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Sunlight: Time for a Rethink? 阳光：是时候反思了吗？
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2023.12.027

UVR is a skin carcinogen, yet no studies link sun exposure to increased all-cause mortality. Epidemiological studies from the United Kingdom and Sweden link sun exposure with reduced all-cause, cardiovascular, and cancer mortality. Vitamin D synthesis is dependent on UVB exposure. Individuals with higher serum levels of vitamin D are healthier in many ways, yet multiple trials of oral vitamin D supplementation show little benefit. Growing evidence shows that sunlight has health benefits through vitamin D–independent pathways, such as photomobilization of nitric oxide from cutaneous stores with reduction in cardiovascular morbidity. Sunlight has important systemic health benefit as well as risks.

紫外线辐射是一种皮肤致癌物质，但没有研究表明日晒与全因死亡率增加有关。英国和瑞典的流行病学研究表明，晒太阳可降低全因死亡率、心血管死亡率和癌症死亡率。维生素 D 的合成依赖于紫外线照射。血清中维生素 D 含量较高的人在许多方面都更健康，但多项口服维生素 D 补充剂的试验表明，维生素 D 补充剂的益处不大。越来越多的证据表明，阳光通过与维生素 D 无关的途径对健康有益，例如从皮肤储存中光动一氧化氮，从而降低心血管发病率。阳光对全身健康既有重要益处，也有风险。
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引用次数: 0
Advances in Hidradenitis Suppurativa Pathogenesis and Therapies from the Symposium on HS Advances 2023 2023 年化脓性扁桃体炎进展研讨会上关于化脓性扁桃体炎发病机制和疗法的研究进展。
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.02.030
Sarah Park , Alexis Bell , Ruby Gibson , Rahul Masson , Steven Daveluy , Stephanie Goldberg , Jennifer Hsiao , Martina Porter , Joslyn Kirby , Vincent Piguet
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引用次数: 0
Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star 成纤维细胞在白癜风中的新作用：昔日被低估的新星。
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.02.007

Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes. Although numerous studies have been conducted on the pathogenesis of vitiligo, the underlying mechanisms remain unclear. Although most studies have focused on melanocytes and keratinocytes, growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin. This review aims to elucidate the role of fibroblasts in both the physiological regulation of skin pigmentation and their pathological contribution to depigmentation, with the goal of shedding light on the involvement of fibroblasts in vitiligo. The topics covered in this review include alterations in the secretome, premature senescence, autophagy dysfunction, abnormal extracellular matrix, autoimmunity, and metabolic changes.

白癜风是一种以黑色素细胞脱失为特征的毁容性色素脱失症。尽管对白癜风的发病机制进行了大量研究，但其基本机制仍不清楚。虽然大多数研究集中于黑色素细胞和角质细胞，但越来越多的证据表明，居住在皮肤深层的真皮成纤维细胞也参与其中。本综述旨在阐明成纤维细胞在皮肤色素沉着的生理调节及其对色素脱失的病理作用，从而揭示成纤维细胞在白癜风中的参与。本综述涉及的主题包括分泌组的改变、早衰、自噬功能障碍、细胞外基质异常、自身免疫和代谢变化。
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引用次数: 0
The Adaptive Immune System: A New Pseudoxanthoma Elasticum Protagonist? 适应性免疫系统：一种新的假黄瘤原体？
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.03.010
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引用次数: 0
Genome-Wide Meta-Analysis Identifies 11 Susceptibility Variants of Vitiligo in the Chinese Han Population 全基因组荟萃分析在中国汉族人群中发现11种白癜风易感变异。
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.01.010

Vitiligo is an autoimmune disease involving loss of melanocytes. Although several genetic studies have confirmed that genetic factors play an important role, its pathogenesis remains incompletely characterized. In this study, a genome-wide meta-analysis was conducted to search for more susceptibility variants of vitiligo. Tang et al performed a GWAS for cohort I (1117 vitiligo cases and 1701 healthy controls) previously, and we conducted a GWAS for cohort II (3323 vitiligo cases and 7186 healthy controls) in this study, with the results subjected to a genome-wide meta-analysis and linkage disequilibrium analysis. We identify, to our knowledge, 11 previously unreported susceptibility variants, of which 6 variants are located in the intronic regions, and the remaining 5 variants are located within intergenic regions between genes. In addition, the results of polygenic risk score show that the best evaluated effect for target data is among significant SNVs of the base data. The susceptibility genes of vitiligo are mainly enriched in the immune-related functions and pathways. The susceptibility variants expand the role of genetic factors associated with vitiligo. The bioinformatics analysis for risk genes provides further insight into the pathogenesis of vitiligo.

白癜风是一种涉及黑色素细胞脱失的自身免疫性疾病。虽然多项遗传学研究证实遗传因素在其中发挥了重要作用，但其发病机制仍未完全定性。本研究进行了一项全基因组荟萃分析（GWMA），以寻找更多的白癜风易感变体。Tang等人曾对队列I（1,117例白癜风病例和1,701例健康对照）进行了全基因组关联研究（GWAS），我们在本研究中对队列II（3,323例白癜风病例和7,186例健康对照）进行了GWAS，并对结果进行了GWMA和连锁不平衡（LD）分析。据我们所知，我们发现了 11 个以前从未报道过的易感性变异，其中 6 个变异位于内含子区，其余 5 个变异位于基因之间的基因间区。此外，PRS 的结果表明，目标数据的最佳评估效果出现在基础数据的重要 SNPs 中。白癜风的易感基因主要富集在与免疫相关的功能和通路中。易感变异扩大了与白癜风相关的遗传因素的作用。对风险基因的生物信息学分析进一步揭示了白癜风的发病机制。
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引用次数: 0
Distinct Signatures of Mitotic Age Acceleration in Cutaneous Melanoma and Acquired Melanocytic Nevi 皮肤黑色素瘤和获得性黑素细胞痣有丝分裂年龄加速的不同特征
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.01.012
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引用次数: 0
047 Donor-derived CD8+ T-lymphocytes re-establish tissue residency and mediate skin graft-versus-host disease 047 源自捐献者的 CD8+ T 淋巴细胞重建组织驻留并介导皮肤移植物抗宿主疾病
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.063
Y. Zhang , Z. Reinstein , S. Ng , J. Lin , A. Pillai , K. Tefft , J. Guitart , J. Choi
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引用次数: 0
085 Dermal papilla cells control hair follicle matrix keratinocytes proliferation through versican 085 皮肤乳头细胞通过 versican 控制毛囊基质角质细胞的增殖
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.101
X. Chen , Z. Song , J. Alfano , Y. Yang , J. Chen
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引用次数: 0
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IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/S0022-202X(24)01743-3
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引用次数: 0
090 Reactive lipids from the secretome of senescent fibroblasts modify the extracellular matrix with functional consequences for resident cells 090 来自衰老成纤维细胞分泌组的活性脂质改变细胞外基质，对驻留细胞产生功能性影响
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.106
S. Jelleschitz , C. Kremslehner , I. Nagelreiter , M. Sochorova , M. Salek , A. Sandgren Fors , N. Noll , A. Stiegler , C. Bauer , M. Fedorova , Z. Ni , G. Gendronneau , A. Tessier , F. Marcato , F. Gruber
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引用次数: 0
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