Journal of geriatric oncology最新文献

{"title":"Tolerability of docetaxel in octogenarians with metastatic prostate cancer in the triplet therapy era: A single-center retrospective cohort study","authors":"Kimitsugu Usui, Atsuto Suzuki, Hayato Kubo, Takahiro Matsumoto, Tomohiko Aigase, Takeshi Kishida, Noboru Nakaigawa","doi":"10.1016/j.jgo.2025.102844","DOIUrl":"10.1016/j.jgo.2025.102844","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102844"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hospital volume on mortality in adult women over 65 with triple-negative breast cancer","authors":"Barnabas T. Obeng-Gyasi ,&nbsp;Demond L. Handley ,&nbsp;Mohamed I. Elsaid ,&nbsp;Eric Schupp ,&nbsp;Daniel G. Stover ,&nbsp;J.C. Chen ,&nbsp;Jesus D. Anampa ,&nbsp;Xiaoyi Teng ,&nbsp;Samilia Obeng-Gyasi","doi":"10.1016/j.jgo.2025.102845","DOIUrl":"10.1016/j.jgo.2025.102845","url":null,"abstract":"<div><h3>Introduction</h3><div>Older adults (≥65 years) with triple-negative breast cancer (TNBC) have higher mortality rates than younger patients, due in part to greater comorbidity and lower rates of treatment. However, the impact of hospital volume on survival outcomes in this population remains understudied. This study examined the relationship between hospital volume and survival among older adults (aged 65 years or older) diagnosed with TNBC.</div></div><div><h3>Materials and methods</h3><div>The National Cancer Database was queried for women ages ≥65 years with stage I–III TNBC diagnosed between 2010 and 2020. Annual hospital volume was the facility-level average of breast cancer cases treated in the years before the year of diagnosis. Volumes were divided into quartiles, with the lowest quartile (≤136 cases/year) defined as low-volume and the remaining three quartiles combined as high-volume. Sociodemographic, clinical, and treatment characteristics were compared according to hospital volume status. Crude and adjusted mortality risk differences and relative risks were estimated using pooled logistic regression models.</div></div><div><h3>Results</h3><div>The study cohort comprised 37,538 older women with TNBC, of whom 25 % (<em>n</em> = 9388) were treated at low-volume hospitals. Patients treated at low-volume hospitals were slightly older (73 years [IQR: 68 to 79] vs. 72 years [IQR: 68 to 78 years]) and traveled a shorter distance to the hospitals (6.80 miles [IQR: 3.00 to 14.30] vs 8.60 miles [IQR: 4.30 to 18.00]) than those treated at high-volume hospitals (<em>p</em> &lt; 0.001). On adjusted analysis, treatment at low-volume hospitals (Low-Value Risk: 0.607, 95 % CI: 0.579 to 0.638) was associated with a 5.5 % increased risk of all-cause mortality compared to treatment at high-volume hospitals (High-Volume Risk: 0.576, 95 % CI: 0.556 to 0.592) (RR: 1.055, 95 % CI: 1.003 to 1.121). Patients treated at low-volume hospitals had a 3.2 % excess adjusted risk of mortality compared to those treated at higher-volume hospitals (RD: 3.2 %, 95 % CI: 0.2 % to 6.9 %).</div></div><div><h3>Discussion</h3><div>Older adults treated at low-volume hospitals had modestly higher mortality than those at high-volume facilities. Future work should identify mechanisms underlying this relationship and assess whether referral patterns for older adults should consider hospital volume.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102845"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality cancer care for older adults from culturally and linguistically diverse backgrounds: Perspectives from the Cancer and Aging Research Group Junior Board","authors":"Surbhi Singhal ,&nbsp;Maya Abdallah ,&nbsp;Tanyanika Phillips ,&nbsp;Nicole A. Arrato ,&nbsp;Mukul Roy ,&nbsp;Samantha Werts-Pelter ,&nbsp;Katherine Ramos ,&nbsp;Chad Yixian Han","doi":"10.1016/j.jgo.2026.102853","DOIUrl":"10.1016/j.jgo.2026.102853","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102853"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From frailty to function: Monitoring-based isometric training in complex geriatric oncology","authors":"B. López de San Vicente Hernández ,&nbsp;M. Nuño Escolástico ,&nbsp;R. Gomez López ,&nbsp;E. Olloquiegui Aristegui ,&nbsp;G. Moreno Lekue ,&nbsp;J. Ciriza Ereño ,&nbsp;P. Martinez del Prado","doi":"10.1016/j.jgo.2026.102869","DOIUrl":"10.1016/j.jgo.2026.102869","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102869"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciding on the decision-maker in older adults with cancer: Patient autonomy, physician paternalism, and caregiver support","authors":"Clark DuMontier","doi":"10.1016/j.jgo.2026.102930","DOIUrl":"10.1016/j.jgo.2026.102930","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102930"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do