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Penijanacoranes A—F, Acorane-Type Sesquiterpenes from a Deep Sea-Derived Fungus Penicillium janthinellum SH0301
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-17 DOI: 10.1002/cjoc.202400836
Lu-Jia Yang, Ling Lv, Zhuang Han, Yu-Cheng Gu, Xin Li, Chang-Lun Shao, Zhi-Qing Liu, Chang-Yun Wang

Six new acorane-type sesquiterpenes, named penijanacoranes A—F (16), as well as one known eudesmane sesquiterpenoid 1α,6β,11-eudesm-triol (7) have been isolated from a deep-sea-derived fungus Penicillium janthinellum SH0301. Their structures and absolute configurations were established by the comprehensive spectroscopic analysis, TDDFT-ECD calculations, and X-ray diffraction. Penijanacorane A (1) was identified as a rare acorane-type sesquiterpene lactone featuring a novel 6/5/6 tricyclic system, while penijanacoranes E and F (5 and 6) represented undescribed examples of nor-acorane sesquiterpenes at C-1. Penijanacorane C (3) exhibited significant inhibitory activity against LPS-induced NO production in Raw264.7 macrophages with an IC50 value of 6.23 μM, which was more potent than that of positive control dexamethasone (IC50 = 11.49 μM). This study expanded the chemical diversity of acorane-type sesquiterpenoids and revealed that compound 3 was a potential molecule for anti-inflammatory agents.

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引用次数: 0
Ytterbium-Catalyzed Tandem Diels–Alder/Claisen Rearrangement/Decarboxylation of Hetero-Allenes for the Synthesis of Diarylmethanes 镱催化串联双分子- alder /Claisen重排/脱羧杂烯合成二芳基甲烷
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-17 DOI: 10.1002/cjoc.202400874
Bin Chen, Shan Zhong, Huilin Zhan, Zhangyu Han, Jianwei Sun, Hai Huang

A tandem Diels–Alder reaction/Claisen rearrangement/decarboxylation strategy of N-allenamides (or aryloxyallenes) with 3-alkoxycarbonyl-2-pyrones has been developed for the efficient synthesis of diarylmethanes with moderate to good yields. The reaction exhibits good functional group tolerance and can be applied to late-stage modifications of known drug molecules. Mechanistic studies indicate that the ester group at the 3-position of 2-pyrones is essential, and the initial Diels–Alder reaction between the 2-pyrones and the proximal C=C bond of the N-allenamides (or aryloxyallenes) is crucial for the success of the reaction.

我们开发了一种 N-烯酰胺(或芳氧基烯)与 3-烷氧羰基-2-吡喃酮的串联 Diels-Alder 反应/克莱森重排/脱羧策略,用于高效合成二芳基甲烷,产率为中等至良好。该反应具有良好的官能团耐受性,可用于已知药物分子的后期修饰。机理研究表明,2-吡喃酮 3 位上的酯基是必不可少的,而 2-吡喃酮与 N-烯酰胺(或芳氧基烯)近端 C=C 键之间最初的 Diels-Alder 反应是反应成功的关键。
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引用次数: 0
Catalytic Asymmetric Conjugate Addition and Allylic Substitution of Cyclobutenones with Arylzinc Halides 芳基卤化锌催化环丁烯酮的不对称共轭加成和烯丙基取代
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-17 DOI: 10.1002/cjoc.202400882
Renming Pan, Ping Lu

Conjugate addition and allylic substitution are two essential chemical transformations, and they could be competitive for substrates with multiple reactive sites. Herein, we report the diversified enantioselective synthesis of cyclobutenes via the functionalization of cyclobutenones. The conjugate addition of cyclobutenones with arylzinc halides provided enantioenriched cyclobutenes with all-carbon quaternary centers. On the other hand, when cyclobutenones with gem-dichloro groups were employed, a chemo- and enantioselective allylic substitution occurred. Further synthetic utility was demonstrated for synthesizing versatile cyclobutane derivatives, together with ring-opening and expansion products.

