Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i1.3927
Khoa PhamDang, D. Thin, N. Nguyen
Introduction: In recent years, the rise of social networks in Vietnam has resulted in an abundance of information. However, it has also made it easier for people to spread fake news, which has done a great disservice to society. It is therefore crucial to verify the reliability of news. This paper presents a hybrid approach that uses a pretrained language model called vELECTRA along with handcrafted features to identify reliable information on Vietnamese social network sites. Methods: The present study employed two primary approaches, namely: 1) fine-tuning the model by utilizing solely textual data, and 2) combining additional meta-data with the text to create an input representation for the model. Results: Our approach performs slightly better than other refined BERT methods and achieves state-of-the-art results on the ReINTEL dataset published by VLSP in 2020. Our method achieved a 0.9575 AUC score, and we used transfer learning and deep learning approaches to detect fake news in the Vietnamese language using meta features. Conclusion: With regards to the results and analysis, it can be inferred that the number of reactions a post receives, and the timing of the event described in the post are indicative of the news' credibility. Furthermore, it was discovered that BERT can encode numerical values that have been converted into text.
{"title":"Improving Vietnamese Fake News Detection based on Contextual Language Model and Handcrafted Features","authors":"Khoa PhamDang, D. Thin, N. Nguyen","doi":"10.32508/stdj.v26i1.3927","DOIUrl":"https://doi.org/10.32508/stdj.v26i1.3927","url":null,"abstract":"Introduction: In recent years, the rise of social networks in Vietnam has resulted in an abundance of information. However, it has also made it easier for people to spread fake news, which has done a great disservice to society. It is therefore crucial to verify the reliability of news. This paper presents a hybrid approach that uses a pretrained language model called vELECTRA along with handcrafted features to identify reliable information on Vietnamese social network sites. Methods: The present study employed two primary approaches, namely: 1) fine-tuning the model by utilizing solely textual data, and 2) combining additional meta-data with the text to create an input representation for the model. Results: Our approach performs slightly better than other refined BERT methods and achieves state-of-the-art results on the ReINTEL dataset published by VLSP in 2020. Our method achieved a 0.9575 AUC score, and we used transfer learning and deep learning approaches to detect fake news in the Vietnamese language using meta features. Conclusion: With regards to the results and analysis, it can be inferred that the number of reactions a post receives, and the timing of the event described in the post are indicative of the news' credibility. Furthermore, it was discovered that BERT can encode numerical values that have been converted into text.","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115618884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i2.4044
V. Pham, Nghi Hoang Khoa, N. H. Quyen, Phan The Duy
With the growth and expansion of the internet, web attacks have become more powerful and pose a significant threat in the cyber world. In response to this, this paper presents a deceptive approach for gathering malicious behavior to understand the strategies used by web attackers. The harmful requests collected through cyber traps or honeypots are analyzed and used to train machine learning (ML) models for web attack detection. Additionally, we implement an ML operations (MLOps) pipeline to automate the continuous training and deployment of these ML models in defensive systems. This pipeline trains the production model with newly collected data by using predefined triggers. Our experiments on two datasets, including Fwaf and our own, demonstrate that a proactive and continuous approach to tracking adversary behavior can effectively detect zero-day attacks, such as CVE-2022-26134 in web application servers.
