Pub Date : 2017-02-16DOI: 10.4172/2475-3203.1000e112
H. Black
A recent review has summarized the evidence that omega-3 fatty acids (FA) have potential in reducing the risk for a common form of cancer [1]. This editorial is a synopsis of that review covering the historical interest in the potential health benefits of omega-3 FA; the mechanistic rationale for such beneficial effect; and the experimental and clinical evidence that omega-3 supplementation could play an important role in cancer prevention.
{"title":"Omega-3 Fatty Acids and Cancer Prevention","authors":"H. Black","doi":"10.4172/2475-3203.1000e112","DOIUrl":"https://doi.org/10.4172/2475-3203.1000e112","url":null,"abstract":"A recent review has summarized the evidence that omega-3 fatty acids (FA) have potential in reducing the risk for a common form of cancer [1]. This editorial is a synopsis of that review covering the historical interest in the potential health benefits of omega-3 FA; the mechanistic rationale for such beneficial effect; and the experimental and clinical evidence that omega-3 supplementation could play an important role in cancer prevention.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76308053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-08DOI: 10.4172/2329-6771.1000188
S. Bansal, Meenu Gupta, V. Nautiyal, C. Agrawal, D. Pruthi, N. Chauhan, S. Verma, Mushtaq Ahmad, S. Saini
Background: There is a lifetime risk of developing another de novo malignancy in diagnosed cancer patients. Detection of new primary has increased due to advances in both diagnostic and treatment modalities. This article aims to analyze the pattern of presentation of second primary neoplasm and to review the relevant literature. Materials and Methods: We analyzed patients presenting with histologically proven synchronous or metachronous second primaries from July 2011 to July 2016. Warren and Gate's criteria have been used to designate a case as second primary neoplasm. Various details such as age at diagnosis, sex, whether synchronous or metachronous, site, stage, histopathology, treatment were collected. Results: Over a period of 5 years total 40 cases were observed, out of which 13 were synchronous (33%) and 27 (67%) were metachronous. The median age at the diagnosis of primary malignancy was 65.5 years (range 27-84). Out of the 40 patients, 28 (70%) were males and 12 (30%) were females. The most common site of primary tumor was head and neck and genito-urinary, 11 cases each. Among the second malignancy most common site was gastrointestinal tract (11 cases), followed by genitourinary (10 cases) and lung (9 cases). Conclusion: The likelihood of diagnosis of second malignancy has increased with the advent of newer diagnostic modalities as well as increased compliance to follow up and progress in the management. Appearance of new signs and symptoms should raise a suspicion and early detection of the disease leads to appropriate management.
{"title":"Second Primary Neoplasms: A Clinico-Pathological Analysis from a Sub Himalayan Cancer Centre in India","authors":"S. Bansal, Meenu Gupta, V. Nautiyal, C. Agrawal, D. Pruthi, N. Chauhan, S. Verma, Mushtaq Ahmad, S. Saini","doi":"10.4172/2329-6771.1000188","DOIUrl":"https://doi.org/10.4172/2329-6771.1000188","url":null,"abstract":"Background: There is a lifetime risk of developing another de novo malignancy in diagnosed cancer patients. Detection of new primary has increased due to advances in both diagnostic and treatment modalities. This article aims to analyze the pattern of presentation of second primary neoplasm and to review the relevant literature. Materials and Methods: We analyzed patients presenting with histologically proven synchronous or metachronous second primaries from July 2011 to July 2016. Warren and Gate's criteria have been used to designate a case as second primary neoplasm. Various details such as age at diagnosis, sex, whether synchronous or metachronous, site, stage, histopathology, treatment were collected. Results: Over a period of 5 years total 40 cases were observed, out of which 13 were synchronous (33%) and 27 (67%) were metachronous. The median age at the diagnosis of primary malignancy was 65.5 years (range 27-84). Out of the 40 patients, 28 (70%) were males and 12 (30%) were females. The most common site of primary tumor was head and neck and genito-urinary, 11 cases each. Among the second malignancy most common site was gastrointestinal tract (11 cases), followed by genitourinary (10 cases) and lung (9 cases). Conclusion: The likelihood of diagnosis of second malignancy has increased with the advent of newer diagnostic modalities as well as increased compliance to follow up and progress in the management. Appearance of new signs and symptoms should raise a suspicion and early detection of the disease leads to appropriate management.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87595554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-26DOI: 10.4172/2329-6771.1000185
Z. Alarcao
In an earlier article by the author, the effectiveness and efficacy of Reiki Therapy when used as complementary therapy in patients with blood cancer was demonstrated. With the present article, the author invites readers to reflect on the importance of further qualitative research study of Reiki Therapy as complementary holistic therapy in these same patients. This proposal results from the fact that there are cancer variables of weight that could not be considered in the previous investigation and that can be evaluated through the spontaneous testimonies of the patients, the registry of the same and also the analysis of the content of an open question made in the previous investigation. It is therefore urgent to continue to investigate.
