Pub Date : 2026-01-26DOI: 10.1177/12034754251408380
Nardin Hanna, Sabrina B Yang, Meghan L McPhie, Mark G Kirchhof
Biologic therapies have revolutionized the management of psoriasis. These agents are often assumed to share similar risk profiles despite targeting distinct cytokines with diverse mechanisms of action. The aim of this study was to evaluate the distribution of cytokines and their receptors targeted by current biologic therapies in order to identify tissues potentially subject to immunomodulation and to better understand potential targets of the biologics. Using publicly available RNA and protein expression databases, we analyzed expression patterns of TNF-α, IL-12, IL-23, IL-17, and their corresponding receptors. Expression profiles varied considerably in both RNA levels and tissue distribution. Some correlations were observed between cytokine expression sites and the adverse event profiles of biologics. Further research is required to validate these associations and to clarify the tissue-specific effects of cytokine-targeted therapies in psoriasis.
{"title":"Distribution of Cytokines and Their Receptors Targeted by Biologics in the Treatment of Psoriasis.","authors":"Nardin Hanna, Sabrina B Yang, Meghan L McPhie, Mark G Kirchhof","doi":"10.1177/12034754251408380","DOIUrl":"https://doi.org/10.1177/12034754251408380","url":null,"abstract":"<p><p>Biologic therapies have revolutionized the management of psoriasis. These agents are often assumed to share similar risk profiles despite targeting distinct cytokines with diverse mechanisms of action. The aim of this study was to evaluate the distribution of cytokines and their receptors targeted by current biologic therapies in order to identify tissues potentially subject to immunomodulation and to better understand potential targets of the biologics. Using publicly available RNA and protein expression databases, we analyzed expression patterns of TNF-α, IL-12, IL-23, IL-17, and their corresponding receptors. Expression profiles varied considerably in both RNA levels and tissue distribution. Some correlations were observed between cytokine expression sites and the adverse event profiles of biologics. Further research is required to validate these associations and to clarify the tissue-specific effects of cytokine-targeted therapies in psoriasis.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251408380"},"PeriodicalIF":3.9,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1177/12034754251411871
Sonia Czyz, Kerry Yang, Fatemeh Jafarian
{"title":"Benzoyl Peroxide in Acne Treatment: Balancing Efficacy and Emerging Safety Considerations.","authors":"Sonia Czyz, Kerry Yang, Fatemeh Jafarian","doi":"10.1177/12034754251411871","DOIUrl":"https://doi.org/10.1177/12034754251411871","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251411871"},"PeriodicalIF":3.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1177/12034754251408403
Andy D Lee, Amrit Thandi, Jinny Choi, Grace Xiong, Sara Pollenan, Kristen Amanda Rachel Yee, Fatemeh Jafarian, Cathryn Sibbald
Despite increasing recognition of the importance of skin-of-color (SOC) representation in dermatology education, significant gaps persist in training medical students to diagnose dermatologic conditions across diverse skin tones. This systematic review analyzed educational interventions aimed at improving SOC diagnostic competency among medical trainees. A comprehensive search of MEDLINE, Embase, APA PsycInfo, and Scopus identified 8 studies comprising 667 participants, revealing categories: didactic teaching (33.1%), seminar-style expert-led teaching (32.4%), workshop-based learning (25.8%), and simulation-based learning (8.7%). Preintervention assessments consistently showed significantly lower confidence in diagnosing conditions in darker skin tones, with 64% to 69% of students reporting no SOC training at undergraduate level. All interventions produced statistically significant improvements in self-assessed knowledge and confidence, though 87.2% of students still lacked confidence postintervention. The most promising approach was Hardin's two-week combined training protocol, which mitigated initial diagnostic bias between light and dark skin diagnoses (P = .007). Critical limitations include predominantly single-session interventions, reliance on self-reported confidence measures, absence of long-term retention data, and persistent condition-specific diagnostic challenges, particularly for melanoma in darker skin. Addressing these educational gaps represents both an imperative for medical education reform and a crucial step toward achieving health equity in dermatologic care.
