing mesenchymal markers by flow cytometry analysis. Combining emulsified harvested tissue prepared with guided SEFFI technique with CaHA products can be exploited to counteract the loss of volume and skin ageing of the human face and body. This approach to regenerative aesthetic treatment is a promising treatment for facial antiaging therapy.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47843531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Metelin, A. A. Fomicheva, Z. Kardashova, P. Bacci, I. Vasilenko
The aim of the study was the apparatus of compressive microvibration “Endospheres Therapy® Body” (Registration certificate RZN 2016/3863 of 29 December 2017) used in women with mild to moderate edematous fibrosclerosis (panniculopathy) of peri- and post-menopausal age. The purpose of the project is to evaluate the effectiveness of the non-invasive technique of compressive microvibration in volunteers of different age groups. The basis for the work is the agreement No. 002/2022-n between the GBUZ MO MONIKI named after M.F. Vladimirsky and ItalConsult, LLC of 01.03.2022. The main tasks were: form 3 cohort groups of volunteers in accordance with the criteria agreed with the Customer (mild or moderate edematous fibrosclerosis, as panniculopathy), aged 30 to 44 years old, 45 to 54 years old and 55-65 years old; ensure that all participants receive a course on procedures (12 procedures every other day) regularly and correctly; evaluate the effectiveness of the non-invasive method of compressive microvibration on local areas of excess fat deposits in volunteers of different age groups through subjective testing (with a questionnaire), objective results of laboratory tests (blood test with hormone levels) and instrumental studies (ultrasound examination of the skin of fat trap zones, in abdomen and thighs) and assessment of the microcirculation system. Hypothesis: compressive microvibration generated by the manipulator-cylinder, consisting of 50 spheres of hypoallergenic silicone that generates low-frequency vibrations, makes it possible to activate microcirculation, stimulate lymphatic drainage, increase muscle tone and improve skin trophism. For all study results, mean values (Mean), standard deviations (Std.Dev.), minimum (Minimum), maximum (Maximum) values, and SD confidence of all results were obtained. The difference between the mean values and the variation coefficients was tested using a two-sample Student’s t-test (considering the distribution’s normality). Our results have convincingly demonstrated the effectiveness of the Endospheres Therapy® procedures for treating cellulite, with the effect maintained for at least 60 days after the course of therapy. Instrumental studies confirmed a pronounced improvement in the skin’s condition, microcirculation, cellular metabolism activation, hypoxia reduction and tissue perfusion improvement. Endospheres Therapy® procedures are safe and effective in treating cellulite in the long term without side effects. Patients noted a high degree of satisfaction with the Endospheres Therapy® course, which indicates the quality of the procedures and the level of specialists.
本研究的目的是在围绝经期和绝经后年龄的轻度至中度水肿性纤维硬化症（脂膜炎）妇女中使用压缩微振动装置“Endospheres Therapy®Body”（注册证书RZN 2016/3863，2017年12月29日）。该项目的目的是评估非侵入性压缩微振动技术在不同年龄组志愿者中的有效性。这项工作的基础是以M.F.Vladimirsky命名的GBUZ MO MONIKI与ItaliConsult，LLC于2022年3月1日签订的第002/2022-n号协议。主要任务是：根据客户同意的标准（轻度或中度水肿性纤维硬化症，如脂膜炎），形成3组志愿者，年龄分别为30至44岁、45至54岁和55至65岁；确保所有参与者定期正确地接受程序课程（每隔一天12个程序）；通过主观测试（使用问卷）评估压缩微振动非侵入性方法对不同年龄组志愿者局部多余脂肪沉积区域的有效性，实验室测试（激素水平的血液测试）和仪器研究（腹部和大腿脂肪捕获区皮肤的超声检查）以及微循环系统评估的目的结果。假设：由50个产生低频振动的低致敏性硅胶球体组成的机械手圆柱体产生的压缩性微振动，可以激活微循环，刺激淋巴引流，增加肌肉张力，改善皮肤营养。对于所有研究结果，获得了所有结果的平均值（mean）、标准差（Std.Dev.）、最小值（minimum）、最大值（maximum）和SD置信度。平均值和变异系数之间的差异使用两个样本的Student t检验进行检验（考虑到分布的正态性）。我们的研究结果令人信服地证明了Endospheres Therapy®程序治疗脂肪团的有效性，该效果在治疗后至少保持60天。仪器研究证实，皮肤状况、微循环、细胞代谢激活、缺氧减少和组织灌注改善显著改善。Endospheres Therapy®程序在长期治疗脂肪团方面是安全有效的，没有副作用。患者对Endospheres Therapy®疗程的满意度很高，这表明了手术的质量和专家水平。