{"title":"Reiki Therapy is Credible in Oncology. A Possible Analysis...","authors":"Z. Alarcao","doi":"10.4172/2329-6771.1000185","DOIUrl":"https://doi.org/10.4172/2329-6771.1000185","url":null,"abstract":"In an earlier article by the author, the effectiveness and efficacy of Reiki Therapy when used as complementary therapy in patients with blood cancer was demonstrated. With the present article, the author invites readers to reflect on the importance of further qualitative research study of Reiki Therapy as complementary holistic therapy in these same patients. This proposal results from the fact that there are cancer variables of weight that could not be considered in the previous investigation and that can be evaluated through the spontaneous testimonies of the patients, the registry of the same and also the analysis of the content of an open question made in the previous investigation. It is therefore urgent to continue to investigate.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"49 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84909397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-18DOI: 10.4172/2329-6771.1000184
J. Sunny, Yal, J. Bajpai
Breast cancer is not only the most common malignancy but also the leading causes of cancer-related deaths in women worldwide. The management of breast cancer is subtype driven and determination of hormone receptor [HR] status, a major driving force for the tumor growth is of paramount importance. The use of hormone therapy [HT] to treat HR positive breast cancer is practiced for more than a century and is one of the pivotal examples of precision medicine. The present perspective focuses on the state of the art hormone therapy for early and advanced breast cancer in both pre and post-menopausal women. Recent advances in HT strategies, with respect to single or combination therapy use, adding agents targeting HT resistance, checkpoint inhibitors, and optimal duration of endocrine therapy are also being addressed. Opportunities for individualized patient care are discussed.
{"title":"Hormone Therapy in Breast Cancer: Where do We Stand?","authors":"J. Sunny, Yal, J. Bajpai","doi":"10.4172/2329-6771.1000184","DOIUrl":"https://doi.org/10.4172/2329-6771.1000184","url":null,"abstract":"Breast cancer is not only the most common malignancy but also the leading causes of cancer-related deaths in women worldwide. The management of breast cancer is subtype driven and determination of hormone receptor [HR] status, a major driving force for the tumor growth is of paramount importance. The use of hormone therapy [HT] to treat HR positive breast cancer is practiced for more than a century and is one of the pivotal examples of precision medicine. The present perspective focuses on the state of the art hormone therapy for early and advanced breast cancer in both pre and post-menopausal women. Recent advances in HT strategies, with respect to single or combination therapy use, adding agents targeting HT resistance, checkpoint inhibitors, and optimal duration of endocrine therapy are also being addressed. Opportunities for individualized patient care are discussed.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"19 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80850237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4172/2329-6771.1000183
S. Jandyal, J. Bajpai
Ovarian function suppression (OFS) an old endocrine therapy has been tested in premenopausal women with early breast cancer (EBC) but not widely accepted in modern practice. The question is re-addressed in recent big trials, however the big dilemma doesn't resolved. This perspective touch upon the ancient as well as current evidence of OFS in these young early breast cancer women and try to enlighten the readers further on this controversial topic wherein there is lots of light but little illumination.
