Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0254
Michael D. Brown, T. Allen, B. Cox, B. Treeby
To obtain high resolution ultrasound images, transducers able to operate at high frequencies are required. Optically generated ultrasound utilising the optoacoustic effect is a promising alternative to piezoelectric transducers to achieve this. To use optically generated ultrasound for imaging, a method to spatially steer and focus the acoustic pulses is desirable. In this paper, the use of binary amplitude holograms to focus broadband ultrasound pulses generated by a pulsed laser was investigated. This was done experimentally with patterned absorbers and in simulation. It was found that applying two or more laser pulses applied to a hologram at its design frequency was sufficient to form a focus. The position of this focus could be moved in 3-D by changing the hologram. Additional focal points to those designed for were also found in both the simulation and experimental data. These were generated by constructive interference of harmonics of the pulsing frequency. Simulations found that increasing hologram resolution and applying greater numbers of laser pulses to the hologram decreased the volume of the primary focal point, and that the volume of this focus decreased more rapidly with increasing laser pulse numbers at higher hologram resolutions.
{"title":"Control of optically generated ultrasound fields using binary amplitude holograms","authors":"Michael D. Brown, T. Allen, B. Cox, B. Treeby","doi":"10.1109/ULTSYM.2014.0254","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0254","url":null,"abstract":"To obtain high resolution ultrasound images, transducers able to operate at high frequencies are required. Optically generated ultrasound utilising the optoacoustic effect is a promising alternative to piezoelectric transducers to achieve this. To use optically generated ultrasound for imaging, a method to spatially steer and focus the acoustic pulses is desirable. In this paper, the use of binary amplitude holograms to focus broadband ultrasound pulses generated by a pulsed laser was investigated. This was done experimentally with patterned absorbers and in simulation. It was found that applying two or more laser pulses applied to a hologram at its design frequency was sufficient to form a focus. The position of this focus could be moved in 3-D by changing the hologram. Additional focal points to those designed for were also found in both the simulation and experimental data. These were generated by constructive interference of harmonics of the pulsing frequency. Simulations found that increasing hologram resolution and applying greater numbers of laser pulses to the hologram decreased the volume of the primary focal point, and that the volume of this focus decreased more rapidly with increasing laser pulse numbers at higher hologram resolutions.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130155428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0312
Mingxu Sun, Pai-Chi Li
Optical-resolution photoacoustic microscopy (OR-PAM) provides high sensitivity and resolution to optical absorption and opens a new window to study biological systems at the cellular level. Cancer cells propagated in vitro partially retain the characteristics of cancer, such as immortality and resistance to apoptosis. For 3D cell imaging, the most widely used imaging modalities, the laser scanning optical microscopies (e.g., confocal and multi-photon microscopy) have limited tissue penetration, and they usually require the use of a fluorescent chromophore as the probe as well. PAM system has deeper penetration, and it does not need depth scanning. In other words, 2D scanning can generate 3D photoacoustic (PA) images. In this paper, a combined laser-scanning OR-PAM with optical microscope (OM) system has been setup in the transmission mode. The proposed OR-PAM system has achieved a lateral resolution of 0.59 μm at cellular level with a penetration depth of 0.60 mm, so it has the ability of do cell imaging and other sub-micron cellular experiments. In our study, B16-F10 murine melanoma cells were measured at different layers in 3D cell culture system mode. Two-dimensional optical or mechanical scanning of the object platform, in combination with optical/ultrasonic detection, can provide volumetric optical and 2D/3D PA images. From proof-of-principle experiments, 2D scanning generated 3D PA images and the distribution of cells at different layers agreed closely to the optical image of their localizations. Thus, the OR-PAM system demonstrated great potential in cell imaging.
