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Journal of Carbohydrate Chemistry最新文献

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Respiratory Patterns in Neurological Injury, Pathophysiology, Ventilation Management, and Future Innovations: A Systematic Review. 神经损伤的呼吸模式、病理生理学、通气管理和未来创新：系统回顾。
4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-10-01 Epub Date: 2022-09-28 DOI: 10.14218/erhm.2022.00081
Matthew Goldman, Brandon Lucke-Wold, Jason Katz, Bavly Dawoud, Abeer Dagra

Traumatic brain injuries (TBI), ischemic stroke, hemorrhagic stroke, brain tumors, and seizures have diverse and sometimes overlapping associated breathing patterns. Homeostatic mechanisms for respiratory control are intertwined with complex neurocircuitry, both centrally and peripherally. This paper summarizes the neurorespiratory control and pathophysiology of its disruption. It also reviews the clinical presentation, ventilatory management, and emerging therapeutics. This review additionally serves to update all recent preclinical and clinical research regarding the spectrum of respiratory dysfunction. Having a solid pathophysiological foundation of disruptive mechanisms would permit further therapeutic development. This novel review bridges experimental/physiological data with bedside management, thus allowing neurosurgeons and intensivists alike to rapidly diagnose and treat respiratory sequelae of acute brain injury.

创伤性脑损伤（TBI）、缺血性中风、出血性中风、脑肿瘤和癫痫发作的相关呼吸模式多种多样，有时甚至相互重叠。呼吸控制的平衡机制与复杂的中枢和外周神经回路相互交织。本文概述了神经呼吸控制及其紊乱的病理生理学。它还回顾了临床表现、通气管理和新兴疗法。此外，本综述还介绍了有关呼吸功能障碍的所有最新临床前和临床研究。有了破坏机制的坚实病理生理学基础，才能进一步开发治疗方法。这篇新颖的综述将实验/生理学数据与床边管理联系起来，从而使神经外科医生和重症监护医生都能快速诊断和治疗急性脑损伤的呼吸系统后遗症。
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引用次数: 0
2021 JCC Best Paper Award 2021 年联合协调委员会最佳论文奖
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2331282
Zhongwu Guo Ph.D.
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引用次数: 0
Chemically modified starch with silicon quantum dots: Structures and properties 硅量子点化学修饰淀粉：结构与特性
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2315529
Filiz Saman , Ebru Al , Bilge Boylu , Osman Arslan
Attachment of Silicon quantum dots (Si QDs) onto starch via sol-gel controlled covalent bonding to form hybrid starch particles was developed to modulate the optical, physical, and mechanical features of starch. Fabricated Si QDs chemically interacted with –OH side groups due to the sol-gel reactions on the starch molecules providing a detectable new molecular bonding to result in fluorescent emission. The produced structures formed nonlinear morphological orientations that provide a nanocomposite material platform for a facile molecular marking in daily applications.
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引用次数: 0
2021 T. Ogawa Young Investigator Award
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2331294
Zhongwu Guo Ph.D
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引用次数: 0
2022 JCC Best Paper Award 2022 年联合协调委员会最佳论文奖
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2331295
Zhongwu Guo Ph.D.
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引用次数: 0
2022 T. Ogawa Young Investigator Award 2022 T. 小川青年研究员奖
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2331299
Zhongwu Guo Ph.D.
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引用次数: 0
Sialic acid analog as inhibitor for human coronavirus OC43-a study by molecular dynamics simulations 作为人类冠状病毒 OC43 抑制剂的硅酸类似物--分子动力学模拟研究
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2325576
J. Jino Blessy , N. R. Siva Shanmugam , K. Veluraja , M. Michael Gromiha
Human coronavirus OC43 (HCoV-OC43) causes severe respiratory tract illness in humans. In the present study, we carried out 100 ns molecular dynamics (MD) simulations to investigate the conformational dynamics of HCoV-OC43 spike (S) glycoprotein complexes with sialic acid (SIA) analogs. The binding affinity between the HCoV-OC43 S and SIA analogs is analyzed using NAMD and MM-PBSA binding free energy calculation. It is concluded from the results of NAMD and MM/PBSA that the order of binding specificity toward HCoV-OC43 S is 9-O-Ac-Sia > SIA > Neu5Gc > zanamivir > Neu5Ac2en.
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引用次数: 0
2022 JCC Best Paper Award
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2331296
Zhongwu Guo Ph.D.
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引用次数: 0
Low-cost and high-performance acetylglucose-based imidazolium salts for copper-catalyzed cyclization of propargylic amines and CO2 用于铜催化丙炔胺和 CO 2 环化的低成本、高性能乙酰葡萄糖基咪唑鎓盐
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2324391
Xian-Jin Zhang , Ling-Fang Kong , Xue Lu , Yu-Ling Liu , Yan Hu , Hui-Wen Gong , Yun-Jia Li , Zhong-Gao Zhou
The rise of carbon dioxide (CO2) in atmosphere is considered as a major cause of global warming. Therefore, CO2 utilization has attracted increasing attention. Among those, using CO2 as C1-feedstock for “value carbon” in advanced chemicals provides a solution. Here, we show an acetylglucose-based imidazolium salt for Cu-catalyzed cyclization of propargylic amines and CO2 with an excellent turnover frequency value of 400 h−1. To the best of our knowledge, it is the first example of acetylglucose-based imidazolium salts for a noble-metal-free Cu catalytic system for the cyclization of propargylic amines and CO2.
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引用次数: 0
2021 T. Ogawa Young Investigator Award 2021 T. 小川青年研究员奖
IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Carbohydrate Chemistry
Pub Date : 2023-07-24 DOI: 10.1080/07328303.2024.2331283
Zhongwu Guo Ph.D.
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引用次数: 0
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