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Perceptions and behavioral patterns of Asian Indian adolescents diagnosed with type 1 diabetes 诊断为1型糖尿病的亚洲印度青少年的认知和行为模式
Pub Date : 2023-01-01 DOI: 10.4103/jod.jod_5_23
Velu Manya, A. Amutha, P. Latha, R. Unnikrishnan, Viswanathan Mohan, R. Anjana
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引用次数: 0
Vitamin D and pathophysiology of polycystic ovary syndrome: A case–control study 维生素D与多囊卵巢综合征病理生理:一项病例对照研究
Pub Date : 2023-01-01 DOI: 10.4103/jod.jod_122_22
Barnali Ray Basu, Sanchari Chakraborty, Ankita Samaddar, Randrita Pal, S. Saha, Nilansu Das
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引用次数: 0
Glycolyzed hemoglobin as a poor prognostic factor in diabetic COVID-19 patients 糖化血红蛋白在糖尿病COVID-19患者中的不良预后因素
Pub Date : 2023-01-01 DOI: 10.4103/jod.jod_120_22
E. Torun Parmaksız, E. Parmaksız
Background: Diabetes mellitus (DM) seems to be conveying increased risk in Coronavirus disease-2019 (COVID-19). We aimed to evaluate the effect of glycemic control on the risk of prevalence and mortality in diabetic COVID-19 patients. Materials and Methods: In this retrospective observational study, the data from diabetic patients admitted to our hospital with the diagnosis of COVID-19 between March 2020 and March 2021 were reviewed. The demographic, clinical, laboratory, and radiological data, and the course and outcomes were recorded. Results: The records of 352 diabetic patients were compared to 333 non-diabetic controls. The mean age of 184 male and 168 female patients was 63.7±13.0 (30–91). The length of hospital stay, rate of Intensive care unit (ICU) admission, and mortality were higher in the diabetic population compared to the non-diabetic counterparts. ICU admission and mortality rates were significantly higher in the group with HbA1c higher than 7%. The rate of ICU admission and mortality was significantly higher in participants with elevated HbA1cConclusions: Uncontrolled DM is among detrimental comorbidities contributing to the severity of SARS-CoV-2 infection and good control of serum glucose levels will improve prognosis in COVID-19. The diabetic population with poor glycemic control succumbed more to COVID-19.
背景:糖尿病(DM)似乎增加了冠状病毒病-2019 (COVID-19)的风险。我们的目的是评估血糖控制对糖尿病COVID-19患者患病率和死亡率的影响。材料与方法:回顾性观察研究收集2020年3月至2021年3月在我院诊断为COVID-19的糖尿病患者的资料。记录患者的人口学、临床、实验室和放射学资料以及治疗过程和结果。结果:352例糖尿病患者与333例非糖尿病对照进行对比。男性184例,女性168例,平均年龄63.7±13.0(30-91岁)。与非糖尿病人群相比,糖尿病人群的住院时间、重症监护病房(ICU)入院率和死亡率更高。HbA1c高于7%组的ICU住院率和死亡率明显高于对照组。结论:未控制的糖尿病是导致SARS-CoV-2感染严重程度的有害合并症之一,良好的血糖水平控制将改善COVID-19患者的预后。血糖控制较差的糖尿病人群更易感染COVID-19。
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引用次数: 0
Novel insights into the physiological functions of glucagon 对胰高血糖素生理功能的新见解
Pub Date : 2023-01-01 DOI: 10.4103/jod.jod_100_23
Kalyan Kumar Gangopadhyay, Jagat Jyoti Mukherjee
Abstract Discovered a hundred years ago, glucagon continues to amaze clinicians globally with its range of functions affecting the entire human physiology. Although initially it was considered just an opposer of insulin action, recent years have seen that glucagon has a plethora of effects on body metabolism. However, many aspects of the complex regulatory mechanisms of glucagon secretion and its impact on nutrient metabolism are yet to be clearly elucidated. Understanding the physiology of glucagon secretion and action is the key to the development of pharmacological agents which would impact on metabolic disorders. Glucagon secretion is regulated by a variety of factors, including meal type, paracrine hormone secretion from α and β cross-talk, incretin hormones, and the autonomic nervous system, among others. On the other hand, glucagon has manifold effects on glucose, fatty acid, and amino acid metabolism, as well as a significant impact on thermogenesis, satiety, and the cardiovascular system. This article collates the physiological mechanisms of glucagon secretion and action, incorporating the latest in glucagon research.
