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Effects of Caffeine on Time Trial Performance and Associated Physiological Responses: A Meta-Analysis 咖啡因对计时赛成绩及相关生理反应的影响:Meta分析
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2019-06-01 DOI: 10.1089/CAFF.2019.0003
M. Glaister, Gavin Moir
Background: The aim of this study was to conduct a systematic review and meta-analysis on the effects of caffeine supplementation on time trial performance and associated physiological responses. M...
背景:本研究的目的是对补充咖啡因对时间试验表现和相关生理反应的影响进行系统综述和荟萃分析。M
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引用次数: 6
Academic Achievement, Stress, and Energy Drink Consumption Among Middle School Youth 中学生的学业成就、压力与能量饮料消耗
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2019-03-15 DOI: 10.1089/CAFF.2018.0011
S KreitzbergDaniel, M GolaszewskiNatalie, LuddenAlison Bryant, LoukasAlexandra, E PaschKeryn
Background: Many early adolescents regularly consume energy drinks (EDs); however, little is known about the associated academic and psychosocial factors. The aim of this study was to examine assoc...
背景:许多早期青少年经常饮用能量饮料;然而,人们对相关的学术和社会心理因素知之甚少。本研究的目的是检验相关的。。。
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引用次数: 5
Assessing the Utility of a Brief Abstinence Test for Initiating Caffeine Abstinence 评估简短节制测试对咖啡因节制的效用
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2019-03-15 DOI: 10.1089/CAFF.2018.0013
G. IronsJessica, T. JoachimBradley, B. StanleyTaylor, M. RiningerAshley, P. JarvisBrantley
Objective: This study investigated the efficacy of using a brief abstinence test (BAT) to initiate caffeine abstinence. Methods: Participants (n = 39) were undergraduate students who self-reported ...
目的:本研究探讨了使用短暂戒断试验(BAT)来启动咖啡因戒断的疗效。方法:参与者(n = 39)是自我报告。。。
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引用次数: 1
Gender Differences in Any-Source Caffeine and Energy Drink Use and Associated Adverse Health Behaviors. 任何来源咖啡因和能量饮料使用的性别差异及相关的不良健康行为。
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2019-03-01 Epub Date: 2019-03-14 DOI: 10.1089/caff.2018.0008
Pamela Dillon, Sydney Kelpin, Kenneth Kendler, Leroy Thacker, Danielle Dick, Dace Svikis

Background: The majority of college students report caffeine use with many using caffeine daily. Energy drink (ED) use, in particular, is common among college students, and numerous studies link these heavily caffeinated drinks to a variety of adverse consequences including substance use and risky behaviors. However, little is known about correlations between any-source caffeine use and other substance use and problems. The purpose of this study was to evaluate patterns of caffeine use and examine the relationships between caffeine, in general, and EDs specifically, and adverse health behaviors in college students. Methods: We used data from a longitudinal study of alcohol use and health-related outcomes to assess caffeine, alcohol, nonprescription drug, and tobacco use and symptoms of alcohol dependence in 1958 freshmen from a mid-Atlantic university during Fall 2012. We compared adverse health behaviors between caffeine users and nonusers and ED users and nonusers. Data were evaluated separately in men and women. Results: While women reported significantly more caffeine use than men, men reported more ED use. EDs, regardless of frequency of use, were associated with all adverse health behaviors, but only in female students. Similarly, daily any-source caffeine use was significantly associated with alcohol, nonprescription drug, and tobacco use in female students, but in men, the association was less robust. Conclusions: This research shows that caffeine use is prevalent among college students, and, in female students, is associated with alcohol, nonprescription drug, and tobacco use and alcohol dependence symptoms. Interventions aimed at promoting healthy behaviors may be especially useful in this population.

