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Evaluation of ventricular pacing suppression algorithms in dual chamber pacemaker: Results of “LEADER” study 评估双腔起搏器的心室起搏抑制算法:LEADER "研究结果
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-16 DOI: 10.1002/joa3.13117
Jongmin Hwang MD, Seongwook Han MD, Hyoung-Seob Park MD, Tae-Wan Chung MD, Minsu Jung MD, Seung-Jung Park MD, Chan-Hee Lee MD, Jin Hee Ahn MD, Eue-Keun Choi MD, Myung Hwan Bae MD, Young Soo Lee MD, Sang Won Park MD, Dae In Lee MD, Yoo-Ri Kim MD, Min-Soo Ahn MD, Jaemin Shim MD

Background

There is limited research on the intra-individual efficacy of ventricular pacing minimization algorithms developed by Biotronik—the Ventricular Pace Suppression algorithm (VpS) and the Intrinsic Rhythm Support plus algorithm (IRSplus) (BIOTRONIK SE & Co. KG, Berlin, Germany). We performed a randomized pilot trial that evaluated the efficacy of two algorithms in patients with symptomatic sinus node dysfunction (SND) who received a dual-chamber pacemaker.

Methods

The trial was conducted in 11 tertiary hospitals in South Korea. The patients were randomized to either the VpS or IRSplus algorithm group after a 3-month period of fixed atrioventricular (AV) delay. The primary outcome was the ventricular pacing percentage (Vp%) at each follow-up visit. The secondary outcomes were the occurrence of heart failure (HF) and atrial fibrillation (AF) during the study period.

Results

Data from 131 patients were analyzed. Initially, their average Vp% over 3 months with a fixed AV interval was 14.1 ± 19.4%. Patients were randomly assigned to VpS and IRSplus groups, with 66 and 65 in each. Algorithms reduced average Vp% to 4.0 ± 11.3% at 9 months and 6.7 ± 14.9% at 15 months. These algorithms were more effective for patients with paced AV delay (PAVD) ≤300 ms compared to those with PAVD >300 ms. Both algorithms were equally effective in reducing Vp%. Clinical AF or HF hospitalization was not observed during the study period.

Conclusion

The VpS and IRSplus algorithms are effective and safe in minimizing unnecessary ventricular pacing in patients with SND.

关于百多力公司开发的心室起搏最小化算法--心室起搏抑制算法(VpS)和本征节律支持附加算法(IRSplus)(BIOTRONIK SE & Co. KG,德国柏林)--的个体内部疗效的研究十分有限。我们进行了一项随机试验,评估了两种算法对接受双腔起搏器治疗的无症状窦房结功能障碍(SND)患者的疗效。患者在固定房室(AV)延迟 3 个月后被随机分配到 VpS 或 IRSplus 算法组。主要结果是每次随访时的心室起搏率(Vp%)。研究分析了 131 名患者的数据。最初,在房室间隔固定的情况下,3 个月的平均 Vp% 为 14.1 ± 19.4%。患者被随机分配到 VpS 组和 IRSplus 组,每组分别有 66 人和 65 人。在 9 个月和 15 个月时,算法将平均 Vp% 分别降至 4.0 ± 11.3% 和 6.7 ± 14.9%。与起搏房室延迟(PAVD)大于 300 毫秒的患者相比,这些算法对起搏房室延迟(PAVD)小于 300 毫秒的患者更有效。两种算法在降低 Vp% 方面同样有效。VpS和IRSplus算法在减少SND患者不必要的心室起搏方面既有效又安全。
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引用次数: 0
Vitamin D as a predictor of clinical response among patients with cardiac resynchronization therapy (CRT) 预测心脏再同步化疗法(CRT)患者临床反应的维生素 D
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-16 DOI: 10.1002/joa3.13116
Phuuwadith Wattanachayakul MD, Thitiphan Srikulmontri MD, Vitchapong Prasitsumrit MD, Thanathip Suenghataiphorn MD, Pojsakorn Danpanichkul MD, Natchaya Polpichai MD, Sakditad Saowapa MD, Abiodun Idowu MD, Aman Amanullah MD

Introduction

Cardiovascular and noncardiovascular comorbidities have been recognized as predictors of clinical response in patients receiving cardiac resynchronization therapy (CRT). However, data on vitamin D as a predictor of CRT response are conflicting.

