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Cardiometabolic health in adolescence and its association with educational outcomes 青少年心脏代谢健康及其与教育成果的关系
Pub Date : 2019-10-01 DOI: 10.1136/jech-2019-212256
P. Correa-Burrows, E. Blanco, S. Gahagan, R. Burrows
Aim To explore the association of selected cardiometabolic biomarkers and metabolic syndrome (MetS) with educational outcomes in adolescents from Chile. Methods Of 678 participants, 632 (52% males) met criteria for the study. At 16 years, waist circumference (WC), systolic blood pressure, triglycerides (TG), high-density lipoprotein and glucose were measured. A continuous cardiometabolic risk score (zMetS) using indicators of obesity, lipids, glucose and blood pressure was computed, with lower values denoting a healthier cardiometabolic profile. MetS was diagnosed with the International Diabetes Federation/American Heart Association/National Heart, Lung, and Blood Institute joint criteria. Data on high school (HS) graduation, grade point average (GPA), college examination rates and college test scores were collected. Data were analysed controlling for sociodemographic, lifestyle and educational confounders. Result zMetS, WC, TG and homeostatic model assessment of insulin resistance at 16 years were negatively and significantly associated with the odds of completing HS and taking college exams. Notably, for a one-unit increase in zMetS, we found 52% (OR: 0.48, 95% CI 0.227 to 0.98) and 39% (OR: 0.61, 95% CI 0.28 to 0.93) reduction in the odds of HS completion and taking college exams, respectively. The odds of HS completion and taking college exams in participants with MetS were 37% (95% CI 0.14 to 0.98) and 33% (95% CI 0.15 to 0.79) that of participants with no cardiometabolic risk factors. Compared with adolescents with no risk factors, those with MetS had lower GPA (515 vs 461 points; p=0.002; Cohen’s d=0.55). Adolescents having the MetS had significantly lower odds of passing the mathematics exam for college compared with peers with no cardiometabolic risk factors (OR: 0.49; 95% CI 0.16 to 0.95). Conclusion In Chilean adolescents, cardiometabolic health was associated with educational outcomes.
目的探讨智利青少年选定的心脏代谢生物标志物和代谢综合征(MetS)与教育结果的关系。方法678名受试者中,632名(52%为男性)符合研究标准。16岁时,测量腰围(WC)、收缩压、甘油三酯(TG)、高密度脂蛋白和葡萄糖。使用肥胖、血脂、血糖和血压等指标计算连续心脏代谢风险评分(zMetS),值越低表示心脏代谢状况越健康。MetS是根据国际糖尿病联合会/美国心脏协会/国家心脏、肺和血液研究所的联合标准诊断的。收集高中(HS)毕业、平均绩点(GPA)、大学考试率和大学考试成绩等数据。对数据进行分析,控制社会人口、生活方式和教育混杂因素。结果16岁时胰岛素抵抗的zMetS、WC、TG和稳态模型评估与完成HS和参加大学考试的几率呈显著负相关。值得注意的是,zMetS每增加一个单位,我们发现完成HS和参加大学考试的几率分别降低52% (OR: 0.48, 95% CI 0.227至0.98)和39% (OR: 0.61, 95% CI 0.28至0.93)。与没有心脏代谢危险因素的参与者相比,met参与者完成HS和参加大学考试的几率分别为37% (95% CI 0.14至0.98)和33% (95% CI 0.15至0.79)。与没有危险因素的青少年相比,met患者的GPA较低(515比461分;p = 0.002;科恩的d = 0.55)。与没有心脏代谢危险因素的同龄人相比,患有met的青少年通过大学数学考试的几率显著降低(OR: 0.49;95% CI 0.16 ~ 0.95)。结论在智利青少年中,心脏代谢健康与教育成果相关。
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引用次数: 2
Onset of type 1 diabetes mellitus in rural areas of the USA 美国农村地区1型糖尿病发病情况
Pub Date : 2019-09-28 DOI: 10.1136/jech-2019-212693
M. Rogers
Background In the USA, the epidemiologic features of type 1 diabetes are not well-defined across all 50 states. However, the advent of large nationwide insurance databases enables the investigation of where type 1 diabetes cases occur throughout the country. Methods An integrated database from a large nationwide health insurer in the USA (Clinformatics Data Mart Database) was used, from 2001 to 2017. The database contained longitudinal information on approximately 77 million people. Results The incidence of type 1 diabetes was greatest in areas of low population density across the 50 states. Individuals in the lowest population density areas had rates that were 2.28 times (95% CI 2.08 to 2.50) that of persons living in high-density areas. This association was consistent across various measures of rural status (p<0.001 for population density; p<0.001 for per cent rural as defined by the US Census Bureau; p=0.026 for farmland). The association between rural areas and the incidence of type 1 diabetes was evident across all four general regions of the USA. Conclusions The predilection of type 1 diabetes in rural areas provides clues to potential factors associated with the onset of this autoimmune disease.
