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Determination of Physicochemical and Functional Properties of Coconut Oil by Incorporating Bioactive Compounds in Selected Spices. 通过在选定香料中加入生物活性化合物确定椰子油的理化和功能特性
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2020-07-28 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8853940
Dilini N Perera, Geeth G Hewavitharana, S B Navaratne

Lipid oxidation has been identified as a major deterioration process of vegetable oils, which leads to the production of primary and secondary oxidative compounds that are harmful to human health. Oleoresins of ginger, garlic, nutmeg, pepper, cloves, and cinnamon were extracted and incorporated into coconut oil, and change occurrence on physicochemical properties, thermal stability, shelf life, and antioxidant activity was monitored against the same properties of pure coconut oil. Lipid oxidation was assessed in terms of the free fatty acid level and peroxide value. For the comparison purpose, another oil sample was prepared by incorporating vitamin E too. Results revealed that both peroxide value and FFA of pure and flavored coconut oil samples after a one-week storage period were 3.989 ± 0.006 and 3.626 ± 0.002 mEq/kg and 0.646 ± 0.001 and 0.604 ± 0.002 (%), respectively. Saponification value, iodine value, smoke point, and the flashpoint of flavored oil were decreased while increasing the viscosity during storage. The highest phenolic content and DPPH free radical scavenging activity were found in flavored coconut oil. Since spices containing antioxidants, the thermal stability of flavored oil was better than that of pure coconut oil. Both oleoresins and vitamin E-incorporated samples showed the same pattern of increment of FFA and peroxide value during storage; however, those increments were slower than those of pure coconut oil.

脂质氧化被认为是植物油的主要变质过程,会产生对人体健康有害的初级和次级氧化化合物。我们提取了生姜、大蒜、肉豆蔻、胡椒、丁香和肉桂的油树脂并将其加入椰子油中,对照纯椰子油的相同特性,监测其在理化特性、热稳定性、保质期和抗氧化活性方面发生的变化。根据游离脂肪酸水平和过氧化值对脂质氧化进行了评估。为了进行比较,还加入了维生素 E 制备了另一种油样。结果显示,纯椰子油和风味椰子油样品在储存一周后的过氧化值和游离脂肪酸含量分别为 3.989 ± 0.006 和 3.626 ± 0.002 mEq/kg,0.646 ± 0.001 和 0.604 ± 0.002 (%)。在贮藏过程中,风味油的皂化值、碘值、烟点和闪点降低,而粘度增加。风味椰子油的酚含量和 DPPH 自由基清除活性最高。由于香料中含有抗氧化剂,风味油的热稳定性优于纯椰子油。油脂和维生素 E 混合物样品在贮藏过程中显示出相同的脂肪酸和过氧化值的增加模式,但增加速度比纯椰子油慢。
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引用次数: 0
Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule. 叛逆的脂蛋白(a):对影响脂蛋白(a)分子的结构、功能、代谢、致病性和药物的新认识》。
IF 5.9 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2020-02-01 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3491764
Motasim M Jawi, Jiri Frohlich, Sammy Y Chan

Lipoprotein(a) [Lp(a)], aka "Lp little a", was discovered in the 1960s in the lab of the Norwegian physician Kåre Berg. Since then, we have greatly improved our knowledge of lipids and cardiovascular disease (CVD). Lp(a) is an enigmatic class of lipoprotein that is exclusively formed in the liver and comprises two main components, a single copy of apolipoprotein (apo) B-100 (apo-B100) tethered to a single copy of a protein denoted as apolipoprotein(a) apo(a). Plasma levels of Lp(a) increase soon after birth to a steady concentration within a few months of life. In adults, Lp(a) levels range widely from <2 to 2500 mg/L. Evidence that elevated Lp(a) levels >300 mg/L contribute to CVD is significant. The improvement of isoform-independent assays, together with the insight from epidemiologic studies, meta-analyses, genome-wide association studies, and Mendelian randomization studies, has established Lp(a) as the single most common independent genetically inherited causal risk factor for CVD. This breakthrough elevated Lp(a) from a biomarker of atherosclerotic risk to a target of therapy. With the emergence of promising second-generation antisense therapy, we hope that we can answer the question of whether Lp(a) is ready for prime-time clinic use. In this review, we present an update on the metabolism, pathophysiology, and current/future medical interventions for high levels of Lp(a).