Method

We identified studies from MEDLINE and Embase databases, searching from inception to May 2024, to investigate the association between 25-OH vitamin D levels before CRT implantation and outcomes. Studies had to report 25-OH vitamin D levels or the proportion of patients with vitamin D insufficiency and categorize outcomes as CRT responders or nonresponders. We extracted mean 25-OH vitamin D and standard deviations for both groups from each study and calculated the pooled mean difference (MD). We also retrieved risk ratios, and 95% confidence intervals (CIs) for the association between vitamin D insufficiency and lack of CRT response, combining them using the generic inverse variance method.

Results

Our meta-analysis included four studies. CRT responders had higher levels of 25-OH vitamin D than nonresponders, with a pooled MD of 8.04 ng/mL (95% CI: 3.16–12.93; I2 = 48%, p < .001). Patients with vitamin D insufficiency before implantation had higher odds of lacking response to CRT, with a pooled RR of 3.28 (95% CI: 1.43–7.50; I2 = 0%, p = .005) compared to those with normal vitamin D.

Conclusions

CRT responders had higher 25-OH vitamin D levels compared to nonresponders. Vitamin D insufficiency was associated with a higher risk of nonresponse to CRT. These findings highlight the importance of monitoring and managing vitamin D levels in these patients.

心血管和非心血管合并症已被认为是预测接受心脏再同步化治疗(CRT)患者临床反应的因素。我们从 MEDLINE 和 Embase 数据库中确定了从开始到 2024 年 5 月的研究,以调查 CRT 植入前 25-OH 维生素 D 水平与预后之间的关系。研究必须报告25-OH维生素D水平或维生素D不足患者的比例,并将结果分为CRT应答者和非应答者。我们从每项研究中提取了两组患者的 25-OH 维生素 D 平均值和标准差,并计算了汇总平均差 (MD)。我们还检索了维生素 D 不足与缺乏 CRT 反应之间的风险比和 95% 置信区间 (CI),并使用通用逆方差法将其合并。与无反应者相比,CRT 反应者的 25-OH 维生素 D 水平更高,汇总的 MD 为 8.04 ng/mL(95% CI:3.16-12.93;I2 = 48%,p < .001)。与维生素D正常的患者相比,植入前维生素D不足的患者对CRT缺乏反应的几率更高,汇总RR为3.28 (95% CI: 1.43-7.50; I2 = 0%, p = .005)。维生素D不足与CRT无反应的风险较高有关。这些发现强调了监测和管理这些患者维生素 D 水平的重要性。
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引用次数: 0
Current status of wearable cardioverter-defibrillator use in Japan 日本可穿戴式心律转复除颤器的使用现状
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-14 DOI: 10.1002/joa3.13113
Reina Tonegawa-Kuji MD, PhD, Taku Nishida MD, PhD, Yoko Sumita, Yoshihiro Miyamoto MD, PhD, Koshiro Kanaoka MD, PhD

Background

The current status of wearable cardiovascular defibrillators (WCD) use in Japan is unclear.

Methods

Using a nationwide claims database of Japan, we assessed characteristics of patients using WCD and factors influencing subsequent implantable cardioverter-defibrillator (ICD) implantation.

Results

In 1049 cases, those with prior cardiopulmonary arrest (CPA) or ventricular arrhythmia, cardiomyopathy, or device-related issues were more likely to require permanent ICDs, whereas females were less likely.

Conclusions

Prior CPA or fatal arrhythmia, underlying cardiomyopathy, or device-related issues were associated with future permanent ICD implantation. These findings offer insights into the current status of WCD use in Japan.

我们利用日本全国范围的理赔数据库,评估了使用可穿戴式心血管除颤器(WCD)患者的特征以及影响后续植入式心律转复除颤器(ICD)的因素。在 1049 个病例中,有心肺骤停(CPA)或室性心律失常、心肌病或设备相关问题的患者更有可能需要永久性 ICD,而女性患者的可能性较低。这些研究结果为了解日本 WCD 的使用现状提供了参考。
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引用次数: 0
SVT quest: The adventure diagnosing narrow QRS tachycardia SVT 探索:窄 QRS 心动过速的诊断探险
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-11 DOI: 10.1002/joa3.13112
Koichi Nagashima MD, PhD, Gregory F. Michaud MD, Reginald T. Ho MD, Yasuo Okumura MD, PhD

