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Journal of Investigative Dermatology最新文献

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025 Utility of salivary gland biopsy in the diagnosis of Sjögren syndrome 025 唾液腺活检在诊断斯约格伦综合征中的作用
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.041
C.J. Orton , Z. Hopkins , B. Trump , A. Bowen , K. Duffy , D. Wada , S.R. Florell
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引用次数: 0
093 A novel non-canonical function for IRF6 in the recycling of E-cadherin 093 IRF6 在 E-cadherin 循环中的一种新的非规范功能
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.109
A. Antiguas, M. Dunnwald
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引用次数: 0
064 Cutaneous T-cell lymphoma tumors undergoing radiation demonstrate immune shifts from malignant inflammation to wound healing and tissue remodeling 064 接受辐射的皮肤 T 细胞淋巴瘤肿瘤表现出从恶性炎症到伤口愈合和组织重塑的免疫转变
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.080
L. Chrisman, Y. Pang, W. Nguyen, S. Evans, Z. Ren, J. Guitart, X. Zhou
{"title":"064 Cutaneous T-cell lymphoma tumors undergoing radiation demonstrate immune shifts from malignant inflammation to wound healing and tissue remodeling","authors":"L. Chrisman, Y. Pang, W. Nguyen, S. Evans, Z. Ren, J. Guitart, X. Zhou","doi":"10.1016/j.jid.2024.06.080","DOIUrl":"10.1016/j.jid.2024.06.080","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 8","pages":"Page S12"},"PeriodicalIF":5.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
059 Industrial compounds mediate allergic sensitization 059 工业化合物介导过敏致敏作用
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.075
A. Eisenstein , I. Brown-Soler , B. Hilliard , A. Wang
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引用次数: 0
Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model 成本刺激分子 CD226 在小鼠模型中调控特应性皮炎
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.01.022

This study investigated the role of CD226 in a 2,4-dinitrochlorobenzene (DNCB)–induced mouse model of atopic dermatitis. The results showed that the lack of CD226 (global and CD4+ T-cell specific) significantly increased ear thickness, reddening, swelling, and scaling of the skin as well as inflammatory cell and mast cell infiltration. RT-qPCR results demonstrated that the mRNA expressions of atopic dermatitis–related inflammatory cytokines and chemokines were markedly increased in the draining lymph nodes and lesioned ear skin tissues of global and CD4+ T-cell–specific CD226-deficient mice compared with that in control mice. In vitro assessment revealed that CD226 directly modulates TGFβ-mediated regulatory T (Treg) cell differentiation and proliferation. Notably, Treg cell–specific deletion of CD226 (Cd226fl/flFoxp3cre mice) resulted in more severe dermatitis and epidermal thickening than those observed in littermate mice upon DNCB treatment. Subsequent analysis showed that the infiltration of Treg cells in ear lesions and the number of Tregs in the spleen were significantly reduced in Cd226fl/flFoxp3cre mice after DNCB treatment. In addition, the lack of CD226 induced apoptosis of Treg cells through the activation of caspase 3. Therefore, these results suggest that CD226 has potential efficacy in atopic dermatitis, correlating with Treg cell inhibition.

本研究调查了CD226在2,4-二硝基氯苯（DNCB）诱导的特应性皮炎（AD）小鼠模型中的作用。qPCR结果表明，与对照组相比，CD226全基因和CD4+ T细胞特异性缺失小鼠引流淋巴结（dLNs）和病变耳部皮肤组织中与特应性皮炎相关的炎性细胞因子和趋化因子的mRNA表达明显增加。体外评估显示，CD226 可直接调节 TGF-β 介导的调节性 T（Treg）细胞的分化和增殖。值得注意的是，CD226 的 Treg 细胞特异性缺失（Cd226fl/flFoxp3cre 小鼠）导致的皮炎和表皮增厚比 DNCB 处理后的同种小鼠更严重。随后的分析表明，DNCB 处理后，Cd226fl/flFoxp3cre 小鼠耳部皮损中 Treg 细胞的浸润和脾脏中 Treg 的数量显著减少。此外，CD226 的缺乏会通过 Caspase3 的激活诱导 Treg 细胞凋亡。因此，这些结果表明，CD226对AD具有潜在的疗效，这与抑制Treg细胞有关。
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引用次数: 0
Leveraging OpenAI's Advanced Data Analysis Tool in Dermatology: Opportunities and Challenges 在皮肤病学中利用 OpenAI 的高级数据分析工具：机遇与挑战。
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.01.023
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引用次数: 0
033 Thromboembolic risk in dermatomyositis patients treated with intravenous immunoglobulin 033 使用静脉注射免疫球蛋白治疗皮肌炎患者的血栓栓塞风险
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.049
C.T. Chang , S. Khattab , K. Shaw , K. Tang , R. Vleugels , Y. Semenov
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引用次数: 0
001 Deficiency in SLC35E1 aggravates mycobacterium marinum infection in mice 001 SLC35E1 的缺陷会加重小鼠的马氏分枝杆菌感染
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.017
X. Lin, B. Yang, M. Man, X. Wang
{"title":"001 Deficiency in SLC35E1 aggravates mycobacterium marinum infection in mice","authors":"X. Lin,&nbsp;B. Yang,&nbsp;M. Man,&nbsp;X. Wang","doi":"10.1016/j.jid.2024.06.017","DOIUrl":"10.1016/j.jid.2024.06.017","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 8","pages":"Page S1"},"PeriodicalIF":5.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
002 CD36-mediated fatty acid transport in keratinocytes promotes psoriasis through increasing mitochondrial reactive oxygen species 002 CD36 介导的角朊细胞脂肪酸转运通过增加线粒体活性氧促进牛皮癣的发生
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.018
B. Jiang , X. Zhang , J. Lan , J. Tao
{"title":"002 CD36-mediated fatty acid transport in keratinocytes promotes psoriasis through increasing mitochondrial reactive oxygen species","authors":"B. Jiang ,&nbsp;X. Zhang ,&nbsp;J. Lan ,&nbsp;J. Tao","doi":"10.1016/j.jid.2024.06.018","DOIUrl":"10.1016/j.jid.2024.06.018","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 8","pages":"Page S1"},"PeriodicalIF":5.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
005 Ccr6-deficient, auto-immune prone B10.RIII mice demonstrate paradoxical hyper-inflammation in an IL23-driven murine model of psoriatic skin and joint disease 005 Ccr6缺陷、自身免疫易感性B10.RIII小鼠在IL23驱动的银屑病皮肤和关节病小鼠模型中表现出矛盾的炎症亢进现象
IF 5.7 2区 医学 Q1 DERMATOLOGY
Journal of Investigative Dermatology
Pub Date : 2024-08-01 DOI: 10.1016/j.jid.2024.06.021
K. Ren, X. Wu, Z. Shi, S. Hwang
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引用次数: 0
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