胰高血糖素在一百年前被发现,其影响整个人体生理的功能范围使全球临床医生感到惊讶。虽然最初它被认为只是胰岛素作用的反对者,但近年来已经看到胰高血糖素对身体代谢有过多的影响。然而,胰高血糖素分泌的复杂调控机制及其对营养物质代谢的影响在许多方面尚不清楚。了解胰高血糖素分泌和作用的生理机制是开发治疗代谢紊乱药物的关键。胰高血糖素的分泌受多种因素调节,包括膳食类型、α和β串扰分泌的旁分泌激素、肠促胰岛素激素和自主神经系统等。另一方面,胰高血糖素对葡萄糖、脂肪酸和氨基酸代谢有多种影响,并对产热、饱腹感和心血管系统有重要影响。本文综述了胰高血糖素分泌和作用的生理机制,并结合了胰高血糖素的最新研究进展。
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引用次数: 0
Availability and accessibility of diabetes-related technologies in IDF-MENA Region 中东和北非地区糖尿病相关技术的可得性和可及性
Pub Date : 2022-12-01 DOI: 10.4103/jod.jod_117_22
Erum Ghafoor, S. Masood, J. Belkhadir, Mohamed Sultan, M. Sandid, S. Baqai, N. Shegem
Diabetes is a global epidemic and public health emergency, which leads to long-term health problems, cardiovascular diseases, diabetic retinopathy, stroke, blindness, dementia, limb loss, cd cancers across the globe. Diabetes not only leads to chronic complications but also compromises the quality of life. Diabetes-related deaths totaled 6.7 million in 2021, with health expenditure reaching USD 966 billion. Diabetes technologies are new novel modalities for the management of diabetes to create ease in the life of people living with diabetes, improve glycemic control and increase life expectancies. The Middle East and North Africa (MENA) Region consists of countries that are diverse not only in terms of culture, norms, practices, and financial and socioeconomic status. The high-income countries in this region have better access to new technologies such as insulin pumps, continuous glucose monitoring (CGM) systems, and integrated self-management applications. Some of these modalities have government support systems, reimbursement, and subsidy policies for people with diabetes (PWD). In contrast, PWD from low- and middle-income countries still find it difficult to access diabetes-related innovations due to lack of awareness, high out-of-pocket costs, lack of trained healthcare providers, weak healthcare infrastructure, absence of reimbursement health policies, universal coverage and lack of health insurance. Diabetes care management in the MENA Region is still deprived of modern diabetes care technologies.
糖尿病是一种全球性流行病和突发公共卫生事件,在全球范围内导致长期健康问题、心血管疾病、糖尿病性视网膜病变、中风、失明、痴呆、肢体丧失和cd癌症。糖尿病不仅会导致慢性并发症,还会影响生活质量。2021年,与糖尿病相关的死亡总数为670万,卫生支出达到9660亿美元。糖尿病技术是糖尿病管理的新模式,为糖尿病患者的生活创造便利,改善血糖控制,延长预期寿命。中东和北非(MENA)地区的国家不仅在文化、规范、做法、金融和社会经济地位方面各不相同。该地区的高收入国家更容易获得胰岛素泵、连续血糖监测系统和综合自我管理应用等新技术。其中一些模式具有针对糖尿病患者的政府支持系统、报销和补贴政策。相比之下,低收入和中等收入国家的残疾患者仍然难以获得与糖尿病相关的创新,原因是缺乏认识、自付费用高、缺乏训练有素的医疗保健提供者、医疗保健基础设施薄弱、缺乏报销医疗政策、全民覆盖和缺乏医疗保险。中东和北非地区的糖尿病护理管理仍然缺乏现代糖尿病护理技术。
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引用次数: 0
Diabetes burden in the IDF-MENA region 中东和北非地区的糖尿病负担
Pub Date : 2022-12-01 DOI: 10.4103/jod.jod_125_22
D. Bodhini, V. Mohan
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引用次数: 1
The status of insulin access in Middle East-North Africa region 中东-北非地区胰岛素可及性现状
Pub Date : 2022-12-01 DOI: 10.4103/jod.jod_106_22
S. Odhaib, S. Masood, N. Shegem, suhad J. Khalifa, M. Abi Saad, M. Eltom, J. Belkhadir, M. Sandid, H. Iraqi, Sara Sedaghat, Hazim Abdul-Kareem, A. Ali Mansour, M. Kamel, A. Bilal
Background and Objective: The current situation in the Middle East-North Africa (MENA) region makes it very difficult for many countries to have an effective policy to ensure the availability and affordability of different insulin types for many individuals with diabetes mellitus in any individual country. This article comprehensively reviews the possible barriers to insulin access in countries of this region and provides some solutions to mitigate these barriers. Materials and Methods: The framework for understanding the life-cycle of medicines of the World Health Organization (WHO) was adopted for this review with country-specific modifications. PubMed was used as an initial search builder using the country name and insulin as query terms in (title/abstract) for articles written in (English and French) which dealt with humans only between (2000–2022). Out of (578) published articles, only (42) articles were relevant and dealt with insulin access. Additional search through references of these articles and the websites of international health organizations added additional (32) references to have (79) references for the review. Review (Results): The countries in the MENA are lagging in the (Research, Development, and Innovation) and production of insulin and insulin delivery systems. There are some attempts by some countries to develop their national plan with the help of some big insulin manufacturers, with a suboptimal outcome. The local insulin production in some countries did not reach full national coverage. The difficult regional economic and political situations in many countries in the MENA imposed negatively on their citizens’ insulin access, availability, affordability, cost, and insurance plans. Conclusions: There is a suboptimal level of insulin access for individuals with diabetes in the MENA countries, especially in the low-resourced countries. There is an urgent need to adopt country-specific healthcare policies to ensure uninterrupted insulin access and improved availability, with a lower affordable cost for individuals with diabetes from the public and private sectors.
