首页 > 最新文献

Journal of Biomolecular Screening最新文献

英文 中文
PRODUCT FOCUS: Analytical and Preparative Instrumentation 产品重点:分析和制备仪器
Q2 Chemistry Pub Date : 2007-10-01 DOI: 10.1177/10870571070120071301
profiling (RAP) technology, RAP id 4 enables real-time, label-free measurement and analysis of biomolecular interactions. RAP measures the oscillation of a resonating quartz crystal, which decreases in proportion to the mass of the molecules binding to its surface. Proprietary electronics and algorithms generate measurements, which provide binding information on biomolecular interactions. RAP measures materials that physically bind to the crystal and is unaffected by solvents. Researchers interrogate and evaluate the data using RAP id workbench software. The system is flow based and generates kinetic, affinity, and concentration measurements from mixtures such as cell culture supernatants and periplasmic extracts. A stand-alone automated platform, RAP id 4 typically processes an average of 400 samples per day. For further information, visit www.akubio.com.
分析(RAP)技术,RAP id 4能够实时、无标签地测量和分析生物分子相互作用。RAP测量谐振石英晶体的振荡,这种振荡与结合在其表面的分子质量成比例地减少。专有的电子和算法产生测量,提供生物分子相互作用的结合信息。RAP测量与晶体物理结合且不受溶剂影响的材料。研究人员使用RAP id工作台软件对数据进行查询和评估。该系统以流动为基础,从细胞培养上清和质周萃取物等混合物中产生动力学、亲和力和浓度测量。作为一个独立的自动化平台,RAP id 4通常每天平均处理400个样品。欲了解更多信息,请访问www.akubio.com。
{"title":"PRODUCT FOCUS: Analytical and Preparative Instrumentation","authors":"","doi":"10.1177/10870571070120071301","DOIUrl":"https://doi.org/10.1177/10870571070120071301","url":null,"abstract":"profiling (RAP) technology, RAP id 4 enables real-time, label-free measurement and analysis of biomolecular interactions. RAP measures the oscillation of a resonating quartz crystal, which decreases in proportion to the mass of the molecules binding to its surface. Proprietary electronics and algorithms generate measurements, which provide binding information on biomolecular interactions. RAP measures materials that physically bind to the crystal and is unaffected by solvents. Researchers interrogate and evaluate the data using RAP id workbench software. The system is flow based and generates kinetic, affinity, and concentration measurements from mixtures such as cell culture supernatants and periplasmic extracts. A stand-alone automated platform, RAP id 4 typically processes an average of 400 samples per day. For further information, visit www.akubio.com.","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"12 1","pages":"1012 - 1018"},"PeriodicalIF":0.0,"publicationDate":"2007-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10870571070120071301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65310370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Product Focus 产品集中
Q2 Chemistry Pub Date : 2007-08-01 DOI: 10.1177/10870571070120051601
BioTek Instruments has announced the SynergyTM 2 Multi-Detection Microplate Reader, which is a 5-mode microplate reader. Detection modes include fluorescence intensity, fluorescence polarization, time-resolved fluorescence, luminescence, and UV-visible absorbance. The reader uses a combination of monochromator, filters and dichroic mirrors, and 3 broad-spectrum light sources. It is driven by BioTek Instruments’ Gen5TM Reader Control and Data Analysis
BioTek Instruments发布了一款名为SynergyTM 2的多检测微孔板读取器,这是一款5模式微孔板读取器。检测模式包括荧光强度、荧光偏振、时间分辨荧光、发光和紫外可见吸光度。阅读器使用单色器、滤光片和二色镜的组合,以及3个广谱光源。它由BioTek Instruments的Gen5TM读取器控制和数据分析驱动
{"title":"Product Focus","authors":"","doi":"10.1177/10870571070120051601","DOIUrl":"https://doi.org/10.1177/10870571070120051601","url":null,"abstract":"BioTek Instruments has announced the SynergyTM 2 Multi-Detection Microplate Reader, which is a 5-mode microplate reader. Detection modes include fluorescence intensity, fluorescence polarization, time-resolved fluorescence, luminescence, and UV-visible absorbance. The reader uses a combination of monochromator, filters and dichroic mirrors, and 3 broad-spectrum light sources. It is driven by BioTek Instruments’ Gen5TM Reader Control and Data Analysis","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"12 1","pages":"748 - 752"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10870571070120051601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65310358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Product Focus 产品集中
Q2 Chemistry Pub Date : 2005-02-01 DOI: 10.1177/108705710501000111
Assay ReagentsSupplies
division. This antibody is targeted against human cyclophilin A, which is thought to play an important role in the mechanism of protein folding. Non-animal-based and in vitro–generated recombinant antibodies are new to the research markets and seem to have several advantages over traditional antibodies. They can be generated within 8 weeks from only a minimum amount of protein, DNA, or peptide. In addition, in vitro–generated antibodies allow for high-throughput production, thus facilitating the development of novel array platforms.