脂蛋白(a)[Lp(a)],又名 "Lp little a",于 20 世纪 60 年代在挪威医生卡雷-伯格(Kåre Berg)的实验室中被发现。从那时起,我们对血脂和心血管疾病(CVD)的认识有了很大提高。脂蛋白(a)是一类神秘的脂蛋白,只在肝脏中形成,由两种主要成分组成,一种是单拷贝的载脂蛋白(apo)B-100(apo-B100),另一种是单拷贝的载脂蛋白(a)apo(a)。脂蛋白(a)的血浆水平在出生后不久就会上升,并在出生后几个月内达到稳定浓度。在成人中,脂蛋白(a)水平的范围很广,从 300 毫克/升到对心血管疾病的影响很大。不依赖于同工酶的检测方法的改进,以及流行病学研究、荟萃分析、全基因组关联研究和孟德尔随机化研究的深入分析,确立了脂蛋白(a)是心血管疾病最常见的独立遗传因果风险因素。这一突破将脂蛋白(a)从动脉粥样硬化风险的生物标志物提升为治疗目标。随着前景看好的第二代反义疗法的出现,我们希望能回答脂蛋白(a)是否已准备好用于临床的问题。在这篇综述中,我们将介绍有关高水平脂蛋白(a)的代谢、病理生理学和当前/未来医疗干预措施的最新情况。
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引用次数: 0
A Transcriptional Regulatory System of theS. cerevisiae OLE1Gene Responds to Fatty Acid Species and Intracellular Amount, and not Simply Membrane Status 这些基因的转录调控系统。酿酒酵母ole1基因响应脂肪酸种类和细胞内数量,而不仅仅是膜状态
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2020-01-25 DOI: 10.1155/2020/3903257
M. Willey, M. Ochs, Clara Busse, V. McDonough
We examined the effects of unsaturated fatty acid (UFA) species and their concentration on the expression ofOLE1,which encodes the stearoyl CoA desaturase, inSaccharomyces cerevisiae. We controlled the amount of UFA taken up by the cell by varying the concentration of tergitol in the medium. When cultured with 1 mM fatty acid in 0.1% tergitol, cells took up much more fatty acid than when cultured with the same concentration of fatty acid at 1% tergitol, although the amount incorporated was dependent on UFA species. For each fatty acid tested, we found that the higher uptake (0.1% tergitol condition) had a stronger impact onOLE1regulation. A principal product of the desaturase 16:1∆9, and the nonnative UFA 18:2∆9,12, most strongly repressed the reporter constructOLE1-lacZtranscription, while the other major product of the desaturase, 18:1∆9, and the nonnative UFA 17:1∆10 caused a more diminished response. Based on these results, our initial hypothesis was thatOLE1was regulated in response to membrane fluidity; however, subsequent work does not support that idea; we have found that conditions that affect membrane fluidity such as growth temperature and growth with saturated ortransfatty acid supplementation, do not regulateOLE1in the direction predicted by fluidity changes. We conclude that at least one signal that regulatesOLE1transcriptional expression is most likely based on the fatty acids themselves.
