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Trends and disparities in cerebral edema-related mortality in the United States: A nationwide analysis using CDC WONDER data, 1999–2023 美国脑水肿相关死亡率的趋势和差异:1999-2023年CDC WONDER数据的全国分析
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-23 DOI: 10.1016/j.jocn.2026.111871
Hadiya Javed , Shahtaj Tariq , Wania Ahmer , Muhammad Khalid Afridi , Raheel Ahmed
Cerebral edema (CE) refers to excess accumulation of fluid in the brain parenchyma, which can result from trauma, stroke, infections, or metabolic insults. Despite its clinical importance, national trends and disparities in CE-related mortality remain understudied. We analyzed mortality data from 1999 to 2023 using the CDC WONDER database. Deaths listing CE, defined by the International Classification of Diseases, 10th Revision, as a contributing cause were included. The trends were stratified by age, sex, race/ethnicity, region, and urbanization level. We calculated crude and age-adjusted mortality rates (AAMRs) and assessed trends using the Joinpoint Regression Program with results considered statistically significant if the two-sided t-test yielded p-values < 0.05. A total of 77,278 CE-related deaths occurred from 1999 to 2023. National AAMRs rose from 0.94 per 100,000 population in 1999 to 1.3 per 100,000 population in 2023, with a significant overall increase (AAPC: +1.41 %, 95 % CI: 1.2–1.6; p < 0.001). Adults aged 25–44 exhibited the sharpest rise (AAPC: 1.56 %; 95 % CI: 1.33 to 1.81). Black individuals experienced the highest mortality (peak AAMR: 0.43, AAPC: +2.08 %, 95 % CI: 1.67–2.51). The South showed the highest regional burden (AAMR: 0.32, AAPC: +1.59 %, 95 % CI: 1.38–1.79), while non-metropolitan areas reported disproportionately high mortality rates (AAPC: +2.4 %, 95 % CI: 1.5–3.2; p < 0.001). CE-related mortality has increased significantly in the U.S., with marked disparities by age, race, and geography. These findings highlight the need for targeted prevention, early detection, and equity-focused intervention strategies.
脑水肿(CE)是指脑实质中液体的过量积聚,可由创伤、中风、感染或代谢损伤引起。尽管其具有临床重要性,但ce相关死亡率的国家趋势和差异仍未得到充分研究。我们使用CDC WONDER数据库分析了1999年至2023年的死亡率数据。根据《国际疾病分类》第十次修订版的定义,将慢性阻塞性肺病列为导致死亡的原因之一。趋势按年龄、性别、种族/民族、地区和城市化水平分层。我们计算粗死亡率和年龄调整死亡率(AAMRs),并使用Joinpoint回归程序评估趋势,如果双侧t检验的p值为<; 0.05,则认为结果具有统计学意义。1999年至2023年期间,共有77278例与ce有关的死亡。全国aamr从1999年的0.94 / 10万人口上升到2023年的1.3 / 10万人口,总体显著增加(AAPC: + 1.41%, 95% CI: 1.2-1.6; p < 0.001)。25-44岁成人的上升幅度最大(AAPC: 1.56%; 95% CI: 1.33 ~ 1.81)。黑人个体死亡率最高(峰值AAMR: 0.43, AAPC: + 2.08%, 95% CI: 1.67 ~ 2.51)。南方显示出最高的区域负担(AAMR: 0.32, AAPC: + 1.59%, 95% CI: 1.38-1.79),而非大都市地区报告了不成比例的高死亡率(AAPC: + 2.4%, 95% CI: 1.5-3.2; p < 0.001)。ce相关的死亡率在美国显著增加,在年龄、种族和地理上存在明显差异。这些发现强调了有针对性的预防、早期发现和以公平为重点的干预策略的必要性。
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引用次数: 0
AICA aneurysm–related subarachnoid hemorrhage in a dural AVF 硬膜AVF中AICA动脉瘤相关蛛网膜下腔出血
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-23 DOI: 10.1016/j.jocn.2026.111880
Ujjwal Agarwal , Rajsrinivas Parthasarathy , Radhey Shyam Singla , Pallav Bhatter
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引用次数: 0
Utilizing internal analytics and physician-director collaborations to enhance neurological health communication on YouTube 利用内部分析和医师-主管合作,加强YouTube上的神经健康交流
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-23 DOI: 10.1016/j.jocn.2026.111878
Benjamin K.P. Woo , Jamie O.P. Chung
The dissemination of health information on YouTube presents a paradox where expert-generated content, despite high clinical accuracy, often lacks the engagement seen in non-expert patient narratives. Recent evaluations of Guillain-Barré Syndrome (GBS) videos confirm that while physician-produced content achieves superior objective quality scores, it frequently suffers from low visibility and fails to correlate popularity with scientific validity. This manuscript proposes a shift toward utilizing internal analytics, specifically Average View Duration (AVD) and Click-Through Rate (CTR), alongside a collaborative physician-director production model to bridge the gap between clinical precision and public engagement. We suggest that adopting this hybrid creative model and prioritizing internal engagement metrics over aggregate view counts will better support patients and caregivers, particularly in complex neurological conditions.
在YouTube上传播健康信息带来了一个悖论,即专家生成的内容尽管具有很高的临床准确性,但往往缺乏非专家患者叙述的参与度。最近对吉兰-巴勒综合征(GBS)视频的评估证实,虽然医生制作的内容在客观质量上得分较高,但它经常存在能见度低的问题,并且无法将受欢迎程度与科学有效性联系起来。本文建议转向利用内部分析,特别是平均观看时间(AVD)和点击率(CTR),以及医生-主任合作生产模型,以弥合临床准确性和公众参与之间的差距。我们建议采用这种混合创新模式,并将内部参与指标优先于总体浏览量,将更好地支持患者和护理人员,特别是在复杂的神经系统疾病中。
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引用次数: 0
Decoding the intricacy of insular glioma-lenticulostriate artery relationship: Results from a prospective comparative study of pre and postoperative magnetic resonance angiographic evaluation 解码岛状胶质瘤-透镜状纹状动脉关系的复杂性:来自术前和术后磁共振血管造影评估的前瞻性比较研究的结果
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-22 DOI: 10.1016/j.jocn.2026.111866
Sudhakar Madheshiya , Kuntal Kanti Das , Shreyash Rai , Vivek Singh , Sudarsana Gogoi , Prabhakar Mishra , Soumen Kanjilal , Ashutosh Kumar , Ved Prakash Maurya , Pawan Kumar Verma , Kamlesh Singh Bhaisora , Anant Mehrotra , Arun Kumar Srivastava , Awadhesh Kumar Jaiswal

