Pub Date : 2026-01-22DOI: 10.1016/j.jhep.2026.01.006
Adam Yopp, Minshan Chen, Ann-Lii Cheng, Ahmed Kaseb, Masatoshi Kudo, Han Chu Lee, Edward Cha, Stephen Paul Hack, Qinshu Lian, Jessica Spahn, Chun Wu, Shukui Qin, Pierce Kah-Hoe Chow
{"title":"Updated data from IMbrave050: Adjuvant atezolizumab plus bevacizumab for high-risk hepatocellular carcinoma","authors":"Adam Yopp, Minshan Chen, Ann-Lii Cheng, Ahmed Kaseb, Masatoshi Kudo, Han Chu Lee, Edward Cha, Stephen Paul Hack, Qinshu Lian, Jessica Spahn, Chun Wu, Shukui Qin, Pierce Kah-Hoe Chow","doi":"10.1016/j.jhep.2026.01.006","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.01.006","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"49 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.jhep.2025.12.030
Zoe A. Clarke, Jawairia Atif, Xinle Wang, Lewis Y. Liu, Lawrence Wood, Damra Camat, Yijia Liu, Ariya Shiwram, Sharon J. Hyduk, Sai Chung, Xue-Zhong Ma, Justin Manuel, Si Lok, Timothy N.H. Lau, Cornelia Thoeni, Tomasz I. Michalak, Ian D. McGilvray, Gary D. Bader, Sonya A. MacParland
{"title":"A single-cell atlas of the woodchuck liver reveals cellular programs conserved in human HBV infection","authors":"Zoe A. Clarke, Jawairia Atif, Xinle Wang, Lewis Y. Liu, Lawrence Wood, Damra Camat, Yijia Liu, Ariya Shiwram, Sharon J. Hyduk, Sai Chung, Xue-Zhong Ma, Justin Manuel, Si Lok, Timothy N.H. Lau, Cornelia Thoeni, Tomasz I. Michalak, Ian D. McGilvray, Gary D. Bader, Sonya A. MacParland","doi":"10.1016/j.jhep.2025.12.030","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.12.030","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"86 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.jhep.2026.01.007
Benedikt Silvester Hofer, Marta Tonon, Laura Buttler, Joana Camões Neves, Queralt Herms, Enrico Pompili, Mina Ignat, Sophie Métivier, Susana Gomes Rodrigues, Daniel Gutmann, Jesús Donate, Jimmy Che-To Lai, Ana Clemente Sánchez, Alba Jiménez-Masip, Josune Cabello, Charlotte Bouzbib, Henrik Karbannek, Jan Embacher, Thomas Sorz-Nechay, Lukas Parandian, Antonio Accetta, Roberta Gagliardi, Marie Griemsmann, Jordi Gratacós-Ginès, Mattias Mandorfer, Guadalupe Garcia-Tsao, Douglas A. Simonetto, Georg Semmler, Alexander Zipprich, Marika Rudler, Jonel Trebicka, Joan Genesca, Rafael Bañares, Terry Cheuk-Fung Yip, Luis Téllez, Emmanuel Tsochatzis, Annalisa Berzigotti, Hélène Larrue, Horia Stefanescu, Paolo Caraceni, Elisa Pose, Dalila Costa, Benjamin Maasoumy, Salvatore Piano, Thomas Reiberger
{"title":"Incidence and implications of abstinence-induced recompensation in alcohol-related cirrhosis","authors":"Benedikt Silvester Hofer, Marta Tonon, Laura Buttler, Joana Camões Neves, Queralt Herms, Enrico Pompili, Mina Ignat, Sophie Métivier, Susana Gomes Rodrigues, Daniel Gutmann, Jesús Donate, Jimmy Che-To Lai, Ana Clemente Sánchez, Alba Jiménez-Masip, Josune Cabello, Charlotte Bouzbib, Henrik Karbannek, Jan Embacher, Thomas Sorz-Nechay, Lukas Parandian, Antonio Accetta, Roberta Gagliardi, Marie Griemsmann, Jordi Gratacós-Ginès, Mattias Mandorfer, Guadalupe Garcia-Tsao, Douglas A. Simonetto, Georg Semmler, Alexander Zipprich, Marika Rudler, Jonel Trebicka, Joan Genesca, Rafael Bañares, Terry Cheuk-Fung Yip, Luis Téllez, Emmanuel Tsochatzis, Annalisa Berzigotti, Hélène Larrue, Horia Stefanescu, Paolo Caraceni, Elisa Pose, Dalila Costa, Benjamin Maasoumy, Salvatore Piano, Thomas Reiberger","doi":"10.1016/j.jhep.2026.01.007","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.01.007","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"115 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.jhep.2026.01.003
Line Molzen, Peter Jepsen, Gro Askgaard
Section snippets
Authors' contributions
LM, GA and PJ wrote and revised the letter, and all approved the final version.
