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Spectral analysis of signals of autonomic regulation of blood circulation in patients with COVID-19 and arterial hypertension 新冠肺炎合并高血压患者血液循环自主调节信号的频谱分析
Pub Date : 2021-12-25 DOI: 10.15275/cardioit.2021.0201
V. Skazkina, K. Popov, N. Krasikova
The work aims to carry out a comparative analysis of the spectral indices of the photoplethysmogram signals and RR-intervals of healthy volunteers, patients with COVID-19, as well as patients with COVID-19 and chronic arterial hypertension of 1-2 degrees. The study included 45 records of pairs of electrocardiogram and photoplethysmogram signals. Each sample included 15 pairs of 20-minute experimental signals. The study revealed an increase in the integrated power of the low-frequency (LF) band over the integrated power of the high-frequency (HF) band in the photoplethysmogram signals in patients with COVID-19, burdened with hypertension. In the signals of the RR-intervals, the largest values of the ratio of the LF to HF indices are associated with patients without cardiovascular diseases. In turn, this may be an indicator of the different effects of viral infection and arterial hypertension on the loops of autonomic control of heart rate and vascular tone.
本研究旨在对健康志愿者、新冠肺炎患者、新冠肺炎合并1-2度慢性动脉高血压患者的光容积图信号光谱指标和rr -区间进行对比分析。本研究包括45对心电图和光容积图信号记录。每个样本包含15对20分钟的实验信号。该研究显示,在患有高血压的COVID-19患者的光容积图信号中,低频(LF)波段的综合功率高于高频(HF)波段的综合功率。在rr区间信号中,LF / HF指数比值的最大值与无心血管疾病的患者相关。反过来,这可能是病毒感染和动脉高血压对心率和血管张力自主控制回路的不同影响的一个指标。
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引用次数: 2
Missing value imputation with linear methods in the database of cardiological patients in prediction of mortality 用线性方法在心脏病患者数据库中缺失值代入预测死亡率
Pub Date : 2021-06-25 DOI: 10.15275/cardioit.2021.0101
Tatiana S. Bibicheva, V. Skazkina, Marina V. Ogneva, M. Simonyan, V. Gridnev, A. Karavaev
This study examines missing value imputation in the Russian Acute Coronary Syndrome Registry (RusACSR) and assessment of the probability of predicting mortality. Linear methods with the most probable or average value were used for imputation. The prediction problem was solved using the k-nearest neighbors method. This work reveals that the imputation method, despite their simplicity, increases the probability of prediction of mortality by 6%.
本研究检验了俄罗斯急性冠状动脉综合征登记处(RusACSR)的缺失值代入和预测死亡率概率的评估。采用最可能值或平均值的线性方法进行估算。利用k近邻法解决了预测问题。这项工作表明,尽管这种方法简单,但预测死亡率的概率提高了6%。
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引用次数: 0
Capabilities of photoplethysmography as a method for screening of cardiovascular system pathology 光容积脉搏波作为心血管系统病理筛查方法的能力
Pub Date : 2020-09-30 DOI: 10.15275/cardioit.2020.0102
M. Simonyan, O. Posnenkova, A. Kiselev
Currently, vegetative dysfunction considered to be one of principal mechanisms in the pathogenesis of cardiovascular pathology, which causes a cascade of events leading to changes in the properties and a structure of vascular wall. This review article contains literature from various databases (Russian science citation index, PubMed, Google Shcolar, Scopus). It presents the methods for assessing vegetative imbalance. In particular, the method of photoplethysmography (PPGV) is considered for recording periodic fluctuations at various frequencies in the distal vascular bed which characterize physiological processes (cardiac activity, respiratory influences, neurogenic, myogenic and endothelial activity). In addition, other diagnostic capabilities of PPGV such as heart rate (HR) assessment, determining the properties of vascular wall and the level of blood saturation are elucidated. This paper demonstrates a wide range of PPGV applications. The simplicity of PPGV reproduction and its cost-effectiveness make it feasible both in routine clinical practice for the purposes of screening for cardiovascular pathology, and for individual health monitoring incorporated in smart devices.