Background and objectives

Insular glioma (IG) resection is technically demanding and carries a high risk of postoperative neurological deficits, primarily due to ischemic injury to the middle cerebral artery (MCA) perforators. Understanding pre- and postoperative lenticulostriate artery (LSA) anatomy may clarify the tumor-perforator relationship and its clinical impact.

Methods

This prospective single-center study analyzed pre- and postoperative three-dimensional time-of-flight magnetic resonance angiography (3D-TOF MRA) to assess IG-LSA relationships. The extent of resection (EOR) and complications were correlated with LSA involvement patterns and postoperative reduction in the number of visible LSAs.

Results

LSA involvement patterns included “displaced” (28%), “contact” (56%), and “engulfed” (16%) types. Postoperatively, mean LSA count declined from 3.76 to 3.0 (p = 0.007). Reduction occurred in all patients with engulfed LSAs and in 30% with contact type. Giant IGs were more frequent in contact and engulfed patterns (p = 0.008). Tumors with reduced LSAs were more often oligodendroglioma or glioblastoma than grade 2 astrocytoma (p = 0.004). LSA loss was unrelated to surgical approach but correlated with radical resection (p = 0.019) and neurological deficits (p = 0.001).

Conclusion

IGs with LSA engulfment should undergo subtotal resection, whereas contact-type lesions require intraoperative judgment regarding EOR. Radical resection in giant IGs with unsafe tumor-LSA relationships, especially in aggressive histologies, increases the risk of permanent deficits. Not all single-LSA injuries result in lasting impairment. Routine preoperative 3D-TOF MRA is recommended for evaluating IG resectability and minimizing ischemic complications.
背景与目的脑岛胶质瘤(IG)切除术技术要求高,术后神经功能缺损风险高,主要是由于大脑中动脉(MCA)穿支缺血性损伤。了解透镜状纹状动脉(LSA)术前和术后的解剖结构可以阐明肿瘤与穿支的关系及其临床影响。方法本前瞻性单中心研究分析了术前和术后三维飞行时间磁共振血管造影(3D-TOF MRA)来评估IG-LSA的关系。切除程度(EOR)和并发症与LSA受累模式和术后可见LSA数量减少相关。结果slsa受累类型包括“移位型”(28%)、“接触型”(56%)和“吞没型”(16%)。术后平均LSA计数从3.76下降到3.0 (p = 0.007)。所有吞没型LSAs患者和30%接触型LSAs患者均出现减少。巨型IGs更频繁地出现接触和吞没模式(p = 0.008)。LSAs降低的肿瘤多为少突胶质细胞瘤或胶质母细胞瘤,多于2级星形细胞瘤(p = 0.004)。LSA丢失与手术入路无关,但与根治性切除(p = 0.019)和神经功能缺损(p = 0.001)相关。结论LSA吞没的igs应进行次全切除,而接触型病变需术中判断EOR。对于具有不安全肿瘤- lsa关系的巨大IGs,特别是在侵袭性组织学中,根治性切除会增加永久性缺损的风险。并不是所有的单lsa损伤都会导致持久的损伤。术前常规3D-TOF MRA被推荐用于评估IG的可切除性和减少缺血性并发症。
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引用次数: 0
Neuromuscular ultrasound and nerve conduction studies as complementary tools for screening of diabetic peripheral neuropathy 神经肌肉超声和神经传导研究作为糖尿病周围神经病变筛查的补充工具
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-22 DOI: 10.1016/j.jocn.2026.111876
Amani Nawito , Shahenda Al Menabbawy , Basma Bahgat El Sayed , Mohamed Magdy Ahmed Mohamed , Alshaimaa Sobhi Khalil