背景:大多数大学生报告咖啡因的使用,许多人每天都在使用咖啡因。尤其是能量饮料(ED)的使用在大学生中很常见,许多研究将这些富含咖啡因的饮料与各种不良后果联系起来,包括物质使用和危险行为。然而,人们对任何来源的咖啡因使用与其他物质使用和问题之间的相关性知之甚少。本研究的目的是评估咖啡因的使用模式,并检查咖啡因(一般而言,特别是ED)与大学生不良健康行为之间的关系。方法:我们使用了一项关于酒精使用和健康相关结果的纵向研究的数据,评估了2012年秋季大西洋中部一所大学1958名新生的咖啡因、酒精、非处方药和烟草使用以及酒精依赖症状。我们比较了咖啡因使用者和非咖啡因使用者以及ED使用者和非使用者的不良健康行为。分别对男性和女性的数据进行评估。结果:虽然女性报告的咖啡因使用量明显多于男性,但男性报告的ED使用量更多。ED,无论使用频率如何,都与所有不良健康行为有关,但仅在女生中。同样,在女生中,每天任何来源的咖啡因使用与酒精、非处方药和烟草使用显著相关,但在男性中,这种关联不那么强烈。结论:这项研究表明,咖啡因的使用在大学生中很普遍,在女学生中,咖啡因与酒精、非处方药、吸烟和酒精依赖症状有关。旨在促进健康行为的干预措施可能对这一人群特别有用。
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引用次数: 19
Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen. 腺苷激酶缺乏增加对致癌物的易感性。
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2019-03-01 Epub Date: 2019-03-14 DOI: 10.1089/caff.2018.0019
Rkia El-Kharrag, Randy Owen, Detlev Boison

Background: Adenosine kinase (ADK) is a key regulator of hepatic metabolism. Its deficiency in the liver causes hepatic steatosis and methylation defects. In this study, we investigated whether reduced ADK expression affects the susceptibility of the liver to a carcinogen. Methods: We investigated ADK expression in samples from 11 liver cancer patients. We used transgenic Adk-tg mice with reduced hepatic ADK to study their susceptibility to a carcinogen. We exposed 45 Adk-tg and 21 wild-type (WT) mice to the carcinogen diethylnitrosamine (DEN) and the tumor promoter phenobarbital (PB) and examined the survival and body weight. Results: Seven of 11 patients with liver cancer had reduced ADK expression. A Kaplan-Meier survival curve showed a significantly increased mortality rate of DEN/PB-exposed Adk-tg mice compared with WT mice. Conclusions: Reduced hepatic ADK increases the susceptibility to the acute toxic effects of a carcinogen. Low hepatic ADK might be a risk factor and biomarker for cancer development.

背景:腺苷激酶(ADK)是肝脏代谢的关键调节因子。它在肝脏中的缺乏会导致肝脂肪变性和甲基化缺陷。在这项研究中,我们研究了ADK表达降低是否会影响肝脏对致癌物质的易感性。方法:对11例肝癌患者标本中ADK的表达进行检测。我们用肝脏ADK降低的转基因ADK -tg小鼠来研究它们对一种致癌物的易感性。我们将45只Adk-tg小鼠和21只野生型(WT)小鼠暴露于致癌物二乙基亚硝胺(DEN)和肿瘤促进剂苯巴比妥(PB)中,观察其存活率和体重。结果:11例肝癌患者中有7例ADK表达降低。Kaplan-Meier生存曲线显示,与WT小鼠相比,DEN/ pb暴露的Adk-tg小鼠死亡率显著增加。结论:肝脏ADK降低增加了对致癌物急性毒性作用的易感性。低肝ADK可能是癌症发展的危险因素和生物标志物。
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引用次数: 7
The Adenosine Hypothesis of Restless Legs Syndrome. 不宁腿综合征的腺苷假说。
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2019-03-01 Epub Date: 2019-03-14 DOI: 10.1089/caff.2019.0001
Sergi Ferré
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引用次数: 4
The Timeline Followback Reliably Assesses Caffeinated Alcohol Beverage Consumption and Outcomes: Caffeinated Alcoholic Beverages Increase Risk Timeline Followback可靠评估含咖啡因酒精饮料的消费和结果:含咖啡因酒精饮品增加风险
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2018-12-01 DOI: 10.1089/CAFF.2018.0003
Melissa M. Norberg, Amie R. Newins, Alastair Henry
Background: Daily diary studies have shown that caffeinated alcoholic beverages (CABs) are associated with more risk than consuming alcohol alone; however, daily diary studies are time intensive. T...
背景:每日日记研究表明,含咖啡因的酒精饮料(CABs)比单独饮酒的风险更高;然而,每天写日记是很费时间的。T…
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引用次数: 2
The Effect of Caffeine on the Neuropathological and Neurobehavioral Outcome in the Newborn Rat 咖啡因对新生大鼠神经病理和神经行为的影响
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2018-12-01 DOI: 10.1089/caff.2017.0036
Omar Abu-Sa’da, Edward A. Armstrong, Ori Scott, Oriana Shaw, Antoinette T. Nguyen, K. Shen, Po-Yin Cheung, Glen B Baker, J. Yager
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引用次数: 3
New Developments on the Adenosine Mechanisms of the Central Effects of Caffeine and Their Implications for Neuropsychiatric Disorders. 咖啡因中枢效应的腺苷机制及其对神经精神疾病的影响的新进展。
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2018-12-01 Epub Date: 2018-12-07 DOI: 10.1089/caff.2018.0017
Sergi Ferré, Manuel Díaz-Ríos, John D Salamone, Rui Daniel Prediger