背景和目的:中东-北非(MENA)地区的现状使得许多国家很难有一个有效的政策来确保任何一个国家的许多糖尿病患者获得和负担不同类型的胰岛素。本文全面回顾了该地区国家胰岛素获取可能存在的障碍,并提供了一些缓解这些障碍的解决方案。材料和方法:本次审查采用了世界卫生组织(世卫组织)的药物生命周期理解框架,并对各国进行了具体修改。PubMed被用作初始搜索构建器,使用国家名称和胰岛素作为(标题/摘要)中以(英语和法语)撰写的文章的查询条件,这些文章仅在(2000-2022)期间涉及人类。在578篇已发表的文章中,只有42篇与胰岛素获取相关。通过对这些文章的参考文献和国际卫生组织网站的进一步搜索,增加了额外的(32)篇参考文献,从而获得了本综述的(79)篇参考文献。回顾(结果):中东和北非国家在胰岛素和胰岛素输送系统的(研究、开发和创新)和生产方面落后。一些国家试图在一些大型胰岛素制造商的帮助下制定国家计划,但结果并不理想。一些国家的当地胰岛素生产没有达到全国完全覆盖。中东和北非许多国家困难的区域经济和政治局势对其公民的胰岛素获取、可得性、可负担性、成本和保险计划造成了负面影响。结论:在中东和北非国家,特别是在资源匮乏的国家,糖尿病患者获得胰岛素的水平不理想。迫切需要采取针对具体国家的卫生保健政策,以确保不间断地获得胰岛素并改善可得性,使公共和私营部门的糖尿病患者负担得起的费用更低。
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引用次数: 0
IDF-MENA Region Guidelines for the Management of Type 2 Diabetes IDF-MENA地区2型糖尿病管理指南
Pub Date : 2022-12-01 DOI: 10.4103/jod.jod_97_22
A. Basit, Prof. Dr. Asher. Fawwad, M. Riaz
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引用次数: 0
Inventory of insulin access in Tunisia, IDF-MENA Region IDF-MENA地区突尼斯胰岛素获取清单
Pub Date : 2022-12-01 DOI: 10.4103/jod.jod_113_22
M. Elleuch, F. Mnif, J. Malouf, Mohamed Benlassoued, M. Kamel, M. Abid
The prevalence of diabetes is rising faster in low- and middle-income countries. In IDF-Middle East and North Africa (MENA), one in six adults (73 million) are living with diabetes, and the number of adults with diabetes is expected to reach 95 million by 2030 and 136 million by 2045. Tunisia, a part of the IDF-MENA Region, is burdened with diabetes that is responsible for substantial morbidity and mortality, as well as considerable healthcare expenditure. The prevalence of type 2 diabetes has increased from 3.8% in 1976 to 18.2% in 2019. It is higher in men. In 2016, distribution by type of treatment analyzed that 22.1% of treated people with diabetes (PWD) were on insulin and 9% were on insulin and oral antidiabetic drugs (OADs). This study confirmed that 27.4% have had good control of diabetes. PWD receiving insulin do not have good control of diabetes as compared to PWD treated on oral antidiabetic drugs. The government controls all medicines pricing including insulin. The prescription of insulin depends on the organization of care. The patients can receive their treatment of diabetes either in the primary healthcare or in the hospital. Therefore, access to insulin is provided, for patients, in both rural and urban areas and in the public and private sectors. Additional challenges to insulin administration include the fact that some health professionals do not know how to use insulin analogs as they were training only on human insulins. Therefore, in Tunisia many efforts are needed to improve the prescription and the accessibility of insulin.