在美国,1型糖尿病的流行病学特征在所有50个州都没有明确定义。然而,大型全国保险数据库的出现使调查1型糖尿病病例在全国范围内发生的地方成为可能。方法使用2001 - 2017年美国一家大型全国性健康保险公司的综合数据库(Clinformatics Data Mart database)。该数据库包含大约7700万人的纵向信息。结果美国50个州的1型糖尿病发病率以低人口密度地区最高。人口密度最低地区的个体发病率是高密度地区的2.28倍(95% CI 2.08 ~ 2.50)。这种关联在农村状况的各种测量中是一致的(人口密度p<0.001;按照美国人口普查局的定义,农村人口的比例p<0.001;农田的P =0.026)。农村地区与1型糖尿病发病率之间的联系在美国所有四个一般地区都很明显。结论1型糖尿病在农村地区的易感性为1型糖尿病发病的潜在因素提供了线索。
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引用次数: 4
Undiagnosed and untreated chronic kidney disease and its impact on renal outcomes in the Japanese middle-aged general population 未确诊和未经治疗的慢性肾脏疾病及其对日本中年一般人群肾脏结局的影响
Pub Date : 2019-09-28 DOI: 10.1136/jech-2019-212858
Yukari Yamada, T. Ikenoue, Yoshiyuki Saito, S. Fukuma
Background The effectiveness of identifying and monitoring early-stage chronic kidney disease (CKD) is not fully recognised. This study quantified people with undiagnosed CKD among the middle-aged Japanese population and clarified potential risks of untreated CKD. Methods We included 71 233 individuals who underwent annual health check-ups (AHC) in 2014 for both baseline and follow-up proteinuria and serum creatine measurements. CKD was identified by AHC data as proteinuria or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. We differentiated undiagnosed from diagnosed CKD using the medical claims database. In undiagnosed CKD, we assessed risk differences for disease progression, defined as an eGFR decline slope >3 mL/min/1.73 m2/year or proteinuria incidence over 3 years, between those who visited a physician for CKD treatment within 6 months after AHC and those who did not. Results CKD prevalence was 5.7% (5.2% undiagnosed and 0.5% diagnosed). Only 2.1% of the patients with undiagnosed CKD visited a physician for CKD treatment within 6 months after AHC. Between-group risk differences in instrumental variable adjustment models showed that those left untreated progressed to kidney diseases 16.3% more often than those who visited physicians for CKD treatment. Conclusion CKD was undiagnosed in 5.2% of the middle-aged general population. Only a few people visited physicians for CKD treatment. Visiting physicians for CKD treatment during the first 6 months after screening may be associated with a lower risk of kidney disease progression.
