{"title":"A New Variant of the 3D PFG Homonuclear Double-Quantum Experiments with NOESY and TOCSY Steps","authors":"Claudio Dalvit","doi":"10.1006/jmrb.1996.0128","DOIUrl":"10.1006/jmrb.1996.0128","url":null,"abstract":"","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 2","pages":"Pages 186-189"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19781161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ziegler , A. Metzler , W. Köckenberger , M. Izquierdo , E. Komor , A. Haase , M. Décorps , M. von Kienlin
Identification and quantitation in conventional1H spectroscopic imagingin vivois often hampered by the small chemical-shift range. To improve the spectral resolution of spectroscopic imaging, homonuclear two-dimensional correlation spectroscopy has been combined with phase encoding of the spatial dimensions. From the theoretical description of the coherence-transfer signal in the Fourier-transform domain, a comprehensive acquisition and processing strategy is presented that includes optimization of the width and the position of the acquisition windows, matched filtering of the signal envelope, and graphical presentation of the cross peak of interest. The procedure has been applied to image the spatial distribution of the correlation peaks from specific spin systems in the hypocotyl of castor bean (Ricinus communis) seedlings. Despite the overlap of many resonances, correlation-peak imaging made it possible to observe a number of proton resonances, such as those of sucrose, β-glucose, glutamine/glutamate, lysine, and arginine.
{"title":"Correlation-Peak Imaging","authors":"A. Ziegler , A. Metzler , W. Köckenberger , M. Izquierdo , E. Komor , A. Haase , M. Décorps , M. von Kienlin","doi":"10.1006/jmrb.1996.0124","DOIUrl":"10.1006/jmrb.1996.0124","url":null,"abstract":"<div><p>Identification and quantitation in conventional<sup>1</sup>H spectroscopic imaging<em>in vivo</em>is often hampered by the small chemical-shift range. To improve the spectral resolution of spectroscopic imaging, homonuclear two-dimensional correlation spectroscopy has been combined with phase encoding of the spatial dimensions. From the theoretical description of the coherence-transfer signal in the Fourier-transform domain, a comprehensive acquisition and processing strategy is presented that includes optimization of the width and the position of the acquisition windows, matched filtering of the signal envelope, and graphical presentation of the cross peak of interest. The procedure has been applied to image the spatial distribution of the correlation peaks from specific spin systems in the hypocotyl of castor bean (<em>Ricinus communis</em>) seedlings. Despite the overlap of many resonances, correlation-peak imaging made it possible to observe a number of proton resonances, such as those of sucrose, β-glucose, glutamine/glutamate, lysine, and arginine.</p></div>","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 2","pages":"Pages 141-150"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19781157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William W. Brey, Thomas H. Mareci, Jerry Dougherty
An approach to transverse field-gradient coil design is presented which locates all current elements in planes perpendicular to the main magnetic field. The linear volume of the resulting coil structure can be made to extend nearly to both ends of the coil. This design is based on forming a concentric return path in the same plane as the field-producing arcs. The coil structure consists of stacked planar units which give a desired field-gradient configuration. The size of the linear-field region is optimized by varying the current in each plane, by varying the location of a plane relative to the others in the stack, or by varying both current and location. Coils with linear regions having a wide range of length-to-diameter ratios can be designed, as illustrated by two examples. The construction of a prototype coil is presented and its performance in imaging confirms the analysis. This type of design is suited to magnetic resonance of the human head without obstruction from the shoulders.
{"title":"A Field-Gradient Coil Using Concentric Return Paths","authors":"William W. Brey, Thomas H. Mareci, Jerry Dougherty","doi":"10.1006/jmrb.1996.0122","DOIUrl":"10.1006/jmrb.1996.0122","url":null,"abstract":"<div><p>An approach to transverse field-gradient coil design is presented which locates all current elements in planes perpendicular to the main magnetic field. The linear volume of the resulting coil structure can be made to extend nearly to both ends of the coil. This design is based on forming a concentric return path in the same plane as the field-producing arcs. The coil structure consists of stacked planar units which give a desired field-gradient configuration. The size of the linear-field region is optimized by varying the current in each plane, by varying the location of a plane relative to the others in the stack, or by varying both current and location. Coils with linear regions having a wide range of length-to-diameter ratios can be designed, as illustrated by two examples. The construction of a prototype coil is presented and its performance in imaging confirms the analysis. This type of design is suited to magnetic resonance of the human head without obstruction from the shoulders.</p></div>","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 2","pages":"Pages 124-130"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19781209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anthony S. Serianni , Paul B. Bondo , Jaroslav Zajicek
{"title":"Verification of the Projection Resultant Method for Two-Bond13C–13C Coupling Sign Determinations in Carbohydrates","authors":"Anthony S. Serianni , Paul B. Bondo , Jaroslav Zajicek","doi":"10.1006/jmrb.1996.0111","DOIUrl":"10.1006/jmrb.1996.0111","url":null,"abstract":"","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 1","pages":"Pages 69-74"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19638084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amino-Acid-Type Identification for Deuterated Proteins with a β-Carbon-Edited HNCOCACB Experiment","authors":"Volker Dötsch, Hiroshi Matsuo, Gerhard Wagner","doi":"10.1006/jmrb.1996.0117","DOIUrl":"10.1006/jmrb.1996.0117","url":null,"abstract":"","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 1","pages":"Pages 95-100"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19638090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiuhong He , Zaver M. Bhujwalla, Jerry D. Glickson
An extension of the Sel-MQC pulse sequence—SEE-SelMQC (spin-echo-enhanced selective multiple-quantum coherence transfer)—that completely suppresses lipid and water in tissues containing mobile lipid in a single scan and detects1H resonances of multiple metabolites is described. As in the Sel-MQC lactate-editing experiments [Q. Heet al., J. Magn. Reson. B106, 203 (1995)], SEE-SelMQC acquires lactate from its ZQ → DQ coherence-transfer pathway; in addition, the method recovers signal from other metabolites by selective generation of additional spin echoes using extra frequency-selective pulses and gradients. This method introduces no loss of lactate signal intensity beyond the 50% that is lost through the multiple-quantum coherence-transfer process. The spatial distributions of choline and lactate with a phantom andin vivo,in subcutaneously implanted murine EMT6 tumors, have been simultaneously mapped.