部门。该抗体针对人亲环蛋白A,该蛋白被认为在蛋白质折叠机制中起重要作用。非动物基础和体外生成的重组抗体是研究市场上的新事物,似乎比传统抗体有几个优势。它们可以在8周内由最少量的蛋白质、DNA或肽生成。此外,体外生成的抗体允许高通量生产,从而促进了新型阵列平台的发展。
{"title":"Product Focus","authors":"Assay ReagentsSupplies","doi":"10.1177/108705710501000111","DOIUrl":"https://doi.org/10.1177/108705710501000111","url":null,"abstract":"division. This antibody is targeted against human cyclophilin A, which is thought to play an important role in the mechanism of protein folding. Non-animal-based and in vitro–generated recombinant antibodies are new to the research markets and seem to have several advantages over traditional antibodies. They can be generated within 8 weeks from only a minimum amount of protein, DNA, or peptide. In addition, in vitro–generated antibodies allow for high-throughput production, thus facilitating the development of novel array platforms.","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"10 1","pages":"80 - 84"},"PeriodicalIF":0.0,"publicationDate":"2005-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/108705710501000111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65309304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Product Focus 产品集中
Q2 Chemistry Pub Date : 2004-12-01 DOI: 10.1177/1087057104272442
and cosmids kept in almost all known media types. Robots perform a series of plate and tube actions that transfer compounds from their original source plate locations to desired destination plate locations for particular screens, providing up to 20,000 picks per day. Housed in a cold-room environment, the MatriStore system operates at –20 °C, with storage capacity from 750,000 to 40 million compounds. Orders are submitted and the status of pending requests verified through an intuitive graphical user interface.
宇宙存在于几乎所有已知的介质类型中。机器人执行一系列板和管动作,将化合物从原始板位置转移到特定屏幕所需的目标板位置,每天可提供多达20,000次拾取。MatriStore系统位于冷室环境中,工作温度为-20°C,存储容量为75万至4000万化合物。通过直观的图形用户界面提交订单并验证待处理请求的状态。
{"title":"Product Focus","authors":"","doi":"10.1177/1087057104272442","DOIUrl":"https://doi.org/10.1177/1087057104272442","url":null,"abstract":"and cosmids kept in almost all known media types. Robots perform a series of plate and tube actions that transfer compounds from their original source plate locations to desired destination plate locations for particular screens, providing up to 20,000 picks per day. Housed in a cold-room environment, the MatriStore system operates at –20 °C, with storage capacity from 750,000 to 40 million compounds. Orders are submitted and the status of pending requests verified through an intuitive graphical user interface.","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"9 1","pages":"737 - 740"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1087057104272442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65306656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
People Changing Places 人们换地方
Q2 Chemistry Pub Date : 2004-12-01 DOI: 10.4324/9781351117623
Isabelle Côté
{"title":"People Changing Places","authors":"Isabelle Côté","doi":"10.4324/9781351117623","DOIUrl":"https://doi.org/10.4324/9781351117623","url":null,"abstract":"","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"9 1","pages":"742 - 742"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70461595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
2002 Meetings Calendar 2002年会议日程表
Q2 Chemistry Pub Date : 2002-02-01 DOI: 10.1089/10870570252906648
{"title":"2002 Meetings Calendar","authors":"","doi":"10.1089/10870570252906648","DOIUrl":"https://doi.org/10.1089/10870570252906648","url":null,"abstract":"","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"7 1","pages":"100 - 101"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60620793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From the Desk of the SBS Executive Director. 来自SBS执行主任的办公桌。
Q2 Chemistry Pub Date : 2001-12-01 DOI: 10.1089/108705701753364850
C. Giordano
{"title":"From the Desk of the SBS Executive Director.","authors":"C. Giordano","doi":"10.1089/108705701753364850","DOIUrl":"https://doi.org/10.1089/108705701753364850","url":null,"abstract":"","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"6 6 1","pages":"363-4"},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60621120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2001-2002 Meetings Calendar 2001-2002年会议日历
Q2 Chemistry Pub Date : 2001-10-01 DOI: 10.1089/10870570152488473
{"title":"2001-2002 Meetings Calendar","authors":"","doi":"10.1089/10870570152488473","DOIUrl":"https://doi.org/10.1089/10870570152488473","url":null,"abstract":"","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"6 1","pages":"357 - 357"},"PeriodicalIF":0.0,"publicationDate":"2001-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60620839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Male caregivers of spouses with Alzheimer's disease: risk factors and health status. 老年痴呆症患者配偶的男性照顾者:风险因素和健康状况。