{"title":"Ovarian Function Suppression: Is it the Right Time to Jump the Gun?","authors":"S. Jandyal, J. Bajpai","doi":"10.4172/2329-6771.1000183","DOIUrl":"https://doi.org/10.4172/2329-6771.1000183","url":null,"abstract":"Ovarian function suppression (OFS) an old endocrine therapy has been tested in premenopausal women with early breast cancer (EBC) but not widely accepted in modern practice. The question is re-addressed in recent big trials, however the big dilemma doesn't resolved. This perspective touch upon the ancient as well as current evidence of OFS in these young early breast cancer women and try to enlighten the readers further on this controversial topic wherein there is lots of light but little illumination.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"82 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79359527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4172/2329-6771.1000201
M. S. Ali
Cancer is a good example where randomized experiments may not be good enough to evaluate effectiveness of care. On one hand, care is a process in a dynamic system, spanning from primary prevention through long-term survival and end-of-life care, involving multiple steps and interfaces that need to proceed smoothly in contracts to a reductionist approach which focuses on improvements in specific technical aspects of care and not the system. The totality of the diagnostic and treatment advances brought by the reductionist approach is less than the integrated care that is desired [1]. On the other hand, cancer patients turn to complementary and alternative medicine, influenced by cultural beliefs, expectations, and family and social support, in hopes of improving clinical outcomes controlling symptoms, and enhancing quality of life [2,3]. Such complementary and alternative therapies include acupuncture, yoga, hypnosis, meditation, guided imagery, biofeedback, aromatherapy, herbal remedies, massages integrated in to the conventional care [2,4]. Existing evidence suggest that the use of alternative medicines instead of conventional treatment is associated with worsened survival [5]. To help patients make informed decisions and improve quality of care, practicing oncologists and health care professionals need to have evidence on how multiple level of influence impact quality of care in addition to the benefit and risk of the different alternative therapies in an integrated healthcare system.
{"title":"Statistical Tool in Integrated Oncology: Propensity Score Methods","authors":"M. S. Ali","doi":"10.4172/2329-6771.1000201","DOIUrl":"https://doi.org/10.4172/2329-6771.1000201","url":null,"abstract":"Cancer is a good example where randomized experiments may not be good enough to evaluate effectiveness of care. On one hand, care is a process in a dynamic system, spanning from primary prevention through long-term survival and end-of-life care, involving multiple steps and interfaces that need to proceed smoothly in contracts to a reductionist approach which focuses on improvements in specific technical aspects of care and not the system. The totality of the diagnostic and treatment advances brought by the reductionist approach is less than the integrated care that is desired [1]. On the other hand, cancer patients turn to complementary and alternative medicine, influenced by cultural beliefs, expectations, and family and social support, in hopes of improving clinical outcomes controlling symptoms, and enhancing quality of life [2,3]. Such complementary and alternative therapies include acupuncture, yoga, hypnosis, meditation, guided imagery, biofeedback, aromatherapy, herbal remedies, massages integrated in to the conventional care [2,4]. Existing evidence suggest that the use of alternative medicines instead of conventional treatment is associated with worsened survival [5]. To help patients make informed decisions and improve quality of care, practicing oncologists and health care professionals need to have evidence on how multiple level of influence impact quality of care in addition to the benefit and risk of the different alternative therapies in an integrated healthcare system.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"108 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81178216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4172/2329-6771.1000182
B. V. Wyk, K. Dumela, Van der Merwe Dg
This study aimed to collect and analyze the recorded daily setup parameters of the bed as incidentally captured on an integrated record and verify system. This was done on some radical head and neck patients treated from 2008 to 2010 at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) in South Africa. Most of these patients had anterior neck fields that were set-up using fixed couch longitudinal movements (meaning more than one treatment isocentre). It was hoped that the ideal absolute position of the patient on the bed relative to the isocentre of the treatment machine, for a course of head and neck radiotherapy at CMJAH, could be established. Knowledge of the set-up margin achievable could also assist in defining the tolerance assigned to couch parameters on the electronic record and verify system, such that setup is restricted accordingly.