Diabetic Polyneuropathy (DPN) is a common debilitating complication of Diabetes Mellitus (DM), causing pain which may progress to numbness and motor involvement. DPN may lead to diabetic foot ulcers and possible amputation. Thus, DPN affects the patients’ quality of life and poses a financial burden if not managed early. Nerve conduction studies (NCS) have been used as an objective method for diagnosis of DPN. Neuromuscular Ultrasound (NMUS) is a more comfortable tool used to complement NCS in diagnosis of many diseases. The study aimed to investigate NMUS as a possible screening tool for DPN. The study included 58 patients with Type-II DM who were divided into two groups according to presence/absence of DPN using the modified Toronto clinical neuropathy score (mTCNS). The cross-sectional area (CSA) and muscle thickness (MT) in the upper and lower limbs as well as their corresponding NCS were compared. CSA of posterior tibial nerve and the sural nerve were significantly larger in the group with DPN. A cut-off value 2 mm2 CSA of the sural nerve showed sensitivity of 93.33%, specificity of 64.29% and area under the curve (AUC) was 80% for detecting DPN. This may be used as a complementary tool in certain situations to the corresponding NCS. Disease duration, HbA1c and mTCNS showed a positive correlation with NMUS findings. Patients with microvascular complications showed a significantly larger CSA of some nerves and less MT as compared to those without. NMUS represents a complementary tool to NCS and may be used for screening DPN.
糖尿病多发性神经病(DPN)是糖尿病(DM)常见的衰弱性并发症,引起疼痛,可发展为麻木和运动受累。DPN可能导致糖尿病足溃疡和可能的截肢。因此,如果不及早治疗,DPN会影响患者的生活质量,并造成经济负担。神经传导研究(NCS)已被用作诊断DPN的客观方法。神经肌肉超声(NMUS)是一种更舒适的工具,用于补充NCS在许多疾病的诊断。本研究旨在探讨NMUS作为DPN可能的筛查工具。该研究纳入了58例ii型糖尿病患者,根据是否存在DPN,采用改良的多伦多临床神经病变评分(mTCNS)将其分为两组。比较上肢和下肢的横截面积(CSA)和肌肉厚度(MT)及其相应的NCS。DPN组胫后神经及腓肠神经CSA明显增大。腓肠神经2 mm2 CSA检测DPN的灵敏度为93.33%,特异性为64.29%,曲线下面积(AUC)为80%。在某些情况下,这可以作为相应NCS的补充工具。病程、HbA1c和mTCNS与NMUS结果呈正相关。与无微血管并发症的患者相比,有微血管并发症的患者某些神经的CSA明显增大,MT明显减少。NMUS是NCS的补充工具,可用于筛查DPN。
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引用次数: 0
Trends in Intervention Modality for Hospitalizations with Infectious Intracranial Aneurysms: A Nationwide Analysis 传染性颅内动脉瘤住院治疗干预方式的趋势:一项全国性分析
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-22 DOI: 10.1016/j.jocn.2026.111852
Giana Dawod, Alis J. Dicpinigaitis, Cenai Zhang, Hooman Kamel, Santosh Murthy, Alexander E. Merkler

Background/Objective

Data regarding the optimal treatment of infectious intracranial aneurysms remains sparse. With growing utilization of endovascular therapy for cerebrovascular disease, we examined trends in endovascular versus neurosurgical treatment of infectious aneurysms and investigated the impact of treatment modality on outcomes.

