Tian Che, Shuai Liu, Yatong Wang, Pin Zhao, Chengpeng Yang, Xiaohang Pan, Hongze Ji, Lin Geng, Qiong Sun, Ziyi Hu, Alei Li, Chengxu Zhou, Li-Chun Xu, Yunlei Zhong, Dan Tian, Yong Yang, Lixing Kang
The advent of one-dimensional van der Waals heterostructure (1D vdWH) nanomaterials has provided valuable opportunities for the advancement of electronic or optical devices, as well as for exploring various condensed matter phenomena. Electron transfer is a fundamental process in host–guest interactions, significantly influencing nanoscale physicochemical processes. Elucidating the mechanism by which the host influences the electronic structure of the guest is essential for elucidating these interactions. This study reports the successful synthesis of a material system consisting of precisely resolved AgBr nanowires encapsulated within single-walled carbon nanotubes (SWCNTs) that has been successfully synthesized and utilized to investigate the intrinsic electron transfer across 1D vdWHs. Cyclic voltammetry (CV) was employed to investigate the 1D vdWH interaction between AgBr and SWCNTs, which provided a more intuitive and accurate characterization of the charge transfer from SWCNTs to AgBr. Furthermore, Kelvin probe force microscopy showed a 149 mV reduction in the average surface potential of carbon nanotubes after AgBr filling, supporting the efficacy of CV in probing electron dynamics in 1D vdWHs. Finally, theoretical calculations indicated a charge transfer of 0.11 e– per simulation cell, reinforcing the effectiveness of CV in assessing the interactions within 1D vdWHs.
{"title":"Interfacial Charge Transfer in One-Dimensional AgBr Encapsulated inside Single-Walled Carbon Nanotube Heterostructures","authors":"Tian Che, Shuai Liu, Yatong Wang, Pin Zhao, Chengpeng Yang, Xiaohang Pan, Hongze Ji, Lin Geng, Qiong Sun, Ziyi Hu, Alei Li, Chengxu Zhou, Li-Chun Xu, Yunlei Zhong, Dan Tian, Yong Yang, Lixing Kang","doi":"10.1021/acsnano.4c09474","DOIUrl":"https://doi.org/10.1021/acsnano.4c09474","url":null,"abstract":"The advent of one-dimensional van der Waals heterostructure (1D vdWH) nanomaterials has provided valuable opportunities for the advancement of electronic or optical devices, as well as for exploring various condensed matter phenomena. Electron transfer is a fundamental process in host–guest interactions, significantly influencing nanoscale physicochemical processes. Elucidating the mechanism by which the host influences the electronic structure of the guest is essential for elucidating these interactions. This study reports the successful synthesis of a material system consisting of precisely resolved AgBr nanowires encapsulated within single-walled carbon nanotubes (SWCNTs) that has been successfully synthesized and utilized to investigate the intrinsic electron transfer across 1D vdWHs. Cyclic voltammetry (CV) was employed to investigate the 1D vdWH interaction between AgBr and SWCNTs, which provided a more intuitive and accurate characterization of the charge transfer from SWCNTs to AgBr. Furthermore, Kelvin probe force microscopy showed a 149 mV reduction in the average surface potential of carbon nanotubes after AgBr filling, supporting the efficacy of CV in probing electron dynamics in 1D vdWHs. Finally, theoretical calculations indicated a charge transfer of 0.11 e<sup>–</sup> per simulation cell, reinforcing the effectiveness of CV in assessing the interactions within 1D vdWHs.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"72 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rocco Duquennoy, Simon Landrieux, Daniele De Bernardis, Juergen Mony, Maja Colautti, Lin Jin, Wolfram H.P. Pernice, Costanza Toninelli
The Stark effect provides a powerful method to shift the spectra of molecules, atoms, and electronic transitions in general, becoming one of the simplest and most straightforward ways to tune the frequency of quantum emitters by means of a static electric field. At the same time, in order to reduce the emitter sensitivity to charge noise, inversion symmetric systems are typically designed, providing a stable emission frequency with a quadratic-only dependence on the applied field. However, such nonlinear behavior might be reflected in correlations between the tuning ability and unwanted spectral fluctuations. Here, we provide experimental evidence of this trend using molecular quantum emitters in the solid state cooled down to liquid helium temperatures. We finally combine the electric field generated by electrodes, which is parallel to the molecule’s induced dipole, with optically excite long-lived charge states acting in the perpendicular direction. Based on the anisotropy of the molecule’s polarizability, our two-dimensional control of the local electric field allows us not only to tune the emitter’s frequency but also to sensibly suppress the spectral instabilities associated with field fluctuations.