我们研究了不饱和脂肪酸(UFA)种类及其浓度对酿酒酵母中编码硬脂酰辅酶a去饱和酶的ole1表达的影响。我们通过改变培养基中特吉糖醇的浓度来控制细胞吸收UFA的量。在0.1%特吉糖醇中添加1 mM脂肪酸培养时,细胞对脂肪酸的吸收比在相同浓度的1%特吉糖醇中培养时要多得多,尽管其吸收量与UFA种类有关。对于测试的每种脂肪酸,我们发现较高的摄取(0.1%特吉糖醇条件)对ole1调节的影响更大。去饱和酶的主要产物16:1∆9和非原生UFA的18:2∆9,12,最强烈地抑制了报告基因构建e1 - lacz转录,而去饱和酶的另一个主要产物18:1∆9和非原生UFA的17:1∆10引起了更大的反应减弱。基于这些结果,我们最初的假设是ole1受到膜流动性的调节;然而,随后的研究并不支持这一观点;我们发现,影响膜流动性的条件,如生长温度和饱和脂肪酸或反式脂肪酸的补充,并没有按照流动性变化预测的方向调节ole1。我们得出结论,至少有一个调节ole1转录表达的信号很可能是基于脂肪酸本身。
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引用次数: 1
Effects of Cinnamon (Cinnamomum cassia) Consumption on Serum Lipid Profiles in Albino Rats. 肉桂对白化大鼠血脂的影响。
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2020-01-23 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8469830
Fahadah Naeef Alsoodeeri, Hissah Mohammed Alqabbani, Norah Mubarak Aldossari

Dyslipidemia is an important cause of cardiovascular diseases (CVDs), which are the most prevalent causes of morbidity and mortality. The purpose of this study was to assess the effects of cinnamon on body weight gain, food intake, and serum lipid profiles of albino rats. This study was conducted on 30 healthy male albino rats weighing approximately 130 ± 5 g. The study was divided into the following two experiments: experiment (1), wherein rats were fed a laboratory diet; and experiment (2), wherein rats were fed a high-fat diet. In experiment 1, a total of 15 rats were divided into three groups. Group A (n = 5, untreated control) was fed laboratory diet, Group B (n = 5) was fed laboratory diet and cinnamon powder (2 g/kg body weight), and Group C (n = 5) was fed laboratory diet and cinnamon powder (4 g/kg body weight) for 30 days. In experiment (2), a total of 15 rats were similarly divided into three groups. Group D (n = 5, treated control) was fed laboratory diet plus high-fat diet, Group E (n = 5) was fed cinnamon powder (2 g/kg body weight) mixed with laboratory diet plus high-fat diet, and Group F (n = 5) was fed cinnamon powder (4 g/kg body weight) mixed with laboratory diet plus high-fat diet daily for 30 days. An administration of 4 g/kg body weight of cinnamon extract powder decreased the final weight by 4.4%, body weight gains by 31.41%, food intake by 1.7%, and food efficiency ratio by 22.38% in hypercholesterolemic adult male rats as well as serum total cholesterol by 31.22%, triglyceride by 24.05%, and LDL-C by 43.49%, with an increase in the levels of HDL-C by 30.16%, furthermore, a significant decrease in serum total cholesterol, triglycerides, and LDL-C levels and increasing serum HDL-C on day 30 were observed (P < 0.001). This finding provides scientific evidence to substantiate the traditional use of cinnamon to treat hyperlipidemia.

血脂异常是导致心血管疾病(cvd)的重要原因,心血管疾病是最常见的发病和死亡原因。本研究的目的是评估肉桂对白化大鼠体重增加、食物摄入和血脂的影响。本研究以体重约130±5 g的健康雄性白化大鼠30只为实验对象。研究分为以下两个实验:实验(1),给大鼠喂食实验室饲料;实验(2)给大鼠喂食高脂肪食物。实验1将15只大鼠分为三组。A组(n = 5)饲喂实验室饲粮,B组(n = 5)饲喂实验室饲粮和肉桂粉(2 g/kg体重),C组(n = 5)饲喂实验室饲粮和肉桂粉(4 g/kg体重),试验期30 d。在实验(2)中,15只大鼠同样分为三组。D组(n = 5)饲喂实验室饲粮+高脂饲粮,E组(n = 5)饲喂肉桂粉(2 g/kg体重)与实验室饲粮混合+高脂饲粮,F组(n = 5)饲喂肉桂粉(4 g/kg体重)与实验室饲粮混合+高脂饲粮,连续30 D。给药4 g/kg体重的肉桂提取物粉使高胆固醇血症成年雄性大鼠终重降低4.4%,增重31.41%,进食量降低1.7%,食物效率提高22.38%,血清总胆固醇降低31.22%,甘油三酯降低24.05%,LDL-C降低43.49%,HDL-C水平提高30.16%,血清总胆固醇、甘油三酯、第30天LDL-C水平升高,血清HDL-C升高(P < 0.001)。这一发现为肉桂治疗高脂血症提供了科学依据。
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引用次数: 26
Corrigendum to "Dietary Lipids in Health and Disease". “健康与疾病中的膳食脂质”的勘误表。
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2020-01-20 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5704752
Kamal A Amin, Abdelgadir M Homeida, Reda H ElMazoudy, Khalid S Hashim, Mahdi Garelnabi

[This corrects the article DOI: 10.1155/2019/5729498.].