背景早期慢性肾脏疾病(CKD)的识别和监测的有效性尚未得到充分认识。本研究量化了日本中年人群中未确诊的CKD患者,并阐明了未经治疗的CKD的潜在风险。方法:我们纳入了2014年接受年度健康检查(AHC)的71 233名个体,包括基线和随访的蛋白尿和血清肌酸测量。AHC数据确定CKD为蛋白尿或估计肾小球滤过率(eGFR) 3 mL/min/1.73 m2/年或3年内蛋白尿发生率,在AHC后6个月内就诊的患者和未就诊的患者之间。结果CKD患病率为5.7%(未确诊5.2%,确诊0.5%)。AHC后6个月内,只有2.1%的未确诊CKD患者去看医生进行CKD治疗。工具变量调整模型的组间风险差异显示,未接受治疗的患者进展为肾脏疾病的几率比接受CKD治疗的患者高16.3%。结论5.2%的中年人群未确诊CKD。只有少数人去看医生治疗慢性肾病。在筛查后的前6个月内拜访医生进行CKD治疗可能与肾脏疾病进展的风险较低有关。
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引用次数: 7
Right-wing populism and self-rated health in Europe: a multilevel analysis 欧洲右翼民粹主义与自评健康:多层次分析
Pub Date : 2019-09-25 DOI: 10.1136/jech-2018-211995
I. Backhaus, S. Kino, G. La Torre, I. Kawachi
Background Individuals who identify as politically conservative have been previously shown to report better self-rated health compared with liberals. We tested whether this association still holds for right-wing populists, which are gaining strength as a political force in Europe in recent decades. Methods We analysed data from 24 617 respondents nested within 18 European countries included in the 2016 European Social Survey. Multilevel analyses were conducted to assess the association between political ideology and self-rated health, adjusting for other individual covariates (happiness and social capital). Results Individuals who voted for right-wing populist parties were 43% more likely to report fair/poor health compared with traditional conservatives (OR=1.43, 95% CI 1.23 to 1.67). The association was attenuated (OR=1.21, 95% CI 1.03 to 1.42) after controlling for additional individual-level variables, including happiness and access to social capital. Higher levels of social capital (informal networks, OR=0.40, 95% CI 0.29 to 0.56; trust, OR=0.82, 95% CI 0.74 to 0.92) and happiness (OR=0.18, 95% CI 0.15 to 0.22) were protectively correlated with fair/poor self-rated health. Conclusions Individuals voting for right-wing populist parties report worse health compared with conservatives. It remains unclear whether ideology is just a marker for health-related practices, or whether the values and beliefs associated with a particular brand of ideology lead to worse health.
与自由主义者相比,政治上保守的人自我评估的健康状况更好。我们测试了这种联系是否仍然适用于右翼民粹主义者,近几十年来,右翼民粹主义者作为一股政治力量在欧洲越来越强大。我们分析了2016年欧洲社会调查中18个欧洲国家的24617名受访者的数据。在对其他个体协变量(幸福和社会资本)进行调整后,进行了多水平分析,以评估政治意识形态与自评健康之间的关系。结果与传统保守派相比,投票给右翼民粹主义政党的个人报告健康状况一般/较差的可能性要高43% (OR=1.43, 95% CI 1.23至1.67)。在控制了额外的个人层面变量,包括幸福和获得社会资本后,这种关联减弱了(OR=1.21, 95% CI 1.03至1.42)。更高水平的社会资本(非正式网络,OR=0.40, 95% CI 0.29至0.56;信任(OR= 0.82, 95% CI 0.74至0.92)和快乐(OR=0.18, 95% CI 0.15至0.22)与自我评价健康的一般/较差具有保护相关。与保守派相比,投票给右翼民粹主义政党的个人健康状况更差。目前尚不清楚,意识形态是否只是与健康相关的实践的标志,还是与特定意识形态品牌相关的价值观和信仰导致健康状况恶化。
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引用次数: 11
Towards a more reliable assessment of health risks associated with the population exposure to bisphenols 争取更可靠地评估与人群接触双酚类物质有关的健康风险
Pub Date : 2019-09-24 DOI: 10.1136/jech-2019-213213
J. Klánová, R. Barouki
The exposure of populations to a wide range of chemicals through their outdoor and indoor environments, food, water and consumer products is a matter of growing concern for the public and health authorities. Chemical risk governance is complicated by a lack of knowledge on the composition of chemical mixtures to which populations are exposed, their spatial variability and major drivers of their toxicity, as well as long-term changes in the chemical exposures with respect to age, gender and occupation. A significant attention has been previously given to persistent pollutants or endocrine disrupting chemicals but there are important knowledge gaps related to compounds for which the concern has only recently emerged due to their increasing environmental concentrations, evidence of human exposures or alerting toxicological data. A need for the development of new approaches to the assessment of human health risks accounting for exposures to emerging chemicals and complex chemical mixtures can be demonstrated on the paper on urinary bisphenol A (BPA) and dyslipidaemia.1 The meta-analysis of National …
