Pub Date : 2026-01-19DOI: 10.1007/s11060-026-05425-6
Liana Nobre, Vijay Ramaswamy, Christina Coleman, Girish Dhall, Akanksha Senapati, Helen Toledano, Nada Jabado, Eric Bouffet, Lucie Lafay-Cousin
{"title":"High-dose chemotherapy and craniospinal irradiation-sparing approach for WNT medulloblastoma of early childhood.","authors":"Liana Nobre, Vijay Ramaswamy, Christina Coleman, Girish Dhall, Akanksha Senapati, Helen Toledano, Nada Jabado, Eric Bouffet, Lucie Lafay-Cousin","doi":"10.1007/s11060-026-05425-6","DOIUrl":"https://doi.org/10.1007/s11060-026-05425-6","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"176 3","pages":"172"},"PeriodicalIF":3.1,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1007/s11060-025-05405-2
Paul M Harary, Yusuke S Hori, Fred C Lam, Deya Abu-Reesh, Sara C Emrich, Armine Tayag, Louisa Ustrzynski, Jennifer Alyono, F Christopher Holsinger, Robert L Dodd, Iris C Gibbs, Gordon Li, David J Park, Steven D Chang
{"title":"Surgical resection versus stereotactic radiosurgery for succinate dehydrogenase-related hereditary head and neck paragangliomas.","authors":"Paul M Harary, Yusuke S Hori, Fred C Lam, Deya Abu-Reesh, Sara C Emrich, Armine Tayag, Louisa Ustrzynski, Jennifer Alyono, F Christopher Holsinger, Robert L Dodd, Iris C Gibbs, Gordon Li, David J Park, Steven D Chang","doi":"10.1007/s11060-025-05405-2","DOIUrl":"10.1007/s11060-025-05405-2","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"176 2","pages":"168"},"PeriodicalIF":3.1,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1007/s11060-025-05394-2
Justyna Żubrowska, Małgorzata Pieniążek, Anna Polakiewicz-Gilowska, Iveta Kolářová, Miroslava Malejčíková, Lenka Rušinová, Miloš Holánek, Renáta Soumarová, Karolina Winsko-Szczęsnowicz, Aleksandra Konieczna, Agnieszka Młodzińska, Daniel Krejčí, Iwona Danielewicz, Magdalena Szymanik-Resko, Tomasz Ciszewski, Maja Lisik-Habib, Anika Pękala, Hana Študentová, Jan Šustr, Agnieszka Rudzińska, Marcin Kubeczko, Bogumiła Czartoryska-Arłukowicz, Jolanta Smok-Kalwat, Aleksandra Łacko, Michał Jarząb, Renata Pacholczak-Madej, Zuzana Bielčiková, Mirosława Püsküllüoğlu
{"title":"Real-world outcomes of sacituzumab govitecan in patients with pretreated triple-negative breast cancer and brain metastases: data from CEBCC-102 study.","authors":"Justyna Żubrowska, Małgorzata Pieniążek, Anna Polakiewicz-Gilowska, Iveta Kolářová, Miroslava Malejčíková, Lenka Rušinová, Miloš Holánek, Renáta Soumarová, Karolina Winsko-Szczęsnowicz, Aleksandra Konieczna, Agnieszka Młodzińska, Daniel Krejčí, Iwona Danielewicz, Magdalena Szymanik-Resko, Tomasz Ciszewski, Maja Lisik-Habib, Anika Pękala, Hana Študentová, Jan Šustr, Agnieszka Rudzińska, Marcin Kubeczko, Bogumiła Czartoryska-Arłukowicz, Jolanta Smok-Kalwat, Aleksandra Łacko, Michał Jarząb, Renata Pacholczak-Madej, Zuzana Bielčiková, Mirosława Püsküllüoğlu","doi":"10.1007/s11060-025-05394-2","DOIUrl":"10.1007/s11060-025-05394-2","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"176 2","pages":"167"},"PeriodicalIF":3.1,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1007/s11060-026-05421-w
Vratko Himic, Victor M Lu, Roxanne C Mayrand, Emma R Sass, Caleigh Roach, Kate Stillman, Sebastian Vargas-George, Jay Chandar, Vaidya Govindarajan, Adham M Khalafallah, Zachary C Gersey, Daniel M Aaronson, Michael E Ivan, Ashish H Shah, Ricardo J Komotar
Purpose: Awake craniotomy (AC) maximizes safe resection of tumors that encroach on functionally critical areas. However, AC presents additive challenges that are further compounded in the geriatric population. We aim to show that AC is safe and feasible in the elderly, and reveal which peri-operative metrics contribute towards post-operative outcomes, including length of stay, readmissions and discharge disposition.