In the field of cardiac electrophysiology, there is a universal desire: the discovery of a flawless diagnostic maneuver for supraventricular tachycardias (SVTs). This is not merely a wish but a shared odyssey. To improve diagnostic accuracy and achieve sufficient sensitivity and specificity, numerous diagnostic maneuvers have been proposed. However, each has its limitations and prompts a search for new diagnostic techniques. This continuous cycle of discovery and refinement, which we titled “SVT Quest” is reviewed in chronological sequence. This adventure in diagnosing narrow QRS tachycardia unfolds in 3 steps: Step 1 involves differentiating atrial tachycardia from other SVTs based on the observations such as V-A-V or V-A-A-V response, ΔAA interval, VA linking, the last entrainment sequence, and response to the atrial extrastimulus. Step 2 focuses on differentiating orthodromic reciprocating tachycardia from atrioventricular nodal reentrant tachycardia based on the observations such as tachycardia reset upon the premature ventricular contraction during His refractoriness, uncorrected/corrected postpacing interval, differential ventricular entrainment, orthodromic His capture, transition zone analysis, and total pacing prematurity. Step 3 characterizes the concealed nodoventricular/nodofascicular pathway and His-ventricular pathway-related tachycardia based on observations such as V-V-A response, ΔatrioHis interval, and paradoxical reset phenomenon. There is no single diagnostic maneuver that fits all scenarios. Therefore, the ability to apply multiple maneuvers in a case allows the operator to accumulate evidence to make a likely diagnosis. Let's embark on this adventure!

在心脏电生理学领域,有一个普遍的愿望:发现一种完美无瑕的室上性心动过速(SVT)诊断方法。这不仅仅是一个愿望,更是一项共同的奥德赛。为了提高诊断准确性并达到足够的灵敏度和特异性,人们提出了许多诊断方法。然而,每种方法都有其局限性,并促使人们寻找新的诊断技术。我们按时间顺序回顾了这一不断发现和改进的循环,并将其命名为 "SVT 探索"。窄 QRS 心动过速的诊断过程分为三个步骤:第 1 步是根据 V-A-V 或 V-A-A-V 反应、ΔAA 间期、VA 连接、最后的夹带序列以及对心房外刺激的反应等观察结果,将房性心动过速与其他 SVT 区分开来。步骤 2 的重点是根据 His 折返时室性早搏引起的心动过速复位、未校正/校正后起搏间期、心室不同的夹带、正交 His 捕获、过渡区分析和总起搏过早等观察结果,区分正交往复性心动过速和房室结复张性心动过速。步骤 3 根据 V-V-A 反应、ΔatrioHis 间期和矛盾复位现象等观察结果,确定隐藏的结/结筋膜通路和 His-心室通路相关心动过速的特征。没有一种诊断方法适用于所有情况。因此,在一个病例中应用多种方法的能力可以让操作员积累证据,做出可能的诊断。让我们开始这次探险吧!
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引用次数: 0
Paradoxical generator impedance behavior during catheter ablation in a patient with severe polycythemia 一名重度多血症患者在导管消融过程中出现的反常发电机阻抗行为
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-10 DOI: 10.1002/joa3.13115
Takayuki Sekihara MD, Tomoaki Nakano MD, Akira Yoshida MD, PhD, Takafumi Oka MD, PhD, Yasushi Sakata MD, PhD

An extremely high generator impedance in the blood pool can be observed in a patient with severe polycythemia. However, ablation can be performed safely as long as the generator impedance during contact with the myocardial tissue is within acceptable limits.

在严重多血症患者的血池中可观察到极高的发生器阻抗。不过,只要发生器与心肌组织接触时的阻抗在可接受的范围内,消融手术就可以安全进行。
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引用次数: 0
Cubital vein access provides a practical alternative to internal jugular vein access for coronary sinus catheter placement 在冠状窦导管置入方面,枕静脉入路是颈内静脉入路的实用替代方案
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-07 DOI: 10.1002/joa3.13110
Haruwo Tashiro MD, Ken Terata MD, PhD, Ryosuke Kato MD, Hiyu Wakabayashi MD, Hidehiro Iwakawa MD, PhD, Hiroyuki Watanabe MD, PhD

Background

Insertion of electrode catheters into the coronary sinus (CS) through the right internal jugular vein (RIJV) carries risks of pneumothorax and severe hematoma formation. This study was performed to compare the safety and feasibility of catheterization through the left cubital superficial vein versus the RIJV.