{"title":"Evaluation of the effectiveness of non-invasive methods of compressive microvibration and ablative sensory microvibration on local areas with excess fat deposits in volunteers of different age groups","authors":"V. Metelin, A. A. Fomicheva, Z. Kardashova, P. Bacci, I. Vasilenko","doi":"10.56609/jac.v41i2.278","DOIUrl":"https://doi.org/10.56609/jac.v41i2.278","url":null,"abstract":"The aim of the study was the apparatus of compressive microvibration “Endospheres Therapy® Body” (Registration certificate RZN 2016/3863 of 29 December 2017) used in women with mild to moderate edematous fibrosclerosis (panniculopathy) of peri- and post-menopausal age. The purpose of the project is to evaluate the effectiveness of the non-invasive technique of compressive microvibration in volunteers of different age groups. The basis for the work is the agreement No. 002/2022-n between the GBUZ MO MONIKI named after M.F. Vladimirsky and ItalConsult, LLC of 01.03.2022. The main tasks were: form 3 cohort groups of volunteers in accordance with the criteria agreed with the Customer (mild or moderate edematous fibrosclerosis, as panniculopathy), aged 30 to 44 years old, 45 to 54 years old and 55-65 years old; ensure that all participants receive a course on procedures (12 procedures every other day) regularly and correctly; evaluate the effectiveness of the non-invasive method of compressive microvibration on local areas of excess fat deposits in volunteers of different age groups through subjective testing (with a questionnaire), objective results of laboratory tests (blood test with hormone levels) and instrumental studies (ultrasound examination of the skin of fat trap zones, in abdomen and thighs) and assessment of the microcirculation system. Hypothesis: compressive microvibration generated by the manipulator-cylinder, consisting of 50 spheres of hypoallergenic silicone that generates low-frequency vibrations, makes it possible to activate microcirculation, stimulate lymphatic drainage, increase muscle tone and improve skin trophism. For all study results, mean values (Mean), standard deviations (Std.Dev.), minimum (Minimum), maximum (Maximum) values, and SD confidence of all results were obtained. The difference between the mean values and the variation coefficients was tested using a two-sample Student’s t-test (considering the distribution’s normality). Our results have convincingly demonstrated the effectiveness of the Endospheres Therapy® procedures for treating cellulite, with the effect maintained for at least 60 days after the course of therapy. Instrumental studies confirmed a pronounced improvement in the skin’s condition, microcirculation, cellular metabolism activation, hypoxia reduction and tissue perfusion improvement. Endospheres Therapy® procedures are safe and effective in treating cellulite in the long term without side effects. Patients noted a high degree of satisfaction with the Endospheres Therapy® course, which indicates the quality of the procedures and the level of specialists.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49579591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Pallanti, G. Gasic, N. Makris, T. Lotti, S. Gerakaris, E. Grassi
Dermotillomania in the Manual for Mental Disorders (DSM5- TR) is included in the chapter "Obsessive-Compulsive Disorders and Related Disorders". Dermotillomania is a disorder characterised by the compulsive damaging of skin tissue through repetitive behaviour. For this reason, patients suffering from this disabling condition are often referred to dermatologists claiming therapy or cosmetic remedies. Repetitive Transcranial Magnetic Stimulation has been approved for the treatment of Obsessive-Compulsive disorder. It has been recently reported to be a promising therapy in other compulsive spectrum disorders, such as trichotillomania and skin picking. According to the "Research Domain Criteria", a circuit-oriented approach targeting the dorsolateral prefrontal cortex to modulate reward and compulsivity circuitries and implied in dermotillomania. A recent report for Obsessive-Compulsive disorder Spectrum Disorders highlights the deleterious effect of inflammation on brain plasticity that affects neuroplasticity and the specific treatment. Given this, some laboratory testing for inflammation has been included in our assessment to reduce the contrast to the therapeutic mechanisms underlying neuroplasticity induced by the Repetitive Transcranial Magnetic Stimulation treatment; this is the first case reporting Repetitive Transcranial Magnetic Stimulation as effective in reducing the dermotillomania to remission. Further studies are needed to validate this proof-of-concept case and this multidisciplinary approach for these disorders, which are not so rare, targeting a brain area highly implicated in the Reward Circuitries.