Methods: We conducted a decade-long retrospective review of AC in patients older than 75 years old. Multivariate linear and logistic regressions were used to identify independent predictors of re-admission, length of stay in ICU and the hospital, and discharge disposition. Variables included Karnofsky Performance Status (KPS), American Society for Anesthesiologists score, frailty index (mFI-11), age in addition to other key metrics.
Results: There were 70 patients with mean age 80 and KPS 75.2 included in our cohort. Glioblastoma was the most common pathology (61.4%) followed by metastasis (22.9%). Only one patient required conversion to general anesthesia, and there were three (4.3%) who had post-operative complications. Re-operation rates following neurosurgical re-admission were 11.4%. Patients with higher pre-operative KPS had shorter hospitalizations (ρ = -0.31, p = 0.011). Regarding readmission, mFI-11 was an independent predictor of all-cause 30-day readmission (OR 2.38, p = 0.007). In contrast, when restricting analysis to neurosurgery-specific readmissions, age emerged as the only inverse predictor (OR 0.59, p = 0.010).
Conclusions: AC is a feasible and necessary tool in the geriatric population. In appropriately organized centers, the surgical success of AC in the elderly can be high. Lower frailty (rather than younger age) predicted shorter stays and reduced all-cause re-admission rates.
目的：清醒开颅术（AC）最大限度地安全切除侵犯关键功能区域的肿瘤。然而，AC提出了附加的挑战，在老年人群中进一步复杂化。我们的目的是证明AC在老年人中是安全可行的，并揭示哪些围手术期指标有助于术后结果，包括住院时间、再入院和出院处置。方法：我们对75岁以上的AC患者进行了长达十年的回顾性研究。采用多变量线性和逻辑回归来确定再入院、ICU和医院住院时间以及出院处置的独立预测因素。变量包括Karnofsky Performance Status （KPS）、美国麻醉师学会评分、虚弱指数（mFI-11）、年龄以及其他关键指标。结果：我们的队列中有70例患者，平均年龄80岁，KPS 75.2。胶质母细胞瘤是最常见的病理（61.4%），其次是转移（22.9%）。只有1例患者需要转全身麻醉，3例（4.3%）出现术后并发症。神经外科再入院后再手术率为11.4%。术前KPS较高的患者住院时间较短（ρ = -0.31, p = 0.011）。关于再入院，mFI-11是全因30天再入院的独立预测因子（OR 2.38, p = 0.007）。相比之下，当限制分析神经外科特异性再入院时，年龄成为唯一的负相关预测因子（OR 0.59, p = 0.010）。结论：AC在老年人群中是一种可行且必要的工具。在适当组织的中心，老年AC的手术成功率可以很高。较低的体弱多病（而不是较年轻的年龄）预示着较短的住院时间和较低的全因再入院率。
{"title":"Awake craniotomy for brain tumor resection in the elderly: an institutional experience.","authors":"Vratko Himic, Victor M Lu, Roxanne C Mayrand, Emma R Sass, Caleigh Roach, Kate Stillman, Sebastian Vargas-George, Jay Chandar, Vaidya Govindarajan, Adham M Khalafallah, Zachary C Gersey, Daniel M Aaronson, Michael E Ivan, Ashish H Shah, Ricardo J Komotar","doi":"10.1007/s11060-026-05421-w","DOIUrl":"10.1007/s11060-026-05421-w","url":null,"abstract":"<p><strong>Purpose: </strong>Awake craniotomy (AC) maximizes safe resection of tumors that encroach on functionally critical areas. However, AC presents additive challenges that are further compounded in the geriatric population. We aim to show that AC is safe and feasible in the elderly, and reveal which peri-operative metrics contribute towards post-operative outcomes, including length of stay, readmissions and discharge disposition.</p><p><strong>Methods: </strong>We conducted a decade-long retrospective review of AC in patients older than 75 years old. Multivariate linear and logistic regressions were used to identify independent predictors of re-admission, length of stay in ICU and the hospital, and discharge disposition. Variables included Karnofsky Performance Status (KPS), American Society for Anesthesiologists score, frailty index (mFI-11), age in addition to other key metrics.