Methods

This prospective nonrandomized study involved consecutive patients who underwent catheter ablation from September 2021 to February 2023. Blind puncture techniques were used in the left cubital vein group; ultrasound-guided insertion was performed in the RIJV group. The success rates of sheath insertion and CS catheterization, the procedure and fluoroscopy times of CS cannulation, and complications were compared between groups.

Results

The left cubital vein group comprised 152 patients, and the RIJV group comprised 58 patients. The sheath insertion success rate was significantly lower in the cubital vein group than in the RIJV group (84.9% vs 100%, respectively; p = .0008). In the cubital vein group, blind puncture attempts failed in 20 patients; three patients developed guidewire-induced venous injury. One arterial puncture occurred in the RIJV group. After successful sheath insertion, no significant differences were observed in the CS cannulation success rate (97% vs 100%, p = .55), procedure time (median [range], 93 [51–174] vs 74 [44–129] s; p = .19), or fluoroscopy time (median [range], 66 [36–134] vs 48 [30–92] s; p = .17). No serious complications requiring procedural discontinuation occurred.

Conclusion

The left cubital vein approach is practical, offering a viable alternative to the RIJV approach.

通过右侧颈内静脉(RIJV)将电极导管插入冠状窦(CS)存在气胸和严重血肿形成的风险。这项前瞻性非随机研究涉及 2021 年 9 月至 2023 年 2 月期间接受导管消融术的连续患者。左眶静脉组采用盲穿技术;RIJV组在超声引导下插入导管。两组患者的鞘插入成功率和CS导管插入成功率、CS插管过程和透视时间以及并发症进行了比较。立方静脉组的鞘插入成功率明显低于 RIJV 组(分别为 84.9% vs 100%;P = 0.0008)。在立方静脉组中,20 名患者的盲穿刺尝试失败;3 名患者出现导丝引起的静脉损伤。RIJV 组发生了一次动脉穿刺。成功插入鞘管后,CS 插管成功率(97% vs 100%,P = .55)、手术时间(中位数[范围],93 [51-174] 秒 vs 74 [44-129] 秒;P = .19)或透视时间(中位数[范围],66 [36-134] 秒 vs 48 [30-92] 秒;P = .17)均无明显差异。左侧肘静脉入路非常实用,是 RIJV 入路的可行替代方案。
{"title":"Cubital vein access provides a practical alternative to internal jugular vein access for coronary sinus catheter placement","authors":"Haruwo Tashiro MD,&nbsp;Ken Terata MD, PhD,&nbsp;Ryosuke Kato MD,&nbsp;Hiyu Wakabayashi MD,&nbsp;Hidehiro Iwakawa MD, PhD,&nbsp;Hiroyuki Watanabe MD, PhD","doi":"10.1002/joa3.13110","DOIUrl":"10.1002/joa3.13110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Insertion of electrode catheters into the coronary sinus (CS) through the right internal jugular vein (RIJV) carries risks of pneumothorax and severe hematoma formation. This study was performed to compare the safety and feasibility of catheterization through the left cubital superficial vein versus the RIJV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective nonrandomized study involved consecutive patients who underwent catheter ablation from September 2021 to February 2023. Blind puncture techniques were used in the left cubital vein group; ultrasound-guided insertion was performed in the RIJV group. The success rates of sheath insertion and CS catheterization, the procedure and fluoroscopy times of CS cannulation, and complications were compared between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The left cubital vein group comprised 152 patients, and the RIJV group comprised 58 patients. The sheath insertion success rate was significantly lower in the cubital vein group than in the RIJV group (84.9% vs 100%, respectively; <i>p</i> = .0008). In the cubital vein group, blind puncture attempts failed in 20 patients; three patients developed guidewire-induced venous injury. One arterial puncture occurred in the RIJV group. After successful sheath insertion, no significant differences were observed in the CS cannulation success rate (97% vs 100%, <i>p</i> = .55), procedure time (median [range], 93 [51–174] vs 74 [44–129] s; <i>p</i> = .19), or fluoroscopy time (median [range], 66 [36–134] vs 48 [30–92] s; <i>p</i> = .17). No serious complications requiring procedural discontinuation occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The left cubital vein approach is practical, offering a viable alternative to the RIJV approach.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"40 4","pages":"991-997"},"PeriodicalIF":2.2,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.13110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing out-of-hospital cardiac arrest with current technology advances: Breaking the deadlock with a mobile network 利用当前的技术进步解决院外心脏骤停问题:利用移动网络打破僵局
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-04 DOI: 10.1002/joa3.13103
Meiso Hayashi MD, PhD, Yu-ki Iwasaki MD, PhD

