Pub Date : 2021-01-01DOI: 10.4236/jcdsa.2021.114031
H. Polonini, C. Zander, J. Radke
Acne vulgaris is the most common skin condition associated with inflammation of the pilosebaceous unit and affects all ethnic and age groups, independent of sex, nationality, or socioeconomic status. Treatment usually includes oral and/or physical and/or topical interventions—the last can be obtained through commercial preparations in fixed doses or as compounded creams/gels, with personalized qualitative and quantitative composition, to be unique to each patient. In this sense, ready-to-use vehicles play an important role as a timesaving strategy and to ensure maximum results from the treatment. In this paper, we present Cleoderm TM Clarifying Cream, a ready-to-use, functional semisolid vehicle for acne treatments and topical products for oily skin, to be used by compounding pharmacies. It contains ingredients that can po-tentiate the effects of the active ingredients added, and has a light and plea-sant skin feel. The current body of evidence shows that Cleoderm TM Clarifying Cream can be an important strategy for compounding personalized acne treatments due to its multiple positive roles on decreasing sebum production, lipid peroxidation, and reactive oxygen species, inhibition of Cutibacterium acnes proliferation, and control of inflammation.
{"title":"CleodermTM Clarifying Cream: A Novel, Topical Vehicle Using Plant-Based Excipients and Actives Targeting Acne and Oily Skin","authors":"H. Polonini, C. Zander, J. Radke","doi":"10.4236/jcdsa.2021.114031","DOIUrl":"https://doi.org/10.4236/jcdsa.2021.114031","url":null,"abstract":"Acne vulgaris is the most common skin condition associated with inflammation of the pilosebaceous unit and affects all ethnic and age groups, independent of sex, nationality, or socioeconomic status. Treatment usually includes oral and/or physical and/or topical interventions—the last can be obtained through commercial preparations in fixed doses or as compounded creams/gels, with personalized qualitative and quantitative composition, to be unique to each patient. In this sense, ready-to-use vehicles play an important role as a timesaving strategy and to ensure maximum results from the treatment. In this paper, we present Cleoderm TM Clarifying Cream, a ready-to-use, functional semisolid vehicle for acne treatments and topical products for oily skin, to be used by compounding pharmacies. It contains ingredients that can po-tentiate the effects of the active ingredients added, and has a light and plea-sant skin feel. The current body of evidence shows that Cleoderm TM Clarifying Cream can be an important strategy for compounding personalized acne treatments due to its multiple positive roles on decreasing sebum production, lipid peroxidation, and reactive oxygen species, inhibition of Cutibacterium acnes proliferation, and control of inflammation.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86870037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4236/jcdsa.2021.114030
Hector Giancarlo Torres-Nuño, W. A. Trujillo-Rangel, Jorge Barrera-Alcocer, Miriam Méndez del Villar, D. M. Hernández-Corona, S. Totsuka-Sutto, L. G. Benavides
Nowadays, fat transfer is an accepted technique that has been popularized in clinical practice, during which large volumes of fat are strategically relocated to increase and improve the contour of the body. In the present study, we investigated the histological and morphometric changes after large volumes of fat were grafted within the subcutaneous cellular tissue. An experimental study was designed using four 3-month-old male pigs. One hundred cc of decanted fat tissue was transferred into the right leg. Volume augmentation achieved by auto lipo-injecting within the subcutaneous cellular tissue persisted up to two months. Although there is a reduction in cell number and size, an increased amount of extracellular matrix and the presence of oily cysts and microcalcifications were observed. Conclusion: The volume augmentation, which is achieved by autologous fat transfer in large quantities in subcutaneous cellular tissue, can remain for months.