{"title":"Enhanced Control of Single-Molecule Emission Frequency and Spectral Diffusion","authors":"Rocco Duquennoy, Simon Landrieux, Daniele De Bernardis, Juergen Mony, Maja Colautti, Lin Jin, Wolfram H.P. Pernice, Costanza Toninelli","doi":"10.1021/acsnano.4c08382","DOIUrl":"https://doi.org/10.1021/acsnano.4c08382","url":null,"abstract":"The Stark effect provides a powerful method to shift the spectra of molecules, atoms, and electronic transitions in general, becoming one of the simplest and most straightforward ways to tune the frequency of quantum emitters by means of a static electric field. At the same time, in order to reduce the emitter sensitivity to charge noise, inversion symmetric systems are typically designed, providing a stable emission frequency with a quadratic-only dependence on the applied field. However, such nonlinear behavior might be reflected in correlations between the tuning ability and unwanted spectral fluctuations. Here, we provide experimental evidence of this trend using molecular quantum emitters in the solid state cooled down to liquid helium temperatures. We finally combine the electric field generated by electrodes, which is parallel to the molecule’s induced dipole, with optically excite long-lived charge states acting in the perpendicular direction. Based on the anisotropy of the molecule’s polarizability, our two-dimensional control of the local electric field allows us not only to tune the emitter’s frequency but also to sensibly suppress the spectral instabilities associated with field fluctuations.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"11 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanxia Pan, Huizhen Zheng, Guanna Li, Yanan Li, Jie Jiang, Jie Chen, Qianqian Xie, Di Wu, Ronglin Ma, Xi Liu, Shujuan Xu, Jun Jiang, Xiaoming Cai, Meng Gao, Weili Wang, Han Zuilhof, Mingliang Ye, Ruibin Li
We identified an error in our recent publication. Specifically, two H&E images were erroneously uploaded in the lung tissue panel (ctrl group) of Figure 3D and heart tissue panel (Ag NP group by oropharyngeal instillation) of Figure S5. The corrected images are provided below. This error does not alter any of the reported results, interpretations, or conclusions of the study. This article has not yet been cited by other publications.
{"title":"Correction to “Antibiotic-Like Activity of Atomic Layer Boron Nitride for Combating Resistant Bacteria”","authors":"Yanxia Pan, Huizhen Zheng, Guanna Li, Yanan Li, Jie Jiang, Jie Chen, Qianqian Xie, Di Wu, Ronglin Ma, Xi Liu, Shujuan Xu, Jun Jiang, Xiaoming Cai, Meng Gao, Weili Wang, Han Zuilhof, Mingliang Ye, Ruibin Li","doi":"10.1021/acsnano.4c14729","DOIUrl":"https://doi.org/10.1021/acsnano.4c14729","url":null,"abstract":"We identified an error in our recent publication. Specifically, two H&E images were erroneously uploaded in the lung tissue panel (ctrl group) of Figure 3D and heart tissue panel (Ag NP group by oropharyngeal instillation) of Figure S5. The corrected images are provided below. This error does not alter any of the reported results, interpretations, or conclusions of the study. This article has not yet been cited by other publications.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"5 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1126/scitranslmed.ado2104
Alexandra Schäfer, Sarah R. Leist, John M. Powers, Ralph S. Baric
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health concern because of the emergence of SARS-CoV-2 variants that can cause severe acute coronavirus disease 2019 (COVID-19) or enhance Long Covid disease phenotypes. About 5 to 10% of SARS-CoV-2–infected individuals develop Long Covid, which, similar to acute COVID 19, often affects the lung. However, Long Covid can also affect other peripheral organs, especially the brain. The causal relationships between acute disease phenotypes, long-term symptoms, and involvement of multiple organ systems remain elusive, and animal model systems mimicking both acute and post-acute phases are imperative. Here, we review the current state of Long Covid animal models, including current and possible future applications.