{"title":"Imaging 3D cell culture systems using an optical resolution photoacoustic microscope","authors":"Mingxu Sun, Pai-Chi Li","doi":"10.1109/ULTSYM.2014.0312","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0312","url":null,"abstract":"Optical-resolution photoacoustic microscopy (OR-PAM) provides high sensitivity and resolution to optical absorption and opens a new window to study biological systems at the cellular level. Cancer cells propagated in vitro partially retain the characteristics of cancer, such as immortality and resistance to apoptosis. For 3D cell imaging, the most widely used imaging modalities, the laser scanning optical microscopies (e.g., confocal and multi-photon microscopy) have limited tissue penetration, and they usually require the use of a fluorescent chromophore as the probe as well. PAM system has deeper penetration, and it does not need depth scanning. In other words, 2D scanning can generate 3D photoacoustic (PA) images. In this paper, a combined laser-scanning OR-PAM with optical microscope (OM) system has been setup in the transmission mode. The proposed OR-PAM system has achieved a lateral resolution of 0.59 μm at cellular level with a penetration depth of 0.60 mm, so it has the ability of do cell imaging and other sub-micron cellular experiments. In our study, B16-F10 murine melanoma cells were measured at different layers in 3D cell culture system mode. Two-dimensional optical or mechanical scanning of the object platform, in combination with optical/ultrasonic detection, can provide volumetric optical and 2D/3D PA images. From proof-of-principle experiments, 2D scanning generated 3D PA images and the distribution of cells at different layers agreed closely to the optical image of their localizations. Thus, the OR-PAM system demonstrated great potential in cell imaging.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130262613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0035
L. Chehami, J. de Rosny, C. Prada, E. Moulin
Passive structural health monitoring (SHM) is an emerging technology. More than 10 years ago, it has been shown that transient response between two sensors can be passively estimated from cross-correlation of ambient noise. The work presented here is an experimental application of this approach dedicated to detect the occurrence of flaws on a thin aluminum plate. The detection sensitivity is directly related to the fidelity of the estimation of the transient response. Using a laser vibrometer, we show that it strongly depends on the number of uncorrelated noise sources. An artificial damage is detected from the difference between the cross-correlation matrices measured before and after defect appearance. To localize the defect, a beamforming array processing is applied on the matrix. The resolution can be as small as half a wavelength.
{"title":"Passive flaw detection and localization in thin plate from ambient noise cross-correlation","authors":"L. Chehami, J. de Rosny, C. Prada, E. Moulin","doi":"10.1109/ULTSYM.2014.0035","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0035","url":null,"abstract":"Passive structural health monitoring (SHM) is an emerging technology. More than 10 years ago, it has been shown that transient response between two sensors can be passively estimated from cross-correlation of ambient noise. The work presented here is an experimental application of this approach dedicated to detect the occurrence of flaws on a thin aluminum plate. The detection sensitivity is directly related to the fidelity of the estimation of the transient response. Using a laser vibrometer, we show that it strongly depends on the number of uncorrelated noise sources. An artificial damage is detected from the difference between the cross-correlation matrices measured before and after defect appearance. To localize the defect, a beamforming array processing is applied on the matrix. The resolution can be as small as half a wavelength.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134022225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0277
W. Yang, M. Alexander, N. Rubert, A. Ingle, M. Lubner, T. Ziemlewicz, J. Hinshaw, F. Lee, J. Zagzebski, T. Varghese
Minimally invasive ablative therapies have become important alternatives to surgical treatment of both hepatocellular carcinoma (HCC) and liver metastases. Image based guidance and monitoring are therefore essential. Although ultrasound (US) imaging suffers from inadequate echogenic contrast between ablated and normal tissue, US based elasticity imaging has shown remarkable ability to depict ablated regions and delineate margins. The purpose of this study is to apply “electrode displacement elastography,” or EDE for monitoring clinical microwave ablation (MWA) treatments for HCC and liver metastases. EDE images were acquired from 10 patients who underwent MWA for their liver tumors. The MWA system used was a Neuwave Medical Certus 140 (Madison, WI, USA) operating at 2.45 GHz. The MWA power and duration was adjusted for each patient, with typical values of 65 watts and 5 minutes. A Siemens S2000 scanner equipped with a curvilinear array transducer (VFX 6C1) pulsed at 4 MHz was used to acquire radiofrequency echo data. Electrode displacement was applied manually by the physician. A multi-seed two-dimensional tracking algorithm, with kernel dimensions of 0.096 mm × 3 A-lines was used to estimate local displacements between consecutive data frames. Strain images were computed as the gradient of the local displacement estimates. The average contrast of the ablated region was 0.23±0.07 (0.14-0.35) on B-mode images and 0.73±0.08 (0.56-0.82) on EDE. The average contrast improvement with EDE over B mode was about 230%. The average tumor size was 2.2±0.8 (0.7-3.5) cm on pre-treatment diagnostic images (CT or MRI). The average size of the ablated region was 3.8±0.7 (2.6-4.9) cm on EDE, with an average ablation margin of 1.6 cm which is within the clinically suggested ablated margin (>0.5 cm).