{"title":"Histological Analysis and Morphometric Changes after Autologous Fat Grafting in Large Volumes on Pigs","authors":"Hector Giancarlo Torres-Nuño, W. A. Trujillo-Rangel, Jorge Barrera-Alcocer, Miriam Méndez del Villar, D. M. Hernández-Corona, S. Totsuka-Sutto, L. G. Benavides","doi":"10.4236/jcdsa.2021.114030","DOIUrl":"https://doi.org/10.4236/jcdsa.2021.114030","url":null,"abstract":"Nowadays, fat transfer is an accepted technique that has been popularized in clinical practice, during which large volumes of fat are strategically relocated to increase and improve the contour of the body. In the present study, we investigated the histological and morphometric changes after large volumes of fat were grafted within the subcutaneous cellular tissue. An experimental study was designed using four 3-month-old male pigs. One hundred cc of decanted fat tissue was transferred into the right leg. Volume augmentation achieved by auto lipo-injecting within the subcutaneous cellular tissue persisted up to two months. Although there is a reduction in cell number and size, an increased amount of extracellular matrix and the presence of oily cysts and microcalcifications were observed. Conclusion: The volume augmentation, which is achieved by autologous fat transfer in large quantities in subcutaneous cellular tissue, can remain for months.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88594815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4236/jcdsa.2021.114025
Min Li, Aixing Fan, Junhong Mao, N. Soliman, K. Shahani, A. M. Morgan, Thomas Boyd
{"title":"The Prebiotic Effect of Triple Biotic Technology on Skin Health","authors":"Min Li, Aixing Fan, Junhong Mao, N. Soliman, K. Shahani, A. M. Morgan, Thomas Boyd","doi":"10.4236/jcdsa.2021.114025","DOIUrl":"https://doi.org/10.4236/jcdsa.2021.114025","url":null,"abstract":"","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85252444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-16DOI: 10.4236/jcdsa.2020.104017
H. Shimoda, Kenchi Miyasaka, Yamada Wakana, Norihito Shimizu
Ameliorating Effects of Delphinol®, Anthocyanin Standardized Maqui Berry Extract, on Skin Brightness and Redness in Japanese Females: A Randomized Double-Blind Placebo-Controlled Pilot Study
{"title":"Ameliorating Effects of Delphinol®, Anthocyanin Standardized Maqui Berry Extract, on Skin Brightness and Redness in Japanese Females: A Randomized Double-Blind Placebo-Controlled Pilot Study","authors":"H. Shimoda, Kenchi Miyasaka, Yamada Wakana, Norihito Shimizu","doi":"10.4236/jcdsa.2020.104017","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.104017","url":null,"abstract":"Ameliorating Effects of Delphinol®, Anthocyanin Standardized Maqui Berry Extract, on Skin Brightness and Redness in Japanese Females: A Randomized Double-Blind Placebo-Controlled Pilot Study","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81817506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-15DOI: 10.4236/jcdsa.2020.104020
F. Fanian, A. Jeudy, A. Elkhyat, T. Lihoreau, P. Humbert
Introduction: Several studies demonstrate the effects of the oral supplementations on the skin while there are limited data for their effects on the nail quality in healthy individuals. Only placebo controlled double blind studies could provide the reliable data considering the physiologic nail growth. Objective: The objective of this study was to evaluate the efficacy of consumption of a micronutrient supplementation on linear nail growth and thickness. Subjects and Method: 60 healthy female volunteers aged 35 to 65 years old were enrolled, randomized blindly in treatment and placebo groups, taking one tablet per day for 3 months. The evaluation was performed on D0 and D90 ± 3 days by measuring the linear nail growth, nail thickness by high frequency ultrasound imaging and also subjects’ self-assessment. Results: All 60 subjects finished the study without any serious adverse event. At D90 both groups revealed a significant linear nail growth (5.20 ± 0.35 for treatment group (p = 0.001) and 5.15 ± 0.30 for placebo group (p = 0.001)). However, the difference between the treatment and placebo group was statistically significant (p = 0.01) demonstrating the efficacy of oral supplementation on linear nail growth. No significant difference was observed at D90 for nail thickness measured with HFUS between 2 groups. The self-assessment score regarding ?brittle nails? and ?split nails? was diminished non-significantly in both groups. Conclusion: The results observed in this trial revealed that the oral micronutrient supplementation can provide beneficial effect on nail growth. This result may be due to the whole formula as the single vitamin treatment like biotin was shown to be non-effective. A longer study would be needed to confirm the efficacy on nail thickness.