Methods

Using data from the National Inpatient Sample from 2000 to 2019, we conducted a trends analysis on rates of treatment modalities among hospitalizations with infective endocarditis with ruptured or unruptured cerebral aneurysms. Treatment modalities were categorized as endovascular versus open neurosurgical repair based on ICD-9 and ICD-10 codes. Logistic regressions were utilized to assess the association between treatment modality and the outcomes of in-hospital mortality and discharge disposition.

Results

We identified 24,461 hospitalizations with an infectious intracranial aneurysm in the setting of infective endocarditis. Mean age was 56.0 years (SD, 17.8) and 61.8 % were male. The overall rate of intervention was 5.8 % (95 % CI, 5.0–6.5 %), and this did not change over time (p = 0.669). There was a significant increase in the rate of endovascular repair (APC = 3.6 %; 95 % CI, 1.2 %-8.1 %) and a significant decrease in the rate of open neurosurgical repair (APC = -5.4 %; 95 % CI, −8.1 % to −3.5 %). Treatment modality was not associated with in-hospital mortality (p = 0.698) or non-home discharge disposition (p = 0.897).

Conclusion

Although rates of infectious intracranial aneurysm intervention for infective endocarditis did not change, utilization of endovascular treatment increased while the use of open neurosurgical treatment decreased without adverse effects on mortality rate. Further directions include elucidating predictors of favorable outcomes for undergoing intervention and the most beneficial timing for the procedure during hospitalization.
背景/目的关于感染性颅内动脉瘤最佳治疗方法的资料仍然很少。随着血管内治疗在脑血管疾病中的应用越来越多,我们研究了感染性动脉瘤的血管内治疗与神经外科治疗的趋势,并调查了治疗方式对结果的影响。方法利用2000 - 2019年全国住院患者样本数据,对感染性心内膜炎合并脑动脉瘤破裂或未破裂患者的治疗方式率进行趋势分析。根据ICD-9和ICD-10编码,治疗方式分为血管内和开放神经外科修复。采用Logistic回归来评估治疗方式与住院死亡率和出院处置结果之间的关系。结果在感染性心内膜炎的背景下,我们确定了24,461例感染性颅内动脉瘤住院病例。平均年龄56.0岁(SD, 17.8), 61.8%为男性。总干预率为5.8% (95% CI, 5.0 - 6.5%),这没有随时间变化(p = 0.669)。血管内修复率显著增加(APC = 3.6%; 95% CI, 1.2% - 8.1%),开放性神经外科修复率显著降低(APC = - 5.4%; 95% CI, - 8.1% - - 3.5%)。治疗方式与住院死亡率(p = 0.698)或非家庭出院处置(p = 0.897)无关。结论感染性心内膜炎的感染性颅内动脉瘤介入率没有变化,但血管内治疗的使用率增加,开放神经外科治疗的使用率下降,对死亡率无不良影响。进一步的方向包括阐明进行干预的有利结果的预测因素和住院期间手术的最有利时机。
{"title":"Trends in Intervention Modality for Hospitalizations with Infectious Intracranial Aneurysms: A Nationwide Analysis","authors":"Giana Dawod,&nbsp;Alis J. Dicpinigaitis,&nbsp;Cenai Zhang,&nbsp;Hooman Kamel,&nbsp;Santosh Murthy,&nbsp;Alexander E. Merkler","doi":"10.1016/j.jocn.2026.111852","DOIUrl":"10.1016/j.jocn.2026.111852","url":null,"abstract":"<div><h3>Background/Objective</h3><div>Data regarding the optimal treatment of infectious intracranial aneurysms remains sparse. With growing utilization of endovascular therapy for cerebrovascular disease, we examined trends in endovascular versus neurosurgical treatment of infectious aneurysms and investigated the impact of treatment modality on outcomes.</div></div><div><h3>Methods</h3><div>Using data from the National Inpatient Sample from 2000 to 2019, we conducted a trends analysis on rates of treatment modalities among hospitalizations with infective endocarditis with ruptured or unruptured cerebral aneurysms. Treatment modalities were categorized as endovascular versus open neurosurgical repair based on ICD-9 and ICD-10 codes. Logistic regressions were utilized to assess the association between treatment modality and the outcomes of in-hospital mortality and discharge disposition.</div></div><div><h3>Results</h3><div>We identified 24,461 hospitalizations with an infectious intracranial aneurysm in the setting of infective endocarditis. Mean age was 56.0 years (SD, 17.8) and 61.8 % were male. The overall rate of intervention was 5.8 % (95 % CI, 5.0–6.5 %), and this did not change over time (p = 0.669). There was a significant increase in the rate of endovascular repair (APC = 3.6 %; 95 % CI, 1.2 %-8.1 %) and a significant decrease in the rate of open neurosurgical repair (APC = -5.4 %; 95 % CI, −8.1 % to −3.5 %). Treatment modality was not associated with in-hospital mortality (p = 0.698) or non-home discharge disposition (p = 0.897).</div></div><div><h3>Conclusion</h3><div>Although rates of infectious intracranial aneurysm intervention for infective endocarditis did not change, utilization of endovascular treatment increased while the use of open neurosurgical treatment decreased without adverse effects on mortality rate. Further directions include elucidating predictors of favorable outcomes for undergoing intervention and the most beneficial timing for the procedure during hospitalization.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"146 ","pages":"Article 111852"},"PeriodicalIF":1.8,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the efficacy of lidocaine and bupivacaine in GON blockade for prophylaxis of chronic migraine 利多卡因与布比卡因阻断谷氨酰胺预防慢性偏头痛的疗效比较
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-22 DOI: 10.1016/j.jocn.2026.111872
Sıddıka Sena İnan , Kübra Mehel Metin , Arzu Muz , İsmail Eren Durmuş , Suna Akın Takmaz , Levent Ertuğrul İnan