糖尿病患病率在低收入和中等收入国家上升得更快。在中东和北非地区,六分之一的成年人(7300万)患有糖尿病,预计到2030年成人糖尿病患者人数将达到9500万,到2045年将达到1.36亿。突尼斯是中东和北非地区的一部分,糖尿病是造成大量发病率和死亡率以及大量保健支出的原因。2型糖尿病的患病率从1976年的3.8%上升到2019年的18.2%。男性的比例更高。2016年,按治疗类型进行的分布分析显示,接受治疗的糖尿病患者(PWD)中有22.1%使用胰岛素,9%使用胰岛素和口服降糖药(oad)。这项研究证实,27.4%的人对糖尿病有良好的控制。与口服降糖药治疗的PWD相比,接受胰岛素治疗的PWD对糖尿病的控制效果不佳。政府控制包括胰岛素在内的所有药品的定价。胰岛素的处方取决于护理的组织。患者可以在初级保健机构或医院接受糖尿病治疗。因此,为农村和城市地区以及公共和私营部门的患者提供了获得胰岛素的途径。胰岛素管理面临的其他挑战包括一些卫生专业人员不知道如何使用胰岛素类似物,因为他们只接受过人类胰岛素的培训。因此,突尼斯需要作出许多努力来改善胰岛素的处方和可及性。
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引用次数: 1
Impact of humanitarian crises on diabetes care in Iraq and Syria—IDF-MENA region 人道主义危机对伊拉克和叙利亚-中东和北非地区糖尿病护理的影响
Pub Date : 2022-12-01 DOI: 10.4103/jod.jod_105_22
S. Odhaib, A. Mansour, suhad J. Khalifa, N. Shegem, Wael Thannon, M. Saad, Hazim Abdulrazaq, J. Belkhadir, Mohamad A. Sandid, S. Masood
This short review tried to discuss the factors that affect diabetes care during humanitarian crises after the political and military conflicts in post-2003 Iraq and post-2011 Syria. The pattern of the devastating effect of the conflicts on the suboptimal healthcare system and infrastructure is quite similar. Both countries’ long-term and continuous geopolitical instability and security concerns were barriers to applying any disaster preparedness plans. They had markedly exhausted diabetes care in these countries with similar mixed public and private healthcare systems. The influx of huge numbers of refugees with chronic diseases, especially diabetes, in the neighboring host countries created pressure on the healthcare systems. It urged some changes in the national policies with the needed help from the aid organizations to an extent. The internal displacement problem for huge nationals in their country exhausted the already exhausted healthcare facilities, with more burdens on the effective equal provision of diabetes-related medication and management tools. Still, diabetes care is not included as a vital part of the mitigation plans during crises in both countries, with the main concern the communicable rather than non-communicable diseases. Type 1 diabetes mellitus received less care during the crisis in both countries, with the insulin shortage being their major concern. The availability and affordability of diabetes medications in camp and non-camp settings were suboptimal and unsatisfactory. More active planning is needed to build a well-prepared healthcare system with diabetes care as an integral part.
这篇简短的综述试图讨论2003年后伊拉克和2011年后叙利亚政治和军事冲突后人道主义危机期间影响糖尿病护理的因素。冲突对次优医疗保健系统和基础设施造成破坏性影响的模式非常相似。这两个国家长期和持续的地缘政治不稳定和安全问题是实施任何备灾计划的障碍。在这些拥有类似公私混合医疗体系的国家,他们明显已经耗尽了糖尿病护理。大量患有慢性病,特别是糖尿病的难民涌入邻国,给卫生保健系统带来了压力。它敦促在一定程度上得到援助组织的必要帮助下改变国家政策。本国庞大国民的国内流离失所问题使本已疲惫不堪的保健设施不堪重负,对有效平等地提供与糖尿病有关的药物和管理工具造成了更大的负担。然而,两国在危机期间没有将糖尿病护理作为缓解计划的重要组成部分,主要关注的是传染性疾病而非非传染性疾病。在危机期间,两国的1型糖尿病患者得到的治疗较少,胰岛素短缺是他们的主要问题。在营地和非营地环境中,糖尿病药物的可获得性和可负担性都不理想,令人不满意。需要更积极的规划来建立一个准备充分的医疗保健系统,将糖尿病护理作为一个组成部分。
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引用次数: 1
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Journal of Diabetology
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