{"title":"Efficacy of Oral Micronutrient Supplementation on Linear Nail Growth in Healthy Individuals","authors":"F. Fanian, A. Jeudy, A. Elkhyat, T. Lihoreau, P. Humbert","doi":"10.4236/jcdsa.2020.104020","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.104020","url":null,"abstract":"Introduction: Several studies demonstrate the effects of the oral supplementations on the skin while there are limited data for their effects on the nail quality in healthy individuals. Only placebo controlled double blind studies could provide the reliable data considering the physiologic nail growth. Objective: The objective of this study was to evaluate the efficacy of consumption of a micronutrient supplementation on linear nail growth and thickness. Subjects and Method: 60 healthy female volunteers aged 35 to 65 years old were enrolled, randomized blindly in treatment and placebo groups, taking one tablet per day for 3 months. The evaluation was performed on D0 and D90 ± 3 days by measuring the linear nail growth, nail thickness by high frequency ultrasound imaging and also subjects’ self-assessment. Results: All 60 subjects finished the study without any serious adverse event. At D90 both groups revealed a significant linear nail growth (5.20 ± 0.35 for treatment group (p = 0.001) and 5.15 ± 0.30 for placebo group (p = 0.001)). However, the difference between the treatment and placebo group was statistically significant (p = 0.01) demonstrating the efficacy of oral supplementation on linear nail growth. No significant difference was observed at D90 for nail thickness measured with HFUS between 2 groups. The self-assessment score regarding ?brittle nails? and ?split nails? was diminished non-significantly in both groups. Conclusion: The results observed in this trial revealed that the oral micronutrient supplementation can provide beneficial effect on nail growth. This result may be due to the whole formula as the single vitamin treatment like biotin was shown to be non-effective. A longer study would be needed to confirm the efficacy on nail thickness.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"18 1","pages":"191-203"},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75079527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-15DOI: 10.4236/jcdsa.2020.104019
Glaucia H O Labinas, F. Amaral, Valeria Maria de Souza Antunes, M. Jardim, L. Bella, C. R. Oliveira
Background: Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of TrichoxidilTM, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. Methods: The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of TrichoxidilTM. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5); TrichosolTM vehicle group, without active (n = 5); Hydroalcoholic vehicle group, without active (n = 4); TrichosolTM vehicle group, with 2.5% minoxidil (n = 5); Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5); TrichosolTM group with 2.5% TrichoxidilTM (n = 5) and Hydroalcoholic vehicle group with 2.5% TrichoxidilTM (n = 4) to dermoscopic and histologic. Results: Fibroblasts exhibited higher proliferation when treated with higher concentrations of TrichoxidilTM. TrichoxidilTM significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that TrichoxidilTM associated with TrichosolTM vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. Conclusion: TrichoxidilTM promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.
