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Kisspeptins centrally modulate food intake and locomotor activity in mice independently of gonadal steroids in a sexually dimorphic manner Kisspeptins以性双态方式调节小鼠的食物摄入量和运动活动,不受性腺类固醇的影响。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-23 DOI: 10.1111/jne.13433
Inmaculada Velasco, Silvia Daza-Dueñas, Encarnación Torres, Francisco Ruiz-Pino, María J. Vázquez, Manuel Tena-Sempere

Kisspeptins are essential regulators of the reproductive axis, with capacity to potently activate gonadotropin-releasing hormone neurons, acting also as central conduits for the metabolic regulation of fertility. Recent evidence suggests that kisspeptins per se may also modulate several metabolic parameters, including body weight, food intake or energy expenditure, but their actual roles and site(s) of action remain unclear. We present herein a series of studies addressing the metabolic effects of central and peripheral administration of kisspeptin-10 (Kp-10; 1 nmol and 3 nmol daily, respectively) for 11 days in mice of both sexes. To assess direct metabolic actions of Kp-10 versus those derived indirectly from its capacity to modulate gonadal hormone secretion, kisspeptin effects were tested in adult male and female mice gonadectomized and supplemented with fixed, physiological doses of testosterone or 17β-estradiol, respectively. Central administration of Kp-10 decreased food intake in male mice, especially during the dark phase (~50%), which was accompanied by a reduction in total and nocturnal energy expenditure (~16%) and locomotor activity (~70%). In contrast, opposite patterns were detected in female mice, with an increase in total and nocturnal locomotor activity (>65%), despite no changes in food intake or energy expenditure. These changes were independent of body weight, as no differences were detected in mice of both sexes at the end of Kp-10 treatments. Peripheral administration of Kp-10 failed to alter any of the metabolic parameters analyzed, except for a decrease in locomotor activity in male mice and a subtle increase in 24 h food intake in female mice, denoting a predominant central role of kisspeptins in the control of energy metabolism. Finally, glucose tolerance and insulin sensitivity were not significantly affected by central or peripheral treatment with Kp-10. In conclusion, our data reveal a potential role of kisspeptins in the control of key metabolic parameters, including food intake, energy expenditure and locomotor activity, with a preferential action at central level, which is sex steroid-independent but sexually dimorphic.

吻肽是生殖轴的重要调节因子,能够有效激活促性腺激素释放激素神经元,同时也是生殖代谢调节的核心通道。最近的证据表明,吻肽本身也可调节一些代谢参数,包括体重、食物摄入量或能量消耗,但其实际作用和作用部位仍不清楚。我们在此进行了一系列研究,探讨了中枢和外周给药吻肽-10(Kp-10;每天分别为 1 nmol 和 3 nmol)对雌雄小鼠 11 天代谢的影响。为了评估Kp-10的直接代谢作用和间接调节性腺激素分泌的作用,我们对性腺切除并分别补充固定生理剂量睾酮或17β-雌二醇的成年雄性和雌性小鼠进行了Kisspeptin作用测试。中枢给药 Kp-10 会降低雄性小鼠的食物摄入量,尤其是在黑暗阶段(约 50%),同时降低总能量消耗和夜间能量消耗(约 16%)以及运动活动(约 70%)。相反,在雌性小鼠中发现了相反的模式,尽管食物摄入或能量消耗没有变化,但总运动量和夜间运动量却增加了(>65%)。这些变化与体重无关,因为在 Kp-10 治疗结束时,雌雄小鼠的体重没有差异。除了雄性小鼠的运动活动减少和雌性小鼠 24 小时食物摄入量的微弱增加外,Kp-10 的外周给药未能改变任何分析的代谢参数,这表明吻肽在能量代谢控制中起着主要的中心作用。最后,糖耐量和胰岛素敏感性并没有受到 Kp-10 中枢或外周处理的显著影响。总之,我们的数据揭示了吻肽在控制关键代谢参数(包括食物摄入、能量消耗和运动活动)中的潜在作用,它优先在中枢水平发挥作用,这种作用与性类固醇无关,但具有性别二态性。
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引用次数: 0
A career in numbers: A citation network analysis of the work of RP Millar and his contribution to GnRH research 数字中的职业生涯:对 RP Millar 工作及其对 GnRH 研究贡献的引文网络分析。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-14 DOI: 10.1111/jne.13430
Rhodri I. Leng, Gareth Leng

