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Sensor Surface Design with NanoMaterials: A New Platform in the Diagnosis of COVID-19 纳米材料传感器表面设计:新冠肺炎诊断平台
Pub Date : 2021-03-29 DOI: 10.5772/INTECHOPEN.97056
Eliete A. Alvin, A. Borges, R. D. P. Martins, M. Lemes, R. M. Barbosa, C. J. Oliveira, Diógenes Meneses, B. G. Lucca, N. Dantas, V. R. Júnior, R. P. A. Balvedi, F. C. Abreu, Marcos Vinícius da Silva, Anielle C. A. Silva
Mass testing for COVID-19 is essential to defining patient management strategies, choosing the best clinical management, and dimensioning strategies for controlling viral dissemination and immunization strategies. Thus, it is of utmost importance to search for devices that allow a quick and reliable diagnosis of low cost that can be transposed from the bench to the bedside, such as biosensors. These devices can help choose the correct clinical management to minimize factors that lead to infected patients developing more severe diseases. The use of nanomaterials to modify biosensors’ surfaces to increase these devices’ sensitivity and their biofunctionality enables high-quality nanotechnological platforms. In addition to the diagnostic benefits, nanotechnological platforms that facilitate the monitoring of anti-SARS-CoV-2 antibodies may be the key to determining loss of protective immune response after an episode of COVID-19, which leads to a possible chance of reinfection, as well as how they can be used to assess and monitor the success of immunization strategies, which are beginning to be administered on a large scale and that the extent and duration of their protection will need to be determined. Therefore, in this chapter, we will cover nanomaterials’ use and their functionalities in the surface design of sensors, thus generating nanotechnological platforms in the various facets of the diagnosis of COVID-19.
COVID-19大规模检测对于确定患者管理策略、选择最佳临床管理以及制定控制病毒传播的策略和免疫策略至关重要。因此,寻找能够实现快速、可靠、低成本诊断的设备是至关重要的,这些设备可以从实验室转移到床边,比如生物传感器。这些设备可以帮助选择正确的临床管理,以尽量减少导致感染患者发展成更严重疾病的因素。利用纳米材料修饰生物传感器的表面,以增加这些设备的灵敏度和生物功能,使高质量的纳米技术平台成为可能。除了诊断益处之外,促进监测抗sars - cov -2抗体的纳米技术平台可能是确定COVID-19发作后保护性免疫反应丧失的关键,这可能导致再次感染的机会,以及如何使用它们来评估和监测免疫策略的成功。这些药物已经开始大规模使用它们的保护范围和持续时间需要确定。因此,在本章中,我们将介绍纳米材料在传感器表面设计中的使用及其功能,从而在COVID-19诊断的各个方面产生纳米技术平台。
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引用次数: 0
Different Therapeutic Strategies to Tackle the Infection Associated with COVID-19 应对COVID-19相关感染的不同治疗策略
Pub Date : 2021-03-24 DOI: 10.5772/INTECHOPEN.96899
Meemansha Sharma, Thakur Uttam Singh, Madhu Cholenahalli Lingaraju, S. Parida
Covid-19 is a pandemic and the whole world is facing the loss in terms of morbidity and mortality of the human resources. Therefore, there is an urgent need for various therapeutic agents or drugs to treat the covid-19 patients. Although, vaccination process is under way, it is not possible to provide the vaccination to whole world in a short period. Therefore, it is an essential strategy to work on the various therapeutic aspects of covid-19 treatment. The present book chapter will discuss and review the various aspects of the treatment strategies of the covid-19. Further, we will provide an overview of the virus and host based potential therapeutic targets along with existing therapeutics which are effective against SARS-CoV-2 virus. Also, the novel vaccines are being developed against covid-19 deadly virus will be discussed.