{"title":"Deception and Continuous Training Approach for Web Attack Detection using Cyber Traps and MLOps","authors":"V. Pham, Nghi Hoang Khoa, N. H. Quyen, Phan The Duy","doi":"10.32508/stdj.v26i2.4044","DOIUrl":"https://doi.org/10.32508/stdj.v26i2.4044","url":null,"abstract":"With the growth and expansion of the internet, web attacks have become more powerful and pose a significant threat in the cyber world. In response to this, this paper presents a deceptive approach for gathering malicious behavior to understand the strategies used by web attackers. The harmful requests collected through cyber traps or honeypots are analyzed and used to train machine learning (ML) models for web attack detection. Additionally, we implement an ML operations (MLOps) pipeline to automate the continuous training and deployment of these ML models in defensive systems. This pipeline trains the production model with newly collected data by using predefined triggers. Our experiments on two datasets, including Fwaf and our own, demonstrate that a proactive and continuous approach to tracking adversary behavior can effectively detect zero-day attacks, such as CVE-2022-26134 in web application servers.","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121766632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i2.4050
ThuyThuTruong, LeThuT, Nguyen, H. Dang, N. Khai, H. Nguyen, Mai Ly Nguyen, D. Nguyen
Introduction: This study elucidates a convenient and uncomplicated synthesis methodology for acquiring novel thermally self-reparable polymer materials exhibiting concurrent efficiency in healing and commendable mechanical properties. This concept was developed through the utilization of the "thio-click" mechanism and the Diels-Alder reaction between polycaprolactone-bisfuran and bismaleimide to produce preliminary products, employing tris-furanic acid as a crosslinker reagent. Investigate the mass ratios of two precursors, PCL-bisfuran and trisfuran, to find the optimal material system (evaluated based on mechanical properties, shape memory, and self-healing capabilities). Methods: In this research, the intermediate products and final material were characterized via proton nuclear magnetic resonance ( 1 H-NMR) to accurately identify the chemical structures. Tensile strength machinery was used to record and evaluate the healing efficiency. The obtained network exhibited self-recovery damage ability under mild temperatures via optical microscopy and tensile analysis. Result: This study was successfully performed due to obtaining accurate product chemical structures, showing a mechanical recovery efficiency of 70–80% and good crack healing at 70 ◦ C in 30 minutes. Conclusion: This concept was intended to partially contribute to the advancement of self-healing polymer research and its applications in various fields.
{"title":"A healable thermoset possessing shape-memory effect assisted recovery efficiency via thiol-click and diels-alder reaction between furanic groups and bismaleimide crosslinker","authors":"ThuyThuTruong, LeThuT, Nguyen, H. Dang, N. Khai, H. Nguyen, Mai Ly Nguyen, D. Nguyen","doi":"10.32508/stdj.v26i2.4050","DOIUrl":"https://doi.org/10.32508/stdj.v26i2.4050","url":null,"abstract":"Introduction: This study elucidates a convenient and uncomplicated synthesis methodology for acquiring novel thermally self-reparable polymer materials exhibiting concurrent efficiency in healing and commendable mechanical properties. This concept was developed through the utilization of the \"thio-click\" mechanism and the Diels-Alder reaction between polycaprolactone-bisfuran and bismaleimide to produce preliminary products, employing tris-furanic acid as a crosslinker reagent. Investigate the mass ratios of two precursors, PCL-bisfuran and trisfuran, to find the optimal material system (evaluated based on mechanical properties, shape memory, and self-healing capabilities). Methods: In this research, the intermediate products and final material were characterized via proton nuclear magnetic resonance ( 1 H-NMR) to accurately identify the chemical structures. Tensile strength machinery was used to record and evaluate the healing efficiency. The obtained network exhibited self-recovery damage ability under mild temperatures via optical microscopy and tensile analysis. Result: This study was successfully performed due to obtaining accurate product chemical structures, showing a mechanical recovery efficiency of 70–80% and good crack healing at 70 ◦ C in 30 minutes. Conclusion: This concept was intended to partially contribute to the advancement of self-healing polymer research and its applications in various fields.","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126496248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i2.4090
HaNgocGiang, H. N. Giang, L. Pham, T. Nguyen, A. Huynh, Pham L T Huynh T N A. Giang H N
Introduction: Astaxanthin, a highly active oxidant, possesses a potential effect on human health. However, with the oily characteristic, the ability to disperse in an aqueous environment has limited its application. Therefore, the aim of this study is the fabrication of a stable astaxanthin emulsion in water. Methods: In this study, an emulsion of astaxanthin was fabricated using polysorbate (tween 60/80) or lecithin. The dispersing methods of the magnetic stirrer and stator-rotor ho-mogenizer were applied and compared. The effect of cellulose derivatives (sodium carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), and hydroxypropyl methylcellulose (HPMC)) on the astaxanthin emulsion system was investigated. The samples were characterized using dynamic light scattering (DLS), a Brookfield viscometer and Fourier transform infrared (FTIR) spectroscopy. Results: The homogenization could provide the system with a small Z-average value ( ~ 500 nm). The emulsion fabricated with lecithin maintained the red color of as-taxanthin and homogeneity even after 5 months. Tween 80 had the worst effect on astaxanthin degradation because of the presence of double bonds in the surfactant's molecular structure. The addition of soluble cellulose could significantly reduce the particle size and polydispersity even by using a magnetic stirrer. However, it could not ensure the protection of astaxanthin when phase separation was detected in many samples with polymers. The FTIR spectra and viscosity results revealed the strong interaction of lecithin with CMC, HEC, and HPC, which might be the reason for the low stability of the system. HPMC exhibited the best capability to stabilize and preserve the astaxanthin emulsion. Without using the high-energy dispersing method, a particle size of 482 nm (polydispersity index: 0.51) could be obtained with the HPMC-lecithin astaxanthin emulsion. Conclusions: A stable astaxanthin emulsion (up to 5 months) could be fabricated successfully. The conventional homogenizer could form a better emulsion with a single surfactant. However, cellulose derivatives could assist the emulsion to have better DLS results even with the magnetic stirring method. Lecithin showed better performance in astaxanthin preservation than polysorbate surfactant. Strong interactions of lecithin with CMC, HEC, and HPC were detected. However, the addition of HPMC could provide a system with a lower particle size and high astaxanthin stability. The study could open a new approach for fabricating a stable astaxanthin emulsion using the low shear mixing method.