Here, we reflect on the long career in neuroendocrinology of a single, highly productive scientist (‘Bob’ Millar), by analysing his oeuvre of published papers through the lens of citation metrics. We use citation network analysis in a novel manner to identify the specific topics to which his papers have made a particular contribution, allowing us to compare the citations of his papers with those of contemporary papers on the same topic, rather than on the same broad field as generally used to normalise citations. It appears that citation rates are highest for topics on which Bob has published a relatively large number of papers that have become core to a tightly-knit community of authors that cite each other. This analysis shows that an author's impact depends on the existence of a receptive community that is alert to the potential utility of papers from that author, and which uses, amplifies, extends and qualifies the contents of their papers—activities that entail reciprocal citation between authors. The obvious conclusion is that a scientist's impact depends on the use that his or her contemporaries make of his or her contributions, rather than on the contributions in themselves.

在此,我们通过引文指标分析一位高产科学家("鲍勃"-米勒)发表的论文,对他在神经内分泌学领域的漫长职业生涯进行反思。我们以一种新颖的方式使用引文网络分析来确定他的论文对哪些特定主题做出了特殊贡献,这样我们就可以将他的论文的引文与同一主题的当代论文的引文进行比较,而不是像通常用来规范引文的那样,将引文与同一广泛领域的论文进行比较。在鲍勃发表了相对较多论文的主题上,引用率似乎是最高的,因为这些论文已经成为一个紧密联系在一起的作者群体的核心,他们会互相引用。这一分析表明,一个作者的影响力取决于是否存在一个乐于接受该作者论文的群体,该群体对该作者论文的潜在效用保持警惕,并使用、扩大、延伸和修饰其论文内容--这些活动需要作者之间的相互引用。显而易见的结论是,科学家的影响力取决于同时代人对其贡献的利用,而不是贡献本身。
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引用次数: 0
Expression of novel androgen receptors in three GnRH neuron subtypes in the cichlid brain 慈鲷大脑中三种 GnRH 神经元亚型中新型雄激素受体的表达。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-10 DOI: 10.1111/jne.13429
Mélanie Dussenne, Beau A. Alward

In teleosts, GnRH1 neurons stand at the apex of the Hypothalamo-Pituitary-Gonadal (HPG) axis, which is responsible for the production of sex steroids by the gonads (notably, androgens). To exert their actions, androgens need to bind to their specific receptors, called androgen receptors (ARs). Due to a teleost-specific whole genome duplication, A. burtoni possess two AR paralogs (ARα and ARβ) that are encoded by two different genes, ar1 and ar2, respectively. In A. burtoni, males stratify along dominance hierarchies, in which an individuals' social status determines its physiology and behavior. GnRH1 neurons have been strongly linked with dominance and circulating androgen levels. Similarly, GnRH3 neurons are implicated in the display of male specific behaviors. Some studies have shown that these GnRH neurons are responsive to fluctuations in circulating androgens levels, suggesting a link between GnRH neurons and ARs. While female A. burtoni do not naturally form a social hierarchy, their reproductive state is positively correlated to androgen levels and GnRH1 neuron size. Although there are reports related to the expression of ar genes in GnRH neurons in cichlid species, the expression of each ar gene remains inconclusive due to technical limitations. Here, we used immunohistochemistry, in situ hybridization chain reaction (HCR), and spatial transcriptomics to investigate ar1 and ar2 expression specifically in GnRH neurons. We find that all GnRH1 neurons intensely express ar1 but only a few of them express ar2, suggesting the presence of genetically-distinct GnRH1 subtypes. Very few ar1 and ar2 transcripts were found in GnRH2 neurons. GnRH3 neurons were found to express both ar genes. The presence of distinct ar genes within GnRH neuron subtypes, most clearly observed for GnRH1 neurons, suggests differential control of these neurons by androgenic signaling. These findings provide valuable insight for future studies aimed at disentangling the androgenic control of GnRH neuron plasticity and reproductive plasticity across teleosts.