selmqc脉冲序列的扩展- see - selmqc(自旋回波增强选择性多量子相干转移)-在单次扫描中完全抑制含有移动脂质的组织中的脂质和水,并检测多种代谢物的1h共振。在self - mqc乳酸编辑实验中[Q]。J. Magn。的原因。B106, 203 (1995)], SEE-SelMQC通过其ZQ→DQ相干转移途径获得乳酸;此外,该方法通过使用额外的频率选择脉冲和梯度选择性地产生额外的自旋回波,从其他代谢物中恢复信号。这种方法不引入乳酸信号强度的损失超过50%的损失是通过多量子相干转移过程。在皮下植入的小鼠EMT6肿瘤中,胆碱和乳酸的空间分布已被同时绘制。
{"title":"Proton Detection of Choline and Lactate in EMT6 Tumors by Spin-Echo-Enhanced Selective Multiple-Quantum-Coherence Transfer","authors":"Qiuhong He , Zaver M. Bhujwalla, Jerry D. Glickson","doi":"10.1006/jmrb.1996.0104","DOIUrl":"10.1006/jmrb.1996.0104","url":null,"abstract":"<div><p>An extension of the Sel-MQC pulse sequence—SEE-SelMQC (spin-echo-enhanced selective multiple-quantum coherence transfer)—that completely suppresses lipid and water in tissues containing mobile lipid in a single scan and detects<sup>1</sup>H resonances of multiple metabolites is described. As in the Sel-MQC lactate-editing experiments [Q. He<em>et al., J. Magn. Reson. B</em>106, 203 (1995)], SEE-SelMQC acquires lactate from its ZQ → DQ coherence-transfer pathway; in addition, the method recovers signal from other metabolites by selective generation of additional spin echoes using extra frequency-selective pulses and gradients. This method introduces no loss of lactate signal intensity beyond the 50% that is lost through the multiple-quantum coherence-transfer process. The spatial distributions of choline and lactate with a phantom and<em>in vivo,</em>in subcutaneously implanted murine EMT6 tumors, have been simultaneously mapped.</p></div>","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 1","pages":"Pages 18-25"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19638176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of the Quadrupolar Carr–Purcell–Meiboom–Gill Pulse Train for Sensitivity Enhancement in Deuteron NMR of Liquid Crystals","authors":"R.S. Prosser , N.J. Heaton , G. Kothe","doi":"10.1006/jmrb.1996.0108","DOIUrl":"10.1006/jmrb.1996.0108","url":null,"abstract":"","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 1","pages":"Pages 51-57"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19638180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Carbon-Relayed Correlation of Intranucleotide Sugar H1′ and Base H6/H8 Protons in Oligonucleotides at Natural Abundance","authors":"V.V. Krishnamurthy","doi":"10.1006/jmrb.1996.0112","DOIUrl":"10.1006/jmrb.1996.0112","url":null,"abstract":"","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 1","pages":"Pages 75-78"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19638085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dana Callihan , John West , Surat Kumar , Barry I. Schweitzer , Timothy M. Logan
{"title":"Simple, Distortion-Free Homonuclear Spectra of Peptides and Nucleic Acids in Water Using Excitation Sculpting","authors":"Dana Callihan , John West , Surat Kumar , Barry I. Schweitzer , Timothy M. Logan","doi":"10.1006/jmrb.1996.0114","DOIUrl":"10.1006/jmrb.1996.0114","url":null,"abstract":"","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 1","pages":"Pages 82-85"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19638087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-Resolution Solid-State NMR Spectra of Integral Membrane Proteins Reconstituted into Magnetically Oriented Phospholipid Bilayers","authors":"Kathleen P. Howard, Stanley J. Opella","doi":"10.1006/jmrb.1996.0116","DOIUrl":"10.1006/jmrb.1996.0116","url":null,"abstract":"","PeriodicalId":16130,"journal":{"name":"Journal of Magnetic Resonance, Series B","volume":"112 1","pages":"Pages 91-94"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/jmrb.1996.0116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19638089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}