{"title":"Fabrication of astaxanthin emulsion and effect of cellulose derivatives","authors":"HaNgocGiang, H. N. Giang, L. Pham, T. Nguyen, A. Huynh, Pham L T Huynh T N A. Giang H N","doi":"10.32508/stdj.v26i2.4090","DOIUrl":"https://doi.org/10.32508/stdj.v26i2.4090","url":null,"abstract":"Introduction: Astaxanthin, a highly active oxidant, possesses a potential effect on human health. However, with the oily characteristic, the ability to disperse in an aqueous environment has limited its application. Therefore, the aim of this study is the fabrication of a stable astaxanthin emulsion in water. Methods: In this study, an emulsion of astaxanthin was fabricated using polysorbate (tween 60/80) or lecithin. The dispersing methods of the magnetic stirrer and stator-rotor ho-mogenizer were applied and compared. The effect of cellulose derivatives (sodium carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), and hydroxypropyl methylcellulose (HPMC)) on the astaxanthin emulsion system was investigated. The samples were characterized using dynamic light scattering (DLS), a Brookfield viscometer and Fourier transform infrared (FTIR) spectroscopy. Results: The homogenization could provide the system with a small Z-average value ( ~ 500 nm). The emulsion fabricated with lecithin maintained the red color of as-taxanthin and homogeneity even after 5 months. Tween 80 had the worst effect on astaxanthin degradation because of the presence of double bonds in the surfactant's molecular structure. The addition of soluble cellulose could significantly reduce the particle size and polydispersity even by using a magnetic stirrer. However, it could not ensure the protection of astaxanthin when phase separation was detected in many samples with polymers. The FTIR spectra and viscosity results revealed the strong interaction of lecithin with CMC, HEC, and HPC, which might be the reason for the low stability of the system. HPMC exhibited the best capability to stabilize and preserve the astaxanthin emulsion. Without using the high-energy dispersing method, a particle size of 482 nm (polydispersity index: 0.51) could be obtained with the HPMC-lecithin astaxanthin emulsion. Conclusions: A stable astaxanthin emulsion (up to 5 months) could be fabricated successfully. The conventional homogenizer could form a better emulsion with a single surfactant. However, cellulose derivatives could assist the emulsion to have better DLS results even with the magnetic stirring method. Lecithin showed better performance in astaxanthin preservation than polysorbate surfactant. Strong interactions of lecithin with CMC, HEC, and HPC were detected. However, the addition of HPMC could provide a system with a lower particle size and high astaxanthin stability. The study could open a new approach for fabricating a stable astaxanthin emulsion using the low shear mixing method.","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133789340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i2.4026
Lecturer HoangThiLanPhuong
Free trade agreements not only offer many opportunities but also pose numerous challenges for Vietnamese businesses. Continuing to operate the current governing administrative system will not promote the initiativeness, positivity and creativity of businesses. In contrast, businesses will fail to attract foreign investors due to concerns about Vietnamese regulatory agencies interfering, imposing on production and business activities, and extremely protecting the interests of domestic enterprises. It is necessary to build a service-oriented administration, taking the satisfaction of businesses and people as the goal, promoting the ownership and capacity of businesses and people, and ensuring a healthy and equal investment and business environment in the context that Viet-nam increasingly participates in the common playing fields created by new-generation free trade agreements.