新冠肺炎是一场大流行,全世界都面临着人力资源发病率和死亡率的损失。因此,迫切需要各种治疗药物或药物来治疗covid-19患者。虽然疫苗接种进程正在进行,但不可能在短时间内向全世界提供疫苗接种。因此,开展covid-19治疗的各个治疗方面的工作是一项必不可少的战略。本章将讨论和回顾covid-19治疗策略的各个方面。此外,我们将概述该病毒和基于宿主的潜在治疗靶点,以及现有的有效对抗SARS-CoV-2病毒的治疗方法。此外,还将讨论针对covid-19致命病毒正在开发的新型疫苗。
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引用次数: 0
A Qualitative Study of Pre-Vaccine Decrease of Mortality from COVID-19 疫苗接种前降低COVID-19死亡率的定性研究
Pub Date : 2021-03-23 DOI: 10.5772/INTECHOPEN.97017
V. Mammadov, L. Jafarova
More than a year has passed since the appearance of disease called COVID-19 in the world. This disease became the reason for unprecedented measures taken so far, having received the classification of pandemic. The world has faced with pandemics before, but society has not yet taken such unprecedented restrictive measures. The restrictions of not only local but even of global nature, such as the suspension of international flights, various scientific and political events were adopted around the world. Media resources have played a key role in the formation and development of the attitude towards the disease in people. Despite all the depressing news, the facts showed a low mortality rate, which is often ignored by the media. As a result, medical staff around the world have faced psychological health issues among the different groups of the population, especially vulnerable ones such as people with chronic disease and with weak immunity. At present, it is early to talk about the results and outcomes of the pandemic. However, previous year has taught us many lessons and can become a key factor in understanding the role of the media in pandemic times, developing strategies for combating diseases and protecting public health.
自2019冠状病毒病在世界上出现以来,已经过去了一年多。这种疾病成为迄今为止采取前所未有措施的原因,已被列为大流行。世界以前也面临过流行病,但社会尚未采取如此前所未有的限制措施。不仅是地方性的,甚至是全球性的限制,如暂停国际航班,各种科学和政治活动,在世界各地都采取了限制措施。媒体资源在人们对疾病态度的形成和发展中发挥了关键作用。尽管有这些令人沮丧的消息,但事实表明,死亡率很低,这一点经常被媒体所忽视。因此,世界各地的医务人员都面临着不同人群的心理健康问题,特别是慢性病患者和免疫力低下者等弱势群体。目前,谈论大流行的结果和后果还为时过早。然而,过去的一年给了我们许多教训,可以成为理解媒体在大流行病时期的作用、制定防治疾病和保护公众健康战略的关键因素。
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引用次数: 1
Development of RT-PCR Based Diagnosis of SARS-CoV-2 基于RT-PCR诊断SARS-CoV-2的研究进展
Pub Date : 2021-03-16 DOI: 10.5772/INTECHOPEN.96823
Rutuja Sunil Patankar, V. Zambare
In the 2020, COVID-19 pandemic disease created an havoc situation world widely and mainly caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). It has been challenging task for researchers, scientists and medico-pharmaceutical organisations to find out rapid and reliable diagnosis methods. Among the all testing services, a Reverse Transcription Polymerase Chain Reaction (RT-PCR) is the more accurate, rapid and authenticated molecular technique used for most of the diagnosis of major diseases. It has been a global priority to fix the rapid diagnosis method to combat against the pandemic COVID-19. Thus, the present chapter mainly focussing on the progress of RT-PCR method development though various processes of data collection on isolation of whole genome sequence, its primer and method designing. In this scenario, India suddenly become the global leader for vaccine development and hence the challenges and RT-PCR kit development in India and rest of the world has been be discussed. World wide many Government and private agencies and industries have taken an initiative for diagnosis of SARS-CoV-2 hence this chapter also summarised the scope of RT-PCR to combat pandemic situation in future.
2020年,COVID-19大流行在世界范围内造成了严重破坏,主要由严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)引起。对于研究人员、科学家和医药组织来说,找到快速可靠的诊断方法一直是一项具有挑战性的任务。在所有检测服务中,逆转录聚合酶链反应(RT-PCR)是最准确、快速和可靠的分子技术,用于大多数重大疾病的诊断。为应对新冠肺炎大流行,解决快速诊断方法一直是全球优先考虑的问题。因此,本章主要通过全基因组序列的分离、引物和方法设计的各个数据收集过程来介绍RT-PCR方法的发展进展。在这种情况下,印度突然成为全球疫苗开发的领导者,因此讨论了印度和世界其他地区面临的挑战和RT-PCR试剂盒的开发。在世界范围内,许多政府和私人机构以及行业已经主动采取了SARS-CoV-2的诊断措施,因此本章还总结了RT-PCR在未来应对大流行情况的范围。
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引用次数: 6
The Link between Electrical Properties of COVID-19 and Electromagnetic Radiation COVID-19电学特性与电磁辐射之间的联系
Pub Date : 2021-03-14 DOI: 10.5772/INTECHOPEN.96815
Awaad K. Al Sarkhi
The ability of a new vaccine design based on control the intracellular physiological consequences of both the electrical properties and the electromagnetic radiation interactions between a virus and a host cell, which is a method to strengthen immune system develop protection against COVID-19 and new strains. The capacity of COVID-19 to bind to angiotensin-converting enzyme 2 (ACE2) and immune evasion mechanisms are only one of the properties required to stimulate a preventative immune response. In this chapter, a multidimensional new strategy is used to exemplify the empowerment function intracellular and extracellular level information can play in the support of immunogen against COVID-19 pathogens. Besides during this chapter, the nature of electromagnetic radiation is described as a vibrating string based on a string-theory and unification of electromagnetic radiation and gravitational waves by supporting with multiple cites strong evidence. Overall, we demonstrate a new approach to understand the important role of the physiological consequences of the interplay between the immune system and COVID-19 and designing vaccine strategy immunogens that take advantage of that information against COVID-19 and new strains.
