Journal of Clinical Neuroscience最新文献

{"title":"Development of Hybrid radiomic Machine learning models for preoperative prediction of meningioma grade on multiparametric MRI","authors":"Steven Zhang ,&nbsp;Jesse Richter ,&nbsp;Jonathon Veale ,&nbsp;Vu Minh Hieu Phan ,&nbsp;Nick Candy ,&nbsp;Santosh Poonnoose ,&nbsp;Marc Agzarian ,&nbsp;Minh-Son To","doi":"10.1016/j.jocn.2025.111118","DOIUrl":"10.1016/j.jocn.2025.111118","url":null,"abstract":"<div><h3>Purpose</h3><div>To develop and compare machine learning models for distinguishing low and high grade meningiomas on multiparametric MRI. Methods: Pre-operative T1-weighted(T1), contrast-enhanced T1-weighted(T1CE), T2-weighted, T2 FLAIR, and DWI/ADC MRI sequences of meningiomas performed between 2000 and 2020 were retrospectively collected from a single tertiary hospital dedicated neurosurgical department. Tumours were manually segmented and handcrafted radiomic features were extracted. Deep learning features were extracted using a fine-tuned foundation model. Various oversampling techniques, feature selection algorithms and classifiers were trialled to build Handcrafted radiomics only (HRO) and handcrafted with deep learning radiomics (HDLR) models. Bootstrap was used for internal validation of model performance and calculating confidence intervals of metrices. Discrimination, calibration, feature importance and clinical utility of models were assessed via ROC AUC, calibration curve, Shapley values and decision curve analysis, respectively. Results: The analysis included 97 low grade and 18 high grade meningiomas. HRO and HDLR models had comparable diagnostic performance, using Random Forest and XGBoost respectively. They achieved mean (95 %CI): ROC AUC 0.825[0.662,0.952] and 0.794[0.662,0.948], specificity 0.913[0.793,0.952] and 0.892[0.796,0.983], sensitivity 0.499[0.204,1] and 0.509[0.225,0.851], NPV 0.909[0.851,0.971] and 0.909[0.851,0.972], and PPV 0.529[0.238,0.924] and 0.465[0.263,0.846], respectively for HRO and HDLR models. HRO and HDLR models selected 11–12 features, with T1 and T1CE having consistent importance. Conclusion: HRO and HDLR can effectively predict meningioma grades preoperatively. Challenges remain in achieving consistent sensitivity and PPV. Larger, multi-centre studies are warranted to confirm our findings, but it holds promise for improving personalized treatment strategies and patient outcomes in meningioma management. Code is available on Github <span><span>https://github.com/stephano41/radiomics_ai</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111118"},"PeriodicalIF":1.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI in neurosurgical education: Can machines learn to see like surgeons?","authors":"Ari Metalin Ika Puspita ,&nbsp;Mimin Ninawati ,&nbsp;Farida Istianah ,&nbsp;Agus Budi Santosa ,&nbsp;Bahrul Sri Rukmini ,&nbsp;Erfan Ramadhani","doi":"10.1016/j.jocn.2025.111153","DOIUrl":"10.1016/j.jocn.2025.111153","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"134 ","pages":"Article 111153"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patient-centric approach to neuro-recovery after acute brain injuries","authors":"Muhammad Aemaz Ur Rehman ,&nbsp;Kristi Emerson ,&nbsp;Vanessa L. Merker ,&nbsp;Michael Young ,&nbsp;David J. Lin ,&nbsp;Sahar F. Zafar","doi":"10.1016/j.jocn.2025.111158","DOIUrl":"10.1016/j.jocn.2025.111158","url":null,"abstract":"<div><h3>Background</h3><div> <!-->Patients discharged after acute brain injuries require ongoing medical care to support recovery and treat secondary neurologic complications. Most therapeutic trials for interventions after acute brain injuries use measures of disability (i.e., the Modified Rankin Scale) as primary outcomes, but systematically collecting these outcomes as part of clinical care remains challenging. In addition, understanding patients’ perspectives on recovery is critical to providing personalized care and ultimately improving outcomes.</div></div><div><h3>Methods</h3><div> <!