严重急性呼吸系统综合征冠状病毒 2（SARS-CoV 2）大流行已造成全球 700 多万人死亡。尽管存在感染和疫苗诱导的免疫力，SARS-CoV-2 感染仍然是全球健康的一大隐患，因为 SARS-CoV-2 变异体的出现可导致 2019 年严重急性冠状病毒病（COVID-19）或增强 Long Covid 疾病表型。约有5%到10%的SARS-CoV-2感染者会患上长Covid病，这种病与急性冠状病毒病（COVID-19）类似，通常会影响肺部。然而，长Covid也可影响其他外周器官，尤其是大脑。急性疾病表型、长期症状和多个器官系统受累之间的因果关系仍然难以捉摸，因此模拟急性期和急性期后的动物模型系统势在必行。在此，我们回顾了 Long Covid 动物模型的现状，包括当前和未来可能的应用。
{"title":"Animal models of Long Covid: A hit-and-run disease","authors":"Alexandra Schäfer, Sarah R. Leist, John M. Powers, Ralph S. Baric","doi":"10.1126/scitranslmed.ado2104","DOIUrl":"https://doi.org/10.1126/scitranslmed.ado2104","url":null,"abstract":"The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health concern because of the emergence of SARS-CoV-2 variants that can cause severe acute coronavirus disease 2019 (COVID-19) or enhance Long Covid disease phenotypes. About 5 to 10% of SARS-CoV-2–infected individuals develop Long Covid, which, similar to acute COVID 19, often affects the lung. However, Long Covid can also affect other peripheral organs, especially the brain. The causal relationships between acute disease phenotypes, long-term symptoms, and involvement of multiple organ systems remain elusive, and animal model systems mimicking both acute and post-acute phases are imperative. Here, we review the current state of Long Covid animal models, including current and possible future applications.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"2 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1126/scitranslmed.ado2101
Michael J. Peluso, Maureen R. Hanson, Steven G. Deeks
The recognition of Long Covid has renewed efforts to understand other infection-associated chronic conditions (IACCs). Here, we describe how studies of Long Covid and other IACCs might inform one another. We argue for the importance of a coordinated research agenda addressing these debilitating illnesses.
对 Long Covid 的认识再次推动了人们对其他感染相关慢性疾病（IACCs）的了解。在此，我们将介绍长Covid和其他IACCs的研究如何相互借鉴。我们认为，针对这些使人衰弱的疾病制定协调的研究议程非常重要。
{"title":"Infection-associated chronic conditions: Why Long Covid is our best chance to untangle Osler’s web","authors":"Michael J. Peluso, Maureen R. Hanson, Steven G. Deeks","doi":"10.1126/scitranslmed.ado2101","DOIUrl":"https://doi.org/10.1126/scitranslmed.ado2101","url":null,"abstract":"The recognition of Long Covid has renewed efforts to understand other infection-associated chronic conditions (IACCs). Here, we describe how studies of Long Covid and other IACCs might inform one another. We argue for the importance of a coordinated research agenda addressing these debilitating illnesses.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"6 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1126/scitranslmed.ado2103
Adriana Marques
Protracted fatigue and other symptoms can occur after Lyme disease and other infections, with numerous possible drivers. Studies on posttreatment Lyme disease have been inconclusive, with no confirmed biomarker emerging. Prolonged antibiotic therapy provides no benefit. Thus, a holistic approach toward understanding and treating this complex disease is necessary.