[这更正了文章DOI: 10.1155/2019/5729498.]
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引用次数: 1
Prevalence of Dyslipidemia in Undiagnosed Palestinian Men: A Cross-Sectional Study 巴勒斯坦未确诊男性血脂异常患病率:一项横断面研究
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2019-10-13 DOI: 10.1155/2019/3473042
Iyad Ali, Aya Kharma, Malaka Samara, Samar Odeh, N. Jaradat, A. Zaid, Mahdi Al Sayed Ahmad
Introduction Dyslipidemia is the most important modifiable risk factor that leads to cardiovascular diseases. The screening for dyslipidemia in Palestine is not established in primary health care centers for healthy people. Our study aims to determine the prevalence of dyslipidemia among healthy undiagnosed adult men in Palestine in order to assess the need for screening and preventive programs for dyslipidemia. Materials and Methods A cross-sectional observational study was carried out in 10 secondary schools at Nablus municipality (Palestine) from August 2017 to February 2018. The study included 140 teachers based on sample calculations. The age of participants ranged between 24 and 60 years. A questionnaire was used to collect demographic data about the lifestyle, past medical, and family histories. Serum lipid profile, and fasting blood glucose levels for each participant were measured. Lipoprotein levels were categorized based on the adult treatment panel III criteria. Results The overall prevalence of dyslipidemia among Palestinian men was 66.4%. The most prevalent type of dyslipidemia was hypo HDL (X < 40 mg/dl, 59.3%), followed by hypertriglyceridemia (X ≥ 200 mg/dl, 20%). The prevalence of hyper LDL (X ≥ 160 mg/dl), hypercholesterolemia (X ≥ 240 mg/dl) was 8.5%, and 3.6%, respectively. About 15% of participants had glucose intolerance, and 4.3% had hyperglycemia (undiagnosed). Those with glucose intolerance, 13 (9.2%) have hypo HDL, while 9 (6.42%) have hypertriglyceridemia. On the other hand, out of hyperglycemic patients: 5 (3.5%) had hypo HDL, and 1 (0.7%) had hypertriglyceridemia. Conclusion Around two-thirds of undiagnosed participants had at least one lipid abnormality. None of them were aware of having dyslipidemia. The prevalence of undiagnosed dyslipidemia was higher than the prevalence of undiagnosed glucose intolerance, and diabetes. This suggests that dyslipidemia plays a major role in developing diabetes. Hence, profound efforts should be done to manage and treat those with dyslipidemia, in order to prevent progression to type II diabetes mellitus.