-->The Post-ICU Neurorecovery clinic at a tertiary care hospital documented two outcome measures as part of routine clinical care: 1) Modified Rankin Scale (mRS), and 2) Free-text response to “What is the single most important thing the NeuroRecovery clinic can do to support you/your loved one in the journey of recovery”. Weekly clinic reminders to providers to use a SmartPhrase that integrated these outcome measures into clinical documentation was implemented. A qualitative content analysis of the SmartPhrase responses was conducted. mRS scores were examined in relation to results from qualitative content analysis.</div></div><div><h3>Results</h3><div> <!-->After the implementation of weekly clinical email reminders, documentation of the smartphrase improved from 29 % to 60 % for all clinic visits over a pilot period of 11 months (July 2022-May 2023). Physical health (<em>n</em> = 82, 37 %), functional recovery (<em>n</em> = 37, 17 %), mental health (<em>n</em> = 31, 14 %), and social health (<em>n</em> = 18, 8 %) were the most common themes (codes) abstracted from the free-text responses. Themes varied by mRS levels; as mRS scores increased (i.e., increased disability), patients reported greater need for physical health support.</div></div><div><h3>Conclusion</h3><div> <!-->Standardized, systematic documentation of outcomes in Neurorecovery clinics may provide an opportunity to develop patient-centric and disability level-specific goals for recovery.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111158"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rates of discontinuation and non-publication of endovascular stroke clinical studies: A cross-sectional analysis","authors":"Ibraheem M. Alkhawaldeh ,&nbsp;Mariam Abdelhady ,&nbsp;Ahmed Aljabali ,&nbsp;Dina Essam Abo-elnour ,&nbsp;Rowan H. Elhalag ,&nbsp;Esraa Zedan ,&nbsp;Marwa Abdelazim Rizk ,&nbsp;Marwa Kabeel ,&nbsp;Jenan A. Alkasasbeh ,&nbsp;Sewar Elejla ,&nbsp;Abdalrhman ALkasabrah ,&nbsp;Moaz Khaled Salama ,&nbsp;Hazem S. Ghaith ,&nbsp;Ahmed Negida","doi":"10.1016/j.jocn.2025.111122","DOIUrl":"10.1016/j.jocn.2025.111122","url":null,"abstract":"<div><h3>Background</h3><div>The discontinuation and non-publication of clinical studies in various medical fields undermine research efforts and may bias the medical evidence base. This study investigates the prevalence and factors associated with these issues in endovascular stroke studies.</div></div><div><h3>Methods</h3><div>Clinical Trials.gov was searched for all studies registered from inception up till May 2022 and included patients with endovascular stroke. Publications from these studies were identified by extensive online searching using the NCT identifier number and other related keywords, and multiple logistic regression analysis was performed to identify characteristics associated with study discontinuation and non-publication.</div></div><div><h3>Results</h3><div>Our search yielded 88 endovascular stroke studies, all including both genders. Among these, 63 (71.6 %) were completed, and 25 (28.4 %) were discontinued. Of the completed studies, 40 (63.5 %) were published. The majority of trials were single-centric (57 %), had a large sample size of &gt;=100 (53.4 %), involved only adults (97.6 %), and were primarily funded by non-industrial sources (70 %). Discontinuation was more frequent in smaller-sized, single-center trials, but the associations diminished after adjustment. The sample size was a significant predictor of non-publication even after adjustment.</div></div><div><h3>Conclusion</h3><div>There is evidence of non-dissemination bias in clinical studies of endovascular stroke. These biases distort the therapeutic information available to inform clinical practice and raise ethical concerns regarding exposing volunteering participants to potential risks without furthering practice.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111122"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible cerebral vasoconstriction syndrome: Transcranial doppler findings in a case series of 90 patients","authors":"Srinath Ramaswamy ,&nbsp;Samuel D. Jacobson ,&nbsp;Cyrus X. Colah ,&nbsp;Jackson Roberts ,&nbsp;Minghua Liu ,&nbsp;Randolph S. Marshall","doi":"10.1016/j.jocn.2025.111157","DOIUrl":"10.1016/j.jocn.2025.111157","url":null,"abstract":"<div><h3>Background</h3><div>Transcranial Doppler (TCD) can be used in the diagnosis and monitoring of reversible cerebral vasoconstriction syndrome (RCVS). Whether TCD abnormalities can extend beyond 8–12 weeks has not been studied. We performed a single-center, retrospective analysis of TCD abnormalities in RCVS, specifically, whether elevated mean flow velocities (MFV) can persist beyond 90 days of symptom onset.