{"title":"Symptoms after Lyme disease: What’s past is prologue","authors":"Adriana Marques","doi":"10.1126/scitranslmed.ado2103","DOIUrl":"https://doi.org/10.1126/scitranslmed.ado2103","url":null,"abstract":"Protracted fatigue and other symptoms can occur after Lyme disease and other infections, with numerous possible drivers. Studies on posttreatment Lyme disease have been inconclusive, with no confirmed biomarker emerging. Prolonged antibiotic therapy provides no benefit. Thus, a holistic approach toward understanding and treating this complex disease is necessary.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"189 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1126/scitranslmed.ado2106
Annukka A. R. Antar, Andrea L. Cox
Long Covid is defined by a wide range of symptoms that persist after the acute phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported symptoms include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other symptoms reported. Symptom range, duration, and severity are highly variable and partially overlap with symptoms of myalgic encephalomyelitis/chronic fatigue syndrome and other post-acute infectious syndromes, highlighting opportunities to define shared mechanisms of pathogenesis. Potential mechanisms of Long Covid are diverse, including persistence of viral reservoirs, dysregulated immune responses, direct viral damage of tissues targeted by SARS-CoV-2, inflammation driven by reactivation of latent viral infections, vascular endothelium activation or dysfunction, and subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, and microbiota dysbiosis. The heterogeneity of symptoms and baseline characteristics of people with Long Covid, as well as the varying states of immunity and therapies given at the time of acute infection, have made etiologies of Long Covid difficult to determine. Here, we examine progress on preclinical models for Long Covid and review progress being made in clinical trials, highlighting the need for large human studies and further development of models to better understand Long Covid. Such studies will inform clinical trials that will define treatments to benefit those living with this condition.
{"title":"Translating insights into therapies for Long Covid","authors":"Annukka A. R. Antar, Andrea L. Cox","doi":"10.1126/scitranslmed.ado2106","DOIUrl":"https://doi.org/10.1126/scitranslmed.ado2106","url":null,"abstract":"Long Covid is defined by a wide range of symptoms that persist after the acute phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported symptoms include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other symptoms reported. Symptom range, duration, and severity are highly variable and partially overlap with symptoms of myalgic encephalomyelitis/chronic fatigue syndrome and other post-acute infectious syndromes, highlighting opportunities to define shared mechanisms of pathogenesis. Potential mechanisms of Long Covid are diverse, including persistence of viral reservoirs, dysregulated immune responses, direct viral damage of tissues targeted by SARS-CoV-2, inflammation driven by reactivation of latent viral infections, vascular endothelium activation or dysfunction, and subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, and microbiota dysbiosis. The heterogeneity of symptoms and baseline characteristics of people with Long Covid, as well as the varying states of immunity and therapies given at the time of acute infection, have made etiologies of Long Covid difficult to determine. Here, we examine progress on preclinical models for Long Covid and review progress being made in clinical trials, highlighting the need for large human studies and further development of models to better understand Long Covid. Such studies will inform clinical trials that will define treatments to benefit those living with this condition.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"35 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1126/scitranslmed.ado2099
Sharon H. Saydah, Angela P. Campbell, Adrienne G. Randolph
Although most children are spared from developing complications from SARS-CoV-2 infection, some may suffer consequences including Long Covid and multisystem inflammatory syndrome in children (MIS-C). Although the occurrence of these conditions has decreased over time, they can still occur, and recognition of symptoms and prompt diagnosis is imperative for early intervention.
{"title":"Consequences beyond acute SARS-CoV-2 infection in children","authors":"Sharon H. Saydah, Angela P. Campbell, Adrienne G. Randolph","doi":"10.1126/scitranslmed.ado2099","DOIUrl":"https://doi.org/10.1126/scitranslmed.ado2099","url":null,"abstract":"Although most children are spared from developing complications from SARS-CoV-2 infection, some may suffer consequences including Long Covid and multisystem inflammatory syndrome in children (MIS-C). Although the occurrence of these conditions has decreased over time, they can still occur, and recognition of symptoms and prompt diagnosis is imperative for early intervention.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"158 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hua-Jie Chen, Liang Zhao, Lei Wang, Zhi-Gang Wang, Dai-Wen Pang, Shu-Lin Liu
Page 22254. The corresponding and first authors’ affiliations are corrected as follows and in the Author Information of this Correction: Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, P. R, China; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, and School of Medicine, Nankai University, Tianjin 300071, P. R. China. The conclusions of this work have not been affected. This article has not yet been cited by other publications.