{"title":"Monitoring microwave ablation for liver tumors with electrode displacement strain imaging","authors":"W. Yang, M. Alexander, N. Rubert, A. Ingle, M. Lubner, T. Ziemlewicz, J. Hinshaw, F. Lee, J. Zagzebski, T. Varghese","doi":"10.1109/ULTSYM.2014.0277","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0277","url":null,"abstract":"Minimally invasive ablative therapies have become important alternatives to surgical treatment of both hepatocellular carcinoma (HCC) and liver metastases. Image based guidance and monitoring are therefore essential. Although ultrasound (US) imaging suffers from inadequate echogenic contrast between ablated and normal tissue, US based elasticity imaging has shown remarkable ability to depict ablated regions and delineate margins. The purpose of this study is to apply “electrode displacement elastography,” or EDE for monitoring clinical microwave ablation (MWA) treatments for HCC and liver metastases. EDE images were acquired from 10 patients who underwent MWA for their liver tumors. The MWA system used was a Neuwave Medical Certus 140 (Madison, WI, USA) operating at 2.45 GHz. The MWA power and duration was adjusted for each patient, with typical values of 65 watts and 5 minutes. A Siemens S2000 scanner equipped with a curvilinear array transducer (VFX 6C1) pulsed at 4 MHz was used to acquire radiofrequency echo data. Electrode displacement was applied manually by the physician. A multi-seed two-dimensional tracking algorithm, with kernel dimensions of 0.096 mm × 3 A-lines was used to estimate local displacements between consecutive data frames. Strain images were computed as the gradient of the local displacement estimates. The average contrast of the ablated region was 0.23±0.07 (0.14-0.35) on B-mode images and 0.73±0.08 (0.56-0.82) on EDE. The average contrast improvement with EDE over B mode was about 230%. The average tumor size was 2.2±0.8 (0.7-3.5) cm on pre-treatment diagnostic images (CT or MRI). The average size of the ablated region was 3.8±0.7 (2.6-4.9) cm on EDE, with an average ablation margin of 1.6 cm which is within the clinically suggested ablated margin (>0.5 cm).","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134256639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0157
T. Jansson, M. Evertsson, Esayas Atile, Roger Andersson, S. Fredriksson, H. Persson, I. Svensson, M. Cinthio
Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move the particles lodged in tissue, and ultrasound is used to detect the resulting tissue movement. In phantom studies we have observed opposite phase motion next to regions containing nanoparticles. We hypothesize that this motion is caused by mechanical coupling from regions where nanoparticles are located. The present study compares experimental data to a numerical simulation with identical geometry as the experimental set-up. The magnetic force acting on particles was modeled as emanating from a coil with a cone shaped iron core, and applied as a body load in nanoparticle-laden regions. The simulation showed opposed motion in-between nanoparticle-laden phantom inserts, in a manner similar to the experimental situation. There is a slight mismatch in the extent of vertical movement, which we interpret as a result of the modeled slip condition tangentially to the surface, which in reality presumably is a combination of slip and stick due to friction.
{"title":"Induced tissue displacement in magnetomotive ultrasound imaging - simulations and experiments","authors":"T. Jansson, M. Evertsson, Esayas Atile, Roger Andersson, S. Fredriksson, H. Persson, I. Svensson, M. Cinthio","doi":"10.1109/ULTSYM.2014.0157","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0157","url":null,"abstract":"Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move the particles lodged in tissue, and ultrasound is used to detect the resulting tissue movement. In phantom studies we have observed opposite phase motion next to regions containing nanoparticles. We hypothesize that this motion is caused by mechanical coupling from regions where nanoparticles are located. The present study compares experimental data to a numerical simulation with identical geometry as the experimental set-up. The magnetic force acting on particles was modeled as emanating from a coil with a cone shaped iron core, and applied as a body load in nanoparticle-laden regions. The simulation showed opposed motion in-between nanoparticle-laden phantom inserts, in a manner similar to the experimental situation. There is a slight mismatch in the extent of vertical movement, which we interpret as a result of the modeled slip condition tangentially to the surface, which in reality presumably is a combination of slip and stick due to friction.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133863626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0349
Shuaiyong Li, Y. Wen, Ping Li, Jin Yang, Jing Wen
The leakage-induced acoustic vibrations are guided by the pipelines and discretized into several modes. Different modes exhibit different dispersive behaviors and generate vibrations of different directions. In this study, the modal characteristics of acoustic vibrations in different directions are investigated theoretically and experimentally. The dispersive natures and the displacement distributions of the guided wave modes in fluid-filled pipelines are analyzed using the guided wave theory. Theoretical analysis predicts that the axial vibrations are dominated by a single non-dispersive longitudinal mode, while the radial and circumferential vibrations are dominated by more than one dispersive modes respectively in the frequency range 0-2.5kHz. Then the experimental investigations convince the theoretical predictions and demonstrate that the axial vibrations are dominated by an individual non-dispersive guided wave with small attenuation rate in the frequency region 0-2.5 kHz. These discoveries demonstrate that, at information acquisition stage, exclusively picking up the axial vibration can significantly improve leak detection and location in the pipelines compared to the conventional detection of the radial vibration.
