Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.238
Gowthami Bainaboina
The effectiveness of fingolimod on clinical and magnetic resonance imaging (MRI) outcomes in patients with multiple sclerosis (MS) has been well established in trials and, to a lesser extent, in the real world
{"title":"Impact of fingolimod on multiple sclerosis","authors":"Gowthami Bainaboina","doi":"10.35248/2376-0389.21.8.238","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.238","url":null,"abstract":"The effectiveness of fingolimod on clinical and magnetic resonance imaging (MRI) outcomes in patients with multiple sclerosis (MS) has been well established in trials and, to a lesser extent, in the real world","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"21 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89403024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.234
Gowthami Bainaboina
Neuroimmunology is study of system and medicine and its disorders is system connected system (central or peripheral) diseases. Differing kinds of interactions area unit concerned in each the nervous and immune systems however not restricted to the physiological functioning of the systems that ends up in disorders and therefore the chemical, physical and environmental stressors
{"title":"An Overview of Neuro Immunological Disorder","authors":"Gowthami Bainaboina","doi":"10.35248/2376-0389.21.8.234","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.234","url":null,"abstract":"Neuroimmunology is study of system and medicine and its disorders is system connected system (central or peripheral) diseases. Differing kinds of interactions area unit concerned in each the nervous and immune systems however not restricted to the physiological functioning of the systems that ends up in disorders and therefore the chemical, physical and environmental stressors","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"19 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89910900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.247
S. Nani
Neurological disorders are medically defined as disorders that affect the brain as well as the nerves found throughout the human body and the spinal cord. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms like paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness. These include Epilepsy; Neuromuscular disease, etc. There are many recognized neurological disorders, some relatively common, but many rare. Mental disorders, on the opposite hand, are "psychiatric illnesses" or diseases which appear primarily as abnormalities of thought, feeling or behavior, producing either distress or impairment of function. According to the U.S. National Library of drugs there are quite 600 neurologic diseases.
{"title":"Patterns of Tissue Pathology in Neurological Diseases","authors":"S. Nani","doi":"10.35248/2376-0389.21.8.247","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.247","url":null,"abstract":"Neurological disorders are medically defined as disorders that affect the brain as well as the nerves found throughout the human body and the spinal cord. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms like paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness. These include Epilepsy; Neuromuscular disease, etc. There are many recognized neurological disorders, some relatively common, but many rare. Mental disorders, on the opposite hand, are \"psychiatric illnesses\" or diseases which appear primarily as abnormalities of thought, feeling or behavior, producing either distress or impairment of function. According to the U.S. National Library of drugs there are quite 600 neurologic diseases.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"54 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89644674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.236
M. Mohammadi
Multiple sclerosis (MS) is the most common potentially disabling disease affecting people. The incidence of MS is increasing day by day around the world, and it also has many social and economic impacts. The underlying causes of MS and the mechanisms behind the development of the disease are so widespread. genetic and environmental interactions are almost certainly contributing to the formation of this disease. MS epidemiology illustrated that low levels of vitamin D, childhood obesity, smoking and infection with Epstein-Barr virus have a very important role in disease progression. Developments in diagnostic criteria and methods aim to increase the early recognition and diagnosis of MS. Hence, given the increasing advances in the medical field, it is now possible to detect MS before symptoms. As a result, potential preventive strategies can be studied. In this review, the MS epidemiology, potential pathogens, pathophysiology, MS types, symptoms, their diagnosis and treatment, and disease management are discussed.
{"title":"Brief Note on Multiple Sclerosis","authors":"M. Mohammadi","doi":"10.35248/2376-0389.21.8.236","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.236","url":null,"abstract":"Multiple sclerosis (MS) is the most common potentially disabling disease affecting people. The incidence of MS is increasing day by day around the world, and it also has many social and economic impacts. The underlying causes of MS and the mechanisms behind the development of the disease are so widespread. genetic and environmental interactions are almost certainly contributing to the formation of this disease. MS epidemiology illustrated that low levels of vitamin D, childhood obesity, smoking and infection with Epstein-Barr virus have a very important role in disease progression. Developments in diagnostic criteria and methods aim to increase the early recognition and diagnosis of MS. Hence, given the increasing advances in the medical field, it is now possible to detect MS before symptoms. As a result, potential preventive strategies can be studied. In this review, the MS epidemiology, potential pathogens, pathophysiology, MS types, symptoms, their diagnosis and treatment, and disease management are discussed.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"16 2 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75946697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.255
Naina Boso
Medical care is a lot of valued than different levels of care and therefore the general practitioner over different professionals. There is overwhelming scientific proof that the systems supported a robust medical care square measure superior. additionally, medical care plays a key role in rising hospital potency (leading coordination and post-acute care, and avoiding surplus hospital admissions because of probably mobile conditions), and in leadership of care integration. medical care provides worth for (a) accessibility, (b) continuity of care and longitudinality, and (c) resolutiveness and comprehensiveness. that nearly half the population anticipate a consultation with their general practitioner for over 5 days may be a real downside of access. Temporary contracts of short period square measure a heavy downside for longitudinality, and an excellent supply of unskillfulness. Restrictions on the family doctor's request for diagnostic tests and procedures scale back their resolutiveness.