we need geriatricians in geriatric oncology? A SIOG geriatricians position statement","authors":"Carolina Gómez-Moreno ,&nbsp;Chiara Russo ,&nbsp;Armida Parala-Metz ,&nbsp;Bérengère Beauplet ,&nbsp;Anupa Pillai ,&nbsp;Anand Kumar ,&nbsp;Domenico Fusco ,&nbsp;Suzanne Festen ,&nbsp;Siri Rostoft","doi":"10.1016/j.jgo.2025.102831","DOIUrl":"10.1016/j.jgo.2025.102831","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102831"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial","authors":"Julia García-García ,&nbsp;Ana Rodriguez-Larrad ,&nbsp;Maren Martinez de Rituerto Zeberio ,&nbsp;Jenifer Gómez Mediavilla ,&nbsp;Borja López-San Vicente ,&nbsp;Nuria Torrego Artola ,&nbsp;Izaskun Zeberio Etxetxipia ,&nbsp;Irati Garmendia ,&nbsp;Ainhoa Alberro ,&nbsp;David Otaegui ,&nbsp;Francisco Borrego Rabasco ,&nbsp;María M. Caffarel ,&nbsp;Kalliopi Vrotsou ,&nbsp;Jon Irazusta ,&nbsp;Haritz Arrieta ,&nbsp;Mireia Pelaez ,&nbsp;Jon Belloso ,&nbsp;Laura Basterretxea","doi":"10.1016/j.jgo.2025.102818","DOIUrl":"10.1016/j.jgo.2025.102818","url":null,"abstract":"<div><h3>Introduction</h3><div>Cancer in older adults is often associated with functional limitations, geriatric syndromes, poor self-rated health, vulnerability, and frailty, and these conditions might worsen treatment-related side effects. Recent guidelines for patients with cancer during and after treatment have documented the beneficial effects of exercise to counteract certain side effects; however, little is known about the role of exercise during cancer treatment in older adults.</div></div><div><h3>Materials and Methods</h3><div>This is a multicentre randomised controlled trial in which 200 participants will be allocated to a control group or an intervention group (the sample size has been calculated to detect a clinical difference of 1 point in Short Physical Performance Battery (SPPB) score, assuming an α error of 0.05, a β error of 0.20, and a 10 % loss rate). Patients aged ≥70 years, diagnosed with any type of solid cancer and candidates for systemic treatment are eligible. Subjects in the intervention group are invited to participate in a 12-week supervised multicomponent exercise programme in addition to receiving usual care. Study assessments are conducted at baseline and three months. The primary outcome measure is physical function as assessed by the SPPB. Secondary outcome measures include comprehensive geriatric assessment scores (including social situation, basic and instrumental activities of daily living, cognitive function, depression, nutritional status, polypharmacy, geriatric syndromes, pain, and emotional distress), anthropometric characteristics, frailty status, physical fitness, physical activity, cognitive function, quality of life, fatigue, and nutritional status. Study assessments also include analysis of inflammatory, endocrine, and nutritional mediators in serum and plasma as potential frailty biomarkers at mRNA and protein levels and multiparametric flow cytometric analysis to measure immunosenescence markers on T and NK cells.</div></div><div><h3>Discussion</h3><div>This study seeks to extend our knowledge on exercise interventions during systemic anticancer treatment in patients over 70 years of age. Results from this research will guide the management of older adults during systemic treatment in hospitals seeking to enhance the standard of care.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Identifier: <span><span>NCT05131113</span><svg><path></path></svg></span>, November 11, 2021.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102818"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-led management approaches in older adults with advanced cancer: Implications for supportive and palliative oncology","authors":"Ana Carolina Fernandes ,&nbsp;Louis John Koizia ,&nbsp;Benjamin Howell Lole Harris","doi":"10.1016/j.jgo.2026.102898","DOIUrl":"10.1016/j.jgo.2026.102898","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102898"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical assessment of geriatric oncology guidelines based on the AGREE II tool","authors":"Gayathri Nair ,&nbsp;Cailyn H. Livingstone ,&nbsp;Jonathon W. Vundum ,&nbsp;Mathew George","doi":"10.1016/j.jgo.2025.102833","DOIUrl":"10.1016/j.jgo.2025.102833","url":null,"abstract":"<div><h3>Introduction</h3><div>The world's population is aging rapidly and older adults carry a disproportionate cancer burden. Despite this, older patients remain underrepresented in clinical research. As a result, the evidence base informing guideline development remains limited. Existing guidelines vary in methodological quality and applicability. We aimed to evaluate the quality and clinical applicability of established geriatric oncology guidelines using the Appraisal of Guidelines Research and Evaluation, version II (AGREE II) instrument.