血脂异常是导致心血管疾病最重要的可改变危险因素。巴勒斯坦的初级卫生保健中心没有为健康人建立血脂异常筛查。我们的研究旨在确定巴勒斯坦未确诊的健康成年男性血脂异常的患病率,以评估对血脂异常进行筛查和预防计划的必要性。材料与方法于2017年8月至2018年2月在巴勒斯坦纳布卢斯市的10所中学开展了一项横断面观察研究。根据抽样计算,该研究包括140名教师。参与者的年龄在24岁到60岁之间。调查问卷用于收集有关生活方式、既往病史和家族史的人口统计数据。测量每位参与者的血清脂质谱和空腹血糖水平。脂蛋白水平根据成人治疗组III标准进行分类。结果巴勒斯坦男性血脂异常总体患病率为66.4%。最常见的血脂异常类型是低HDL (X < 40 mg/dl, 59.3%),其次是高甘油三酯血症(X≥200 mg/dl, 20%)。高LDL (X≥160 mg/dl)和高胆固醇血症(X≥240 mg/dl)的患病率分别为8.5%和3.6%。大约15%的参与者患有葡萄糖耐受不良,4.3%患有高血糖症(未确诊)。葡萄糖耐受不良的患者中,13例(9.2%)有低HDL, 9例(6.42%)有高甘油三酯血症。另一方面,在高血糖患者中:5例(3.5%)患有低HDL, 1例(0.7%)患有高甘油三酯血症。结论:约三分之二未确诊的参与者至少有一种脂质异常。他们都没有意识到自己患有血脂异常。未确诊的血脂异常的患病率高于未确诊的葡萄糖耐受不良和糖尿病的患病率。这表明血脂异常在糖尿病的发生中起着重要作用。因此,为了防止发展为II型糖尿病,我们应该努力管理和治疗这些血脂异常患者。
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引用次数: 6
Dietary Lipids in Health and Disease 膳食脂在健康和疾病中的作用
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2019-07-01 DOI: 10.1155/2019/5729498
K. Amin, A. M. Homeida, Reda H. El Mazoudy, Khalid S. Hashim, M. Garelnabi
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引用次数: 3
Acacia Senegal (Gum Arabic) Supplementation Modulate Lipid Profile and Ameliorated Dyslipidemia among Sickle Cell Anemia Patients 补充阿拉伯胶可调节镰状细胞性贫血患者的脂质分布和改善血脂异常
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2019-06-18 DOI: 10.1155/2019/3129461
L. Kaddam, imad Mohamed Fadl Elmula, O. A. Eisawi, Haydar Awad Abdelrazig, A. Saeed
Background Sickle cell disease (SCD) is an inherited haemolytic anemia with a variable course and severity. Knowledge of prognostic biomarkers may help in the establishment of therapeutic intervention, management, and follow-up of patients. There have been scattered reports of low high-density lipoprotein cholesterol (HDL-C) and increased triglyceride (TG) in SCD patients. In addition, TG levels have been suggested to be elevated in patients with increased endothelial activation. An increased TG level has been associated with haemolysis, vascular dysfunction, and increased prevalence of pulmonary hypertension. Gum Arabic (GA) is an edible, dried, gummy exudate from the acacia Senegal tree. Several studies on GA ingestion have shown reduced plasma cholesterol and low-density lipoprotein (LDL) concentrations in both animals and humans. We investigated GA's therapeutic potential to modulate serum lipids in patients with sickle cell anemia. Methods This study recruited and documented secondary outcomes in 47 patients (aged 5–42 years) carrying hemoglobin SS. The patients received 30 g/day of GA for 12 weeks. Total cholesterol, TG, LDL, and HDL were measured before and after GA intake. Cobas C311 (Roche, Germany) automated chemistry analyser was used for direct determination of the values of the lipid profile. Results GA significantly decreased total cholesterol (TC), TG, and LDL (p = 0.006, 0.04, and 0.02, resp.). GA showed no effect on HDL level. Baseline serum TG and LDL correlated significantly with the hydrogen peroxide (H2O2) level, which is known as an oxidative stress marker (p = 0.003 and 0.04, resp.). None of the lipid profile elements correlated with age. Conclusion Our results revealed that dyslipidemia in sickle cell patients is associated with oxidative stress but not associated with age. The findings showed that GA significantly decreased TC, LDL, and TG levels, revealing a novel effect of GA, which is considered a natural dietary fibre that can modulate lipid profile in patients with sickle cell anemia. Trial Registration This retrospective trial is registered with ClinicalTrials.gov Identifier: NCT02467257 on 3 June, 2015.