目前,植物性功能障碍被认为是心血管病理发病的主要机制之一,它引起一系列事件,导致血管壁性质和结构的改变。这篇综述文章包含来自不同数据库的文献(俄罗斯科学引文索引,PubMed, Google Shcolar, Scopus)。介绍了植物营养失衡的评价方法。特别是,光容积脉搏波描记法(PPGV)被认为可以记录远端血管床不同频率的周期性波动,这些波动表征了生理过程(心脏活动、呼吸影响、神经源性、肌源性和内皮活性)。此外,PPGV的其他诊断能力,如心率(HR)评估,确定血管壁的性质和血饱和度水平的阐明。本文展示了PPGV的广泛应用。PPGV复制的简单性及其成本效益使其在常规临床实践中用于心血管病理筛查和智能设备中的个人健康监测都是可行的。
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引用次数: 2
Effect of angiotensin/neprilysin inhibition on ventricular repolarization and clinical arrhythmogenesis 抑制血管紧张素/奈普利素对心室复极和临床心律失常的影响
Pub Date : 2020-06-25 DOI: 10.15275/cardioit.2020.0103
S. Gul, O. C. Yontar, M. Yenerçağ, Onur Seker, Güney Erdoğan, U. Arslan
Background: The most common reason for sudden cardiac death in heart failure is malign ventricular arrhythmias. LCZ 696 improves hospitalization and sudden cardiac death outcomes in heart failure, however mechanisms in preventing sudden cardiac death are still unknown. There is little information available assessing effect of LCZ 696 on Tp-e interval and related calculations. In this study, we aimed to investigate the impact of Sacubitril/valsartan therapy on Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in heart failure patients and its reflections on clinical arrhythmogenesis. Methods: The study was designed as a prospective observational fashion. 265 patients with implantable cardioverter-defibrillator (ICD), who were on regular follow up at Samsun Training and Research Hospital Outpatient Heart Failure Clinic, were validated for the study. Clinical, echocardiographic, electrocardiogram and device data before initiation and six months after dose optimizing were obtained. Results: Stroke volume, cardiac output and ejection fraction significantly improved after LCZ 696 treatment. T wave related parameters, QT and QTC intervals significantly diminished. Furthermore, there was a negative correlation between baseline Tp-e interval duration and the absolute percentile increase of stroke volume(r:-0.234, p: 0.042) and cardiac output (r: -0.240, p: 0.037). Conclusion: In our study, switching Renin-Angiotensin-Aldosterone-System inhibitor with Angiotensin receptor/neprilysin inhibitor was associated with increase in left ventricle performance and decrease of sustained ventricular arrhythmias that required ICD shocks. These positive findings were accompanied by improvements in surface electrocaridogram changes such as Tp-e and related indices.
背景:心力衰竭中心源性猝死最常见的原因是恶性室性心律失常。LCZ 696可改善心力衰竭患者的住院治疗和心源性猝死结局,但其预防心源性猝死的机制尚不清楚。目前关于lcz696对Tp-e段影响及计算的资料很少。本研究旨在探讨苏比利/缬沙坦治疗对心力衰竭患者Tp-e间期、Tp-e/QT比值、Tp-e/QTc比值的影响及其对临床心律失常的启示。方法:本研究采用前瞻性观察方式。在三星培训研究医院心衰门诊接受定期随访的265例植入式心律转复除颤器(ICD)患者进行了研究验证。获得起始治疗前和剂量优化后6个月的临床、超声心动图、心电图和设备数据。结果:lcz696治疗后卒中容量、心输出量和射血分数均有显著改善。T波相关参数、QT、QTC间隔明显缩短。此外,基线Tp-e间期持续时间与卒中量(r:-0.234, p: 0.042)和心输出量(r: -0.240, p: 0.037)的绝对百分位数增加呈负相关。结论:在我们的研究中,将肾素-血管紧张素-醛固酮系统抑制剂与血管紧张素受体/neprilysin抑制剂切换与左心室功能的增加和需要ICD电击的持续性室性心律失常的减少相关。这些积极的发现伴随着表面心电图变化的改善,如Tp-e和相关指数。
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引用次数: 2
The Deming–Shuhart cycle in problems of modeling the process of telemedical rehabilitation and preventive monitoring of cardiological patients 心脏病患者远程医疗康复和预防性监测过程建模中的Deming-Shuhart循环问题
Pub Date : 2019-12-18 DOI: 10.15275/cardioit.2019.0202
E. Kotelnikova
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引用次数: 0
Application of information technologies for selection of treatment strategy in patients with stable coronary artery disease 信息技术在稳定期冠心病患者治疗策略选择中的应用
Pub Date : 2019-12-18 DOI: 10.15275/cardioit.2019.0201
O. Posnenkova, E. Genkal, Y. V. Popova, A. Kiselev, V. Gridnev
Purpose: to study the frequency of divergence occurrence between decisions which have been made on the basis of 2018 ESC guidelines on myocardial revascularization (ESC 2018) and 2012 Appropriate use criteria for coronary revascularization (AUC 2012) and develop the algorithm for support of clinical decision making on the need for revascularization and the appropriateness of performed intervention in patients with stable coronary artery disease (CAD). Material and Methods — The data of 1531 patients with stable CAD (mean age 61,7±9,8 yrs, 78% men) derived from multicenter Russian registry of patients with stable CAD were studied. Indications for myocardial revascularization were determined according ESC 2018 and AUC 2012. The following clinical characteristics were considered: severity of angina, the degree of coronary arteries stenoses, the data of non-invasive testing, volume of medication. Results — In 34% of patients treatment strategy according to ESC 2018 and AUC 2012 was similar. In 15% of patients ESC 2018 and AUC 2012 differed concerning revascularization appropriateness. In 50% of patients AUC 2012 have not been defined, predominantly due to insufficient examination. The algorithm was developed which allows on the basis of co-using of ESC 2018 and AUC 2012 compose groups of patients for whom myocardial revascularization indicated primarily (ЕSC 2018+, AUC 2012+), in whom intervention can be delayed (ЕSC ISSN 2313-0318, Cardio-IT DOI: 10.15275/cardioit.2019.0201 2/4 2019. Volume 6 Issue 2 Article CID e0201 Coronary Artery Disease © 2019, Cardio-IT www.cardio-it.ru 2018 +, AUC 2012 -/±/?) and for whom only drug treatment indicated (ЕSC 2018 -, AUC 2012 -/±/?). Developed algorithm was realized as an automated module of data analytics system of CAD registry. Its implementation in the studied group revealed that only 20% who underwent myocardial revascularization were referred to the group of primary revascularization. Among 334 patients for whom intervention was indicated on the primarily basis just 37% underwent it. Conclusion — Implementation of the developed algorithm as an automated analytical registry module allows processing of unlimited volume of clinical data and defining priority of myocardial revascularization performance. Patients with the maximal benefit from intervention should be operated on the primarily basis.