共轭加成和烯丙基取代是两种基本的化学转化,它们对于具有多个反应位点的底物具有竞争性。在此,我们报告了通过环丁烯酮的官能化合成环丁烯的多样化对映选择性。环丁烯酮与芳基卤化锌的共轭加成提供了具有全碳季中心的对映体环丁烯。另一方面,当环丁烯酮含有二氯基团时,会发生化学和对映体选择性烯丙基取代。在合成多功能环丁烷衍生物以及开环和扩环产物方面,我们还展示了进一步的合成用途。
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引用次数: 0
Tumor Cell-Specific Metabolic Labelling of Surface Sialoglycans and Post-Click with Multivalent Rhamnose Enable Precise Immune Killing by Endogenous Antibody 表面唾液聚糖的肿瘤细胞特异性代谢标记和多价鼠李糖的Post-Click实现内源性抗体的精确免疫杀伤
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-16 DOI: 10.1002/cjoc.202400855
Haofei Hong, Yanchun Li, Dan Li, Han Lin, Jie Zhao, Zheng Wang, Zhimeng Wu

We report the design and development of a β-glucuronidase (β-Glu)-responsive ManNAz derivative, Glu-AAM, for tumor-selective metabolic glycoengineering. Glu-AAM enables specific labeling of tumor cell surface sialoglycans in the presence of overexpressed β-Glu in cancer cells, including breast, leukemia, and colorectal cancer cells. We demonstrate the high selectivity and efficiency of Glu-AAM-mediated metabolic glycoengineering across multiple cancer cell lines. Furthermore, we synthesized multivalent antibody-recruiting molecules (DBCO-Rha) that can be covalently attached to the azido-modified tumor cell surface, leading to potent antibody-dependent cellular phagocytosis and complement-dependent cytotoxicity. The octameric DBCO-Rha8 construct exhibited the most effective immune response. This integrated strategy of β-Glu-responsive metabolic glycoengineering and antibody-recruiting immunotherapy provides a promising platform for targeted cancer therapies and expands the toolbox of metabolic glycoengineering for cancer immunotherapy.

我们报道了一种用于肿瘤选择性代谢糖工程的β-葡萄糖醛酸酶(β-Glu)响应ManNAz衍生物,glua - aam的设计和开发。Glu-AAM能够在乳腺癌、白血病和结直肠癌细胞中存在过表达的β-Glu的情况下特异性标记肿瘤细胞表面唾液聚糖。我们证明了葡萄糖aam介导的代谢糖工程在多种癌细胞系中的高选择性和高效率。此外,我们合成了多价抗体招募分子(DBCO-Rha),该分子可以共价附着在叠氮修饰的肿瘤细胞表面,导致有效的抗体依赖性细胞吞噬和补体依赖性细胞毒性。八聚体DBCO-Rha8构建体表现出最有效的免疫应答。这种β-葡萄糖反应性代谢糖工程和抗体招募免疫治疗的整合策略为靶向癌症治疗提供了一个有前途的平台,并扩展了代谢糖工程用于癌症免疫治疗的工具箱。
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引用次数: 0
An Intelligent Triple Assisted Gold Cluster-Based Nanosystem for Enhanced Tumor Photodynamic Therapy 用于增强肿瘤光动力治疗的智能三辅助金簇纳米系统
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-16 DOI: 10.1002/cjoc.202400837
Fangli Gao, Yanru Liu, Liang Zhu, Jie Zhang, Yi Chang, Weihua Gao, Guanglei Ma, Xiaoming Ma, Yuming Guo