</div></div><div><h3>Methods</h3><div>Consecutive patients were identified retrospectively using our hospital coding and billing data, and EMR search (2012–2023). Inclusion criteria were diagnosis of<!--> <!-->RCVS, any age, and available Spectral TCD (non-imaging) (TCD-S). Exclusion criteria were RCVS patients without TCD-S studies, or patients deemed to have other vasculopathies upon adjudication. We recorded demographics, RCVS triggers, and clinical and imaging features. Presence of elevated MFV on TCD-S above the upper reference range was considered abnormal.</div></div><div><h3>Results</h3><div>Ninety patients with RCVS had TCD-S performed (mean age 39.8 ± 11.8 years, 91% female). Six patients (6.7%) were pregnant and 25 (27.8%) were postpartum. Vasoconstriction was seen on imaging in 56 (62.2%). Median RCVS₂ score was 9 (7–10). Complications of RCVS included subarachnoid hemorrhage in 25 (27.8%), intracerebral hemorrhage in 19 (21.1%), and cerebral infarction in 11 (12.2%). TCD-S was abnormal (elevated MFV) in seventy-nine (87.8%). Among those with serial (≥2) TCD-S (n = 67), twenty-two (32.8%) had normalization in MFV at a median time of 73 days (50–132) from symptom onset. Forty-five (67.2%) did not show normalization as per their last available TCD-S at a median of 41 days (16–177). Twenty-six (31.9%) patients had available TCD-S results beyond 90 days, of which 21 (81%) had elevated MFV.</div></div><div><h3>Conclusions</h3><div>Patients with RCVS can have elevated TCD-S mean flow velocities beyond 90 days. TCD-S may have utility in the diagnosis of RCVS in the early or mild cases, where CTA or MRA may not capture the vasospasm. Prospective studies of the duration of TCD-S abnormalities are necessary to confirm these findings, and to inform clinical management, such as the duration of follow-up and the effects of calcium channel blocker treatment.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111157"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hospital-acquired infection among patients with acute neurological conditions in the ICU","authors":"Raghav Kumar ,&nbsp;Pradeep Kumar Maurya ,&nbsp;Ajai Kumar Singh ,&nbsp;Abdul Qavi ,&nbsp;Dinkar Kulshreshtha ,&nbsp;Manodeep Sen","doi":"10.1016/j.jocn.2025.111072","DOIUrl":"10.1016/j.jocn.2025.111072","url":null,"abstract":"<div><h3>Introduction</h3><div>Healthcare-associated infections (HAIs) are a significant cause of morbidity and mortality. HAIs become crucial in patients with neurological illnesses, as they need invasive procedures and extended care, prolonging the hospital stay in most cases. In this study, we report the type, microbial etiology, and outcome of patients with HAIs in a Neurology Intensive Care Unit setting.</div></div><div><h3>Methods</h3><div>In this prospective study, 213 neurologically ill patients were recruited. Patient demographics, primary diagnosis, comorbidities, invasive interventions, device specific data, and length of hospital stay were recorded. Data collected for each episode of HAI included- site of infection, causative organisms, and susceptibility. Site specific infections were categorised as per CDC/NHSN definitions for HAIs.</div></div><div><h3>Results</h3><div>The median age of patients was 60 years (range 15–88) and 66.70 % were male. HAIs were observed in 135 (63.38 %) patients. Majority of the patients had stroke (ischemic/haemorrhagic) [n = 142;66.66 %] followed by neuromuscular [n = 18; 8.45 %] and seizure disorder [n = 14; 6.57 %]. Most prevalent site of HAIs was urinary tract infections (UTI) (n = 80;37.55 %) followed by pneumonia (n = 74;34.74 %) and blood stream infections (n = 53;24.88 %). 