基于控制病毒与宿主细胞之间电学性质和电磁辐射相互作用的细胞内生理后果的新疫苗设计的能力,是加强免疫系统对COVID-19和新毒株的保护的一种方法。COVID-19与血管紧张素转换酶2 (ACE2)结合的能力和免疫逃避机制只是刺激预防性免疫反应所需的特性之一。在本章中,我们采用了一种多维度的新策略来举例说明细胞内和细胞外水平信息在支持免疫原对抗COVID-19病原体方面发挥的增强功能。此外,在本章中,基于弦理论和电磁辐射与引力波的统一,通过多个强有力的证据,将电磁辐射的本质描述为振动的弦。总的来说,我们展示了一种新的方法来理解免疫系统与COVID-19相互作用的生理后果的重要作用,并设计疫苗策略免疫原,利用这些信息来对抗COVID-19和新菌株。
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引用次数: 2
Cellular Therapy as Promising Choice of Treatment for COVID-19 细胞疗法是治疗COVID-19的有希望的选择
Pub Date : 2021-03-13 DOI: 10.5772/INTECHOPEN.96900
Duygu Koyuncu Irmak, E. Karaoz
In the pandemic of COVID-19, while living normals have been changing, there have been a huge effort globally to find out effective and safe treatment agents and vaccines. As of now, the advances show the progress in vaccine development, however the treatment of the COVID-19 is yet not fully specified. The drugs, i.e. antibiotics, antivirals, antimalarians, even anti-HIV agents which have been known already were taken out of the shelves and brought into use in different combinations. On the other hand, the cellular treatment, more specifically the mesenchymal stem cell therapy has been encouraged, resulting in various evidence published all over the world. This chapter aims to compile the published information, in means of methods, disease manifestations, results and limitations, about the stem cell treatment of the COVID-19 and to provide a source of harmonized reference for scientific society.
在新冠肺炎大流行期间,虽然生活常态发生了变化,但全球为寻找有效安全的治疗药物和疫苗做出了巨大努力。到目前为止,疫苗开发取得了进展,但新冠肺炎的治疗方法还没有完全确定。这些药物,即抗生素、抗病毒药物、抗疟疾药物,甚至是已知的抗艾滋病毒药物,都被下架,并以不同的组合投入使用。另一方面,细胞治疗,特别是间充质干细胞治疗一直受到鼓励,导致各种证据在世界各地发表。本章旨在整理已发表的干细胞治疗新冠肺炎的方法、疾病表现、结果和局限性等方面的信息,为科学界提供统一的参考来源。
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引用次数: 1
Whole Genome Sequencing: A Powerful Tool for Understanding the Diversity of Genotypes and Phenotypes among COVID-19 Infected Patients to Help in Controlling Outbreaks 全基因组测序:了解COVID-19感染患者基因型和表型多样性以帮助控制疫情的有力工具
Pub Date : 2021-02-15 DOI: 10.5772/INTECHOPEN.96260
Rayan A. Ahmed
In Wuhan, China (December 2019), viral pneumonia cases of uncertain origin have been reported. The emergency has drawn global attention. To determine the pathogenic potential, joint efforts were conducted by Chinese Multidisciplinary Task Forces. An integral component of wide range of research applications is not only determining the causative agent but also the nucleic acid bases order in biological samples. Research techniques determining genetic material features and its order is called “sequencing”, classified into three generations. Moreover, the first sequencing attempt was conducted and a genetic link identified between samples isolated from China and other previously sequenced Coronaviruses. However, there was patient to patient diversity in terms of clinical and laboratory manifestations and diseases severity. After the genetic material of the causative agent was successfully sequenced, it was named the novel coronavirus causing COVID-19. Here, we review the genome sequences of novel coronavirus infected patients from different countries such as India, Bangladesh and Ecuador compared to China (first reported case), seeking not only to recognize similarities and differences between genome sequences of novel coronavirus, but also to compare them with other forms of coronaviruses family. Utilizing this data will assist in making right decisions minimizing negative consequences of the outbreak.