在长尾类动物中,GnRH1 神经元位于下丘脑-垂体-性腺轴(HPG)的顶端,该轴负责由性腺产生性类固醇(主要是雄激素)。雄激素需要与特定的受体结合才能发挥作用,这种受体被称为雄激素受体(ARs)。由于远东鱼类特有的全基因组复制,伯顿蛙拥有两个AR旁系亲属(ARα和ARβ),分别由两个不同的基因ar1和ar2编码。在 A. burtoni 中,雄性按照优势等级分层,个体的社会地位决定其生理和行为。GnRH1 神经元与支配地位和循环雄激素水平密切相关。同样,GnRH3 神经元也与雄性特定行为的表现有关。一些研究表明,这些 GnRH 神经元对循环雄激素水平的波动有反应,这表明 GnRH 神经元与 ARs 之间存在联系。虽然雌性伯顿猿不会自然形成社会等级,但其繁殖状态与雄激素水平和 GnRH1 神经元大小呈正相关。虽然有关于慈鲷 GnRH 神经元中 ar 基因表达的报道,但由于技术限制,每个 ar 基因的表达仍然没有定论。在这里,我们利用免疫组化、原位杂交连锁反应(HCR)和空间转录组学研究了 ar1 和 ar2 在 GnRH 神经元中的特异性表达。我们发现所有 GnRH1 神经元都强烈表达 ar1,但只有少数神经元表达 ar2,这表明存在基因上不同的 GnRH1 亚型。在 GnRH2 神经元中发现的 ar1 和 ar2 转录物很少。GnRH3 神经元同时表达两种 ar 基因。在 GnRH 神经元亚型中存在不同的 ar 基因,在 GnRH1 神经元中观察到的最为明显,这表明雄激素信号对这些神经元的控制存在差异。这些发现为今后研究雄激素控制 GnRH 神经元的可塑性和长尾目动物的生殖可塑性提供了有价值的见解。
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引用次数: 0
European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours 欧洲神经内分泌肿瘤学会(ENETS)2024 年分化良好的小肠神经内分泌肿瘤治疗指导文件。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-08 DOI: 10.1111/jne.13423
Angela Lamarca, Detlef K. Bartsch, Martyn Caplin, Beata Kos-Kudla, Andreas Kjaer, Stefano Partelli, Anja Rinke, Eva Tiensuu Janson, Christina Thirlwell, Marie-Louise F. van Velthuysen, Marie-Pierre Vullierme, Marianne Pavel

Both the incidence and prevalence of well-differentiated neuroendocrine tumours from the small intestine (Si-NET) are gradually increasing. Most patients have non-functioning tumours with subtle GI symptoms and tumours are often discovered incidentally by endoscopy or at advanced disease stages by imaging depicting mesenteric lymph node and /or liver metastases while around 30% of the patients present with symptoms of the carcinoid syndrome. Adequate biochemical assessment and staging including functional imaging is crucial for treatment-related decision-making that should take place in an expert multidisciplinary team setting. Preferably, patients should be referred to specialised ENETS Centres of Excellence or centres of high expertise in the field. This guidance paper provides the current evidence and best knowledge for the management of Si-NET grade (G) 1–3 following 10 key questions of practical relevance for the diagnostic and therapeutic decision making.

小肠分化良好的神经内分泌肿瘤(Si-NET)的发病率和患病率都在逐渐上升。大多数患者的肿瘤没有功能,但有轻微的消化道症状,肿瘤通常是在内镜检查中偶然发现的,或在疾病晚期通过影像学检查发现肠系膜淋巴结和/或肝转移,约有30%的患者出现类癌综合征症状。充分的生化评估和分期(包括功能成像)对治疗决策至关重要,应由专家组成的多学科团队进行。最好将患者转诊至专业的ENETS卓越中心或该领域的高水平专业中心。本指导文件提供了治疗Si-NET 1-3级的现有证据和最佳知识,其中包括与诊断和治疗决策实际相关的10个关键问题。
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引用次数: 0
Letter to ‘New developments and concepts in the diagnosis and management of diabetes insipidus (AVP-deficiency and resistance)’ 致 "诊断和治疗糖尿病性尿崩症(AVP 缺乏和抵抗)的新进展和新概念 "的信。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-04 DOI: 10.1111/jne.13426
Meric Coskun, Ethem Turgay Cerit
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引用次数: 0
Advancement in perioperative management of pituitary adenomas—Current concepts and best practices 垂体腺瘤围手术期管理的进展--当前概念和最佳实践。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-04 DOI: 10.1111/jne.13427
Ismat Shafiq, Zoë R. Williams, G. Edward Vates

