Pub Date : 2023-11-28DOI: 10.1080/10601325.2023.2287044
Retno Ariadi Lusiana, Dian Tri Pratama, Hasan Muhtar
Modifications were successfully carried out on the polyvinylidene fluoride (PVDF) flat sheet membrane, involving the sulfonation and adding polyethylene glycol (PEG), along with variations in the c...
对聚偏氟乙烯(PVDF)平板膜进行了成功的改性，包括磺化和添加聚乙二醇(PEG)，以及c…
{"title":"Facile modification of polyvinylidene fluoride membrane for enhancing dialysis performance: sulfonation, adding polyethylene glycol and tuning coagulation bath temperature","authors":"Retno Ariadi Lusiana, Dian Tri Pratama, Hasan Muhtar","doi":"10.1080/10601325.2023.2287044","DOIUrl":"https://doi.org/10.1080/10601325.2023.2287044","url":null,"abstract":"Modifications were successfully carried out on the polyvinylidene fluoride (PVDF) flat sheet membrane, involving the sulfonation and adding polyethylene glycol (PEG), along with variations in the c...","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"47 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138513039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-25DOI: 10.1080/10601325.2023.2283604
Guifeng Xia, Xinhong Xiong, Hong Wang, Jian Chen, Jiaxi Cui
Perylene diimides (PDI) are known for their excellent performance and stability as dyes used in photovoltaics and optoelectronic devices. Herein we report their photo-liability in the presence of r...
{"title":"Unexpected photo-liability of perylene diimides for fluorescent patterns","authors":"Guifeng Xia, Xinhong Xiong, Hong Wang, Jian Chen, Jiaxi Cui","doi":"10.1080/10601325.2023.2283604","DOIUrl":"https://doi.org/10.1080/10601325.2023.2283604","url":null,"abstract":"Perylene diimides (PDI) are known for their excellent performance and stability as dyes used in photovoltaics and optoelectronic devices. Herein we report their photo-liability in the presence of r...","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138513052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-25DOI: 10.1080/10601325.2023.2277211
Sarita, Pal Manisha D., Bharat Singh, Ambak K. Rai, Ravi Prakash Tewari, Pradip Kumar Dutta
Injectable hydrogel provides an excellent substrate for bone tissue engineering (BTE) applications due to its water base, and capacity to encapsulate, manipulate, and easily reach to the adjacent t...
{"title":"An injectable blend hydrogel for bone tissue engineering application: synthesis and characterization","authors":"Sarita, Pal Manisha D., Bharat Singh, Ambak K. Rai, Ravi Prakash Tewari, Pradip Kumar Dutta","doi":"10.1080/10601325.2023.2277211","DOIUrl":"https://doi.org/10.1080/10601325.2023.2277211","url":null,"abstract":"Injectable hydrogel provides an excellent substrate for bone tissue engineering (BTE) applications due to its water base, and capacity to encapsulate, manipulate, and easily reach to the adjacent t...","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"46 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138513040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fluorine-containing liquid crystal polymers have excellent hydrophobic stability, making them attractive for use in the field of stable hydrophobic coatings. To improve the hydrophobic stability of...
含氟液晶聚合物具有优异的疏水稳定性，在稳定疏水涂料领域具有广泛的应用前景。提高…的疏水稳定性。
{"title":"Synthesis and performance of novel fluoro acrylate polymer containing rigid cyclohexane group as a mesogenic core","authors":"Wei Xu, Hao Liu, Bowen Zhang, Yupei Gao, Lifen Hao, Xuechuan Wang","doi":"10.1080/10601325.2023.2284794","DOIUrl":"https://doi.org/10.1080/10601325.2023.2284794","url":null,"abstract":"Fluorine-containing liquid crystal polymers have excellent hydrophobic stability, making them attractive for use in the field of stable hydrophobic coatings. To improve the hydrophobic stability of...","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"53 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-16DOI: 10.1080/10601325.2023.2279605
Mei Yang, Sitong Lin, Mei Shi, Jinsen Gao, Liang Zhao, Dichu Lin
The hydrogel capsule adsorbent with honeycomb architectures was prepared via the one-step titration-gel method (OSTGM), which the casting solution contained polyvinyl alcohol (PVA), sodium alginate...