Background

Numerous studies have evaluated greater occipital nerve (GON) blockade for migraine prophylaxis using various techniques and anesthetic agents, yet a standardized protocol remains lacking. Although both lidocaine and bupivacaine are effective compared with placebo, no direct comparison exists. This study aimed to compare the efficacy of lidocaine and bupivacaine in GON blockade for chronic migraine.

Materials and methods

Data from 79 chronic migraine patients who underwent ultrasound-guided GON blockade at the University of Health Sciences Ankara Training and Research Hospital were retrospectively analyzed. Patients received either 1.5 mL of 2% lidocaine + 1 mL saline or 1.5 mL of 0.5% bupivacaine + 1 mL saline. Multivariate path analysis was used to evaluate the factors affecting pain reduction and to adjust for baseline differences. Blocks were administered weekly during the first month and monthly for two subsequent months on the side corresponding to pain. The number of headache days, attack duration, and Visual Analog Scale (VAS) scores were recorded before and after each session.

Results

Both groups showed significant reductions in headache days, attack duration, and VAS scores after treatment. Baseline values were similar except for disease duration, which was significantly longer in the bupivacaine group (p = 0.028). At the first month, the bupivacaine group reported significantly more headache days than the lidocaine group (P = 0.046), but no further intergroup differences were found. Although the lidocaine group showed lower pain scores in the first month in univariate analysis, multivariate path analysis revealed that the treatment group (Lidocaine vs. Bupivacaine) did not have a statistically significant effect on the change in VAS scores (p > 0.05). The baseline VAS score was the only significant predictor of pain reduction (β = -0.70, p < 0.001).

Conclusion

Lidocaine and bupivacaine were both effective for migraine prophylaxis via GON blockade. While lidocaine appeared to provide faster relief initially, regression analysis suggests that baseline pain severity, rather than the choice of agent or disease duration, is the primary determinant of treatment response.
背景:许多研究已经评估了使用各种技术和麻醉剂阻断大枕神经(GON)预防偏头痛的效果,但仍然缺乏标准化的方案。虽然利多卡因和布比卡因与安慰剂相比都有效,但没有直接的比较。本研究旨在比较利多卡因和布比卡因对慢性偏头痛的谷氨酰胺阻断的疗效。材料和方法回顾性分析安卡拉健康科学大学培训和研究医院超声引导下的79例慢性偏头痛患者的数据。患者接受1.5 mL 2%利多卡因+ 1ml生理盐水或1.5 mL 0.5%布比卡因+ 1ml生理盐水。多变量路径分析用于评估影响疼痛减轻的因素,并调整基线差异。第一个月每周给药,随后两个月每月给药。记录每次治疗前后头痛天数、发作持续时间和视觉模拟评分(VAS)。结果两组患者治疗后头痛天数、发作持续时间和VAS评分均显著减少。基线值相似,但布比卡因组的病程明显更长(p = 0.028)。在第一个月,布比卡因组报告的头痛天数明显多于利多卡因组(P = 0.046),但组间无进一步差异。虽然单因素分析中,利多卡因组第一个月疼痛评分较低,但多因素通径分析显示,治疗组(利多卡因vs布比卡因)对VAS评分变化无统计学意义(p > 0.05)。基线VAS评分是疼痛减轻的唯一显著预测因子(β = -0.70, p < 0.001)。结论利多卡因和布比卡因均可通过神经素阻断预防偏头痛。虽然利多卡因最初似乎提供更快的缓解,但回归分析表明,基线疼痛严重程度,而不是药物选择或疾病持续时间,是治疗反应的主要决定因素。
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引用次数: 0
Association between the cumulative defined daily dose of statins and ischemic stroke recurrence: a cohort study 他汀类药物每日累积剂量与缺血性卒中复发之间的关系:一项队列研究
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-22 DOI: 10.1016/j.jocn.2026.111873
Yue Han , Zhe Bian , Haochen Gu , Dunzhu Guo , Rui Li , Liping Liu , Dali Wang , Yanbo Peng