Pituitary adenomas are very common representing 18.1% of all brain tumors and are the second most common brain pathology. Transsphenoidal surgery is the mainstay of treatment for all pituitary adenomas except for prolactinomas which are primarily treated medically with dopamine agonists. A thorough endocrine evaluation of pituitary adenoma preoperatively is crucial to identify hormonal compromise caused by the large sellar mass, identifying prolactin-producing tumors and comorbidities associated with Cushing and acromegaly to improve patient care and outcome. Transsphenoidal surgery is relatively safe in the hands of experienced surgeons, but still carries a substantial risk of causing hypopituitarism that required close follow-up in the immediate postoperative period to decrease mortality. A multidisciplinary team approach with endocrinologists, ophthalmologists, and neurosurgeons is the cornerstone in the perioperative management of pituitary adenomas.

垂体腺瘤非常常见,占所有脑肿瘤的 18.1%,是第二大最常见的脑部病变。经蝶窦手术是治疗所有垂体腺瘤的主要方法,但泌乳素瘤除外,后者主要通过多巴胺激动剂进行药物治疗。术前对垂体腺瘤进行全面的内分泌评估至关重要,有助于识别巨大蝶窦肿块导致的内分泌失调,识别催乳素分泌性肿瘤以及与库欣和肢端肥大症相关的合并症,从而改善患者的护理和预后。经蝶窦手术在经验丰富的外科医生手中相对安全,但仍有导致垂体功能减退的巨大风险,因此需要在术后立即进行密切随访,以降低死亡率。由内分泌科医生、眼科医生和神经外科医生组成的多学科团队是垂体腺瘤围手术期管理的基石。
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引用次数: 0
Sex differences in intestinal morphology and increase in diencephalic neuropeptide Y gene expression in female but not male Pekin ducks exposed to chronic heat stress. 暴露于慢性热应激的雌性而非雄性北京鸭肠道形态的性别差异和间脑神经肽 Y 基因表达的增加
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-03 DOI: 10.1111/jne.13424
E M Oluwagbenga, M Bergman, K M Ajuwon, G S Fraley

The impact of heat stress (HS) on production is intricately linked with feed intake. We investigated the effects of HS on intestines and diencephalic genes in Pekin ducks. One hundred and sixty adult ducks were allocated to two treatment rooms. The control room was maintained at 22°C and the HS room at 35°C for the first 10 h of the day then reduced to 29.5°C. After 3 weeks, 10 hens and 5 drakes were euthanized from each room and jejunum and ileum collected for histology. Brains were collected for gene expression analysis using qRT-PCR. Intestinal morphology data were analyzed with two-way ANOVA and diencephalic gene data were analyzed with Kruskal-Wallis test. There was an increase in villi width in the ileum (p = .0136) and jejunum (p = .0019) of HS hens compared to controls. HS drakes showed a higher crypt depth (CD) in the jejunum (p = .0198) compared to controls. There was an increase in crypt goblet cells (GC) count in the ileum (p = .0169) of HS drakes compared to HS hens. There was higher villi GC count (p = .07) in the jejunum of HS drakes compared to controls. There was an increase in the crypt GC density (p = .0054) in the ileum, not jejunum, of HS drakes compared to HS hens. Further, there were no differences in the proopiomelanocortin gene expression in either sex but there was an increase in the expression of neuropeptide Y (NPY) gene in HS hens (p = .031) only and a decrease in the corticotropin releasing hormone gene in the HS drakes (p = .037) compared to controls. These data show that there are sex differences in the effect of HS on gut morphology while the upregulation in NPY gene may suggest a role in mediating response to chronic HS.