{"title":"Hair Growth Promoting Effect of TrichoxidilTM: A New Natural Compound for Hair Loss","authors":"Glaucia H O Labinas, F. Amaral, Valeria Maria de Souza Antunes, M. Jardim, L. Bella, C. R. Oliveira","doi":"10.4236/jcdsa.2020.104019","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.104019","url":null,"abstract":"Background: Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of TrichoxidilTM, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. Methods: The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of TrichoxidilTM. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5); TrichosolTM vehicle group, without active (n = 5); Hydroalcoholic vehicle group, without active (n = 4); TrichosolTM vehicle group, with 2.5% minoxidil (n = 5); Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5); TrichosolTM group with 2.5% TrichoxidilTM (n = 5) and Hydroalcoholic vehicle group with 2.5% TrichoxidilTM (n = 4) to dermoscopic and histologic. Results: Fibroblasts exhibited higher proliferation when treated with higher concentrations of TrichoxidilTM. TrichoxidilTM significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that TrichoxidilTM associated with TrichosolTM vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. Conclusion: TrichoxidilTM promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80842586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-15DOI: 10.4236/jcdsa.2020.104022
Theeoo Lwin, Cho Yi Myint, H. Win, Wah Wah Oo, Khit Chit
Lipstick is the most widely used cosmetic product. Although lipstick gives a lot of social, psychological and therapeutic benefits, it may harm the consumers. Because most lipsticks contained high lead level and long term use of high lead level lipstick may harm the consumers. Research findings have suggested that administration of various antioxidants can prevent or subdue various toxic effects of lead and generation of oxidative stress. Hylocereus polyrhizus (Red dragon fruit) is widely available in Myanmar and it contains powerful antioxidant amaranth colorant called betacyanin pigment. It can prevent the oxidative stress caused by low level of lead, thus suitable as natural colorant for lipstick. As a role of pharmacist, this research was intended to minimize the adverse effects of lipsticks by formulating natural lipstick with betacyanin pigment obtained from H. polyrhizus and other natural ingredients. Formulation of lipstick was carried out by heating and blending method with homogenizer at a speed of 12000 rpm. Then, pH, melting point, surface abnormalities, aging stability, perfume stability and antioxidant activity were performed as quality evaluation. Skin irritation test, microbial analysis and lead content determination were carried out as safety evaluation. Formulated lipsticks with betacyanin pigment of H. polyrhizus have acceptable quality. The IC50 of standard ascorbic acid and formulated lipstick were 4.51 μg/ml and 22.23 μg/ml respectively. In quantitative analysis for microbiological control, formulated lipstick had no visible colony and in qualitative analysis, Staphylococcus aureus, E. coli and Pseudomonas aeruginosa were not detected in 0.5 g of formulated lipsticks. Moreover, lead content of formulated lipstick was only 2.9 ppm that is within allowable limit and it had negligible skin irritancy. Therefore, lipstick with betacyanin pigment of H. polyrhizus can utilize as Cosmeceutical.
{"title":"Formulation and Evaluation of Lipstick with Betacyanin Pigment of Hylocereus polyrhizus (Red Dragon Fruit)","authors":"Theeoo Lwin, Cho Yi Myint, H. Win, Wah Wah Oo, Khit Chit","doi":"10.4236/jcdsa.2020.104022","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.104022","url":null,"abstract":"Lipstick is the most widely used cosmetic product. Although lipstick gives a lot of social, psychological and therapeutic benefits, it may harm the consumers. Because most lipsticks contained high lead level and long term use of high lead level lipstick may harm the consumers. Research findings have suggested that administration of various antioxidants can prevent or subdue various toxic effects of lead and generation of oxidative stress. Hylocereus polyrhizus (Red dragon fruit) is widely available in Myanmar and it contains powerful antioxidant amaranth colorant called betacyanin pigment. It can prevent the oxidative stress caused by low level of lead, thus suitable as natural colorant for lipstick. As a role of pharmacist, this research was intended to minimize the adverse effects of lipsticks by formulating natural lipstick with betacyanin pigment obtained from H. polyrhizus and other natural ingredients. Formulation of lipstick was carried out by heating and blending method with homogenizer at a speed of 12000 rpm. Then, pH, melting point, surface abnormalities, aging stability, perfume stability and antioxidant activity were performed as quality evaluation. Skin irritation test, microbial analysis and lead content determination were carried out as safety evaluation. Formulated lipsticks with betacyanin pigment of H. polyrhizus have acceptable quality. The IC50 of standard ascorbic acid and formulated lipstick were 4.51 μg/ml and 22.23 μg/ml respectively. In quantitative analysis for microbiological control, formulated lipstick had no visible colony and in qualitative analysis, Staphylococcus aureus, E. coli and Pseudomonas aeruginosa were not detected in 0.5 g of formulated lipsticks. Moreover, lead content of formulated lipstick was only 2.9 ppm that is within allowable limit and it had negligible skin irritancy. Therefore, lipstick with betacyanin pigment of H. polyrhizus can utilize as Cosmeceutical.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76651322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-15DOI: 10.4236/jcdsa.2020.104021