{"title":"Transcranial magnetic stimulation treatment for dermotillomania: a multidisciplinary approach focused on circuitries and neuroplasticity","authors":"S. Pallanti, G. Gasic, N. Makris, T. Lotti, S. Gerakaris, E. Grassi","doi":"10.56609/jac.v41i2.280","DOIUrl":"https://doi.org/10.56609/jac.v41i2.280","url":null,"abstract":"Dermotillomania in the Manual for Mental Disorders (DSM5- TR) is included in the chapter \"Obsessive-Compulsive Disorders and Related Disorders\". Dermotillomania is a disorder characterised by the compulsive damaging of skin tissue through repetitive behaviour. For this reason, patients suffering from this disabling condition are often referred to dermatologists claiming therapy or cosmetic remedies. Repetitive Transcranial Magnetic Stimulation has been approved for the treatment of Obsessive-Compulsive disorder. It has been recently reported to be a promising therapy in other compulsive spectrum disorders, such as trichotillomania and skin picking. According to the \"Research Domain Criteria\", a circuit-oriented approach targeting the dorsolateral prefrontal cortex to modulate reward and compulsivity circuitries and implied in dermotillomania. A recent report for Obsessive-Compulsive disorder Spectrum Disorders highlights the deleterious effect of inflammation on brain plasticity that affects neuroplasticity and the specific treatment. Given this, some laboratory testing for inflammation has been included in our assessment to reduce the contrast to the therapeutic mechanisms underlying neuroplasticity induced by the Repetitive Transcranial Magnetic Stimulation treatment; this is the first case reporting Repetitive Transcranial Magnetic Stimulation as effective in reducing the dermotillomania to remission. Further studies are needed to validate this proof-of-concept case and this multidisciplinary approach for these disorders, which are not so rare, targeting a brain area highly implicated in the Reward Circuitries.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48362366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Barillari, A. Pardo, P. Faccioni, S. Guariglia, C. Cavedon, M. Zarantonello, F. Melloni, P. Zanutto, R. Bettini, G. Mansueto, N. Zerman, F. Lonardi
The aim of this study was to compare Orthopantomograms (OPT) and Computed Tomography (CT) with Cone Beam Computed Tomography (CBCT) in patients with Medication-Related OsteoNecrosis of the Jaws (MRONJ). The study included 25 patients (6 males and 19 females) with MRONJ who had a history of long-term bisphosphonate therapy or one of the recently re-entered MRONJ drugs and underwent OPT, CT and/or CBCT for determination of the extent of disease. We excluded patients with maxillary neoplasia. Considering the presence of early and late signs, OPT was diagnostic in 6 out of 17 cases (35%), while CT and CBCT were diagnostic in 25 out of 25 cases (100%). Analysing the different radiant doses delivered by the selected radiological methods on a phantom, it was found that a more significant effective dose was spread by CT (2.6 mSv) than CBCT (0.164 mSv) or OPT (0.02 mSv). CBCT, from our experience, is a candidate to replace OPT in the first diagnostic step in patients with suspected MRONJ, generating less effective doses and artefacts from metal components than CT.