尽管越来越多的人认识到肤色（SOC）代表在皮肤科教育中的重要性，但在培养医学生诊断不同肤色的皮肤病方面仍然存在显著差距。本系统回顾分析了旨在提高医学实习生SOC诊断能力的教育干预措施。对MEDLINE， Embase， APA PsycInfo和Scopus进行全面搜索，确定了8项研究，包括667名参与者，揭示了类别：教学式教学（33.1%），研讨会式专家主导教学（32.4%），基于研讨会的学习（25.8%）和基于模拟的学习（8.7%）。干预前评估一致显示，肤色较深的学生在诊断疾病方面的信心明显较低，64%至69%的学生报告在本科阶段没有接受过SOC培训。尽管87.2%的学生在干预后仍然缺乏信心，但所有干预措施都在自我评估知识和信心方面产生了统计学上显著的改善。最有希望的方法是哈丁的两周联合训练方案，该方案减轻了浅色皮肤和深色皮肤诊断之间的初始诊断偏差（P = .007）。主要的限制包括主要是单次干预，依赖于自我报告的信心措施，缺乏长期保留数据，以及持续的条件特异性诊断挑战，特别是对于深色皮肤的黑色素瘤。解决这些教育差距既是医学教育改革的当务之急，也是实现皮肤病护理卫生公平的关键一步。
{"title":"Training Medical Students/Medical Practitioners to Diagnose Dermatologic Conditions in Skin of Color: A Systematic Review of Educational Interventions.","authors":"Andy D Lee, Amrit Thandi, Jinny Choi, Grace Xiong, Sara Pollenan, Kristen Amanda Rachel Yee, Fatemeh Jafarian, Cathryn Sibbald","doi":"10.1177/12034754251408403","DOIUrl":"https://doi.org/10.1177/12034754251408403","url":null,"abstract":"<p><p>Despite increasing recognition of the importance of skin-of-color (SOC) representation in dermatology education, significant gaps persist in training medical students to diagnose dermatologic conditions across diverse skin tones. This systematic review analyzed educational interventions aimed at improving SOC diagnostic competency among medical trainees. A comprehensive search of MEDLINE, Embase, APA PsycInfo, and Scopus identified 8 studies comprising 667 participants, revealing categories: didactic teaching (33.1%), seminar-style expert-led teaching (32.4%), workshop-based learning (25.8%), and simulation-based learning (8.7%). Preintervention assessments consistently showed significantly lower confidence in diagnosing conditions in darker skin tones, with 64% to 69% of students reporting no SOC training at undergraduate level. All interventions produced statistically significant improvements in self-assessed knowledge and confidence, though 87.2% of students still lacked confidence postintervention. The most promising approach was Hardin's two-week combined training protocol, which mitigated initial diagnostic bias between light and dark skin diagnoses (<i>P</i> = .007). Critical limitations include predominantly single-session interventions, reliance on self-reported confidence measures, absence of long-term retention data, and persistent condition-specific diagnostic challenges, particularly for melanoma in darker skin. Addressing these educational gaps represents both an imperative for medical education reform and a crucial step toward achieving health equity in dermatologic care.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251408403"},"PeriodicalIF":3.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety and Legal Implications of Benzoyl Peroxide Prescriptions in Dermatology: Analysis of Legal Precedents.","authors":"Ghassan Barnawi, Houriah Nukaly, Raquel Lazarowitz, Ammar Saed Aldien, Elsa Awad, Shari R Lipner","doi":"10.1177/12034754251410186","DOIUrl":"https://doi.org/10.1177/12034754251410186","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251410186"},"PeriodicalIF":3.9,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1177/12034754251411901
Alexa Moschella, Edgar Akuffo-Addo, Shakira Brathwaite, Tatiana Lapa, Miranda Waugh, Marissa Joseph
{"title":"Assessing ChatGPT as an Educational Tool for Image Generation in Dermatology.","authors":"Alexa Moschella, Edgar Akuffo-Addo, Shakira Brathwaite, Tatiana Lapa, Miranda Waugh, Marissa Joseph","doi":"10.1177/12034754251411901","DOIUrl":"https://doi.org/10.1177/12034754251411901","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251411901"},"PeriodicalIF":3.9,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1177/12034754251408360
Sarah Aly, Osama Roshdy
{"title":"Tinea Corporia due to <i>Trichophyton indotinease</i>.","authors":"Sarah Aly, Osama Roshdy","doi":"10.1177/12034754251408360","DOIUrl":"https://doi.org/10.1177/12034754251408360","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251408360"},"PeriodicalIF":3.9,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1177/12034754251410174
Serena Dienes, Arya Rahmani, Eleanor Rebecca Lena, Kyle Seigel, Shireen Fikree, Joy Xu, David Croitoru, Vincent Piguet
{"title":"Keratosis Lichenoides Chronica: Disease Associations and Treatment Response in Adult and Pediatric Populations.","authors":"Serena Dienes, Arya Rahmani, Eleanor Rebecca Lena, Kyle Seigel, Shireen Fikree, Joy Xu, David Croitoru, Vincent Piguet","doi":"10.1177/12034754251410174","DOIUrl":"https://doi.org/10.1177/12034754251410174","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251410174"},"PeriodicalIF":3.9,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1177/12034754251411893
Ajay K Pandey, Shari R Lipner
{"title":"Prevalence of Food Insecurity in Patients with Prurigo Nodularis: A Cross-Sectional Study.","authors":"Ajay K Pandey, Shari R Lipner","doi":"10.1177/12034754251411893","DOIUrl":"https://doi.org/10.1177/12034754251411893","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251411893"},"PeriodicalIF":3.9,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1177/12034754251404454
Abdul Aziz Abdul Ghafoor, Mahan Maazi, Jihad Abou Ali Waked, Khalad Maliyar, Abrahim Abduelmula, Laurence Mainville, David Croitoru
{"title":"Development of Autoimmune Bullous Disorders in Patients Exposed to Radiation Therapy: A Systematic Review.","authors":"Abdul Aziz Abdul Ghafoor, Mahan Maazi, Jihad Abou Ali Waked, Khalad Maliyar, Abrahim Abduelmula, Laurence Mainville, David Croitoru","doi":"10.1177/12034754251404454","DOIUrl":"https://doi.org/10.1177/12034754251404454","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251404454"},"PeriodicalIF":3.9,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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