Photodynamic therapy (PDT) has been attracted a surge of research interest. However, there are several obstacles to limit the efficacy of PDT, such as hypoxic tumor microenvironment (TME), overexpressed glutathione (GSH), inefficient reactive oxygen species (ROS) generation, and so on. Herein, a smart responsive nanosystem was constructed, which was composed of Au25 modified with triphenylphosphine (Au25-TPP), catalase (CAT) and GSH-responsive diselenide-bridged mesoporous silica nanoparticles (Se-MSN). When the nanosystem arrived at tumor site, Se-MSN was degraded by the intracellular overexpressed GSH to release Au25-TPP and CAT. The Au25-TPP was targeted to mitochondria and generated ROS under the 808 nm NIR laser irradiation to kill tumor cells. Simultaneously, CAT could catalyze hydrogen peroxide to provide oxygen for relieving the hypoxia of TME. Besides, GSH was consumed by the diselenide bond to diminish the ROS loss. The above tactics (mitochondria targeting, hypoxia relieving and GSH consuming) jointly enhanced the PDT efficacy. The nanosystem showed distinct in vitro anticancer effect significantly stronger than other groups containing one or two assistance. Moreover, the in vivo results suggested that the tumors could be restrained obviously. The current study provides a new inspiration for constructing novel inorganic nanomedicines with multiple enhancement effect of PDT efficacy.

光动力疗法(PDT)引起了人们极大的研究兴趣。然而,PDT的疗效存在一些障碍,如低氧肿瘤微环境(TME)、谷胱甘肽(GSH)过表达、活性氧(ROS)生成效率低下等。本文构建了一个智能响应纳米系统,该系统由三苯基膦修饰的Au25 (Au25- tpp)、过氧化氢酶(CAT)和gsh响应的二烯桥接介孔二氧化硅纳米颗粒(Se-MSN)组成。当纳米系统到达肿瘤部位时,Se-MSN被细胞内过表达的GSH降解,释放Au25-TPP和CAT。Au25-TPP靶向线粒体,在808 nm近红外激光照射下产生ROS杀死肿瘤细胞。同时,CAT可以催化过氧化氢提供氧气,缓解TME的缺氧。此外,GSH被二硒键消耗,以减少ROS损失。上述策略(靶向线粒体、缓解缺氧和消耗GSH)共同增强了PDT的疗效。纳米系统具有明显的体外抗癌作用,明显强于其他含有一种或两种助剂的纳米系统。体内实验结果表明,该方法对肿瘤有明显的抑制作用。本研究为构建具有多重PDT增强效应的新型无机纳米药物提供了新的启示。
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引用次数: 0
Photolabile ortho-Nitro-Benzyl Carbonate as a Permanent Hydroxyl Protecting Group for the Synthesis of Digalactosyl Diacylglycerol 光不稳定的邻硝基碳酸苄作为永久羟基保护基用于合成双半乳糖二酰基甘油
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-16 DOI: 10.1002/cjoc.202400866
Jibin Zheng, Hongyu Chen, Jintao Shang, Lvfeng Zhang, Youling Liang, Dongsheng Chang, You Yang

Traditional protecting groups are often removed under harsh conditions with potentially hazardous reagents, thereby impeding the convenient synthesis of oligosaccharides and glycosides. Herein, we present to utilize the photolabile ortho-nitro-benzyl carbonate (oNBC) as a permanent hydroxyl protecting group for stereocontrolled synthesis of glycosides. The Ph3PO-modulated glycosylation with strongly disarmed per-O-oNBC-protected glycosyl ynenoates preferred to afford glycosides with excellent α-selectivities via the β-phosphonium transition state. Based on the oNBC-mediated galactosylation, synthesis of the glycolipid digalactosyl diacylglycerol (DGDG) containing six double bonds and two esters was achieved in a straightforward manner.

传统的保护基通常需要在苛刻的条件下使用具有潜在危险的试剂才能去除,从而阻碍了低聚糖和苷类的便捷合成。在此,我们提出利用可光降的邻硝基苄基碳酸酯(oNBC)作为永久性羟基保护基团来立体可控地合成糖苷。Ph3PO 调节的糖基化与强解除的过-O-oNBC 保护糖基 ynenoates 首选通过 β-膦过渡态得到具有优异 α 选择性的糖苷。在 oNBC 介导的半乳糖基化作用的基础上,含有六个双键和两个酯的二半乳糖基二酰甘油(DGDG)糖脂的合成以简单的方式实现。
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引用次数: 0
Inside Cover Picture 封面内页图片
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-15 DOI: 10.1002/cjoc.202490222

Practical CO2 and CO electroreduction are often operated at elevated temperatures, yet the correlation between the temperature increase and catalytic activity and selectivity has not been well-defined. This study uncovers that higher temperatures enhance *CO coverages, but in CO2 reduction, they also promote *CO desorption to vapor-phase CO, lowering C2H4 selectivity. In CO reduction, elevated temperatures facilitate CO diffusion to overcome the unfavorable *CO adsorption thermodynamics, which promotes C—C coupling. More details are discussed in the article by Wang et al. on pages 2705—2711.