{"title":"Analysis of Set-up Parameters in Head and Neck Patients at the Charlotte Maxeke Johannesburg Academic Hospital (A Review of Current Clinical Practice)","authors":"B. V. Wyk, K. Dumela, Van der Merwe Dg","doi":"10.4172/2329-6771.1000182","DOIUrl":"https://doi.org/10.4172/2329-6771.1000182","url":null,"abstract":"This study aimed to collect and analyze the recorded daily setup parameters of the bed as incidentally captured on an integrated record and verify system. This was done on some radical head and neck patients treated from 2008 to 2010 at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) in South Africa. Most of these patients had anterior neck fields that were set-up using fixed couch longitudinal movements (meaning more than one treatment isocentre). It was hoped that the ideal absolute position of the patient on the bed relative to the isocentre of the treatment machine, for a course of head and neck radiotherapy at CMJAH, could be established. Knowledge of the set-up margin achievable could also assist in defining the tolerance assigned to couch parameters on the electronic record and verify system, such that setup is restricted accordingly.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"22 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85913261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4172/2329-6771.1000189
M. Z. Zafar, M. Asim, Muhammad Ahsan, T. Bashir, S. Rasheed
Typhoid fever is an infection caused by a strain of bacteria called Salmonella typhi, which is related to the bacteria that causes salmonella food poisoning. The infection can affect the whole body and damage multiple organs. Unless treated, this infection can have life threatening consequences. A 20 year old girl was examined suffering from high fever from one week and abdominal pain for few days. The patient had suffered from typhoid fever last year. Ultra-sonogram of abdominal, hematology-cell analysis, serology (widal test), urine analysis and blood culture were performed for accurate diagnosis. Ultra-sonogram shows multiple organ infection by Salmonella typhi. Hematological analysis shows the elevated level of tlymphocytes and anemia. In widal test, patient serum was agglutinated with the bacterial antigen i.e. lipopolysaccharide and flagellar proteins. The typhidot test was positive for IgG. The patient was diagnosed with typhoid fever. Patient possesses multi drug resistance and the rational treatment was with ceftriaxone for one week and patient recovered.
{"title":"A Case Report \"Typhoid Resistant to Chloramphenicol\"","authors":"M. Z. Zafar, M. Asim, Muhammad Ahsan, T. Bashir, S. Rasheed","doi":"10.4172/2329-6771.1000189","DOIUrl":"https://doi.org/10.4172/2329-6771.1000189","url":null,"abstract":"Typhoid fever is an infection caused by a strain of bacteria called Salmonella typhi, which is related to the bacteria that causes salmonella food poisoning. The infection can affect the whole body and damage multiple organs. Unless treated, this infection can have life threatening consequences. A 20 year old girl was examined suffering from high fever from one week and abdominal pain for few days. The patient had suffered from typhoid fever last year. Ultra-sonogram of abdominal, hematology-cell analysis, serology (widal test), urine analysis and blood culture were performed for accurate diagnosis. Ultra-sonogram shows multiple organ infection by Salmonella typhi. Hematological analysis shows the elevated level of tlymphocytes and anemia. In widal test, patient serum was agglutinated with the bacterial antigen i.e. lipopolysaccharide and flagellar proteins. The typhidot test was positive for IgG. The patient was diagnosed with typhoid fever. Patient possesses multi drug resistance and the rational treatment was with ceftriaxone for one week and patient recovered.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"719 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87339817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-24DOI: 10.4172/2329-6771.1000181
Tomasz WaÅniewski, Joanna Staszkiewicz, Izabela WocÅawek-Potocka
Lysophosphatidic acid (LPA), one of the simplest and most potent lysophospholipids exerting many physiological and pathological actions on various cell types, plays also an essential role in tumorigenesis and cancer metastasis. Overexpression of LPA and its receptors is a common phenomenon in metastatic carcinomas that can be used in new diagnostics strategies. Both, in the ovarian and endometrial cancer cells, LPA activates various signal transduction pathways, leading to the increased proliferation and metastatic abilities of the cells. In this review we would like to prove that development of potential treatment strategies by targeting LPA has a great promise in therapeutics.