背景镰状细胞病(SCD)是一种病程和严重程度不同的遗传性溶血性贫血。了解预后生物标志物可能有助于建立治疗干预、管理和患者随访。在SCD患者中有低高密度脂蛋白胆固醇(HDL-C)和甘油三酯(TG)升高的零散报道。此外,研究表明,内皮细胞活化增加的患者TG水平也会升高。TG水平升高与溶血、血管功能障碍和肺动脉高压患病率增加有关。阿拉伯胶(GA)是一种可食用的,干燥的,粘状渗出物,来自塞内加尔阿拉伯胶树。几项关于GA摄入的研究表明,动物和人类的血浆胆固醇和低密度脂蛋白(LDL)浓度均有所降低。我们研究了GA在镰状细胞性贫血患者中调节血脂的治疗潜力。方法本研究招募并记录了47例携带血红蛋白SS的患者(5-42岁)的次要结局。患者接受30 g/天的GA治疗,持续12周。摄入GA前后分别测量总胆固醇、TG、LDL和HDL。使用Cobas C311 (Roche, Germany)自动化学分析仪直接测定脂质谱值。结果GA显著降低总胆固醇(TC)、TG和LDL (p = 0.006、0.04和0.02)。GA对HDL水平无影响。基线血清TG和LDL与过氧化氢(H2O2)水平显著相关,过氧化氢被称为氧化应激标志物(p = 0.003和0.04,分别对应)。脂质谱元素与年龄无关。结论镰状细胞患者血脂异常与氧化应激有关,但与年龄无关。研究结果显示,GA显著降低TC、LDL和TG水平,揭示了GA的一种新作用,GA被认为是一种天然膳食纤维,可以调节镰状细胞性贫血患者的脂质特征。该回顾性试验于2015年6月3日在ClinicalTrials.gov注册,注册编号:NCT02467257。
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引用次数: 10
Scavenger Receptor Class B Member 1 Independent Uptake of Transthyretin by Cultured Hepatocytes Is Regulated by High Density Lipoprotein 体外培养肝细胞对清道夫受体B类成员1的独立摄取受高密度脂蛋白的调控
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2019-06-18 DOI: 10.1155/2019/7317639
K. Landers, M. d’Emden, K. Richard
Thyroid hormone (thyroxine, T4) is essential for the normal function of all cell types and is carried in serum bound to several proteins including transthyretin. Recently, evidence has emerged of alternate pathways for hormone entry into cells that are dependent on hormone binding proteins. Transthyretin and transthyretin bound T4 are endocytosed by placental trophoblasts through the high-density lipoprotein receptor, Scavenger Receptor Class B Type 1 (SR-B1). High density lipoprotein (HDL) affects the expression and function of SR-B1 in trophoblast cells. SR-B1 is also expressed in hepatocytes and we sought to determine if hepatocyte SR-B1 was involved in transthyretin or transthyretin-T4 uptake and whether uptake was affected by HDL. Transthyretin and transthyretin-T4 uptake by hepatocytes is not dependent on SR-B1. HDL treatment reduced SR-B1 expression. However, pretreatment of hepatocytes with HDL increased uptake of transthyretin-T4. Knockdown of SR-B1 expression using siRNA also increased transthyretin-T4 uptake. Coaddition of HDL to transthyretin uptake experiments blocked both transthyretin and transthyretin-T4 uptake. Hepatocyte uptake of transthyretin-T4 uptake is influenced by, but is not dependent on, SR-B1 expression. HDL also decreases transthyretin-T4 uptake and therefore diet or drugs may interfere with this process. This suggests that multiple lipoprotein receptors may be involved in the regulation of uptake of transthyretin-T4 in a cell-type specific manner. Further study is required to understand this important process.