在中国武汉(2019年12月),报告了来源不明的病毒性肺炎病例。这一紧急情况引起了全球的关注。为了确定致病潜力,中国多学科工作队进行了联合努力。在广泛的研究应用中,一个不可分割的组成部分不仅是确定病原体,而且是确定生物样品中的核酸碱基顺序。确定遗传物质特征及其顺序的研究技术称为“测序”,分为三代。此外,进行了第一次测序尝试,并确定了从中国分离的样本与其他先前测序的冠状病毒之间的遗传联系。然而,在临床和实验室表现以及疾病严重程度方面,患者之间存在差异。病原遗传物质测序成功后,将其命名为新型冠状病毒。本文对来自印度、孟加拉国、厄瓜多尔等不同国家的新型冠状病毒感染患者的基因组序列与中国(首例报告病例)的基因组序列进行比较,不仅寻求识别新型冠状病毒基因组序列之间的异同,而且将其与其他形式的冠状病毒科进行比较。利用这些数据将有助于做出正确的决定,最大限度地减少疫情的负面后果。
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引用次数: 0
Epidemiology, Pathogenesis, and Healing Strategies of COVID-19 COVID-19的流行病学、发病机制和治疗策略
Pub Date : 2021-02-11 DOI: 10.5772/INTECHOPEN.96200
B. Bhowmik
In the present chapter, some notable features (epidemiology, pathogenesis, and clinical characteristics) regarding recent outbreak COVID-19 have been reviewed. Most significant features related to COVID-19 such as (i) roots of infection and disease manifestation, (ii) shape and structure of viral S-protein, (iii) genome sequence study and replication in host cell, (iv) role of environmental factors, (v) diagnosis tools and (vi) role of biosensor have been critically investigated. The biological and behavioral risk factors for pregnant women before and after child birth have been dictated clearly. Pulmonary abnormalities due to COVID-19 of the patient having diabetes, cancer etc. history have been clarified with help of CT imaging. Finally, prevention and cure strategies adopted by many health professionals based on the existing drugs are mentioned with their side effects.
在本章中,综述了最近爆发的COVID-19的一些值得注意的特征(流行病学、发病机制和临床特征)。与COVID-19相关的最重要特征,如(i)感染根源和疾病表现,(ii)病毒s蛋白的形状和结构,(iii)基因组序列研究和宿主细胞中的复制,(iv)环境因素的作用,(v)诊断工具和(vi)生物传感器的作用,已被严格研究。孕妇在分娩前后的生物学和行为风险因素已经明确。有糖尿病、癌症等病史的患者,通过CT影像学明确新冠肺炎所致肺部异常。最后,提到了许多卫生专业人员在现有药物的基础上采取的预防和治疗策略及其副作用。
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引用次数: 0
COVID-19 and Cancer: Biological Interconnection and Treatment COVID-19和癌症:生物互联和治疗
Pub Date : 1900-01-01 DOI: 10.5772/intechopen.97482
N. Jyotsana
The COVID-19 pandemic has affected more than 125 million lives worldwide and more than 2.5 million people have died so far. Cancer in itself increases the risk of infection especially, cancer patients undergoing cancer-associated treatments are more susceptible to SARS-CoV2 infection. However, many questions related to the biological interconnection between the two diseases remain to be answered. This chapter summarizes some of the biological components that connect cancer to COVID-19 and provide knowledge to not only understand but also, target the co-morbidities.
到目前为止,COVID-19大流行已影响到全球超过1.25亿人的生命,250多万人死亡。癌症本身增加了感染的风险,特别是接受癌症相关治疗的癌症患者更容易感染SARS-CoV2。然而,关于这两种疾病之间的生物学联系的许多问题仍有待解答。本章总结了将癌症与COVID-19联系起来的一些生物学成分,并提供了不仅了解而且针对合并症的知识。
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引用次数: 1
期刊
Biotechnology to Combat COVID-19 [Working Title]
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