{"title":"Correction to“Simultaneous Mapping of the Nanoscale Organization and Redox State of Extracellular Space in Living Brain Tissue”","authors":"Hua-Jie Chen, Liang Zhao, Lei Wang, Zhi-Gang Wang, Dai-Wen Pang, Shu-Lin Liu","doi":"10.1021/acsnano.4c15022","DOIUrl":"https://doi.org/10.1021/acsnano.4c15022","url":null,"abstract":"Page 22254. The corresponding and first authors’ affiliations are corrected as follows and in the Author Information of this Correction: Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, P. R, China; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, and School of Medicine, Nankai University, Tianjin 300071, P. R. China. The conclusions of this work have not been affected. This article has not yet been cited by other publications.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"34 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1001/jamasurg.2024.5009
Sara Sakowitz, Syed Shahyan Bakhtiyar, Saad Mallick, Jane Yanagawa, Peyman Benharash
ImportanceOngoing efforts have encouraged the regionalization of esophageal adenocarcinoma treatment to high-volume centers (HVCs). Yet such centralization has been linked with increased patient travel burden and reduced postoperative continuity of care.ObjectiveTo determine whether traveling to undergo esophagectomy at HVCs is linked with superior overall survival compared with receiving care locally at low-volume centers (LVC).Design, Setting, and ParticipantsThis cohort study considered data for all patients diagnosed with stage I through III esophageal adenocarcinoma in the 2010-2021 National Cancer Database. Patients were stratified based on distance traveled to receive care and the annual esophagectomy volume at the treating hospital: the travel-HVC cohort included patients in the top 25th percentile of travel burden who received care at centers in the top volume quartile, and the local-LVC cohort represented those in the bottom 25th percentile of travel burden who were treated at centers in the lowest volume quartile. Data were analyzed from July 2023 to January 2024.Main Outcomes and MeasuresThe primary end points were overall survival at 1 year and 5 years. Secondary end points included perioperative outcomes and factors linked with traveling to receive care.ResultsOf 17 970 patients, 2342 (13%) comprised the travel-HVC cohort, and 1969 (11%), the local-LVC cohort. The median (IQR) age was 65 (58-71) years; 3748 (87%) were male and 563 (13%) were female. After risk adjustment and with care at local LVCs as the reference, traveling to HVC was associated with superior survival at 1 year (hazard ratio for mortality [HR], 0.69; 95% CI, 0.58-0.83) and 5 years (HR, 0.80; 95% CI, 0.70-0.90). Stratifying by stage, traveling to HVCs was associated with comparable outcomes for stage I disease but reduced mortality for stage III (1-year HR, 0.72; 95% CI, 0.60-0.87; 5-year HR, 0.83; 95% CI, 0.74-0.93). Further, traveling to HVC was associated with greater lymph node harvest (β, 5.08 nodes; 95% CI, 3.78-6.37) and likelihood of margin-negative resection (adjusted odds ratio, 1.83; 95% CI, 1.29-2.60).Conclusions and RelevanceTraveling to HVCs for esophagectomy was associated with improved 1-year and 5-year survival compared with receiving care locally at LVCs, particularly among patients with locoregionally advanced disease. Future studies are needed to ascertain barriers to care and develop novel targeted pathways to ensure equitable access to high-volume facilities and high-quality oncologic care.