Q2 Chemistry Pub Date : 2001-05-01 DOI: 10.1177/153331750101600308
H A Shanks-McElroy, J Strobino

Caregiving for persons with Alzheimer's disease (AD) has been shown to pose a challenge to the health of the spousal caregiver. Because most of the caregiving literature focuses on the female caregiver, there is some question about the generalizability of such literature to the male caregiver. This report focuses on male caregivers of spouses with AD and represents a subsample from a larger descriptive study that examined the relationship between risk factors and the health status of spousal caregivers. Twenty-nine male caregivers affiliated with Alzheimer's organizations in Pennsylvania and Ontario, Canada, returned mail surveys. On average, physical health symptoms increased by one-third when comparing pre- and post-caregiving data. Caregivers also were experiencing moderate to severe depression and burden. Male caregivers generally rated their physical health as fair to excellent and exhibited fewer than expected physical health symptoms. Caregiver health was related to perceptions of stress surrounding the provision of activities of daily living (ADL) assistance, the frequency of behavioral problems, perceptions of stress associated with the AD spouse's dysfunctional behaviors, and satisfaction with leisure opportunities. The identification of the role that caregiver perceptions of stressfulness associated with caregiving and the need for leisure satisfaction offer important implications for community-based education and respite services to maintain health status for spousal caregivers.

事实证明,照顾阿尔茨海默病患者(AD)对配偶照顾者的健康构成挑战。由于大多数护理文献都侧重于女性护理者,因此这些文献对男性护理者的普适性存在一些疑问。本报告的重点是患有注意力缺失症的配偶的男性护理者,是一项大型描述性研究的子样本,该研究考察了风险因素与配偶护理者健康状况之间的关系。宾夕法尼亚州和加拿大安大略省阿尔茨海默氏症组织的 29 名男性护理人员寄回了邮件调查表。护理前和护理后的数据相比,身体健康症状平均增加了三分之一。护理人员还经历了中度到重度抑郁和负担。男性照护者一般将自己的身体健康状况评为一般到优秀,并表现出比预期更少的身体健康症状。照顾者的健康状况与提供日常生活活动(ADL)帮助的压力感知、行为问题的发生频率、与注意力缺失症配偶的功能失调行为相关的压力感知以及对休闲机会的满意度有关。研究发现,照顾者对与照顾相关的压力的感知以及对休闲满意度的需求,对基于社区的教育和临时服务以保持配偶照顾者的健康状况具有重要意义。
{"title":"Male caregivers of spouses with Alzheimer's disease: risk factors and health status.","authors":"H A Shanks-McElroy, J Strobino","doi":"10.1177/153331750101600308","DOIUrl":"10.1177/153331750101600308","url":null,"abstract":"<p><p>Caregiving for persons with Alzheimer's disease (AD) has been shown to pose a challenge to the health of the spousal caregiver. Because most of the caregiving literature focuses on the female caregiver, there is some question about the generalizability of such literature to the male caregiver. This report focuses on male caregivers of spouses with AD and represents a subsample from a larger descriptive study that examined the relationship between risk factors and the health status of spousal caregivers. Twenty-nine male caregivers affiliated with Alzheimer's organizations in Pennsylvania and Ontario, Canada, returned mail surveys. On average, physical health symptoms increased by one-third when comparing pre- and post-caregiving data. Caregivers also were experiencing moderate to severe depression and burden. Male caregivers generally rated their physical health as fair to excellent and exhibited fewer than expected physical health symptoms. Caregiver health was related to perceptions of stress surrounding the provision of activities of daily living (ADL) assistance, the frequency of behavioral problems, perceptions of stress associated with the AD spouse's dysfunctional behaviors, and satisfaction with leisure opportunities. The identification of the role that caregiver perceptions of stressfulness associated with caregiving and the need for leisure satisfaction offer important implications for community-based education and respite services to maintain health status for spousal caregivers.</p>","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"12 1","pages":"167-75"},"PeriodicalIF":0.0,"publicationDate":"2001-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10833828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87384563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2001 Meetings Calendar 2001年会议日历
Q2 Chemistry Pub Date : 2001-02-01 DOI: 10.1089/108705701300362764
{"title":"2001 Meetings Calendar","authors":"","doi":"10.1089/108705701300362764","DOIUrl":"https://doi.org/10.1089/108705701300362764","url":null,"abstract":"","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"6 1","pages":"59 - 59"},"PeriodicalIF":0.0,"publicationDate":"2001-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60620716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Biomolecular Screening
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1