Background

The cumulative defined daily dose (cDDD) enables quantification of statin exposure, balancing therapeutic intensity and patient adherence. However, the relationship between statin cDDD and recurrence risk in ischemic stroke (IS) patients remains unclear.

Objective

The aim of this study was to investigate the impact of statin cDDD on recurrence risk in IS patients.

Methods

This prospective cohort study enrolled 728 patients with acute ischemic stroke (AIS). After 1 year of follow-up, participants were stratified into four groups (Q1-Q4) according to the quartiles of statin cDDD, and Kaplan-Meier curves were used to estimate the risk of stroke recurrence. The association between cDDD and recurrence risk was examined using restricted cubic spline (RCS) and Cox proportional hazards models, with sensitivity analyses employed to assess population heterogeneity and confirm the robustness of the findings.

Results

Kaplan-Meier survival analysis revealed statistically significant differences in recurrence rates across quartiles (P < 0.001). RCS analysis confirmed a nonlinear negative correlation between cDDD and recurrence risk (P for nonlinearity < 0.001). Multivariate Cox regression demonstrated that the recurrence risk in Q4 was 87.7% lower than in Q1. Sensitivity analysis further confirmed that the association between cDDD and IS recurrence risk was independent of antihypertensive or antidiabetic medication use.

Conclusions

Statin cDDD shows a significant nonlinear inverse correlation with stroke recurrence, and exhibits a dose-dependent threshold effect.
累积定义日剂量(cDDD)可以量化他汀类药物暴露,平衡治疗强度和患者依从性。然而,他汀类药物cDDD与缺血性卒中(IS)患者复发风险之间的关系尚不清楚。目的探讨他汀类药物cDDD对IS患者复发风险的影响。方法本前瞻性队列研究纳入728例急性缺血性卒中(AIS)患者。随访1年后,根据他汀类药物cDDD的四分位数将参与者分为四组(Q1-Q4),采用Kaplan-Meier曲线估计卒中复发风险。使用限制性三次样条(RCS)和Cox比例风险模型检查cDDD与复发风险之间的关系,并采用敏感性分析评估群体异质性并确认研究结果的稳健性。结果kaplan - meier生存分析显示,四分位数间复发率差异有统计学意义(P < 0.001)。RCS分析证实cDDD与复发风险之间存在非线性负相关(P为非线性<; 0.001)。多因素Cox回归分析显示,Q4复发风险较Q1降低87.7%。敏感性分析进一步证实,cDDD与IS复发风险的相关性与降压或降糖药物的使用无关。结论他汀类药物cDDD与脑卒中复发呈显著的非线性负相关,且具有剂量依赖性阈值效应。
{"title":"Association between the cumulative defined daily dose of statins and ischemic stroke recurrence: a cohort study","authors":"Yue Han ,&nbsp;Zhe Bian ,&nbsp;Haochen Gu ,&nbsp;Dunzhu Guo ,&nbsp;Rui Li ,&nbsp;Liping Liu ,&nbsp;Dali Wang ,&nbsp;Yanbo Peng","doi":"10.1016/j.jocn.2026.111873","DOIUrl":"10.1016/j.jocn.2026.111873","url":null,"abstract":"<div><h3>Background</h3><div>The cumulative defined daily dose (cDDD) enables quantification of statin exposure, balancing therapeutic intensity and patient adherence. However, the relationship between statin cDDD and recurrence risk in ischemic stroke (IS) patients remains unclear.</div></div><div><h3>Objective</h3><div>The aim of this study was to investigate the impact of statin cDDD on recurrence risk in IS patients.</div></div><div><h3>Methods</h3><div>This prospective cohort study enrolled 728 patients with acute ischemic stroke (AIS). After 1 year of follow-up, participants were stratified into four groups (Q1-Q4) according to the quartiles of statin cDDD, and Kaplan-Meier curves were used to estimate the risk of stroke recurrence. The association between cDDD and recurrence risk was examined using restricted cubic spline (RCS) and Cox proportional hazards models, with sensitivity analyses employed to assess population heterogeneity and confirm the robustness of the findings.</div></div><div><h3>Results</h3><div>Kaplan-Meier survival analysis revealed statistically significant differences in recurrence rates across quartiles (<em>P</em> &lt; 0.001). RCS analysis confirmed a nonlinear negative correlation between cDDD and recurrence risk (<em>P</em> for nonlinearity &lt; 0.001). Multivariate Cox regression demonstrated that the recurrence risk in Q4 was 87.7% lower than in Q1. Sensitivity analysis further confirmed that the association between cDDD and IS recurrence risk was independent of antihypertensive or antidiabetic medication use.</div></div><div><h3>Conclusions</h3><div>Statin cDDD shows a significant nonlinear inverse correlation with stroke recurrence, and exhibits a dose-dependent threshold effect.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"146 ","pages":"Article 111873"},"PeriodicalIF":1.8,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of sleep disorder with bulbar weakness and short-term outcomes in myasthenia gravis 重症肌无力患者睡眠障碍与球无力及短期预后的关系
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-17 DOI: 10.1016/j.jocn.2026.111863
Nan Xue , Wan Zhang , Xinyan Guo , Tianyu Ma , Mengwen Lu , Xinyi Ye , Min Jiang , Li Sun , Mingjin Yang , Xiaoyu Huang , Yong Zhang , Zhouao Zhang , Yanbo Wang , Ying Sheng