Out-of-hospital cardiac arrest (OHCA) is a global public health problem, with survival rates remaining low at around 10% or less despite widespread cardiopulmonary resuscitation (CPR) training and availability of automated external defibrillators (AEDs). This is partly due to the challenges of knowing when and where a sudden OHCA occurs and where the nearest AED is located. In response, countries around the world have begun to use network technology-based smartphone applications. These applications are activated by emergency medical service dispatchers and alert preregistered volunteer first responders (VFRs) to nearby OHCAs using Global Positioning System localization. Accumulating evidence, although mostly from observational studies, shows their effectiveness in increasing the rate of bystander CPR, defibrillation, and patient survival. Current guidelines recommend the use of these VFR alerting systems, and the results of ongoing randomized trials are awaited for further dissemination. This article also proposed the concept of a life-saving mobile network (LMN), which uses opportunistic network and wireless sensor network technologies to create a dynamic mesh network of potential victims, rescuers, and defibrillators. The LMN works by detecting a fatal arrhythmia with a wearable sensor device, localizing the victim and the nearest AED with nearby smartphones, and notifying VFRs through peer-to-peer communication. While there are challenges and limitations to implementing the LMN in society, this innovative network technology would reduce the tragedy of sudden cardiac death from OHCA.

院外心脏骤停(OHCA)是一个全球性的公共卫生问题,尽管心肺复苏(CPR)培训和自动体外除颤器(AED)的普及率很高,但存活率仍然很低,大约只有 10%,甚至更低。这部分是由于很难知道突发 OHCA 的时间和地点,以及最近的自动体外除颤器在哪里。为此,世界各国已开始使用基于网络技术的智能手机应用程序。这些应用程序由紧急医疗服务调度员激活,并利用全球定位系统定位功能提醒预先注册的志愿急救人员(VFR)注意附近的心脏骤停患者。越来越多的证据(尽管大多来自观察性研究)表明,这些应用程序在提高旁观者心肺复苏率、除颤率和患者存活率方面非常有效。现行指南建议使用这些 VFR 警报系统,目前正在进行的随机试验结果有待进一步传播。这篇文章还提出了救生移动网络(LMN)的概念,它利用机会性网络和无线传感器网络技术创建了一个由潜在受害者、救援人员和除颤器组成的动态网状网络。LMN 的工作原理是利用可穿戴传感设备检测致命性心律失常,利用附近的智能手机定位受害者和最近的自动体外除颤器,并通过点对点通信通知自愿去纤颤器。虽然在社会中实施 LMN 还面临挑战和限制,但这一创新网络技术将减少 OHCA 导致心脏性猝死的悲剧。
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引用次数: 0
A case of a permanent form of junctional reciprocating tachycardia with negative linking on atrial differential pacing 一例永久性交界性往复性心动过速,对心房差频起搏有负面影响
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-03 DOI: 10.1002/joa3.13109
Keisuke Suzuki MD, PhD, Kosuke Aoki MD, Eiji Sato MD, PhD, Akihiko Ishida MD, Tetsuo Yagi MD, PhD

This case of PJRT shows negative linking on ventriculoatrial intervals after atrial differential pacing. Interpreting the results of atrial differential pacing may be challenging in cases where the pacing site affects retrograde conduction or when retrograde conduction is unstable.

这个 PJRT 病例显示,心房差频起搏后心室间期呈负向联系。在起搏部位影响逆行传导或逆行传导不稳定的情况下,解释心房差搏的结果可能具有挑战性。
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引用次数: 0
Effects of antiarrhythmic drug responsiveness and diagnosis-to-ablation time on outcomes after catheter ablation for persistent atrial fibrillation 抗心律失常药物反应性和诊断到消融时间对持续性心房颤动导管消融术后疗效的影响
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-02 DOI: 10.1002/joa3.13104
Hong-Ju Kim MD, Daehoon Kim MD, Kipoong Kim MS, Sung Hwa Choi MD, Moon-Hyun Kim MD, Je-Wook Park MD, Hee Tae Yu MD, Tae-Hoon Kim MD, Jae-Sun Uhm MD, Boyoung Joung MD, Moon-Hyoung Lee MD, Hui-Nam Pak MD

Background

The impact of delaying atrial fibrillation catheter ablation (AFCA) for antiarrhythmic drug (AAD) management on the disease course remains unclear. This study investigated AFCA rhythm outcomes based on the diagnosis-to-ablation time (DAT) and AAD responsiveness in participants with persistent AF (PeAF).