重要性目前正在鼓励将食管腺癌的治疗区域化，将其集中到高容量中心（HVC）。目标确定与在当地低流量中心（LVC）接受治疗相比，前往高流量中心接受食管切除术是否与较高的总生存率有关。这项队列研究考虑了 2010-2021 年国家癌症数据库中所有确诊为 I 期至 III 期食管腺癌患者的数据。根据患者接受治疗的旅行距离和治疗医院的年食管切除术量对患者进行分层：旅行-HVC队列包括旅行负担最高的第25个百分位数的患者，他们在治疗量最高的四分位数的中心接受治疗；当地-LVC队列代表旅行负担最低的第25个百分位数的患者，他们在治疗量最低的四分位数的中心接受治疗。主要结果和测量指标主要终点是1年和5年的总生存率。次要终点包括围手术期结果以及与出差接受治疗相关的因素。结果在17 970名患者中，有2342人（13%）属于出差-HVC队列，1969人（11%）属于本地-LVC队列。中位数（IQR）年龄为 65（58-71）岁；3748（87%）人为男性，563（13%）人为女性。经过风险调整后，以当地 LVC 的护理为参照，前往 HVC 与 1 年（死亡率危险比 [HR]，0.69；95% CI，0.58-0.83）和 5 年（HR，0.80；95% CI，0.70-0.90）的较高生存率相关。根据分期进行分层，前往 HVC 与 I 期疾病的结果相当，但 III 期疾病的死亡率降低（1 年 HR，0.72；95% CI，0.60-0.87；5 年 HR，0.83；95% CI，0.74-0.93）。此外，前往 HVC 与更多的淋巴结切除（β，5.08 个结节；95% CI，3.78-6.37）和边缘阴性切除的可能性（调整后的几率比为 1.83；95% CI，1.29-2.60）相关。未来的研究需要确定治疗障碍，并开发新的有针对性的途径，以确保患者能公平地获得高容量设施和高质量的肿瘤治疗。
{"title":"Travel to High-Volume Centers and Survival After Esophagectomy for Cancer","authors":"Sara Sakowitz, Syed Shahyan Bakhtiyar, Saad Mallick, Jane Yanagawa, Peyman Benharash","doi":"10.1001/jamasurg.2024.5009","DOIUrl":"https://doi.org/10.1001/jamasurg.2024.5009","url":null,"abstract":"ImportanceOngoing efforts have encouraged the regionalization of esophageal adenocarcinoma treatment to high-volume centers (HVCs). Yet such centralization has been linked with increased patient travel burden and reduced postoperative continuity of care.ObjectiveTo determine whether traveling to undergo esophagectomy at HVCs is linked with superior overall survival compared with receiving care locally at low-volume centers (LVC).Design, Setting, and ParticipantsThis cohort study considered data for all patients diagnosed with stage I through III esophageal adenocarcinoma in the 2010-2021 National Cancer Database. Patients were stratified based on distance traveled to receive care and the annual esophagectomy volume at the treating hospital: the travel-HVC cohort included patients in the top 25th percentile of travel burden who received care at centers in the top volume quartile, and the local-LVC cohort represented those in the bottom 25th percentile of travel burden who were treated at centers in the lowest volume quartile. Data were analyzed from July 2023 to January 2024.Main Outcomes and MeasuresThe primary end points were overall survival at 1 year and 5 years. Secondary end points included perioperative outcomes and factors linked with traveling to receive care.ResultsOf 17 970 patients, 2342 (13%) comprised the travel-HVC cohort, and 1969 (11%), the local-LVC cohort. The median (IQR) age was 65 (58-71) years; 3748 (87%) were male and 563 (13%) were female. After risk adjustment and with care at local LVCs as the reference, traveling to HVC was associated with superior survival at 1 year (hazard ratio for mortality [HR], 0.69; 95% CI, 0.58-0.83) and 5 years (HR, 0.80; 95% CI, 0.70-0.90). Stratifying by stage, traveling to HVCs was associated with comparable outcomes for stage I disease but reduced mortality for stage III (1-year HR, 0.72; 95% CI, 0.60-0.87; 5-year HR, 0.83; 95% CI, 0.74-0.93). Further, traveling to HVC was associated with greater lymph node harvest (β, 5.08 nodes; 95% CI, 3.78-6.37) and likelihood of margin-negative resection (adjusted odds ratio, 1.83; 95% CI, 1.29-2.60).Conclusions and RelevanceTraveling to HVCs for esophagectomy was associated with improved 1-year and 5-year survival compared with receiving care locally at LVCs, particularly among patients with locoregionally advanced disease. Future studies are needed to ascertain barriers to care and develop novel targeted pathways to ensure equitable access to high-volume facilities and high-quality oncologic care.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"80 1","pages":""},"PeriodicalIF":16.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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