Background

Sleep disorder is increasingly recognized in myasthenia gravis (MG). However, its specific link to bulbar muscle weakness and short-term outcomes is not well established. This study aimed to investigate the prevalence of subjective sleep disorder (based on Pittsburgh Sleep Quality Index [PSQI] score) in a cohort of acetylcholine receptor (AChR) antibody-positive MG patients, and to explore its associations with bulbar muscle weakness, disease severity, and its value for the short-term outcome of MG.

Methods

We conducted a prospective cohort study of 163 AChR-MG patients. Subjective sleep quality was assessed using the PSQI score. Disease severity was evaluated with MG Specific Activities of Daily Living (MG-ADL) score, the Quantitative MG (QMG) score, and Myasthenia Gravis Foundation of America (MGFA) classification. Univariate and multivariable logistic regression were used to identify independent risk factors and establish prediction model for outcome. The predictive values were evaluated by receiver operating characteristic (ROC) curves. Moreover, calibration analysis and decision curve analysis (DCA) of the model were performed.

Results

The median PSQI score was 7.0 (5.0, 9.0) and the prevalence of sleep disorder (PSQI > 5) was 73.6 %. Patients with bulbar weakness had significantly higher PSQI scores than those without (P < 0.001). PSQI score showed significant positive correlations with MG-ADL (r = 0.319, P < 0.001),QMG (r = 0.356, P < 0.001) in MG patients. A higher baseline PSQI score was identified as an independent risk factor for poor outcome at 6 months (odds ratio: 1.642 [95 % CI: 1.340–2.014], P < 0.001), with a area under curve (AUC) of 0.797. A predictive model combining PSQI score, bulbar weakness, and female gender demonstrated good discrimination, with a AUC of 0.840, a sensitivity of 0.688, and a specificity of 0.870.