Methods

We included data from 1038 AAD-resistant PeAF participants, all of whom had a clear time point for AF diagnosis, especially PeAF at diagnosis time, and had undergone an AFCA for the first time. Participants who experienced recurrences of paroxysmal type on AAD therapy were analyzed as a cohort of AAD-partial responders; those maintaining PeAF on AAD were AAD-non-responders. We determined the DAT cutoff for best discriminating long-term rhythm outcomes using a maximum log-likelihood estimation method based on the Cox proportional hazard regression model.

Results

Of the participants (79.8% male; median age 61), 806 (77.6%) were AAD-non-responders. AAD-non-responders had a higher body mass index and a larger left atrial diameter than AAD-partial-responders. They also had a higher incidence of AF recurrence after AFCA (adjusted hazard ratio 1.75, 95% confidence interval 1.33–2.30; log-rank p < .001) compared to AAD-partial-responders. The maximum log-likelihood estimation showed bimodal cutoffs at 22 and 40 months. The optimal DAT cutoff rhythm outcome was 22 months, which discriminated better in the AAD-partial-responders than in the AAD-non-responders.

Conclusions

Both DAT and AAD responsiveness influenced AFCA rhythm outcomes. Delaying AFCA to a DAT of longer than 22 months was inadvisable, particularly in the participants in whom PeAF was changed to paroxysmal AF during AAD therapy.

延迟房颤导管消融(AFCA)以进行抗心律失常药物(AAD)治疗对疾病进程的影响仍不清楚。本研究调查了基于诊断到消融时间(DAT)和持续性房颤(PeAF)参与者的 AAD 反应性的 AFCA 节律结果。我们纳入了 1038 名 AAD 抗性 PeAF 参与者的数据,他们都有明确的房颤诊断时间点,尤其是在诊断时为 PeAF,并且首次接受了 AFCA。接受 AAD 治疗后出现阵发性复发的参试者作为 AAD 部分应答者队列进行分析;接受 AAD 治疗后 PeAF 仍然存在的参试者为 AAD 无应答者。我们使用基于 Cox 比例危险回归模型的最大对数似然估计法确定了最能区分长期心律转归的 DAT 临界值。在参与者(79.8% 为男性;中位年龄 61 岁)中,806 人(77.6%)为 AAD 无应答者。与AAD部分应答者相比,AAD未应答者的体重指数更高,左心房直径更大。与 AAD 部分应答者相比,他们在 AFCA 后的房颤复发率也更高(调整后危险比为 1.75,95% 置信区间为 1.33-2.30;对数秩 P < .001)。最大对数似然估计结果显示,在22个月和40个月时存在双峰截点。最佳的 DAT 切点节律结果是 22 个月,它对 AAD 部分应答者的鉴别优于 AAD 无应答者。AAD和AAD的反应性都会影响AFCA节律结果。将AFCA延迟到超过22个月的DAT是不可取的,尤其是在AAD治疗期间PeAF转变为阵发性房颤的参与者。
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引用次数: 0
A case of biatrial tachycardia involving the intercaval bundle with assumed dual loop reentry 一例假定为双环再入的涉及锁骨间束的双房性心动过速。
IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-06-28 DOI: 10.1002/joa3.13106
Takeshi Fujita MD, Masato Kawasaki MD, Takahisa Yamada MD, PhD, Tetsuya Watanabe MD, PhD, Masatake Fukunami MD, PhD

Epicardial connections provided the anatomical substrate for the biatrial reentry circuit. The connections between the right atrium and right pulmonary vein were called “intercaval bundle,” and there are few reports of atrial flutter related to this bundle. We present a case of a biatrial tachycardia, involving the intercaval bundle.

心外膜连接为心房再入电路提供了解剖基础。右心房和右肺静脉之间的连接被称为 "室间束",与该束有关的心房扑动报道很少。我们报告了一例涉及腔间束的房性心动过速病例。
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引用次数: 0
期刊
Journal of Arrhythmia
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