{"title":"Use of Cone Beam Computed Tomography for identification and evaluation of medication-related osteonecrosis of the jaws: a dosimetric and multimodal imaging comparison","authors":"M. Barillari, A. Pardo, P. Faccioni, S. Guariglia, C. Cavedon, M. Zarantonello, F. Melloni, P. Zanutto, R. Bettini, G. Mansueto, N. Zerman, F. Lonardi","doi":"10.56609/jac.v41i1.273","DOIUrl":"https://doi.org/10.56609/jac.v41i1.273","url":null,"abstract":"The aim of this study was to compare Orthopantomograms (OPT) and Computed Tomography (CT) with Cone Beam Computed Tomography (CBCT) in patients with Medication-Related OsteoNecrosis of the Jaws (MRONJ). The study included 25 patients (6 males and 19 females) with MRONJ who had a history of long-term bisphosphonate therapy or one of the recently re-entered MRONJ drugs and underwent OPT, CT and/or CBCT for determination of the extent of disease. We excluded patients with maxillary neoplasia. Considering the presence of early and late signs, OPT was diagnostic in 6 out of 17 cases (35%), while CT and CBCT were diagnostic in 25 out of 25 cases (100%). Analysing the different radiant doses delivered by the selected radiological methods on a phantom, it was found that a more significant effective dose was spread by CT (2.6 mSv) than CBCT (0.164 mSv) or OPT (0.02 mSv). CBCT, from our experience, is a candidate to replace OPT in the first diagnostic step in patients with suspected MRONJ, generating less effective doses and artefacts from metal components than CT.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45958628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U. Luciano, D. De Santis, N. Modena, P. Faccioni, M. Bonioli, M. Magi, A. Iurlaro, C. Alberti, F. Melloni, T. Zambotti, F. Gelpi, N. Zerman, A. Trotolo
The object of this study was to compare, through meta-analysis, the accuracy in implant placement obtained in Dynamic Navigation (DN) with Static Navigation (SN) and with Conventional Free-Hand Surgery (CS) and to provide some useful clinical parameters to consider during the planning phase of the intervention. A meta-analysis was performed, dividing the selected studies into two groups based on the statistical technique adopted: DN vs CS and DN vs SN. The heterogeneity between the various studies was assessed with the homonymous test and quantified with I2. The results were graphically represented using a forest plot. Egger’s test and funnel plot was used to investigate the “small study effect”. The search was performed through the PubMed database, and the Cochrane Library database identified 448 articles. After applying the inclusion criteria, 14 articles were selected and used for quantitative synthesis (meta-analysis). From the results obtained from this meta-analysis, it can be stated that the DN mode allows for better accuracy than conventional surgery, the most used type of surgery, and is comparable to static navigation, the gold standard for accuracy.
{"title":"Investigation on the accuracy of implant surgery in dynamic navigation: metanalysis and systematic review of literature","authors":"U. Luciano, D. De Santis, N. Modena, P. Faccioni, M. Bonioli, M. Magi, A. Iurlaro, C. Alberti, F. Melloni, T. Zambotti, F. Gelpi, N. Zerman, A. Trotolo","doi":"10.56609/jac.v41i1.271","DOIUrl":"https://doi.org/10.56609/jac.v41i1.271","url":null,"abstract":" The object of this study was to compare, through meta-analysis, the accuracy in implant placement obtained in Dynamic Navigation (DN) with Static Navigation (SN) and with Conventional Free-Hand Surgery (CS) and to provide some useful clinical parameters to consider during the planning phase of the intervention. A meta-analysis was performed, dividing the selected studies into two groups based on the statistical technique adopted: DN vs CS and DN vs SN. The heterogeneity between the various studies was assessed with the homonymous test and quantified with I2. The results were graphically represented using a forest plot. Egger’s test and funnel plot was used to investigate the “small study effect”. The search was performed through the PubMed database, and the Cochrane Library database identified 448 articles. After applying the inclusion criteria, 14 articles were selected and used for quantitative synthesis (meta-analysis). From the results obtained from this meta-analysis, it can be stated that the DN mode allows for better accuracy than conventional surgery, the most used type of surgery, and is comparable to static navigation, the gold standard for accuracy.","PeriodicalId":15008,"journal":{"name":"Journal of applied cosmetology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45778812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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