</div></div><div><h3>Materials and methods</h3><div>A systematic search was conducted across PubMed, Embase, and the Cochrane Library, in addition to official oncology society websites (ASCO, NCCN, SoFOG, Japanese Geriatric Oncology Group). The search covered publications from January 2000 to May 2025 and was limited to English and to guidelines that specifically address cancer care in older adults and provide documented methodologies. Two reviewers independently appraised each guideline using the AGREE II tool across six domains: scope and purpose, stakeholder involvement, rigor of development, clarity of presentation, applicability, and editorial independence.</div></div><div><h3>Results</h3><div>A total of 807 records were identified,out of which only 6 guidelines met the eligibility criteria. The AGREE II assessment revealed significant variability in guideline quality. Most guidelines scored high in clarity of presentation and scope and purpose, but showed moderate to low scores in stakeholder involvement and applicability. The recent ASCO guidelines demonstrated higher overall methodological rigor, whereas others lacked comprehensive documentation of evidence synthesis and user applicability.</div></div><div><h3>Discussion</h3><div>While several geriatric oncology guidelines demonstrate acceptable quality, inconsistencies remain, particularly in stakeholder engagement and practical implementation. Enhanced methodological rigor and inclusive development processes are essential for future guideline improvement and effective translation into geriatric oncology practice.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102833"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graft versus host disease treatment and prevention in older adults: A single-database review","authors":"William Ciurylo ,&nbsp;Anahid Hamparsumian ,&nbsp;Sarah Wall ,&nbsp;Gabrielle Meyers","doi":"10.1016/j.jgo.2026.102848","DOIUrl":"10.1016/j.jgo.2026.102848","url":null,"abstract":"<div><h3>Introduction</h3><div>Hematopoietic stem cell transplantation (SCT) is increasingly used to treat hematological conditions in patients 60 years and older. Graft vs host disease (GVHD), a complication of SCT, is a major cause of morbidity, nonrelapse mortality, and interference with quality of life (QOL). Concern that older adults are at higher risk for developing GVHD has limited the use of SCT in this population. Older adults are also at higher risk for adverse events from the mainstay treatment of GVHD: corticosteroids. There is no standard of care for the management of GVHD in older adults, which may limit older adults' access to SCT. We aimed to review the literature on non-corticosteroid immune modulating agents used to prevent and treat GVHD for outcomes data specific to older adults.</div></div><div><h3>Materials and methods</h3><div>We performed a scoping review using Pubmed, identifying 31 studies comparing immunosuppressive prophylaxis and treatment modalities for GVHD (acute, chronic, mixed, and corticosteroid refractory) within a 10-year span (February 13, 2013 - February 13, 2023). Articles exploring cutaneous GVHD only or corticosteroid treatments were excluded. Articles were reviewed for inclusion of patients 65+ years, response rate, mortality rate, adverse events, degree of corticosteroid sparing, and QOL scores before and after treatment.</div></div><div><h3>Results</h3><div>Seventeen articles met inclusion criteria, for a total of 2534 patients with GVHD. Two articles did not include patients 65+, ten did not specify the number of patients 65+, and five articles indicated the number of patients 65+ (<em>n</em> = 160). No articles specified response rate, mortality rate, or adverse events in patients 65+. Twelve articles indicated degree of corticosteroid sparing. Six articles included QOL scores, but did not assess impact of treatment on QOL scores or specify QOL scores in patients 65+. Overall, 3.5% of study participants were identified as aged 65+ and 4.7% aged 60 + .</div></div><div><h3>Discussion</h3><div>There is a lack of relevant outcomes data to guide best practice in the prevention and treatment of GVHD in older adults Understanding the risk of GVHD in older adults and identifying effective prophylactic and treatment strategies for GVHD in older adults may result in more older adults having access to SCT.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102848"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}