热应激(HS)对生产的影响与采食量密切相关。我们研究了热应激对北京鸭肠道和间脑基因的影响。160 只成年鸭被分配到两个处理室。对照室的温度保持在 22°C,HS 室的温度保持在 35°C,每天前 10 小时,然后降至 29.5°C。3 周后,对每个房间的 10 只母鸭和 5 只公鸭实施安乐死,收集空肠和回肠进行组织学检查。收集大脑,使用 qRT-PCR 进行基因表达分析。肠道形态学数据采用双向方差分析,脑膜基因数据采用 Kruskal-Wallis 检验。与对照组相比,HS母鸡回肠(p = .0136)和空肠(p = .0019)的绒毛宽度有所增加。与对照组相比,HS雌鸽的空肠隐窝深度(CD)更高(p = .0198)。与 HS 雌鸽相比,HS 雄鸽回肠隐窝腺泡细胞 (GC) 数量增加(p = .0169)。与对照组相比,HS 雄鸽空肠中的绒毛 GC 数量较高(p = .07)。与 HS 雌鸽相比,HS 雄鸽回肠(而非空肠)隐窝 GC 密度增加(p = .0054)。此外,与对照组相比,HS雌鸽和HS雄鸽的前绒毛膜促皮质素基因表达均无差异,但仅HS雄鸽的神经肽Y(NPY)基因表达增加(p = .031),而HS雌鸽的促肾上腺皮质激素释放激素基因表达减少(p = .037)。这些数据表明,HS 对肠道形态的影响存在性别差异,而 NPY 基因的上调可能表明其在调解对慢性 HS 的反应方面发挥了作用。
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引用次数: 0
NETest in advanced high-grade gastroenteropancreatic neuroendocrine neoplasms 晚期高级别胃肠胰神经内分泌肿瘤的 NETest。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-27 DOI: 10.1111/jne.13428
H. Sorbye, G. O. Hjortland, L. W. Vestermark, A. Sundlov, J. Assmus, A. Couvelard, A. Perren, S. W. Langer

Molecular blood biomarkers are lacking for high-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN). To histologically distinguish between neuroendocrine carcinoma (NEC), neuroendocrine tumors G3 (NET G3), adenocarcinoma and MINEN is often challenging. The mRNA-based NETest has diagnostic, prognostic and predictive value in neuroendocrine tumors G1-2 but has not been studied in HG GEP-NEN. Patients with advanced HG GEP-NEN were prospectively included in an observational study. A blood sample was collected before the start of chemotherapy and pseudonymised before NETest was performed. NETest results are expressed as an activity index (NETest score) from 0 to 100. The normal score cut-off is 20. Histological sections were pseudonymised before centralized pathological re-evaluation. Samples from 60 patients were evaluable with the NETest. Main primary tumor sites were colon (14), rectum (12), pancreas (11) and esophagus (7). Re-classification: 30 NEC, 12 NET G3, 3 HG-NEN ambiguous morphology, 8 MiNEN, 3 adenocarcinomas with neuroendocrine differentiation (ADNE), 3 adenocarcinomas and 1 NET G2. Elevated NETest (>20) was seen in 38/45 (84%) HG GEP-NEN, all 17 large-cell NEC (100%), 11/13 (85%) small-cell NEC, all ambiguous cases and 7/12 (64%) NET G3. NETest was elevated in 5/8 (63%) MiNEN, 2/3 ADNE, however not in 3 adenocarcinomas. Median survival was 10.2 months (9.6–10.8 95%CI) for evaluable HG GEP-NEN treated with palliative chemotherapy (n = 39), and survival was significantly shorter in patients with NETest >60 with an OS of only 6.5 months. This is the first study to evaluate use of the NETest in advanced HG GEP-NEN. The NETest was almost always elevated in GEP-NEC and in all large-cell NEC. The NETest was also frequently elevated in NET G3 and MiNEN, however cases were limited. Baseline NETest was not predictive for benefit of chemotherapy, however a NETest >60 was prognostic with a shorter survival for patients receiving chemotherapy.