{"title":"Lysophosphatidic Acid- A Target in Ovarian and Endometrial Cancer Therapy","authors":"Tomasz WaÅniewski, Joanna Staszkiewicz, Izabela WocÅawek-Potocka","doi":"10.4172/2329-6771.1000181","DOIUrl":"https://doi.org/10.4172/2329-6771.1000181","url":null,"abstract":"Lysophosphatidic acid (LPA), one of the simplest and most potent lysophospholipids exerting many physiological \u0000 and pathological actions on various cell types, plays also an essential role in tumorigenesis and cancer metastasis. \u0000 Overexpression of LPA and its receptors is a common phenomenon in metastatic carcinomas that can be used in \u0000 new diagnostics strategies. Both, in the ovarian and endometrial cancer cells, LPA activates various signal \u0000 transduction pathways, leading to the increased proliferation and metastatic abilities of the cells. In this review we \u0000 would like to prove that development of potential treatment strategies by targeting LPA has a great promise in \u0000 therapeutics.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"11 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88899131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-01DOI: 10.4172/2329-6771.1000180
M. Bandar, Yoon Dae Han, M. Cho, H. Hur, B. Min, K. Lee, N. Kim
Background and objectives: Advanced rectal cancers require local and systemic control. Chemo radiotherapy (CRT) is adequate to achieve adequate local control. Systemic control, however, is a dominant obstacle remained in debates. We compared oncology outcome in both arms in patients with advanced rectal cancers in order to identify high-risk group of distant metastasis. Methods: Data for 723 patients for advanced rectal cancer from 2005 to 2013 retrieved retrospectively. Patients were classified to CRT (n=364) or no CRT (n=359) arms. Results: CRT group showed greater local control and achieved pT stage 0, 1, or 2 in 43.7% vs. 28.4% in no CRT (p<0.001) and less CEA marker (11.17 ± 25.2 vs. 6.14 ± 11.3, p<0.001), respectively. Although CRT group had higher rates of advanced tumors, cT3 or T4 (341(93.7%) vs. 294(81.9%), p<0.001) and CRM threat (167 (45.9%) vs. 30(8.4%); p<0.001). Overall local recurrence rate observed in no CRT 3% compared to 2.1% in CRT arm, (p<0.005). Systemic recurrence rate was similar in both groups, (22.5% vs. 23%), respectively. Conclusion: CRT is efficient to downstage locally advanced rectal cancer, not systemic control though. Early recognition of high-risk group is recommended in order to consider CRT modification ahead of planned surgery.
{"title":"Impact of Preoperative Chemo-radiation Therapy on Systemic Failure in LocallyAdvanced Rectal Cancer","authors":"M. Bandar, Yoon Dae Han, M. Cho, H. Hur, B. Min, K. Lee, N. Kim","doi":"10.4172/2329-6771.1000180","DOIUrl":"https://doi.org/10.4172/2329-6771.1000180","url":null,"abstract":"Background and objectives: Advanced rectal cancers require local and systemic control. Chemo radiotherapy (CRT) is adequate to achieve adequate local control. Systemic control, however, is a dominant obstacle remained in debates. We compared oncology outcome in both arms in patients with advanced rectal cancers in order to identify high-risk group of distant metastasis. Methods: Data for 723 patients for advanced rectal cancer from 2005 to 2013 retrieved retrospectively. Patients were classified to CRT (n=364) or no CRT (n=359) arms. Results: CRT group showed greater local control and achieved pT stage 0, 1, or 2 in 43.7% vs. 28.4% in no CRT (p<0.001) and less CEA marker (11.17 ± 25.2 vs. 6.14 ± 11.3, p<0.001), respectively. Although CRT group had higher rates of advanced tumors, cT3 or T4 (341(93.7%) vs. 294(81.9%), p<0.001) and CRM threat (167 (45.9%) vs. 30(8.4%); p<0.001). Overall local recurrence rate observed in no CRT 3% compared to 2.1% in CRT arm, (p<0.005). Systemic recurrence rate was similar in both groups, (22.5% vs. 23%), respectively. Conclusion: CRT is efficient to downstage locally advanced rectal cancer, not systemic control though. Early recognition of high-risk group is recommended in order to consider CRT modification ahead of planned surgery.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83555934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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