Y. Kimura, A. Tanemura, Yukiho Kurosaki, Madoka Takafuji, K. Yokoi, E. Kiyohara, N. Arase, M. Fujimoto
Although vitiligo lesion especially in static state is characterized as sharply demarcated and complete depigmented macule, we encounter patients who have various manners of hypopigmented lesions. We examined the 81 lesions using the newly released Wood’s lamp (Woody®) and investigated whether or not vitiliginous lesions could be uniformly classified under Wood’s lamp illumination and also this classification helped to estimate the tendency of repigmentation after treatment. As result, the vitiliginous lesions were categorized into 4 types on intra- and peri-lesions prior to treatment by using the Wood’s lamp. The inside and border of the lesions were classified as follows: clear white, faint, multi-dot, and perifollicular for the inside, and sharp, blunt, confetti, and trichrome for the border. Suggestive residual pigmentation was detected in 73.6% of patients at the first visit and repigmentation was observed in 67.9% of patients at least 3 months after treatment. Lesions with the “clear white” inside pattern showed significantly lower repigmentation frequency in 38.5% of patients compared to others. The borders with 4 enlarged lesions were composed of 3 of confetti-type and one of sharp-type. This preliminary study demonstrated that detailed observation with a Wood’s lamp could be the basis to classify vitiliginous lesions and might be useful for predicting not only disease progression but also repigmentation prior to treatment.
{"title":"Clinical Observation and Proposed Classification of Vitiliginous Patches by a Wood’s Lamp","authors":"Y. Kimura, A. Tanemura, Yukiho Kurosaki, Madoka Takafuji, K. Yokoi, E. Kiyohara, N. Arase, M. Fujimoto","doi":"10.4236/jcdsa.2020.104021","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.104021","url":null,"abstract":"Although vitiligo lesion especially in static state is characterized as sharply demarcated and complete depigmented macule, we encounter patients who have various manners of hypopigmented lesions. We examined the 81 lesions using the newly released Wood’s lamp (Woody®) and investigated whether or not vitiliginous lesions could be uniformly classified under Wood’s lamp illumination and also this classification helped to estimate the tendency of repigmentation after treatment. As result, the vitiliginous lesions were categorized into 4 types on intra- and peri-lesions prior to treatment by using the Wood’s lamp. The inside and border of the lesions were classified as follows: clear white, faint, multi-dot, and perifollicular for the inside, and sharp, blunt, confetti, and trichrome for the border. Suggestive residual pigmentation was detected in 73.6% of patients at the first visit and repigmentation was observed in 67.9% of patients at least 3 months after treatment. Lesions with the “clear white” inside pattern showed significantly lower repigmentation frequency in 38.5% of patients compared to others. The borders with 4 enlarged lesions were composed of 3 of confetti-type and one of sharp-type. This preliminary study demonstrated that detailed observation with a Wood’s lamp could be the basis to classify vitiliginous lesions and might be useful for predicting not only disease progression but also repigmentation prior to treatment.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"13 1","pages":"204-211"},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78371153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-15DOI: 10.4236/jcdsa.2020.104018
Neil J Fisher, D. Carati
We describe a novel, non-invasive peptide-based product intended to counter several pathophysiological signs of aged skin through the topical application of signalling molecule mimics. Several aesthetic parameters of skin physiology were assessed. The product was tested on 20 healthy Caucasian women (35 - 55 years-old) who applied the product twice-daily to the face for 30 days. Skin elasticity, firmness, sagging, brightness, and luminosity were assessed. Additionally, over a period of 3 hours, the hydrating effect of the product vs placebo vs non-treated skin was assessed. After 30 days, participants showed significant increases in skin elasticity (11.8% increase, p < 0.01), luminosity (2.5% increase, p < 0.01), and brightness (110% increase, p < 0.001) with concomitant significant decreases in skin sagging (6.3% decrease, p < 0.05). The product gave a rapid and sustained hydrating action that was significantly greater than placebo alone (10.2% increase, p < 0.05). No adverse reactions were reported. Cosmetic products based on the action of synthetic peptide mimics of endogenous signalling molecules show promise for combatting the pathological degradation of skin as seen in the elderly. Strategies to reverse these symptoms through non-invasive techniques warrant further investigation. This study provides support for the application of peptides to combat signs of aging and to improve the general condition of the skin.