Recent studies on interactions between striatal adenosine and dopamine and one of its main targets, the adenosine A2A receptor-dopamine D2 receptor (A2AR-D2R) heteromer, have provided a better understanding of the mechanisms involved in the psychostimulant effects of caffeine and have brought forward new data on the mechanisms of operation of classical orthosteric ligands within G protein-coupled receptor heteromers. The striatal A2AR-D2R heteromer has a tetrameric structure and forms part of a signaling complex that includes a Gs and a Gi protein and the effector adenyl cyclase (subtype AC5). Another target of caffeine, the adenosine A1 receptor-dopamine D1 receptor (A1R-D1R) heteromer, seems to have a very similar structure. Initially suggested to be localized in the striatum, the A1R-D1R heteromer has now been identified in the spinal motoneuron and shown to mediate the spinally generated caffeine-induced locomotion. In this study, we review the recently discovered properties of A2AR-D2R and A1R-D1R heteromers. Our studies demonstrate that these complexes are a necessary condition to sustain the canonical antagonistic interaction between a Gs-coupled receptor (A2AR or D1R) and a Gi-coupled receptor (D2R or A1R) at the adenylyl cyclase level, which constitutes a new concept in the field of G protein-coupled receptor physiology and pharmacology. A2AR antagonists targeting the striatal A2AR-D2R heteromer are already being considered as therapeutic agents in Parkinson's disease. In this study, we review the preclinical evidence that indicates that caffeine and A2AR antagonists could be used to treat the motivational symptoms of depression and attention-deficit/hyperactivity disorder, while A1R antagonists selectively targeting the spinal A1R-D1R heteromer could be used in the recovery of spinal cord injury.

近年来对纹状体腺苷与多巴胺及其主要靶点之一腺苷A2A受体-多巴胺D2受体(A2AR-D2R)异聚体相互作用的研究,使我们对咖啡因的精神兴奋作用机制有了更好的了解,并对G蛋白偶联受体异聚体中经典正位配体的作用机制提供了新的数据。纹状体A2AR-D2R异聚体具有四聚体结构,是信号复合体的一部分,该复合体包括Gs和Gi蛋白以及效应腺苷环化酶(亚型AC5)。咖啡因的另一个目标,腺苷A1受体-多巴胺D1受体(A1R-D1R)异聚体,似乎有着非常相似的结构。A1R-D1R异聚体最初被认为定位于纹状体,现在已经在脊髓运动神经元中被发现,并被证明介导脊髓产生的咖啡因诱导的运动。本文综述了近年来发现的A2AR-D2R和A1R-D1R异构体的性质。我们的研究表明,这些复合物是维持gs偶联受体(A2AR或D1R)与gi偶联受体(D2R或A1R)在腺苷酸环化酶水平上的典型拮抗相互作用的必要条件,构成了G蛋白偶联受体生理学和药理学领域的新概念。针对纹状体A2AR- d2r异构体的A2AR拮抗剂已经被认为是帕金森病的治疗药物。在本研究中,我们回顾了临床前证据,表明咖啡因和A2AR拮抗剂可用于治疗抑郁症和注意缺陷/多动障碍的动机症状,而选择性靶向脊髓A1R- d1r异构体的A1R拮抗剂可用于脊髓损伤的恢复。
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引用次数: 33
Correlates of Alcohol Mixed with Energy Drink Use Among First Year College Students: Clinical and Research Implications. 大学一年级学生使用酒精混合能量饮料的相关因素:临床和研究意义
IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2018-09-01 DOI: 10.1089/caff.2018.0004
John G Spangler, Euyoung Y Song, Kathleen L Egan, Kimberly G Wagoner, Beth A Reboussin, Mark Wolfson, Erin L Sutfin