人们通过其室外和室内环境、食物、水和消费品接触各种化学品,这是公众和卫生当局日益关注的一个问题。由于缺乏对人群所接触的化学混合物的组成、其空间变异性和毒性的主要驱动因素以及化学品接触在年龄、性别和职业方面的长期变化的了解,化学品风险治理变得复杂。以前对持久性污染物或干扰内分泌的化学品给予了极大的关注,但由于其环境浓度不断增加、人类接触的证据或令人警惕的毒理学数据,这些化合物最近才引起人们的关注,因此存在重要的知识空白。关于尿双酚A (BPA)和血脂异常的文件可以证明,有必要开发新的方法来评估暴露于新兴化学品和复杂化学混合物的人类健康风险国家的元分析…
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引用次数: 0
Trends in the association of different forms of precarious employment and self-rated health in Germany. An analysis with the German Socio-Economic Panel between 1995 and 2015 德国不同形式的不稳定就业与自评健康之间联系的趋势。1995年至2015年德国社会经济委员会的分析
Pub Date : 2019-09-12 DOI: 10.1136/jech-2018-211933
T. Pförtner, H. Pfaff, K. Hower
Background Precarious employment has increased in Germany by means of labour market flexibilisation throughout the 1990s and 2000s. In this study, trends in the association of self-rated health (SRH) with different dimensions of precarious employment by gender in Germany between 1995 and 2015 were assessed considering different periods of labour market reforms and the Great Recession. Methods Analyses were conducted using the German Socio-Economic Panel from 1995 to 2015. All employed individuals aged 18–67 years and living in private households were considered for analysis to examine the risks of poor SRH by low wage, working poverty, non-standard working time arrangements and perceived job insecurity by gender. Predicted probabilities, adjusted risk ratio (ARR), adjusted risk difference (ARD) and trends were examined using pooled interval logistic regression with individual-clustered standard errors. Results Relative and absolute differences in SRH rose significantly over time by perceived job insecurity for men, but not for women. Working poverty appeared to be significantly associated with SRH in the Great Recession and the post-Recession period for both gender. Non-standard working time arrangements were not significantly associated with SRH for both gender, and low wage appeared to be significantly associated with SRH only for men in the post-Recession period. Conclusions The results highlighted the relevance of labour market reforms of deregulation and flexibilisation in Germany to differences in SRH by specific forms of precarious employment and gender differences in the impact of labour market reforms on precarious employment and health.
在20世纪90年代和21世纪初,由于劳动力市场的灵活性,德国的不稳定就业有所增加。在这项研究中,考虑到劳动力市场改革和大衰退的不同时期,评估了1995年至2015年间德国按性别划分的自评健康(SRH)与不同不稳定就业方面的关联趋势。方法采用德国社会经济调查小组1995 - 2015年进行分析。所有年龄在18-67岁、住在私人家庭的雇员都被纳入分析范围,以检查低工资、工作贫困、非标准工作时间安排和性别感知的工作不安全感对不良性健康和生殖健康的风险。预测概率、调整风险比(ARR)、调整风险差(ARD)和趋势采用具有个体聚类标准误差的混合区间逻辑回归进行检验。结果:随着时间的推移,男性对工作不安全感的感知,SRH的相对和绝对差异显著上升,而女性则没有。无论男女,在大衰退时期和后衰退时期,工作贫困似乎都与性健康和健康显著相关。非标准的工作时间安排与两性的性健康风险没有显著关联,在经济衰退后的时期,低工资似乎只与男性的性健康风险有显著关联。结论:研究结果强调了德国放松管制和灵活化的劳动力市场改革与不稳定就业的具体形式导致的两性健康状况差异的相关性,以及劳动力市场改革对不稳定就业和健康影响的性别差异。
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引用次数: 12
Cognitive tips for changing mindsets: improving policies to protect health and environment 改变思维方式的认知技巧:改善保护健康和环境的政策
Pub Date : 2019-09-05 DOI: 10.1136/jech-2018-210465
S. Riva
It is difficult enough to persuade people to adopt a healthy lifestyle, such as eating well, doing physical exercise or avoiding smoking— all of which have a direct impact on their lives ; however, it is an even greater challenge to persuade them to take significant actions for the future benefit of others. One such challenge is related to the protection of our environment.Unfortunately, people consider environmental protection as a separate domain to health protection, but it is not: the environment can affect human health, and environmental hazards increase the risk of diseases with adverse consequences for the entire world.1Various measures are proposed by national and international organisations, agencies and public institutions