{"title":"Viet Nam With Developing A Service Oriented Public Administration To Meet The Requirements Of New Generations Of Free Trade Agreements","authors":"Lecturer HoangThiLanPhuong","doi":"10.32508/stdj.v26i2.4026","DOIUrl":"https://doi.org/10.32508/stdj.v26i2.4026","url":null,"abstract":"Free trade agreements not only offer many opportunities but also pose numerous challenges for Vietnamese businesses. Continuing to operate the current governing administrative system will not promote the initiativeness, positivity and creativity of businesses. In contrast, businesses will fail to attract foreign investors due to concerns about Vietnamese regulatory agencies interfering, imposing on production and business activities, and extremely protecting the interests of domestic enterprises. It is necessary to build a service-oriented administration, taking the satisfaction of businesses and people as the goal, promoting the ownership and capacity of businesses and people, and ensuring a healthy and equal investment and business environment in the context that Viet-nam increasingly participates in the common playing fields created by new-generation free trade agreements.","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115436695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i2.4094
{"title":"Optimization Planning Method of Renewable distributed Generation in Radial Distribution Systems","authors":"","doi":"10.32508/stdj.v26i2.4094","DOIUrl":"https://doi.org/10.32508/stdj.v26i2.4094","url":null,"abstract":"","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132146486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i2.4051
{"title":"Characterization of graft-type polymer electrolyte membranes at low grafting degrees for fuel cells","authors":"","doi":"10.32508/stdj.v26i2.4051","DOIUrl":"https://doi.org/10.32508/stdj.v26i2.4051","url":null,"abstract":"","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121656426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i2.4083
TranThiThanhHien, BuiTrangViet, Nguyen Hong Buu, Vinh
White turmeric has underground stems that develop rhizomes. It has been used as an Eastern traditional herb for a long time. As with many other monocotyledons, the growth of white turmeric is mainly due to the presence of the primary thickening meristem. Currently, the study of the primary thickening meristem, radial growth, and accumulation of secondary material as essential oil in turmeric rhizomes, including white turmeric, is still limited. In this study, we observed the anatomical structural changes in white turmeric in early growth stages in vitro : we counted the number of PTM layers, the number of vascular bundles, and the number of essential oil drops in the rhizomes and determined physiological and biochemical indicators, such as respiratory intensity, tuber diameter, fresh weight, dry weight, total sugar content, and starch level, according to each stage of early growth (0, 2, 4 and 6 weeks) of white turmeric. The results showed that at 0 weeks of age (resting buds), the PTM consists of 1-2 layers of cells, and there is no formation of vascular bundles and essential oils in tubers. At 2 weeks of age, the PTM consists of 6-7 layers of cells, and there is the formation of vascular bundles and the appearance of essential oil droplets in the parenchyma. The number of PTM cell players decreases to 3-4 layers at 4 weeks of age and 2-3 layers at 6 weeks of age, but the tuber diameter and the number of vascular bundles increase rapidly. Along with an increase in fresh weight, dry weight, starch content, and the number of drops of essential oils, there was a decrease in the sugar content and respiratory intensity in the rhizome. The relationship between the number of PTM layers, the number of vascular bundles and diameter, sugar content, starch, and the number of essential oil droplets was also discussed.
{"title":"Study on the formation and growth of white turmeric rhizomes (Curcuma aromatica Salisb.)","authors":"TranThiThanhHien, BuiTrangViet, Nguyen Hong Buu, Vinh","doi":"10.32508/stdj.v26i2.4083","DOIUrl":"https://doi.org/10.32508/stdj.v26i2.4083","url":null,"abstract":"White turmeric has underground stems that develop rhizomes. It has been used as an Eastern traditional herb for a long time. As with many other monocotyledons, the growth of white turmeric is mainly due to the presence of the primary thickening meristem. Currently, the study of the primary thickening meristem, radial growth, and accumulation of secondary material as essential oil in turmeric rhizomes, including white turmeric, is still limited. In this study, we observed the anatomical structural changes in white turmeric in early growth stages in vitro : we counted the number of PTM layers, the number of vascular bundles, and the number of essential oil drops in the rhizomes and determined physiological and biochemical indicators, such as respiratory intensity, tuber diameter, fresh weight, dry weight, total sugar content, and starch level, according to each stage of early growth (0, 2, 4 and 6 weeks) of white turmeric. The results showed