{"title":"Controllable microfluidic fabrication of honeycomb capsule adsorbent via the one-step titration-gel method","authors":"Mei Yang, Sitong Lin, Mei Shi, Jinsen Gao, Liang Zhao, Dichu Lin","doi":"10.1080/10601325.2023.2279605","DOIUrl":"https://doi.org/10.1080/10601325.2023.2279605","url":null,"abstract":"The hydrogel capsule adsorbent with honeycomb architectures was prepared via the one-step titration-gel method (OSTGM), which the casting solution contained polyvinyl alcohol (PVA), sodium alginate...","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138526045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-05DOI: 10.1080/10601325.2023.2251534
Mohammad Hossein Jandaghian, A. Sepahi, S. Hosseini, Romina Esmaeilzade, Ehsan Nikzinat, Ali Salimzadeh, Reza Zaeri, Maryam Masoori
Abstract The present study encompasses the utilization of a mixture of 1-butene and 1-hexene comonomers for the large-scale production of a film-grade linear low-density polyethylene (LLDPE) resin. The goal involves assessing the impact stemming from the partial replacement of 1-butene with 1-hexene on the thermal, physical, mechanical and rheological properties of the resultant resin, juxtaposed against an LLDPE counterpart exclusively produced by 1-butene as the comonomer. Although the comprehensive examination of key physical, thermal, rheological and mechanical characteristics indicates nominal influence due to the substitution, a marked escalation materializes in both the tear resistance and slow crack growth (SCG) resilience of the LLDPE resins formulated through the amalgamation of these comonomers. Specifically, the tear and SCG resistance of the proposed resin exhibit an extraordinary surge exceeding 60% and 30%, respectively. This discernible enhancement underscores the viability of the proposed technique as a propitious avenue for augmenting the requisite mechanical properties, obviating the need for an all-encompassing shift from 1-butene to longer-chain α-olefin comonomers. Graphical Abstract
{"title":"Tuning tear and slow crack growth resistance of linear low-density polyethylene resins through partial replacement of 1-butene with 1-hexene","authors":"Mohammad Hossein Jandaghian, A. Sepahi, S. Hosseini, Romina Esmaeilzade, Ehsan Nikzinat, Ali Salimzadeh, Reza Zaeri, Maryam Masoori","doi":"10.1080/10601325.2023.2251534","DOIUrl":"https://doi.org/10.1080/10601325.2023.2251534","url":null,"abstract":"Abstract The present study encompasses the utilization of a mixture of 1-butene and 1-hexene comonomers for the large-scale production of a film-grade linear low-density polyethylene (LLDPE) resin. The goal involves assessing the impact stemming from the partial replacement of 1-butene with 1-hexene on the thermal, physical, mechanical and rheological properties of the resultant resin, juxtaposed against an LLDPE counterpart exclusively produced by 1-butene as the comonomer. Although the comprehensive examination of key physical, thermal, rheological and mechanical characteristics indicates nominal influence due to the substitution, a marked escalation materializes in both the tear resistance and slow crack growth (SCG) resilience of the LLDPE resins formulated through the amalgamation of these comonomers. Specifically, the tear and SCG resistance of the proposed resin exhibit an extraordinary surge exceeding 60% and 30%, respectively. This discernible enhancement underscores the viability of the proposed technique as a propitious avenue for augmenting the requisite mechanical properties, obviating the need for an all-encompassing shift from 1-butene to longer-chain α-olefin comonomers. Graphical Abstract","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"9 1","pages":"661 - 667"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79902962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-21DOI: 10.1080/10601325.2023.2249032
M. Pakhira, Akash Karmakar, D. P. Chatterjee, A. Nandi