</p><p><strong>Results: </strong>There were 70 patients with mean age 80 and KPS 75.2 included in our cohort. Glioblastoma was the most common pathology (61.4%) followed by metastasis (22.9%). Only one patient required conversion to general anesthesia, and there were three (4.3%) who had post-operative complications. Re-operation rates following neurosurgical re-admission were 11.4%. Patients with higher pre-operative KPS had shorter hospitalizations (ρ = -0.31, p = 0.011). Regarding readmission, mFI-11 was an independent predictor of all-cause 30-day readmission (OR 2.38, p = 0.007). In contrast, when restricting analysis to neurosurgery-specific readmissions, age emerged as the only inverse predictor (OR 0.59, p = 0.010).</p><p><strong>Conclusions: </strong>AC is a feasible and necessary tool in the geriatric population. In appropriately organized centers, the surgical success of AC in the elderly can be high. Lower frailty (rather than younger age) predicted shorter stays and reduced all-cause re-admission rates.</p>","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"176 2","pages":"169"},"PeriodicalIF":3.1,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12804262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1007/s11060-025-05238-z
Niklas Grassl, Abigail K Suwala, Tobias Kessler, Lukas Bunse, Iris Mildenberger, Michael O Breckwoldt, Miriam Ratliff, Stefanie Brehmer, Christel Herold-Mende, Nima Etminan, Wolfgang Wick, Felix Sahm, Michael Platten, Katharina Sahm
{"title":"Early distant progression in adult Histone-3 K27-altered diffuse midline gliomas.","authors":"Niklas Grassl, Abigail K Suwala, Tobias Kessler, Lukas Bunse, Iris Mildenberger, Michael O Breckwoldt, Miriam Ratliff, Stefanie Brehmer, Christel Herold-Mende, Nima Etminan, Wolfgang Wick, Felix Sahm, Michael Platten, Katharina Sahm","doi":"10.1007/s11060-025-05238-z","DOIUrl":"10.1007/s11060-025-05238-z","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"176 2","pages":"166"},"PeriodicalIF":3.1,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12799738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1007/s11060-025-05395-1
Jack M Shireman, Simon Ammanuel, Lingxin Cheng, Emily Distler, Yilong Tao, Christina Kendziorski, Mahua Dey
{"title":"Glioblastoma immunotherapy in the context of the aging immune system: a systematic review and meta-analysis.","authors":"Jack M Shireman, Simon Ammanuel, Lingxin Cheng, Emily Distler, Yilong Tao, Christina Kendziorski, Mahua Dey","doi":"10.1007/s11060-025-05395-1","DOIUrl":"10.1007/s11060-025-05395-1","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"176 2","pages":"164"},"PeriodicalIF":3.1,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09DOI: 10.1007/s11060-025-05400-7
Riho Nakajima, Masashi Kinoshita, Hirokazu Okita, Sho Tamai, Mitsutoshi Nakada
{"title":"Surgical history and temporal muscle thickness as predictors of successful awake surgery in older patients with glioma.","authors":"Riho Nakajima, Masashi Kinoshita, Hirokazu Okita, Sho Tamai, Mitsutoshi Nakada","doi":"10.1007/s11060-025-05400-7","DOIUrl":"10.1007/s11060-025-05400-7","url":null,"abstract":"","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":"176 2","pages":"161"},"PeriodicalIF":3.1,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12789115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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