that at 0 weeks of age (resting buds), the PTM consists of 1-2 layers of cells, and there is no formation of vascular bundles and essential oils in tubers. At 2 weeks of age, the PTM consists of 6-7 layers of cells, and there is the formation of vascular bundles and the appearance of essential oil droplets in the parenchyma. The number of PTM cell players decreases to 3-4 layers at 4 weeks of age and 2-3 layers at 6 weeks of age, but the tuber diameter and the number of vascular bundles increase rapidly. Along with an increase in fresh weight, dry weight, starch content, and the number of drops of essential oils, there was a decrease in the sugar content and respiratory intensity in the rhizome. The relationship between the number of PTM layers, the number of vascular bundles and diameter, sugar content, starch, and the number of essential oil droplets was also discussed.","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123135435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i1.3919
{"title":"How Female Physical Attractiveness Affects Others’ Judgments of Personality and Ability in a Simulated Recruitment Situation","authors":"","doi":"10.32508/stdj.v26i1.3919","DOIUrl":"https://doi.org/10.32508/stdj.v26i1.3919","url":null,"abstract":"","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124184167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.32508/stdj.v26i1.4021
Tran Phan Huynh Nhu, Tran Chieu An, P. Ngoc, Doan Le Quynh Nhu, Pham Thi Lan, L. Hung, N. Hiep, P. V. Trung
Introduction: Hedera helix is a species of the Araliaceae family, which contains flavonoids, coumarins, phenolic acids, sterols, alkaloids, anthocyanins, and triterpene saponins. a -Hederin is a saponin compound of the H. helix that possesses many potential biological activities. In previous studies, several methods were used to isolate and purify a -hederin from ivy leaves. However, the loss of a -hederin obtained during solid chromatography purification was relatively high, and it was difficult to obtain a -hederin with high purity. In this research, a centrifugal partition chromatogra-phy(CPC)methodwasestablishedfortheisolationof a -hederindirectlyfromethanolcrudeextract of Hedera helix leaves from Da Lat, Lam Dong province, Vietnam. Methods : The separation of a - hederin was carried out by applying centrifugal partition chromatography with a PLC 2250 system (Gilson Inc., France) coupled with an SCPC-250 column (Armen Instrument, France). In a CPC run, a two-phase solvent system consisting of n-hexane–ethyl acetate–methanol–water (2:3:2:3, v/v) in ascending mode (the lower phase was the stationary phase), with a rotation speed of 1600 rpm and a flow rate of 8.0 mL/min, was used. Results : The purity of the isolated a -hederin was 95.7%, as confirmed by HPLC-DAD at 210 nm. The structure of purified a -hederin was determined by 1 H-NMR and 13 C-NMR. The yield of a -hederin was 12.7%. Conclusion : This investigation might be used as a reference for the large-scale separation of high-purity a -hederin from H. helix leaves .
{"title":"Highly pure alpha-hederin from Hedera helix leaves isolated by centrifugal partition chromatography","authors":"Tran Phan Huynh Nhu, Tran Chieu An, P. Ngoc, Doan Le Quynh Nhu, Pham Thi Lan, L. Hung, N. Hiep, P. V. Trung","doi":"10.32508/stdj.v26i1.4021","DOIUrl":"https://doi.org/10.32508/stdj.v26i1.4021","url":null,"abstract":"Introduction: Hedera helix is a species of the Araliaceae family, which contains flavonoids, coumarins, phenolic acids, sterols, alkaloids, anthocyanins, and triterpene saponins. a -Hederin is a saponin compound of the H. helix that possesses many potential biological activities. In previous studies, several methods were used to isolate and purify a -hederin from ivy leaves. However, the loss of a -hederin obtained during solid chromatography purification was relatively high, and it was difficult to obtain a -hederin with high purity. In this research, a centrifugal partition chromatogra-phy(CPC)methodwasestablishedfortheisolationof a -hederindirectlyfromethanolcrudeextract of Hedera helix leaves from Da Lat, Lam Dong province, Vietnam. Methods : The separation of a - hederin was carried out by applying centrifugal partition chromatography with a PLC 2250 system (Gilson Inc., France) coupled with an SCPC-250 column (Armen Instrument, France). In a CPC run, a two-phase solvent system consisting of n-hexane–ethyl acetate–methanol–water (2:3:2:3, v/v) in ascending mode (the lower phase was the stationary phase), with a rotation speed of 1600 rpm and a flow rate of 8.0 mL/min, was used. Results : The purity of the isolated a -hederin was 95.7%, as confirmed by HPLC-DAD at 210 nm. The structure of purified a -hederin was determined by 1 H-NMR and 13 C-NMR. The yield of a -hederin was 12.7%. Conclusion : This investigation might be used as a reference for the large-scale separation of high-purity a -hederin from H. helix leaves .","PeriodicalId":160917,"journal":{"name":"Science & Technology Development Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128848842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：