甲状腺激素(甲状腺素,T4)对所有细胞类型的正常功能至关重要,并在血清中与包括转甲状腺素在内的几种蛋白质结合。最近,有证据表明激素进入细胞的其他途径依赖于激素结合蛋白。转甲状腺素和转甲状腺素结合的T4通过高密度脂蛋白受体B类1型清道夫受体(SR-B1)被胎盘滋养细胞内吞。高密度脂蛋白(HDL)影响滋养细胞SR-B1的表达和功能。SR-B1也在肝细胞中表达,我们试图确定肝细胞SR-B1是否参与转甲状腺素或转甲状腺素- t4的摄取,以及摄取是否受到HDL的影响。肝细胞对促甲状腺素和促甲状腺素- t4的摄取不依赖于SR-B1。HDL治疗降低SR-B1表达。然而,用HDL预处理肝细胞会增加转甲状腺素- t4的摄取。使用siRNA敲低SR-B1表达也会增加甲状腺素- t4的摄取。在转甲状腺素摄取实验中加入HDL可阻断转甲状腺素和转甲状腺素- t4的摄取。肝细胞对转甲状腺素- t4的摄取受SR-B1表达的影响,但不依赖于SR-B1表达。高密度脂蛋白也会减少甲状腺素- t4的摄取,因此饮食或药物可能会干扰这一过程。这表明多种脂蛋白受体可能以细胞类型特异性的方式参与促甲状腺素- t4摄取的调节。要了解这一重要过程,还需要进一步的研究。
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引用次数: 3
Dyslipidemia Associated with Hypertension Increases the Risks for Coronary Heart Disease: A Case-Control Study in Harapan Kita Hospital, National Cardiovascular Center, Jakarta. 与高血压相关的血脂异常增加冠心病的风险:雅加达国家心血管中心Harapan Kita医院的病例对照研究
IF 5.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2019-04-30 eCollection Date: 2019-01-01 DOI: 10.1155/2019/2517013
Rea Ariyanti, Besral Besral

Background. Coronary Heart Disease (CHD) is the main highlight of the major cardiovascular diseases. In Indonesia, CHD is the leading cause of death from all deaths, with rates reaching 26.4%, which is four times greater than cancer mortality rates. Objective. This study aims to determine whether dyslipidemia associated with hypertension increases the risks for the incidence of CHD in Harapan Kita Hospital, National Cardiovascular Center, Jakarta, or does not. Methods. The study design was case control. The sample was 163 respondents, 82 respondents in the case group and 81 respondents in the control group. The data were analyzed by using logistic regression. Results. In the CHD group, the percentage of respondents with dyslipidemia was 50%, while in the control group, the percentage of respondents with dyslipidemia was 17.3%. The relationship of dyslipidemia with the incidence of CHD differed according to hypertension status. After being controlled for age, in hypertensive respondents, those with dyslipidemia was 18.1 times more likely to develop CHD compared with those nondyslipidemic, whereas in nonhypertensive respondents, those with dyslipidemia was 2.5 times more likely to develop CHD compared with those nondyslipidemic. Recommendation. It is recommended that the community have medical checkup regularly and change lifestyles by taking healthy diet to control lipid profile and blood pressure.

背景。冠心病(冠心病)是主要心血管疾病的主要亮点。在印度尼西亚,冠心病是导致死亡的主要原因,其死亡率达到26.4%,是癌症死亡率的四倍。目标。本研究旨在确定与高血压相关的血脂异常是否会增加雅加达国立心血管中心Harapan Kita医院冠心病发病率的风险。方法。研究设计为病例对照。样本为163名受访者,病例组为82名受访者,对照组为81名受访者。采用logistic回归对数据进行分析。结果。在冠心病组中,有血脂异常的受访者比例为50%,而在对照组中,有血脂异常的受访者比例为17.3%。血脂异常与冠心病发病率的关系因高血压状况而异。在年龄控制后,在高血压应答者中,血脂异常的人患冠心病的可能性是非血脂异常者的18.1倍,而在非高血压应答者中,血脂异常的人患冠心病的可能性是非血脂异常者的2.5倍。建议。建议市民定期体检,改变生活方式,健康饮食,控制血脂和血压。
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引用次数: 41
期刊
Journal of Lipids
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