实际的二氧化碳和一氧化碳电还原通常在较高温度下进行,但温度升高与催化活性和选择性之间的相关性尚未明确。本研究发现,温度升高会提高*CO的覆盖率,但在二氧化碳还原中,温度升高也会促进*CO解吸为气相CO,从而降低C2H4的选择性。在一氧化碳还原过程中,温度升高有利于一氧化碳的扩散,克服不利的*CO吸附热力学,从而促进C-C耦合。更多详情请参见 Wang 等人的文章(第 2705-2711 页)。
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引用次数: 0
Catalyst-Free, Radical Tri- and Difluoromethylation of Isocyanides and N-Arylacrylamides Using Rotating Magnetic Field and Metal Rods 利用旋转磁场和金属棒的无催化剂、自由基异氰化物和n -芳基丙烯酰胺的三氟甲基化和二氟甲基化
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-07 DOI: 10.1002/cjoc.202400854
Xuliang Han, Haodong Liu, Xiaomei Feng, Fuchao Jia, Zengdian Zhao, Xinjin Li

The pursuit of sustainable and environmentally benign synthetic methods continues to challenge organic chemists. Herein, we introduce a magnetoredox system for tri- and difluoromethylation of isocyanides and N-arylacrylamides using a rotating magnetic field and steel rods. This magnetoredox approach enables facile synthesis of functionalized phenanthridines and oxindoles without the need for catalysts and additives under mild conditions. Such a system potentially represents an attractive strategy for selective formation of bonds through multifaceted regulation of magnetic intensity, rotating frequency, and rod size.

追求可持续和环境友好的合成方法继续挑战有机化学家。在此,我们介绍了一种磁氧化还原系统,用于异氰化物和n -芳基丙烯酰胺的三氟甲基化和二氟甲基化,使用旋转磁场和钢棒。这种磁氧化还原方法可以在温和的条件下,在不需要催化剂和添加剂的情况下,方便地合成功能化的菲菲和吲哚。这种系统潜在地代表了一种有吸引力的策略,通过多方面调节磁场强度、旋转频率和棒的大小来选择性地形成键。
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引用次数: 0
Exploring the Magnetism of C5/C2B3 Heteroleptic Organolanthanide Sandwiches C5/C2B3杂电有机镧系三明治的磁性研究
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-07 DOI: 10.1002/cjoc.202400730
Ye-Ye Liu, Qian-Cheng Luo, Peng-Bo Jin, Yan-Zhen Zheng

Two families of cyclopentadienyl (Cp)/carboranyl heteroleptic sandwiched organolanthanide complexes, namely [Ln{η5:σ-Me2C(C5H4)(C2B10H10)}2][Li(DME)3] (1Ln, Ln = Tb, Dy, Ho, Er) and [2-THF-2'-(μ2-Cl)Li(THF)3-2,2'-Ln(nido-1,7-C2B9H11)Cp*] (2Dy), were synthesized. Family of 1Ln has been proposed based on the mixing-ligands idea by linking Cp and nido-dicarborllide. However, the carborane cage of [Me2C(C5H4)(C2B10H10)]2− deprotons and forms a mono-C anion rather than deboron to form dicarborllide dianion. Hence, the family of 1Ln features a dysprosocenium skeleton with extra two coordination of C anions of carborllides. Such coordination geometry is more like a tetrahedron if abstracting the centroids of two coordinated Cp rings. In this cubic-type geometry, no significant magnetic axiality is presented; only 1Dy and 1Tb show field-induced slow magnetic relaxation behavior below 10 K. Inspired by 1Ln, the free pentamethylcyclopentadienyl (Cp*) and nido-dicarborllide ligands are used to sandwich central Dy3+ ion, achieving heteroleptic complex 2Dy. The bending angle by linking the centroid of Cp*, Dy3+ and C2B32− in 2Dy is increased to 132.8(1)°. As such, the effective energy barrier for magnetic reversal (Ueff) and magnetic blocking temperature TB (ZFC) are both increased (Ueff = 616(10) K; TB = 6 K). The effort of further enhancing Ueff and TB in such heteroleptic organolanthanide sandwiches should rely on keeping increasing the ligand axiality.