with the objective of regulating adequate action from citizens regarding the protection of their environment. Generally, economic actions such as taxes, subventions, fee structures and laws are, in many countries, the most frequently adopted measures.2Recently, however, psychology (particularly cognitive psychology) and behavioural sciences have been involved in a search for solutions and suggestions for improved policies and directives.3 There is a growing awareness that in different fields of human life,4 5 personal behaviours and attitudes can bring about change. With regard to green behaviour, current literature highlights how, in many situations, environmental protection may also be influenced by people’s behaviours and individual choices. Reflecting this, psychology and behavioural sciences can provide specific insight in examining individual people’s actions and behaviours to support the resolution of environmental issues.Their contribution is often called ‘soft’,6 because it is based on techniques and methods that aim to adapt and modify people’s attitudes and perceptions, rather than impose a radical modification through taxes, economical actions or other ‘hard’ mandatory policies (directed by legislation and regulatory monitoring). There are a number of soft techniques. In …
说服人们采取健康的生活方式,比如吃得好、做体育锻炼或不吸烟,已经够困难的了——所有这些都对他们的生活有直接影响;然而,说服他们为他人的未来利益采取重大行动是一个更大的挑战。其中一个挑战与环境保护有关。不幸的是,人们认为环境保护是健康保护的一个独立领域,但事实并非如此:环境可以影响人类健康,环境危害会增加疾病的风险,对整个世界产生不利后果。1 .国家和国际组织、机构和公共机构提出了各种措施,目的是规范公民在保护其环境方面的适当行动。一般来说,在许多国家,税收、补助、收费结构和法律等经济行动是最常采取的措施。然而,最近,心理学(特别是认知心理学)和行为科学已经参与到寻找改进政策和指令的解决办法和建议中来人们越来越认识到,在人类生活的不同领域,个人的行为和态度可以带来变化。关于绿色行为,目前的文献强调,在许多情况下,环境保护也可能受到人们的行为和个人选择的影响。反映这一点,心理学和行为科学可以提供具体的见解,检查个人的行动和行为,以支持解决环境问题。他们的贡献通常被称为“软”贡献6,因为它基于旨在适应和改变人们的态度和观念的技术和方法,而不是通过税收、经济行动或其他“硬”强制性政策(由立法和监管监督指导)强加彻底的改变。有许多软技术。在…
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引用次数: 2
Experience of maternal and paternal adversities in childhood as determinants of self-harm in adolescence and young adulthood 童年时期父母逆境的经历是青春期和青年期自残的决定因素
Pub Date : 2019-08-20 DOI: 10.1136/jech-2019-212689
Joonas Pitkänen, H. Remes, Mikko Aaltonen, P. Martikainen
Introduction Previous studies suggest that childhood experience of parental adversities increases the risk of subsequent offspring self-harm, but studies on distinct paternal and maternal characteristics are few and it remains unclear how these interact with childhood social position. The study aims to assess whether paternal and maternal adversities have different associations with offspring self-harm in adolescence and young adulthood. Interaction by offspring gender and childhood income are investigated, as well as cumulative effects of multiple adversities. Methods The study uses administrative register data on a 20% random sample of Finnish households with children aged 0–14 years in 2000. We follow children born in 1986–1998 (n=155 855) from their 13th birthday until 2011. Parental substance abuse, psychiatric disorders, criminality and hospitalisations due to interpersonal violence or self-harm are used to predict offspring self-harm with Cox proportional hazards models. Results The results show a clear increase in the risk of self-harm among those exposed to maternal or paternal adversities with HRs between 1.5 and 5.4 among boys and 1.7 and 3.9 among girls. The excess risks hold for every measure of maternal and paternal adversities after adjusting for childhood income and parental education. Evidence was found suggesting that low income, accumulation of adversity and female gender may exacerbate the consequences of adversities. Conclusions Our findings suggest that both parents’ adversities increase the risk of self-harm and that multiple experiences of parental adversities in childhood are especially harmful, regardless of parent gender. Higher levels of childhood income can protect from the negative consequences of adverse experiences.