209 patients (98.12 %) underwent urinary catheterization, 90 (42.3 %) required intubation and mechanical ventilation, and 70 (32.86 %) central venous catheterisations. Amongst various HAIs, commonly isolated bacterial pathogens in UTI were <em>Escherichia coli</em> [18/48;37.59 %], <em>Enterococcus</em> [10/48;20.83 %] while <em>Candida species</em> [35/40;87.50 %] was the most common amongst fungal pathogens. Causative organisms in Pneumonia were <em>Klebsiella pneumoniae</em> (27/104;25.96 %), <em>Acinetobacter baumannii</em> (n = 25/104;24.03 %), and <em>Pseudomonas aeruginosa</em> [14/104;13.46 %]. Among the blood stream infections, <em>Staphylococcus species</em> were the most common [39/161;24.22 %] followed by <em>candida species</em> [5/161;3.10 %]. Out of 55 patients who died, HAI was observed in 39 patients (70.90 %). Mean length of hospital stay was 17.56 ± 13.17 days. Presence of coronary artery disease, pulmonary site infection, low Glasgow Coma Scale, central venous catheterization, mechanical ventilation, abnormal chest x-ray, and multiple site infections were significantly associated with high mortality (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>In our study 63.38% of neurological patients had HAIs. The most common sites were urinary, pulmonary, and blood stream infections. Device associated infections were common and significantly associated with poor outcome. Considering the high incidence of HAIs early recognition and treatment of site-specific pathogens may improve the outcome in these patients.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"134 ","pages":"Article 111072"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and efficacy of tyrosine kinase inhibitors against EGFR in patients with glioma; A systematic review, meta-analysis, and sub-group analysis on glioblastoma","authors":"Mohammad Amin Habibi ,&nbsp;Muhammad Hussain Ahmadvand ,&nbsp;Pouria Delbari ,&nbsp;Mohammad Sina Mirjani ,&nbsp;Amir Hessam Zare ,&nbsp;Baran Mehdizadeh ,&nbsp;Ali Allahdadi ,&nbsp;Zahra Ardestani ,&nbsp;Romina Hamidi Rad ,&nbsp;Aliakbar Aliasgary ,&nbsp;Saba Sabet ,&nbsp;Mohammad Shahir Eftekhar ,&nbsp;Ibrahim Mohammadzadeh ,&nbsp;Bardia Hajikarimloo","doi":"10.1016/j.jocn.2025.111138","DOIUrl":"10.1016/j.jocn.2025.111138","url":null,"abstract":"<div><h3>Background</h3><div>Gliomas, particularly glioblastoma (GBM), remain challenging to treat and have a poor prognosis. Tyrosine kinase inhibitors (TKIs) targeting EGFR have shown promise, but their efficacy in gliomas is not well established. This study aimed to systematically review and <em>meta</em>-analyze the safety and efficacy of EGFR TKIs in patients with glioma, specifically for primary and recurrent GBM.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across PubMed, Embase, Scopus, and Web of Science up to January 1, 2024. Randomized controlled trials and observational studies evaluating TKIs in glioma patients were included. Primary outcomes were overall survival (OS), progression-free survival (PFS), and adverse events. A random-effects <em>meta</em>-analysis was performed to pool results. All statistical analysis was performed using STATA v.17.</div></div><div><h3>Results</h3><div>A total of 2,424 patients from 51 studies were included. The pooled mean OS was 12.68 months (95 % CI: 6.29–19.08) with 1-year and 2-year OS rates of 43 % (95 % CI: 34 %-52 %) and 14 % (95 % CI: 8 %-20 %), respectively. The mean PFS was 9.61 months (95 % CI: 4.83–14.38). The overall response rate was 19 % (95 % CI: 1 %-36 %). Grade ≥ 3 adverse events occurred in 35 % of patients (95 % CI: 13 %-57 %). Subgroup analyses revealed that combination therapies outperformed TKI monotherapy, and some newer TKIs, like vandetanib, showed improved efficacy.</div></div><div><h3>Conclusions</h3><div>TKIs demonstrate modest but meaningful benefits in glioma treatment, particularly when combined with other therapies. While initial survival improvements are observed, long-term outcomes remain challenging. Further research is needed to develop more potent, brain-penetrant TKIs and optimize combination strategies to improve outcomes in glioma patients.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111138"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbar spinal stenosis with degenerative spondylolisthesis in twins: An observational study from the national Swedish spine registry and the Swedish twin registry","authors":"Anders Joelson ,&nbsp;Lilla Szigethy ,&nbsp;Freyr Gauti Sigmundsson","doi":"10.1016/j.jocn.2025.111155","DOIUrl":"10.1016/j.jocn.2025.111155","url":null,"abstract":"<div><h3>Background</h3><div>Only a few studies have investigated the genetic background of lumbar spinal stenosis (LSS) with degenerative spondylolisthesis (DS) requiring surgery. The purpose of this study was to determine the concordance rates for LSS with DS requiring surgery by studying monozygotic (MZ) and dizygotic (DZ) twin pairs.