{"title":"Risks and Challenges in the Family Medicine","authors":"Naina Boso","doi":"10.35248/2376-0389.21.8.255","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.255","url":null,"abstract":"Medical care is a lot of valued than different levels of care and therefore the general practitioner over different professionals. There is overwhelming scientific proof that the systems supported a robust medical care square measure superior. additionally, medical care plays a key role in rising hospital potency (leading coordination and post-acute care, and avoiding surplus hospital admissions because of probably mobile conditions), and in leadership of care integration. medical care provides worth for (a) accessibility, (b) continuity of care and longitudinality, and (c) resolutiveness and comprehensiveness. that nearly half the population anticipate a consultation with their general practitioner for over 5 days may be a real downside of access. Temporary contracts of short period square measure a heavy downside for longitudinality, and an excellent supply of unskillfulness. Restrictions on the family doctor's request for diagnostic tests and procedures scale back their resolutiveness.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"101 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79352111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.237
Gowthami Bainaboina
This article explains about what the effects of multiple sclerosis on motor movement are which includes muscle weakness and what is the reason for muscle weakness, spasticity & loss of coordination and what are the symptoms of multiple sclerosis.
{"title":"Effects of Multiple Sclerosis on Motor Movement","authors":"Gowthami Bainaboina","doi":"10.35248/2376-0389.21.8.237","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.237","url":null,"abstract":"This article explains about what the effects of multiple sclerosis on motor movement are which includes muscle weakness and what is the reason for muscle weakness, spasticity & loss of coordination and what are the symptoms of multiple sclerosis.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"16 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77055547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.245
Naina Boso
Medical care is a lot of valued than different levels of care and therefore the general practitioner over different professionals. There is overwhelming scientific proof that the systems supported a robust medical care square measure superior. additionally, medical care plays a key role in rising hospital potency (leading coordination and post-acute care, and avoiding surplus hospital admissions because of probably mobile conditions), and in leadership of care integration. medical care provides worth for (a) accessibility, (b) continuity of care and longitudinality, and (c) resolutiveness and comprehensiveness. that nearly half the population anticipate a consultation with their general practitioner for over 5 days may be a real downside of access. Temporary contracts of short period square measure a heavy downside for longitudinality, and an excellent supply of unskillfulness. Restrictions on the family doctor's request for diagnostic tests and procedures scale back their resolutiveness.
{"title":"Family Medicine: Risks and Challanges","authors":"Naina Boso","doi":"10.35248/2376-0389.21.8.245","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.245","url":null,"abstract":"Medical care is a lot of valued than different levels of care and therefore the general practitioner over different professionals. There is overwhelming scientific proof that the systems supported a robust medical care square measure superior. additionally, medical care plays a key role in rising hospital potency (leading coordination and post-acute care, and avoiding surplus hospital admissions because of probably mobile conditions), and in leadership of care integration. medical care provides worth for (a) accessibility, (b) continuity of care and longitudinality, and (c) resolutiveness and comprehensiveness. that nearly half the population anticipate a consultation with their general practitioner for over 5 days may be a real downside of access. Temporary contracts of short period square measure a heavy downside for longitudinality, and an excellent supply of unskillfulness. Restrictions on the family doctor's request for diagnostic tests and procedures scale back their resolutiveness.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"25 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73913923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.260
Shungu
As another sort of addictive practices and unmistakable from conventional web game compulsion on personal computers, portable game fixation has stood out for researchers because of its conceivable pessimistic impacts on emotional well-being issues. Be that as it may, not many investigations have especially analyzed the connection between portable game compulsion and emotional wellness results, because of an absence of determined instrument for estimating this new sort of conduct habit. In this examination, we inspected the connection between versatile game expansion and social uneasiness, discouragement, and dejection among teenagers. We tracked down that versatile game compulsion was decidedly connected with social uneasiness, sadness, and depression.