先前的研究表明,童年时期父母逆境的经历会增加后代自残的风险,但关于父亲和母亲独特特征的研究很少,而且这些特征如何与童年社会地位相互作用仍不清楚。该研究旨在评估父亲和母亲的逆境是否与子女在青春期和成年早期的自我伤害有不同的联系。研究了后代性别和童年收入的相互作用,以及多重逆境的累积效应。方法采用2000年20%随机抽样的芬兰0-14岁儿童家庭的行政登记数据。我们跟踪了1986-1998年出生的孩子(n=155 855),从他们的13岁生日到2011年。父母药物滥用、精神障碍、犯罪和因人际暴力或自残而住院使用Cox比例风险模型来预测后代的自残。结果结果显示,在父母逆境环境中,男孩的hr值在1.5 ~ 5.4之间,女孩的hr值在1.7 ~ 3.9之间,自残的风险明显增加。在调整了童年收入和父母教育之后,对母亲和父亲逆境的每一项测量都存在超额风险。有证据表明,低收入、逆境的积累和女性性别可能会加剧逆境的后果。我们的研究结果表明,父母双方的逆境都会增加自残的风险,并且无论父母性别如何,童年时期多次经历父母的逆境都尤其有害。较高的童年收入水平可以保护儿童免受不良经历的负面影响。
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引用次数: 8
Effort–reward imbalance and long-term benzodiazepine use: longitudinal findings from the CONSTANCES cohort 努力-回报不平衡和长期苯二氮卓类药物使用:来自constance队列的纵向研究结果
Pub Date : 2019-08-12 DOI: 10.1136/jech-2019-212703
G. Airagnes, C. Lemogne, S. Kab, N. Hoertel, M. Goldberg, M. Wahrendorf, J. Siegrist, Y. Roquelaure, F. Limosin, M. Zins
Objectives To examine the association between effort–reward imbalance and incident long-term benzodiazepine use (LTBU). Methods We included 31 077 employed participants enrolled in the French population-based CONSTANCES cohort between 2012 and 2014 who had not undergone LTBU in the 2 years before enrolment. LTBU was examined using drug reimbursement administrative databases. The effort–reward imbalance was calculated in quartiles. We computed ORs (95% CIs) for LTBU according to effort–reward imbalance over a 2-year follow-up period. We adjusted for age, gender, education, occupational grade, income, marital status, tobacco smoking, risk of alcohol use disorder, depressive symptoms and self-rated health. Results Over the 2-year follow-up, 294 (0.9%) participants experienced incident LTBU. In the univariable analysis, effort–reward imbalance was associated with subsequent LTBU with ORs of 1.79 (95% CI 1.23 to 2.62) and 2.73 (95% CI 1.89 to 3.95) for the third and fourth quartiles, respectively, compared with the first quartile. There was no interaction between effort–reward imbalance and any of the considered variables other than tobacco smoking (p=0.033). The association remained significant in both smokers and non-smokers, with higher odds for smokers (p=0.031). In the fully adjusted model, the association remained significant for the third and fourth quartiles, with ORs of 1.74 (95% CI 1.17 to 2.57) and 2.18 (95% CI 1.50 to 3.16), respectively. These associations were dose dependent (p for trend <0.001). Conclusions Effort–reward imbalance was linked with incident LTBU over a 2-year follow-up period after adjustment for sociodemographic and health-related factors. Thus, screening and prevention of the risk of LTBU should be systematised among individuals experiencing effort–reward imbalance, with special attention paid to smokers.