Abstract Sensing of lectins are utmost necessary for its inflammatory, digestive disorder, gut pains and toxicity to human beings and for this purpose we have chosen polythiophene (PT) for its exciting optoelectronic properties. Because of precise carbohydrate specificities of lectin and to make PT water soluble for sensing of lectin, we have synthesized polythiophene-g-poly(N,N-dimethylaminoethyl methacrylate) -co-poly(glucose-hydroxyethyl methacrylate) (PT-g-pDMAEMA-co-pGLU-HEM), [PTDG]) from polythiophene macroinitiator (PTI) by copolymerizing DMAEMA and GLU-HEM monomers mixture with CuCl/HMTETA catalyst/ligand followed by hydrolysis using alcoholic NaOMe solution. The Mn of PTI was 38000, polydispersity 2.5, head-tail (H-T) regioregularity 70 mol % and Mn of unhydrolyzed PTDG is 98,900. The UV-Vis spectra of PTDG solution shows two absorption peaks at 430 and 462 nm but it shows a sharp emission peak at 544 nm which quenches with increasing pH. Concanavalin A (ConA) shows an absorbance peak at 278 nm and with addition of PTDG solution absorbance intensity increases showing hypochromic effect. Benesi–Hildebrand plot of reciprocal molar extinction coefficients with concentration suggests 1:1 complex formation between PTDG and ConA. With addition of ConA fluorescence quenching of PTDG solution occurred and using the fluorescence intensity ratio vs concentration plot the limit of detection (LOD) of Con A lectin is found to be 57 µg/L and storing the polymer solution for two months exhibits good durability. The morphology of PTDG changes from vesicle to compound micellar aggregate on addition of Con A lectin. Graphical Abstract We have synthesized a polythiophene glcopolymer (PT-g-pDMAEMA-co-pGLU-HEM), PTDG) using ATRP technique and its UV-Vis and fluorescence spectra indicates pH responsivity and lectin sensing property with LOD of 57 µg/L.
{"title":"Synthesis of carbohydrate based polythiophene graft poly(N,N-dimethylaminoethyl methacrylate)-co-poly(GLU-HEM) copolymer for lectin sensing","authors":"M. Pakhira, Akash Karmakar, D. P. Chatterjee, A. Nandi","doi":"10.1080/10601325.2023.2249032","DOIUrl":"https://doi.org/10.1080/10601325.2023.2249032","url":null,"abstract":"Abstract Sensing of lectins are utmost necessary for its inflammatory, digestive disorder, gut pains and toxicity to human beings and for this purpose we have chosen polythiophene (PT) for its exciting optoelectronic properties. Because of precise carbohydrate specificities of lectin and to make PT water soluble for sensing of lectin, we have synthesized polythiophene-g-poly(N,N-dimethylaminoethyl methacrylate) -co-poly(glucose-hydroxyethyl methacrylate) (PT-g-pDMAEMA-co-pGLU-HEM), [PTDG]) from polythiophene macroinitiator (PTI) by copolymerizing DMAEMA and GLU-HEM monomers mixture with CuCl/HMTETA catalyst/ligand followed by hydrolysis using alcoholic NaOMe solution. The Mn of PTI was 38000, polydispersity 2.5, head-tail (H-T) regioregularity 70 mol % and Mn of unhydrolyzed PTDG is 98,900. The UV-Vis spectra of PTDG solution shows two absorption peaks at 430 and 462 nm but it shows a sharp emission peak at 544 nm which quenches with increasing pH. Concanavalin A (ConA) shows an absorbance peak at 278 nm and with addition of PTDG solution absorbance intensity increases showing hypochromic effect. Benesi–Hildebrand plot of reciprocal molar extinction coefficients with concentration suggests 1:1 complex formation between PTDG and ConA. With addition of ConA fluorescence quenching of PTDG solution occurred and using the fluorescence intensity ratio vs concentration plot the limit of detection (LOD) of Con A lectin is found to be 57 µg/L and storing the polymer solution for two months exhibits good durability. The morphology of PTDG changes from vesicle to compound micellar aggregate on addition of Con A lectin. Graphical Abstract We have synthesized a polythiophene glcopolymer (PT-g-pDMAEMA-co-pGLU-HEM), PTDG) using ATRP technique and its UV-Vis and fluorescence spectra indicates pH responsivity and lectin sensing property with LOD of 57 µg/L.","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"2016 1","pages":"599 - 608"},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86311273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-18DOI: 10.1080/10601325.2023.2245855
Rahul Yadav, S. K. Rath, Sangeeta Sankhla, S. Neogi, N. Singha