Financial support
The study was funded by the Novo Nordisk Foundation (NNF: NNF22OC0079565). The funder was not involved in the design, conduct of the study or in the decision to submit the manuscript for publication.
Conflict of interest
The authors declare that they do not have any conflicts of interest related to this letter.Please refer to the accompanying ICMJE disclosure forms for further details.
{"title":"Absolute risk estimation of liver disease cannot be based on time-varying covariates","authors":"Line Molzen, Peter Jepsen, Gro Askgaard","doi":"10.1016/j.jhep.2026.01.003","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.01.003","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>LM, GA and PJ wrote and revised the letter, and all approved the final version.</section></section><section><section><h2>Financial support</h2>The study was funded by the <span>Novo Nordisk Foundation</span> (NNF: <!-- -->NNF22OC0079565<!-- -->). The funder was not involved in the design, conduct of the study or in the decision to submit the manuscript for publication.</section></section><section><section><h2>Conflict of interest</h2>The authors declare that they do not have any conflicts of interest related to this letter.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"12 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1016/j.jhep.2025.12.018
Lisa Sandmann
{"title":"Tobevibart and elebsiran for the treatment of chronic hepatitis delta","authors":"Lisa Sandmann","doi":"10.1016/j.jhep.2025.12.018","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.12.018","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"33 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-17DOI: 10.1016/j.jhep.2026.01.004
Henry Lik Yuen Chan, Vincent Wai Sun Wong, Grace Lai Hung Wong
Section snippets
Authors' contributions
HLY Chan, VWS Wong, and GLH Wong were responsible for the study concept and design. HLY Chan was responsible for drafting of the paper. HLY Chan is the submission’s guarantor of the article. All authors had critically reviewed the manuscript and approved the final version of the article.
Financial support
None
Conflict of interest
HLY Chan has served as an advisor of Aligos, Roche, Virion Therapeutics; a speaker for Echosens, Gilead, Roche; a data and safety monitoring board member for Aligos, Arbutus, Barinthus Biotherapeutics, Roche, Precision Biosciences, and Shanghai Zhimeng Bioipharma. He has received a research grant from Gilead Sciences.VWS Wong has served as a consultant or advisory committee member for AbbVie, Boehringer Ingelheim, Echosens, Intercept, Inventiva, Novo Nordisk, Pfizer, and TARGET PharmaSolutions;
{"title":"Is Partial Cure a Realistic Endpoint for Novel Hepatitis B Therapy?","authors":"Henry Lik Yuen Chan, Vincent Wai Sun Wong, Grace Lai Hung Wong","doi":"10.1016/j.jhep.2026.01.004","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.01.004","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>HLY Chan, VWS Wong, and GLH Wong were responsible for the study concept and design. HLY Chan was responsible for drafting of the paper. HLY Chan is the submission’s guarantor of the article. All authors had critically reviewed the manuscript and approved the final version of the article.</section></section><section><section><h2>Financial support</h2>None</section></section><section><section><h2>Conflict of interest</h2>HLY Chan has served as an advisor of Aligos, Roche, Virion Therapeutics; a speaker for Echosens, Gilead, Roche; a data and safety monitoring board member for Aligos, Arbutus, Barinthus Biotherapeutics, Roche, Precision Biosciences, and Shanghai Zhimeng Bioipharma. He has received a research grant from Gilead Sciences.VWS Wong has served as a consultant or advisory committee member for AbbVie, Boehringer Ingelheim, Echosens, Intercept, Inventiva, Novo Nordisk, Pfizer, and TARGET PharmaSolutions;</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"38 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145993319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-17DOI: 10.1016/j.jhep.2025.12.028
Pusen Wang, Lin Zhong
{"title":"Thrombotic microangiopathy or rejection in first pig-to-human patient liver xenotransplantation","authors":"Pusen Wang, Lin Zhong","doi":"10.1016/j.jhep.2025.12.028","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.12.028","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"39 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-17DOI: 10.1016/j.jhep.2025.12.026
Aleksander Krag, Frank Tacke, Mads Israelsen, Zobair M. Younossi
{"title":"Is liver steatosis a disease or the emperor’s new clothes?","authors":"Aleksander Krag, Frank Tacke, Mads Israelsen, Zobair M. Younossi","doi":"10.1016/j.jhep.2025.12.026","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.12.026","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"99 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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