{"title":"Modal analysis of leakage-induced acoustic vibrations in different directions for leak detection and location in fluid-filled pipelines","authors":"Shuaiyong Li, Y. Wen, Ping Li, Jin Yang, Jing Wen","doi":"10.1109/ULTSYM.2014.0349","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0349","url":null,"abstract":"The leakage-induced acoustic vibrations are guided by the pipelines and discretized into several modes. Different modes exhibit different dispersive behaviors and generate vibrations of different directions. In this study, the modal characteristics of acoustic vibrations in different directions are investigated theoretically and experimentally. The dispersive natures and the displacement distributions of the guided wave modes in fluid-filled pipelines are analyzed using the guided wave theory. Theoretical analysis predicts that the axial vibrations are dominated by a single non-dispersive longitudinal mode, while the radial and circumferential vibrations are dominated by more than one dispersive modes respectively in the frequency range 0-2.5kHz. Then the experimental investigations convince the theoretical predictions and demonstrate that the axial vibrations are dominated by an individual non-dispersive guided wave with small attenuation rate in the frequency region 0-2.5 kHz. These discoveries demonstrate that, at information acquisition stage, exclusively picking up the axial vibration can significantly improve leak detection and location in the pipelines compared to the conventional detection of the radial vibration.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133991753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0514
S. Wagle, A. Decharat, F. Melandsø
Adhesive free dual-layer ultrasonic transducers have been produced using a layer-by-layer deposition method. The proposed method deposits P(VDF-TrFE) copolymer from the fluid phase with intermediate electrodes on top of a PEI substrate. The processed transducers were characterized using a LCR analyzer, a pulse-echo experimental setup, and a numerical FEM model. The ultrasonic signals and frequency spectra from the different characterization methods were compared. By using one of transducer layers as a sender and the other as a receiver with an intermediate grounded electrode, the capacitive coupling between the layers was reduced significantly.
{"title":"Adhesive-free dual layer piezoelectric PVDF copolymer transducers in sender and receiver sequences","authors":"S. Wagle, A. Decharat, F. Melandsø","doi":"10.1109/ULTSYM.2014.0514","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0514","url":null,"abstract":"Adhesive free dual-layer ultrasonic transducers have been produced using a layer-by-layer deposition method. The proposed method deposits P(VDF-TrFE) copolymer from the fluid phase with intermediate electrodes on top of a PEI substrate. The processed transducers were characterized using a LCR analyzer, a pulse-echo experimental setup, and a numerical FEM model. The ultrasonic signals and frequency spectra from the different characterization methods were compared. By using one of transducer layers as a sender and the other as a receiver with an intermediate grounded electrode, the capacitive coupling between the layers was reduced significantly.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131003620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0012
Minghui Li, G. Hayward
In this paper, we present a rapid technique to reduce the speckle noise in ultrasonic non-destructive evaluation (NDE) and enhance the image quality using matched filters. This method implicitly explores the signatures and profiles of echoes from legitimate defects and echoes from random reflectors, uses the temporal and spectral distinction to design the filter, and utilizes a particle swarm optimization (PSO) paradigm to optimize the filter parameters with an objective to maximize the output signal-to-noise ratio (SNR). An optimized matched filter approximating the desired defect echoes is then applied to the received A-scan waveforms. Experiments with a 128-element 5MHz transducer on a mild steel sample are conducted. It has been demonstrated that clutter is significantly reduced and the image SNR is improved by more than 20dB when the matched filter is applied to A-scan waveforms prior to image formation. Given the fact that the matched filter can be implemented in real-time, the great performance advantages are obtained with extremely low extra computational cost.