Abstract In addition to being bio-degradable, cellulose nanocrystals (CNC) provide high mechanical strength to polymer composites. They exhibit outstanding properties like high strength-to-weight ratio, abundant surface functional groups and sustainability. In this study, we prepared nanocomposites of poly (ethylene-co-methyl acrylate) (EMA) and CNC using the melt-mixing technique. The mechanical properties of EMA were improved after adding CNC to it. The ultimate tensile stress and maximum elongation increased from 6 MPa and 860% (for pristine EMA) to 9.5 MPa and 1090% (for 2 wt.% EMA/CNC composite). Thermal properties of the EMA/CNC composites were analyzed by using DSC and TGA analysis. The dispersion of CNC in the composite was analyzed by SEM and XRD analyses. The EMA/CNC composites showed interesting birefringence properties on analysis via polarized optical microscopy (POM). The POM analysis indicated that the CNC in composites aligns themselves in the direction of applied stress, enhancing the mechanical strength of nanocomposites. Biodegradation of the bio-composite was also studied via soil-burial test. Graphical Abstract
{"title":"Polymer nano-biocomposite based on poly (ethylene-co-methyl acrylate) (EMA)/cellulose nanocrystals (CNC); preparation and properties","authors":"Rahul Yadav, S. K. Rath, Sangeeta Sankhla, S. Neogi, N. Singha","doi":"10.1080/10601325.2023.2245855","DOIUrl":"https://doi.org/10.1080/10601325.2023.2245855","url":null,"abstract":"Abstract In addition to being bio-degradable, cellulose nanocrystals (CNC) provide high mechanical strength to polymer composites. They exhibit outstanding properties like high strength-to-weight ratio, abundant surface functional groups and sustainability. In this study, we prepared nanocomposites of poly (ethylene-co-methyl acrylate) (EMA) and CNC using the melt-mixing technique. The mechanical properties of EMA were improved after adding CNC to it. The ultimate tensile stress and maximum elongation increased from 6 MPa and 860% (for pristine EMA) to 9.5 MPa and 1090% (for 2 wt.% EMA/CNC composite). Thermal properties of the EMA/CNC composites were analyzed by using DSC and TGA analysis. The dispersion of CNC in the composite was analyzed by SEM and XRD analyses. The EMA/CNC composites showed interesting birefringence properties on analysis via polarized optical microscopy (POM). The POM analysis indicated that the CNC in composites aligns themselves in the direction of applied stress, enhancing the mechanical strength of nanocomposites. Biodegradation of the bio-composite was also studied via soil-burial test. Graphical Abstract","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"1243 1","pages":"618 - 627"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86797072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Bottlebrushes have intensive applications in photonics, surfactants, supersoft elastomers, medical imaging, drug delivery and nanomaterials owing to their unique morphology and properties. While the traditional grafting from method required low monomer conversion to avoid gelation, and resulted shorter side chain length. Compared with the traditional grafting from method, the bottlebrushes with improved longer side chains were successfully prepared by combining grafting through and grafting from methods. In this approach, RAFT and ROMP polymerizations were used in sequence to synthesize a series of main chains: including PNB-PMA7, PNB-PMA13 and PNB-PMA25. RAFT polymerization was then used to prepare bottlebrushes with different kinds of main chains under the same conditions. In the meantime, homo-polymerization of PMA was appeared inevitably, which was related to the polymerization time. Owing to the greater molecular weight of PNB-PMA13 and PNB-PMA25, the polymerized solutions transformed into gel in shorter time, and resulted to the lower proportion of homo-polymerization (<11%). Compared with PNB-SCS as main chain, the side chain’s degree of polymerization increased from 41 to 80 when PNB-PMA13 was used as main chain. Graphical Abstract
{"title":"The synthesis of bottlebrushes with improved longer side chains by combining grafting through and grafting from methods","authors":"Lifen Xiao, Xiaoming Zhu, Liang Li, Dongyang Lin, Geng Huang, Wei Li","doi":"10.1080/10601325.2023.2247038","DOIUrl":"https://doi.org/10.1080/10601325.2023.2247038","url":null,"abstract":"Abstract Bottlebrushes have intensive applications in photonics, surfactants, supersoft elastomers, medical imaging, drug delivery and nanomaterials owing to their unique morphology and properties. While the traditional grafting from method required low monomer conversion to avoid gelation, and resulted shorter side chain length. Compared with the traditional grafting from method, the bottlebrushes with improved longer side chains were successfully prepared by combining grafting through and grafting from methods. In this approach, RAFT and ROMP polymerizations were used in