目的:研究《2018年ESC心肌血运重建术指南》(ESC 2018)与《2012年冠状动脉血运重建术适当使用标准》(AUC 2012)决策差异的发生频率,并开发算法,为稳定型冠状动脉疾病(CAD)患者是否需要血运重建术及实施干预的适宜性的临床决策提供支持。材料和方法:研究了1531例稳定型CAD患者(平均年龄61,7±9,8岁,78%为男性)的数据,这些数据来自俄罗斯多中心的稳定型CAD患者登记。心肌血运重建指征根据ESC 2018和AUC 2012确定。考虑以下临床特征:心绞痛严重程度、冠状动脉狭窄程度、无创检测数据、用药量。结果-根据ESC 2018和AUC 2012, 34%的患者的治疗策略相似。在15%的患者中,ESC 2018和AUC 2012在血运适宜性方面存在差异。50%的患者2012年AUC没有明确定义,主要是由于检查不充分。该算法的开发允许在ESC 2018和AUC 2012共同使用的基础上,组成心肌血管重建术主要指的患者组(ЕSC 2018+, AUC 2012+),其中可以延迟干预(ЕSC ISSN 2313-0318, Cardio-IT DOI: 10.15275/cardioit.2019.0201 /4 2019)。第6卷第2期文章CID e0201冠状动脉疾病©2019,Cardio-IT www.cardio-it.ru 2018 +, AUC 2012 -/±/?),仅适用于药物治疗(ЕSC 2018 -, AUC 2012 -/±/?)。所开发的算法作为CAD注册表数据分析系统的自动化模块实现。其在研究组的实施显示,只有20%的心肌血运重建术患者被归为原发性血运重建术组。在334名接受干预的患者中,只有37%的人接受了干预。结论:将开发的算法实现为自动分析注册模块,可以处理无限量的临床数据,并确定心肌血运重建性能的优先级。从干预中获益最大的患者应首先进行手术。
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引用次数: 0
Comparing methods of the identification of phase in analysis of electroencephalogram and cardiointervalogrogram 脑电图与心电间期图相鉴别方法的比较
Pub Date : 2019-06-25 DOI: 10.15275/cardioit.2019.0101
V. Skazkina, M. Simonyan, Elena V. Navrotskay, Elena P. Chernets, A. N. Khramkov, Dmitriy M. Yezhov, A. Kiselev
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引用次数: 0
The impact of environmental quality on the level of blood pressure and the prevalence of cardiovascular diseases among residents of Saratov 环境质量对萨拉托夫居民血压水平和心血管疾病发病率的影响
Pub Date : 2019-06-25 DOI: 10.15275/cardioit.2019.0102
O. Abrosimova, Ludmila A. Rycheva, O. Posnenkova
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引用次数: 0
Simulation of autonomic blockade in mathematical model of cardiovascular regulation 心血管调节数学模型中自主神经阻滞的模拟
Pub Date : 2018-12-25 DOI: 10.15275/cardioit.2018.0201
Yurii M. Ishbulatov, A. Karavaev
The article presents a multicomponent model of the autonomic regulation of blood circulation, which takes into account the self-oscillatory properties of the regulation systems. The adequacy of the model was tested by reproducing the dynamics of the parameters of blood circulation after the pharmacological blockade of the regulatory systems.
本文提出了血液循环自主调节的多组分模型,该模型考虑了调节系统的自振荡特性。该模型的充分性是通过再现血液循环参数的动态后,药理学封锁的调节系统进行测试。
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引用次数: 0
Heart rate variability in patients with cardiomyopathy of various etiologies 不同病因的心肌病患者的心率变异性
Pub Date : 2018-12-25 DOI: 10.15275/cardioit.2018.0202
M. Simonyan
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引用次数: 0
期刊
Cardio-IT
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