Background: Alcohol mixed with energy drink (AmED) use among college students is associated with specific adverse effects (e.g., sexual assault, driving while intoxicated). This study offered the opportunity to evaluate correlates of past year AmED use in a large sample of college students. Methods: In autumn 2010, emails were sent to all first year students (n = 29,536) at 11 colleges and universities in North Carolina and Virginia, inviting them to participate in a brief web-based survey to be used to establish a cohort for the parent tobacco use study; 10,340 (35%) students responded to the web-based survey, which elicited items on demographics, past year use of AmED, and other health behaviors. Results: Past year of AmED was reported by 29.4% of students. Logistic regression analysis revealed that female gender (adjusted odds ratios [AOR] = 1.28, 95% confidence interval [CI] = 1.16-1.42); ever use of smokeless tobacco (AOR = 3.51, 95% CI = 3.00-4.10); current smoking (AOR = 4.97, 95% CI = 4.34-5.69); 2 or fewer days of physical activity per week (AOR = 1.16, 95% CI = 1.04-1.28); and 7 or 8 hours of sleep per day (AOR = 1.12, 95% CI = 1.02-1.24) predicted risk of past year use of AmED. Conclusions: Nearly a third of first year college students reported past year use of AmED. Our finding of increased past year use of AmED use among women is new and might reflect the changing epidemiology of female college alcohol use. Of additional concern, such use might also reflect targeted marketing to women by the energy drink industry. Findings can guide future research as well as substance counseling to college students.

背景:大学生使用酒精混合能量饮料(AmED)与特定的不良影响(如性侵犯、醉酒驾驶)有关。本研究提供了一个机会,以评估大样本大学生在过去一年中使用混合能量饮料的相关性。研究方法2010年秋季,向北卡罗来纳州和弗吉尼亚州11所高校的所有一年级新生(n = 29,536)发送了电子邮件,邀请他们参加一项简短的网络调查,该调查将用于建立家长烟草使用研究的队列;10,340名学生(35%)对网络调查做出了回应,调查内容包括人口统计学、过去一年AmED的使用情况以及其他健康行为。调查结果显示29.4%的学生报告过去一年使用过 AmED。逻辑回归分析显示,女性(调整赔率 [AOR] = 1.28,95% 置信区间 [CI] = 1.16-1.42)、曾经使用无烟烟草(AOR = 3.51,95% CI = 3.00-4.10)、目前吸烟(AOR = 4.97,95% CI = 4.34-5.69);每周体育活动 2 天或少于 2 天(AOR = 1.16,95% CI = 1.04-1.28);每天睡眠 7 或 8 小时(AOR = 1.12,95% CI = 1.02-1.24)可预测过去一年使用 AmED 的风险。结论近三分之一的大学一年级学生报告过去一年使用过 AmED。我们发现女性在过去一年中使用氨苯喋啶的情况有所增加,这是一项新发现,可能反映了女大学生饮酒流行病学的变化。更值得关注的是,这种使用也可能反映了能量饮料行业对女性的定向营销。研究结果可以指导未来的研究以及对大学生的物质咨询。
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引用次数: 0
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Journal of Caffeine and Adenosine Research
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