目的探讨长期苯二氮卓类药物使用与努力-回报失衡的关系。方法:我们纳入了2012年至2014年法国人群为基础的constes队列的31,077名在职参与者,他们在入组前2年内未接受过LTBU。使用药品报销管理数据库检查LTBU。付出与回报的不平衡以四分位数计算。我们根据2年随访期间的努力-回报不平衡计算LTBU的or (95% ci)。我们调整了年龄、性别、教育程度、职业等级、收入、婚姻状况、吸烟、酒精使用障碍风险、抑郁症状和自评健康状况。结果在2年的随访中,294名(0.9%)参与者经历了LTBU事件。在单变量分析中,与第一个四分位数相比,第三和第四个四分位数的努力-奖励失衡与随后的LTBU相关,其or分别为1.79 (95% CI 1.23至2.62)和2.73 (95% CI 1.89至3.95)。努力-报酬不平衡与除吸烟外的其他变量均无交互作用(p=0.033)。这种关联在吸烟者和非吸烟者中仍然显著,吸烟者的几率更高(p=0.031)。在完全调整后的模型中,第三和第四个四分位数的相关性仍然显著,or分别为1.74 (95% CI 1.17至2.57)和2.18 (95% CI 1.50至3.16)。这些关联是剂量依赖性的(p表示趋势<0.001)。结论:在调整社会人口统计学和健康相关因素后,2年随访期间,努力-奖励失衡与LTBU事件有关。因此,在经历努力-回报不平衡的个体中筛查和预防LTBU风险应该是系统化的,特别要注意吸烟者。
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引用次数: 4
Residence change during the first trimester of pregnancy and adverse birth outcomes 妊娠前三个月的居住地变化和不良分娩结局
Pub Date : 2019-07-30 DOI: 10.1136/jech-2018-211937
Julia C. Bond, Amanda Mancenido, Divya M Patil, Seth Rowley, J. Goldberg, A. Littman
Background There are few published studies evaluating the impact of perinatal residence change on infant outcomes and whether these associations differ by socioeconomic status. Methods We conducted a population-based cohort study using Washington State birth certificate data from 2007 to 2014 to assess whether women who moved during the first trimester of pregnancy (n=28 011) had a higher risk of low birth weight, preterm birth and small for gestational age than women who did not move during the first trimester (n=112 367). ‘Non-first-trimester movers’ were frequency matched 4:1 to movers by year. We used generalised linear models to calculate risk ratios and risk differences adjusted for maternal age, race, marital status, parity, education, smoking, income and insurance payer for the birth. We also stratified analyses by variables related to socioeconomic status to see whether associations differed across socioeconomic strata. Results Moving in the first trimester was associated with an increased risk of low birth weight (6.4% vs 4.5%, adjusted risk ratio 1.37 (95% CI 1.29 to 1.45)) and preterm birth (9.1% vs 6.4%, adjusted risk ratio 1.42 (95% CI 1.36 to 1.49)) and a slight increased risk of small for gestational age (9.8% vs 8.7%, adjusted risk ratio 1.09 (95% CI 1.00 to 1.09)). Residence change was associated with low birth weight and preterm birth in all socioeconomic strata. Conclusion Moving during the first trimester of pregnancy may be a risk factor for adverse birth outcomes in US women. Healthcare providers may want to consider screening for plans to move and offering support.
背景很少有已发表的研究评估围产期居住改变对婴儿结局的影响,以及这些关联是否因社会经济地位而异。方法采用2007年至2014年华盛顿州出生证明数据进行了一项基于人群的队列研究,以评估在妊娠前三个月搬家的妇女(n= 28011)是否比在妊娠前三个月不搬家的妇女(n= 112367)有更高的低出生体重、早产和小胎龄风险。“非孕早期推动者”与推动者的频率按年份匹配为4:1。我们使用广义线性模型来计算风险比和风险差异,调整了产妇年龄、种族、婚姻状况、性别、教育程度、吸烟、收入和生育保险支付者。我们还通过与社会经济地位相关的变量进行分层分析,以了解社会经济阶层之间的关联是否存在差异。结果妊娠早期运动与低出生体重(6.4% vs 4.5%,调整风险比1.37 (95% CI 1.29 ~ 1.45))和早产(9.1% vs 6.4%,调整风险比1.42 (95% CI 1.36 ~ 1.49))和胎龄小的风险轻微增加(9.8% vs 8.7%,调整风险比1.09 (95% CI 1.00 ~ 1.09))相关。在所有社会经济阶层中,居住地变化与低出生体重和早产有关。结论妊娠前三个月搬家可能是美国妇女不良分娩结局的危险因素。医疗保健提供者可能会考虑为搬家计划进行筛查并提供支持。
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引用次数: 6
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Journal of Epidemiology & Community Health
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