</div></div><div><h3>Methods</h3><div>Patients between 18 and 85 years of age who underwent surgery for LSS with DS between 1996 and 2022 were identified in the national Swedish spine registry (14,614 patients) and matched with the Swedish Twin Registry to identify MZ and DZ twins. The concordance rates, the MZ/DZ concordance ratios, and the limits of genetic determination were calculated.</div></div><div><h3>Results</h3><div>We identified 145 twin pairs (27 MZ and 118 DZ pairs) of whom 1 or both twins underwent surgery for LSS with DS. We found no concordant MZ pair and 2 concordant DZ pairs. When we evaluated pairs where at least one twin was operated for LSS with DS we found 2 concordant MZ pairs and 4 concordant DZ pairs (the co-twins were operated for LSS without DS) resulting in the probandwise concordance rate 0.14 (95% CI, 0 to 0.31) for MZ twins and 0.07 (95% CI, 0.02 to 0.13) for DZ twins. The probandwise MZ/DZ concordance ratio was 2.1 (95% CI 0–11.9). The limits of genetic determination were 0.27 to 0.36.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that heredity may not be of major etiologic importance in most cases of LSS with DS requiring surgery.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111155"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing intraoperative bulbocavernosus reflex monitoring: From prediction to prevention of postoperative voiding dysfunction","authors":"Jongsuk Choi ,&nbsp;Kieob Kim","doi":"10.1016/j.jocn.2025.111154","DOIUrl":"10.1016/j.jocn.2025.111154","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"134 ","pages":"Article 111154"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do gastrointestinal symptoms influence neurocognitive functioning in COVID-19 patients?","authors":"Kalliopi Megari ,&nbsp;Evanthia Thomaidou ,&nbsp;Maria Theodoratou ,&nbsp;Georgios Kougioumtzis ,&nbsp;Soultana Papadopoulou ,&nbsp;Dimitra V. Katsarou ,&nbsp;Eleni Argiriadou","doi":"10.1016/j.jocn.2025.111147","DOIUrl":"10.1016/j.jocn.2025.111147","url":null,"abstract":"<div><h3>Background and objectives</h3><div>SARS-Cov-19 virus is known to attack multiple organ systems including the brain and as a result, numerous of these patients manifest neurocognitive disorders. Moreover COVID-19, causes gastrointestinal symptoms such as nausea and vomiting, abdominal pain, diarrhea or constipation, loss of appetite and weight loss and these symptoms have been linked to neurocognitive dysfunction. According to studies, COVID-19 patients who report gastrointestinal symptoms as the predominant manifestations, perform worse on neurocognitive tests than those who do not suffer from such symptoms. In this study, we examined whether hospitalized COVID-19 patients with gastrointestinal symptoms presented neurocognitive dysfunction.</div></div><div><h3>Materials and methods</h3><div>The study enrolled 92 COVID-19 patients, hospitalized for 6–20 days, who were divided into 2 groups: the gastrointestinal group (GI) (n = 44) who presented with predominant gastrointestinal symptoms such as anorexia, nausea, vomiting, diarrhea and abdominal pain and the group without GI symptoms, (nGI) (n = 48), who reported fever, fatigue and symptoms from the respiratory system as the main symptoms. Neurocognitive assessment was performed by questionnaires administered to all patients, three months after the first positive PCR test for COVID-19.</div></div><div><h3>Results</h3><div>T-test was conducted for each test. Results revealed that patients with GI symptoms had significantly lower performance on neuropsychological functions such as complex scanning and long-term memory, visuospatial perception, executive function, verbal working memory and short-term memory, compared to patients without GI symptoms.</div></div><div><h3>Conclusions</h3><div>We found that there was a significant relationship between cognitive function and GI symptoms. This indicates that COVID-19 patients with GI symptoms may be at increased risk for developing deficits with their memory and other aspects of cognition.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111147"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}