Conclusion

Poor sleep quality is highly prevalent in AChR-MG and was more serious in patients with bulbar weakness. PSQI score was an independent risk factor for poor short-term outcome. Routine assessment of sleep may aid in risk stratification and personalized management.
背景:睡眠障碍在重症肌无力(MG)中得到越来越多的认识。然而,其与球肌无力和短期预后的具体联系尚不明确。本研究旨在调查主观睡眠障碍(基于匹兹堡睡眠质量指数[PSQI]评分)在乙酰胆碱受体(AChR)抗体阳性MG患者队列中的患病率,并探讨其与球肌无力、疾病严重程度的关系,及其对MG短期预后的价值。方法对163例AChR-MG患者进行前瞻性队列研究。主观睡眠质量采用PSQI评分进行评估。采用MG特定日常生活活动(MG- adl)评分、定量MG (QMG)评分和美国重症肌无力基金会(MGFA)分级评估疾病严重程度。采用单因素和多因素logistic回归识别独立危险因素,建立预后预测模型。采用受试者工作特征(ROC)曲线评价预测价值。对模型进行了标定分析和决策曲线分析(DCA)。结果PSQI评分中位数为7.0(5.0,9.0),睡眠障碍患病率(PSQI > 5)为73.6%。有球无力的患者PSQI评分明显高于无球无力的患者(P < 0.001)。MG患者PSQI评分与MG- adl (r = 0.319, P < 0.001)、QMG (r = 0.356, P < 0.001)呈显著正相关。较高的基线PSQI评分被确定为6个月预后不良的独立危险因素(优势比:1.642 [95% CI: 1.340-2.014], P < 0.001),曲线下面积(AUC)为0.797。结合PSQI评分、球无力和女性性别的预测模型具有良好的鉴别能力,AUC为0.840,敏感性为0.688,特异性为0.870。结论睡眠质量差在AChR-MG患者中普遍存在,且在球无力患者中更为严重。PSQI评分是短期预后不良的独立危险因素。常规睡眠评估有助于风险分层和个性化管理。
{"title":"Association of sleep disorder with bulbar weakness and short-term outcomes in myasthenia gravis","authors":"Nan Xue ,&nbsp;Wan Zhang ,&nbsp;Xinyan Guo ,&nbsp;Tianyu Ma ,&nbsp;Mengwen Lu ,&nbsp;Xinyi Ye ,&nbsp;Min Jiang ,&nbsp;Li Sun ,&nbsp;Mingjin Yang ,&nbsp;Xiaoyu Huang ,&nbsp;Yong Zhang ,&nbsp;Zhouao Zhang ,&nbsp;Yanbo Wang ,&nbsp;Ying Sheng","doi":"10.1016/j.jocn.2026.111863","DOIUrl":"10.1016/j.jocn.2026.111863","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disorder is increasingly recognized in myasthenia gravis (MG). However, its specific link to bulbar muscle weakness and short-term outcomes is not well established. This study aimed to investigate the prevalence of subjective sleep disorder (based on Pittsburgh Sleep Quality Index [PSQI] score) in a cohort of acetylcholine receptor (AChR) antibody-positive MG patients, and to explore its associations with bulbar muscle weakness, disease severity, and its value for the short-term outcome of MG.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study of 163 AChR-MG patients. Subjective sleep quality was assessed using the PSQI score. Disease severity was evaluated with MG Specific Activities of Daily Living (MG-ADL) score, the Quantitative MG (QMG) score, and Myasthenia Gravis Foundation of America (MGFA) classification. Univariate and multivariable logistic regression were used to identify independent risk factors and establish prediction model for outcome. The predictive values were evaluated by receiver operating characteristic (ROC) curves. Moreover, calibration analysis and decision curve analysis (DCA) of the model were performed.</div></div><div><h3>Results</h3><div>The median PSQI score was 7.0 (5.0, 9.0) and the prevalence of sleep disorder (PSQI &gt; 5) was 73.6 %. Patients with bulbar weakness had significantly higher PSQI scores than those without (P &lt; 0.001). PSQI score showed significant positive correlations with MG-ADL (r = 0.319, P &lt; 0.001),QMG (r = 0.356, P &lt; 0.001) in MG patients. A higher baseline PSQI score was identified as an independent risk factor for poor outcome at 6 months (odds ratio: 1.642 [95 % CI: 1.340–2.014], P &lt; 0.001), with a area under curve (AUC) of 0.797. A predictive model combining PSQI score, bulbar weakness, and female gender demonstrated good discrimination, with a AUC of 0.840, a sensitivity of 0.688, and a specificity of 0.870.</div></div><div><h3>Conclusion</h3><div>Poor sleep quality is highly prevalent in AChR-MG and was more serious in patients with bulbar weakness. PSQI score was an independent risk factor for poor short-term outcome. Routine assessment of sleep may aid in risk stratification and personalized management.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"145 ","pages":"Article 111863"},"PeriodicalIF":1.8,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meningitis secondary to clival communication with the sphenoid sinus 继发于蝶窦与斜坡交通的脑膜炎
IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2026-01-16 DOI: 10.1016/j.jocn.2026.111862
Kyle Bennett , Yi Chen Zhao , James King
{"title":"Meningitis secondary to clival communication with the sphenoid sinus","authors":"Kyle Bennett ,&nbsp;Yi Chen Zhao ,&nbsp;James King","doi":"10.1016/j.jocn.2026.111862","DOIUrl":"10.1016/j.jocn.2026.111862","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"145 ","pages":"Article 111862"},"PeriodicalIF":1.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Clinical Neuroscience
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