{"title":"A rapid approach to speckle noise reduction in ultrasonic non-destructive evaluation using matched filters","authors":"Minghui Li, G. Hayward","doi":"10.1109/ULTSYM.2014.0012","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0012","url":null,"abstract":"In this paper, we present a rapid technique to reduce the speckle noise in ultrasonic non-destructive evaluation (NDE) and enhance the image quality using matched filters. This method implicitly explores the signatures and profiles of echoes from legitimate defects and echoes from random reflectors, uses the temporal and spectral distinction to design the filter, and utilizes a particle swarm optimization (PSO) paradigm to optimize the filter parameters with an objective to maximize the output signal-to-noise ratio (SNR). An optimized matched filter approximating the desired defect echoes is then applied to the received A-scan waveforms. Experiments with a 128-element 5MHz transducer on a mild steel sample are conducted. It has been demonstrated that clutter is significantly reduced and the image SNR is improved by more than 20dB when the matched filter is applied to A-scan waveforms prior to image formation. Given the fact that the matched filter can be implemented in real-time, the great performance advantages are obtained with extremely low extra computational cost.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"191 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132906780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0646
D. Barauskas, G. Vanagas, D. Viržonis, A. Makaraviciute, A. Ramanavičienė
The array of the CMUT sensors was fabricated by the direct bonding of the silicon membranes provided as a device layer of the SOI wafer with the oxidized and pre-patterned highly doped silicon wafer. The active surface of the sensors was coated with thin gold film. We demonstrate the detection of the formed immune complex over the CMUT surface modified by the bovine leukemia virus antigen BLV gp51. The modified CMUT surface was allowed to interact with the specific antibody anti-gp51 labeled by the horseradish peroxidase. Antibody labels were actvated after the interaction by wetting the sensor surface with tetramethylbenzidine to provide the reference quantification of the formation of the immune complex. CMUT sensor readings (resonance frequency and the resonance value of the impedance real part, “resistance”) were obtained before and after modification by the BLV gp51 and after the interaction with antig-p51. The readings were interpreted and fitted by the finite element analysis. It was determined that increase of the elasticity modulus and stress of the sensor structure caused increase of the resonance frequency and some decrease of the resonance quality (resistance value). After the immune complex is established, we observe decrease of the resonance frequency by 4% on average from the initial value. Finite element analysis model fitting to the experimental results revealed the mass loading function of the CMUT structure in the presence of increased elasticity of the proteins.
{"title":"Capacitive micromachined ultrasound transducers (CMUT) for resonant gravimetric immunosensing","authors":"D. Barauskas, G. Vanagas, D. Viržonis, A. Makaraviciute, A. Ramanavičienė","doi":"10.1109/ULTSYM.2014.0646","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0646","url":null,"abstract":"The array of the CMUT sensors was fabricated by the direct bonding of the silicon membranes provided as a device layer of the SOI wafer with the oxidized and pre-patterned highly doped silicon wafer. The active surface of the sensors was coated with thin gold film. We demonstrate the detection of the formed immune complex over the CMUT surface modified by the bovine leukemia virus antigen BLV gp51. The modified CMUT surface was allowed to interact with the specific antibody anti-gp51 labeled by the horseradish peroxidase. Antibody labels were actvated after the interaction by wetting the sensor surface with tetramethylbenzidine to provide the reference quantification of the formation of the immune complex. CMUT sensor readings (resonance frequency and the resonance value of the impedance real part, “resistance”) were obtained before and after modification by the BLV gp51 and after the interaction with antig-p51. The readings were interpreted and fitted by the finite element analysis. It was determined that increase of the elasticity modulus and stress of the sensor structure caused increase of the resonance frequency and some decrease of the resonance quality (resistance value). After the immune complex is established, we observe decrease of the resonance frequency by 4% on average from the initial value. Finite element analysis model fitting to the experimental results revealed the mass loading function of the CMUT structure in the presence of increased elasticity of the proteins.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133376349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-23DOI: 10.1109/ULTSYM.2014.0634
Ruchuan Shi, Chenrui Zhang, Tao Han, Jing Chen
It is increasingly urgent to improve the intelligent level of the equipment management for modern international airports. This is the first attempt of SAW RFID on aerodrome lights. SAW tag with temperature sensing function and anti-metal patch antennas are designed. The position of the tag fixed in different kinds of lights such as the runway light and the taxiway light is demonstrated. The experimental results show that SAW RFID has been successfully applied to the inspection management of aerodrome light.
{"title":"Application of SAW RFID in the inspection management of aerodrome lights","authors":"Ruchuan Shi, Chenrui Zhang, Tao Han, Jing Chen","doi":"10.1109/ULTSYM.2014.0634","DOIUrl":"https://doi.org/10.1109/ULTSYM.2014.0634","url":null,"abstract":"It is increasingly urgent to improve the intelligent level of the equipment management for modern international airports. This is the first attempt of SAW RFID on aerodrome lights. SAW tag with temperature sensing function and anti-metal patch antennas are designed. The position of the tag fixed in different kinds of lights such as the runway light and the taxiway light is demonstrated. The experimental results show that SAW RFID has been successfully applied to the inspection management of aerodrome light.","PeriodicalId":153901,"journal":{"name":"2014 IEEE International Ultrasonics Symposium","volume":"10 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133684964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：