合成了两类环戊二烯基(Cp)/碳硼基杂电性夹心有机镧系配合物[Ln{η5:σ-Me2C(C5H4)(C2B10H10)}2][Li(DME)3] (1Ln, Ln = Tb, Dy, Ho, Er)和[2-THF-2′-(μ2-Cl)Li(THF)3-2,2′-Ln(nido-1,7- c2b9h11)Cp*] (2Dy)。基于Cp和二羰基二羰基内酯的混合配体思想,提出了1Ln族。然而,碳硼烷笼[Me2C(C5H4)(C2B10H10)]的2 -脱质子形成单- c -阴离子而不是德波子形成二碳核素离子。因此,1Ln家族的特征是具有碳素的C -阴离子额外的两个配位的异早熟骨架。如果抽象出两个配位Cp环的质心,这种配位几何更像一个四面体。在这种立方型几何中,没有明显的磁轴性;只有1Dy和1Tb在10 K以下表现出场致慢磁弛豫行为。受1Ln的启发,游离的五甲基环戊二烯基(Cp*−)和中性二羰基二羰基配体被用于夹心Dy3+离子,得到异电络合物2Dy。将Cp*−、Dy3+和C2B32−的质心连接在2Dy中的弯曲角提高到132.8(1)°。因此,磁极反转的有效能垒(Ueff)和磁阻塞温度TB (ZFC)均有所提高(Ueff = 616(10) K;进一步提高这种杂性有机镧系三明治的Ueff和TB的努力应依赖于不断增加配体轴向性。
{"title":"Exploring the Magnetism of C5/C2B3 Heteroleptic Organolanthanide Sandwiches","authors":"Ye-Ye Liu,&nbsp;Qian-Cheng Luo,&nbsp;Peng-Bo Jin,&nbsp;Yan-Zhen Zheng","doi":"10.1002/cjoc.202400730","DOIUrl":"https://doi.org/10.1002/cjoc.202400730","url":null,"abstract":"<div>\u0000 \u0000 <p>Two families of cyclopentadienyl (Cp)/carboranyl heteroleptic sandwiched organolanthanide complexes, namely [Ln{<i>η</i><sup>5</sup>:<i>σ</i>-Me<sub>2</sub>C(C<sub>5</sub>H<sub>4</sub>)(C<sub>2</sub>B<sub>10</sub>H<sub>10</sub>)}<sub>2</sub>][Li(DME)<sub>3</sub>] (<b>1Ln</b>, Ln = Tb, Dy, Ho, Er) and [2-THF-2'-(<i>μ</i><sup>2</sup>-Cl)Li(THF)<sub>3</sub>-2,2'-Ln(<i>nido</i>-1,7-C<sub>2</sub>B<sub>9</sub>H<sub>11</sub>)Cp*] (<b>2Dy</b>), were synthesized. Family of <b>1Ln</b> has been proposed based on the mixing-ligands idea by linking Cp and <i>nido</i>-dicarborllide. However, the carborane cage of [Me<sub>2</sub>C(C<sub>5</sub>H<sub>4</sub>)(C<sub>2</sub>B<sub>10</sub>H<sub>10</sub>)]<sup>2−</sup> deprotons and forms a mono-C<sup>−</sup> anion rather than deboron to form dicarborllide dianion. Hence, the family of <b>1Ln</b> features a dysprosocenium skeleton with extra two coordination of C<sup>−</sup> anions of carborllides. Such coordination geometry is more like a tetrahedron if abstracting the centroids of two coordinated Cp rings. In this cubic-type geometry, no significant magnetic axiality is presented; only <b>1Dy</b> and <b>1Tb</b> show field-induced slow magnetic relaxation behavior below 10 K. Inspired by <b>1Ln</b>, the free pentamethylcyclopentadienyl (Cp*<sup>−</sup>) and <i>nido</i>-dicarborllide ligands are used to sandwich central Dy<sup>3+</sup> ion, achieving heteroleptic complex <b>2Dy</b>. The bending angle by linking the centroid of Cp*<sup>−</sup>, Dy<sup>3+</sup> and C<sub>2</sub>B<sub>3</sub><sup>2−</sup> in <b>2Dy</b> is increased to 132.8(1)°. As such, the effective energy barrier for magnetic reversal (<i>U</i><sub>eff</sub>) and magnetic blocking temperature <i>T</i><sub>B</sub> (ZFC) are both increased (<i>U</i><sub>eff</sub> = 616(10) K; <i>T</i><sub>B</sub> = 6 K). The effort of further enhancing <i>U</i><sub>eff</sub> and <i>T</i><sub>B</sub> in such heteroleptic organolanthanide sandwiches should rely on keeping increasing the ligand axiality.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 2","pages":"131-138"},"PeriodicalIF":5.5,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bottlebrush Random Copolymers at Oil-Oil Interfaces 油-油界面的瓶刷无规共聚物
IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-07 DOI: 10.1002/cjoc.202400703
Yaxin Wang, Yunhui Wen, Yuzheng Luo, Shuailong Li, Jiaqiu Luo, Shaowei Shi