{"title":"Application of Synthetic Peptides to Improve Parameters of Skin Physiology: An Open Observational 30-Day Study","authors":"Neil J Fisher, D. Carati","doi":"10.4236/jcdsa.2020.104018","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.104018","url":null,"abstract":"We describe a novel, non-invasive peptide-based product intended to counter several pathophysiological signs of aged skin through the topical application of signalling molecule mimics. Several aesthetic parameters of skin physiology were assessed. The product was tested on 20 healthy Caucasian women (35 - 55 years-old) who applied the product twice-daily to the face for 30 days. Skin elasticity, firmness, sagging, brightness, and luminosity were assessed. Additionally, over a period of 3 hours, the hydrating effect of the product vs placebo vs non-treated skin was assessed. After 30 days, participants showed significant increases in skin elasticity (11.8% increase, p < 0.01), luminosity (2.5% increase, p < 0.01), and brightness (110% increase, p < 0.001) with concomitant significant decreases in skin sagging (6.3% decrease, p < 0.05). The product gave a rapid and sustained hydrating action that was significantly greater than placebo alone (10.2% increase, p < 0.05). No adverse reactions were reported. Cosmetic products based on the action of synthetic peptide mimics of endogenous signalling molecules show promise for combatting the pathological degradation of skin as seen in the elderly. Strategies to reverse these symptoms through non-invasive techniques warrant further investigation. This study provides support for the application of peptides to combat signs of aging and to improve the general condition of the skin.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"173 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83536788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-11DOI: 10.4236/jcdsa.2020.103015
B. Vân, Nguyen Thi Ngoc Oanh, Đặng Văn Em, Huynh Thi Xuan Tam, Nguyễn Lan Anh, P. Phuong
Objective: To evaluate the efficacy of He-Ne laser in combination with topical clindamycin in the treatment of AV at 108 Military Central Hospital from Oct 2015 to Aug 2016. Subjects and Methods: 61 patients with AV were divided into 2 groups: Group 1: 31 patients were treated with He-Ne laser in combination with topical Clindamycin, Group 2: 30 patients were only treated with topical clindamycin. Laser HE-NE was applied 2 times/week for 6 weeks. Result: After 3 months of treatment Group 1: very good—51.6%, good—48.4%. Group 2: very good—30%, good—50% and moderate—20%. Conclusion: The combination of He-Ne laser with topical clindamycin shows more rapid clinical improvement compared to topical clindamycin alone in the treatment of mild and moderate AV.
{"title":"Efficacy of He-Ne Laser in Combination with Topical Clindamycin in the Treatment of Acne Vulgaris (AV)","authors":"B. Vân, Nguyen Thi Ngoc Oanh, Đặng Văn Em, Huynh Thi Xuan Tam, Nguyễn Lan Anh, P. Phuong","doi":"10.4236/jcdsa.2020.103015","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.103015","url":null,"abstract":"Objective: To evaluate the \u0000efficacy of He-Ne laser in combination with topical clindamycin in the \u0000treatment of AV at 108 Military Central Hospital from Oct 2015 to Aug 2016. Subjects \u0000and Methods: 61 patients with AV were divided into 2 groups: Group 1: 31 patients \u0000were treated with He-Ne laser in combination \u0000with topical Clindamycin, Group 2: 30 patients were only treated with \u0000topical clindamycin. Laser HE-NE was applied 2 times/week for 6 weeks. Result: \u0000After 3 months of treatment Group 1: very good—51.6%, good—48.4%. Group 2: very good—30%, good—50% and moderate—20%. Conclusion: The combination of He-Ne laser with topical \u0000clindamycin shows more rapid clinical improvement compared to topical \u0000clindamycin alone in the treatment of mild and moderate AV.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83063743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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