{"title":"Dependency on Internet Games and Social Applications: Adolescents","authors":"Shungu","doi":"10.35248/2376-0389.21.8.260","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.260","url":null,"abstract":"As another sort of addictive practices and unmistakable from conventional web game compulsion on personal computers, portable game fixation has stood out for researchers because of its conceivable pessimistic impacts on emotional well-being issues. Be that as it may, not many investigations have especially analyzed the connection between portable game compulsion and emotional wellness results, because of an absence of determined instrument for estimating this new sort of conduct habit. In this examination, we inspected the connection between versatile game expansion and social uneasiness, discouragement, and dejection among teenagers. We tracked down that versatile game compulsion was decidedly connected with social uneasiness, sadness, and depression.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"106 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72877291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.265
M. Al-Ahmad
Different sclerosis (MS) is a neurodegenerative issue that influences the focal sensory system (CNS), saving the fringe sensory system and uncovering its first signs in early adulthood, with a variable clinical course going from a harmless condition to a quickly developing debilitating infection. MS is the most widely recognized infection of the CNS and the most well-known reason for neurological handicap in youthful grown-ups, influencing around 2.5 million around the world, with variable movement and guess. The occurrence and commonness paces of MS shift significantly among locales and populaces, showing a run of the mill latitudinal slope most likely because of hereditary and social varieties. Europe is viewed as a high recurrence region for MS (predominance ≥ 30/100,000); other high commonness locales incorporate the northern USA, Israel, Canada, Southern Australia, New Zealand and Eastern Russia. Constant aggravation, perivenular binding, demyelization, gliosis and neuronal misfortune are signs of the pathology, creating plaque development and tissue annihilation in the white matter as well as in the cerebral cortex. In spite of significant advances in immunology and atomic science, MS is ineffectively perceived concerning etiology and its resistant trigger and causal pathways are generously obscure. Additionally, how etiopathological instruments impact the course of this illness stays indistinct. Studies with attractive reverberation imaging (MRI) have exhibited that white matter injuries correspond feebly with neurological handicap and longitudinal examinations including MS patients have shown sped up dark matter decay as result of dim matter sores. Dark matter (GM) decay corresponds with physical and psychological handicap more unequivocally than white matter decay. Numerous hypotheses have been created, and numerous potential causes have been distinguished: hereditary inclination, ecological components, contaminations, vascular danger factors, and horrible mind injury.
{"title":"Cardiovascular Danger Disease in Patients with Microcirculation Factors in Multiple Sclerosis","authors":"M. Al-Ahmad","doi":"10.35248/2376-0389.21.8.265","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.265","url":null,"abstract":"Different sclerosis (MS) is a neurodegenerative issue that influences the focal sensory system (CNS), saving the fringe sensory system and uncovering its first signs in early adulthood, with a variable clinical course going from a harmless condition to a quickly developing debilitating infection. MS is the most widely recognized infection of the CNS and the most well-known reason for neurological handicap in youthful grown-ups, influencing around 2.5 million around the world, with variable movement and guess. The occurrence and commonness paces of MS shift significantly among locales and populaces, showing a run of the mill latitudinal slope most likely because of hereditary and social varieties. Europe is viewed as a high recurrence region for MS (predominance ≥ 30/100,000); other high commonness locales incorporate the northern USA, Israel, Canada, Southern Australia, New Zealand and Eastern Russia. Constant aggravation, perivenular binding, demyelization, gliosis and neuronal misfortune are signs of the pathology, creating plaque development and tissue annihilation in the white matter as well as in the cerebral cortex. In spite of significant advances in immunology and atomic science, MS is ineffectively perceived concerning etiology and its resistant trigger and causal pathways are generously obscure. Additionally, how etiopathological instruments impact the course of this illness stays indistinct. Studies with attractive reverberation imaging (MRI) have exhibited that white matter injuries correspond feebly with neurological handicap and longitudinal examinations including MS patients have shown sped up dark matter decay as result of dim matter sores. Dark matter (GM) decay corresponds with physical and psychological handicap more unequivocally than white matter decay. Numerous hypotheses have been created, and numerous potential causes have been distinguished: hereditary inclination, ecological components, contaminations, vascular danger factors, and horrible mind injury.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"34 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90557375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2376-0389.21.8.268
Khushwant Pritam
Depression is a potentially life - compromising turmoil that influences countless individuals everywhere on the world. It can happen at whatever stage in life from youth to late life and is an enormous expense to society as this problem causes serious pain and interruption of life and, whenever left untreated, can be lethal. The psychopathological state includes a group of three of indications with low or discouraged mindset, anhedonia, and low energy or weakness. Different side effects, like rest and psychomotor unsettling influences, sensations of blame, low confidence, self-destructive propensities, just as autonomic and gastrointestinal aggravations, are likewise frequently present.
{"title":"Suicide prediction among men and women with depression: Role of Pathophysiological Model on Depression","authors":"Khushwant Pritam","doi":"10.35248/2376-0389.21.8.268","DOIUrl":"https://doi.org/10.35248/2376-0389.21.8.268","url":null,"abstract":"Depression is a potentially life - compromising turmoil that influences countless individuals everywhere on the world. It can happen at whatever stage in life from youth to late life and is an enormous expense to society as this problem causes serious pain and interruption of life and, whenever left untreated, can be lethal. The psychopathological state includes a group of three of indications with low or discouraged mindset, anhedonia, and low energy or weakness. Different side effects, like rest and psychomotor unsettling influences, sensations of blame, low confidence, self-destructive propensities, just as autonomic and gastrointestinal aggravations, are likewise frequently present.","PeriodicalId":16369,"journal":{"name":"Journal of multiple sclerosis","volume":"68 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80336401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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