sequence to synthesize a series of main chains: including PNB-PMA7, PNB-PMA13 and PNB-PMA25. RAFT polymerization was then used to prepare bottlebrushes with different kinds of main chains under the same conditions. In the meantime, homo-polymerization of PMA was appeared inevitably, which was related to the polymerization time. Owing to the greater molecular weight of PNB-PMA13 and PNB-PMA25, the polymerized solutions transformed into gel in shorter time, and resulted to the lower proportion of homo-polymerization (<11%). Compared with PNB-SCS as main chain, the side chain’s degree of polymerization increased from 41 to 80 when PNB-PMA13 was used as main chain. Graphical Abstract","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"5 1","pages":"609 - 617"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73174682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-17DOI: 10.1080/10601325.2023.2240824
Yunxin Zhang, Jiange Liu
Abstract Current clinical therapies for invasive breast cancer have low therapeutic effectiveness and substantial systemic adverse effects, leading to poor patient compliance. In this investigation, we developed dual anticancer drugs (sorafenib (SFB) and kaempferol (KMF)) encapsulated in PEGylated gold nanomaterial (PEG-AuNPs@SFB/KMF) for a drug delivery system targeting breast cancer to circumvent this problem. Subsequent research examined whether pH affects drug release. The current study results show that sorafenib and kaempferol work better together than each treatment individually in eliciting cytotoxic effects. In vitro cytotoxicity studies confirmed that PEG-AuNPs@SFB/KMF were more effective than sorafenib alone in MCF-7 and MDA-MB-231 cells, with less toxicity in NIH3T3 cells. The cancer cell proliferation was measured by Click-iT EdU assay, which indicates that the NPs effectively induce apoptosis in cancer cells. The different biochemical staining (acridine orange and ethidium bromide (AO-EB and nuclear staining (DAPI)) methods confirmed the morphological investigation of the cells. PEG-AuNPs@SFB/KMF increased apoptosis ratio, confirmed by flow cytometric analysis via Annexin V-FITC/PI staining methods. Therefore, we believe that the built multifunctional nanocarrier based on developed nanoparticle delivery could be an alternative therapeutic strategy for breast cancer therapy. Graphical Abstract
{"title":"Facile fabrication of combination delivery of kaempferol and sorafenib with PEGylated gold nanoparticles delivery to breast cancer: Investigation of cytotoxicity and apoptosis induction","authors":"Yunxin Zhang, Jiange Liu","doi":"10.1080/10601325.2023.2240824","DOIUrl":"https://doi.org/10.1080/10601325.2023.2240824","url":null,"abstract":"Abstract Current clinical therapies for invasive breast cancer have low therapeutic effectiveness and substantial systemic adverse effects, leading to poor patient compliance. In this investigation, we developed dual anticancer drugs (sorafenib (SFB) and kaempferol (KMF)) encapsulated in PEGylated gold nanomaterial (PEG-AuNPs@SFB/KMF) for a drug delivery system targeting breast cancer to circumvent this problem. Subsequent research examined whether pH affects drug release. The current study results show that sorafenib and kaempferol work better together than each treatment individually in eliciting cytotoxic effects. In vitro cytotoxicity studies confirmed that PEG-AuNPs@SFB/KMF were more effective than sorafenib alone in MCF-7 and MDA-MB-231 cells, with less toxicity in NIH3T3 cells. The cancer cell proliferation was measured by Click-iT EdU assay, which indicates that the NPs effectively induce apoptosis in cancer cells. The different biochemical staining (acridine orange and ethidium bromide (AO-EB and nuclear staining (DAPI)) methods confirmed the morphological investigation of the cells. PEG-AuNPs@SFB/KMF increased apoptosis ratio, confirmed by flow cytometric analysis via Annexin V-FITC/PI staining methods. Therefore, we believe that the built multifunctional nanocarrier based on developed nanoparticle delivery could be an alternative therapeutic strategy for breast cancer therapy. Graphical Abstract","PeriodicalId":16228,"journal":{"name":"Journal of Macromolecular Science, Part A","volume":"11 1","pages":"628 - 639"},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82395639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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