Oil-in-oil nonaqueous emulsions are of great interest for developing emulsion-templated polymers and encapsulation systems that are incompatible with water-sensitive substances. Tailor-made amphiphilic block copolymers are by far the most efficient stabilizers for oil-in-oil emulsions while less attention is given to copolymers with more complex architectures. Here, we report the stabilization of DMSO-silicone oil interface by bottlebrush random copolymers (BRCPs) containing norbornene backbones with densely grafted poly(methyl methacrylate) (PMMA) and polystyrene (PS) side chains. The assembly kinetics of BRCPs at the DMSO-silicone oil interface can be divided into three processes, including diffusion, reconfiguration and reorganization, and can be varied by tuning the degree of polymerization of the backbone (NB). Due to the high efficiency of BRCPs in reducing the interfacial tension, when using BRCPs as stabilizers, stable silicone oil-in-DMSO traditional emulsions and high internal phase emulsions (HIPEs) can be successfully obtained, while no stable emulsions can be achieved with linear PMMA-b-PS serving as the stabilizer. This study, for the first time, underscores the great potential of amphiphilic bottlebrush copolymers in preparing oil-in-oil emulsions. Given the advances in polymerization strategy, a broad variety of amphiphilic bottlebrush copolymers are expected to be synthesized and applied in the stabilization of nonaqueous biphasic systems.

油包油非水乳液对于开发与水敏感物质不相容的乳液模板聚合物和包封系统具有重要意义。定制的两亲嵌段共聚物是迄今为止最有效的油包油乳液稳定剂,而具有更复杂结构的共聚物却很少受到关注。在这里,我们报道了含有降冰片烯骨架和密集接枝聚甲基丙烯酸甲酯(PMMA)和聚苯乙烯(PS)侧链的瓶刷无规共聚物(BRCPs)对dmso -硅油界面的稳定作用。BRCPs在dmso -硅油界面上的组装动力学可分为扩散、重构和重组三个过程,并可通过调整主链聚合度(NB)而改变。由于BRCPs降低界面张力的效率高,当使用BRCPs作为稳定剂时,可以成功获得稳定的硅油- dmso传统乳剂和高内相乳剂(HIPEs),而使用线性PMMA-b-PS作为稳定剂则无法获得稳定的乳剂。这项研究首次强调了两亲性瓶刷共聚物在制备油中乳液方面的巨大潜力。鉴于聚合策略的进步,各种两亲性瓶刷共聚物有望被合成并应用于非水双相体系的稳定。
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引用次数: 0
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Chinese Journal of Chemistry
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