高级(HG)胃肠胰(GEP)神经内分泌肿瘤(NEN)缺乏分子血液生物标记物。从组织学角度区分神经内分泌癌(NEC)、神经内分泌肿瘤 G3(NET G3)、腺癌和 MINEN 通常具有挑战性。基于 mRNA 的 NETest 对神经内分泌肿瘤 G1-2 具有诊断、预后和预测价值,但尚未对 HG GEP-NEN 进行研究。一项前瞻性观察研究纳入了晚期 HG GEP-NEN 患者。化疗开始前采集血液样本,化名后进行NETest检测。NETest结果以活动指数(NETest得分)表示,从0到100。正常分值为 20 分。组织学切片在集中病理再评估前进行化名。60 名患者的样本可通过 NETest 进行评估。主要原发肿瘤部位为结肠(14 例)、直肠(12 例)、胰腺(11 例)和食道(7 例)。重新分类:30例NEC、12例NET G3、3例HG-NEN形态不清、8例MiNEN、3例神经内分泌分化腺癌(ADNE)、3例腺癌和1例NET G2。38/45(84%)例 HG GEP-NEN、所有 17 例大细胞 NEC(100%)、11/13(85%)例小细胞 NEC、所有不明确病例和 7/12 (64%)例 NET G3 均出现 NETest 升高(>20)。5/8(63%)例 MiNEN 和 2/3 例 ADNE 中的 NETest 升高,但 3 例腺癌中的 NETest 没有升高。接受姑息化疗的可评估 HG GEP-NEN 的中位生存期为 10.2 个月(9.6-10.8 95%CI)(n = 39),NETest >60 的患者生存期明显较短,仅为 6.5 个月。这是第一项评估在晚期 HG GEP-NEN 中使用 NETest 的研究。在 GEP-NEC 和所有大细胞 NEC 中,NETest 几乎总是升高。NETest 在 G3 和 MiNEN 中也经常升高,但病例有限。基线NETest不能预测化疗的疗效,但NETest>60则预示接受化疗的患者生存期缩短。
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引用次数: 0
Role of neoadjuvant peptide receptor radionuclide therapy in unresectable and metastatic gastro-entero-pancreatic neuroendocrine neoplasms: A scoping review. 新辅助肽受体放射性核素疗法在不可切除和转移性胃肠胰神经内分泌肿瘤中的作用:范围综述。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-27 DOI: 10.1111/jne.13425
Raghava Kashyap, Senthil Raja, Ajay Adusumilli, Murali Mohan Reddy Gopireddy, Benjamin P T Loveday, Ramin Alipour, Grace Kong

Peptide receptor radionuclide therapy (PRRT) is an established therapy for metastatic neuroendocrine neoplasms (NEN). The role of PRRT as a neoadjuvant treatment prior to surgery or other local therapies is uncertain. This scoping review aimed to define the landscape of evidence available detailing the utility of PRRT in the neo-adjuvant setting, including the clinical contexts, efficacy, and levels of evidence. A comprehensive literature search of PUBMED, SCOPUS, and EMBASE through to December 2022 was performed to identify reports of PRRT use as neoadjuvant therapy prior to local therapies. Observational studies and clinical trials were included. A total of 369 records were identified by the initial search, and 17 were included in the final analysis, comprising 179 patients treated with neoadjuvant PRRT. Publications included case reports, retrospective cohort series and a phase 2 trial. Definitions of unresectable disease were variable. Radioisotopes used included 177Lu (n = 142) and 90Y (n = 36), used separately (n = 178) or in combination (n = 1). A combination of PRRT with chemotherapy was also explored (n = 2). Toxicity data was reported in 11/17 studies. Survival analysis was reported in 3/17 studies. Surgical resection following PRRT was reported for both the primary tumor (n = 71) and metastases (n = 12). Resection rates could not be calculated as not all publications reported whether resection was completed. Published literature exploring the use of PRRT in the neoadjuvant setting is mostly limited to case reports and retrospective cohort studies. From these limited data there is reported to be a role of PRRT in neoadjuvant setting in the literature. However, the low quality of evidence precludes any definite conclusion on the grade of disease, site of primary, isotope used or use of concomitant chemotherapy that can benefit from this application. Further prospective studies will require collaboration between multiple centers to gain sufficient high-quality evidence.

肽受体放射性核素疗法(PRRT)是一种治疗转移性神经内分泌肿瘤(NEN)的成熟疗法。在手术或其他局部疗法之前,PRRT 作为新辅助疗法的作用尚不确定。本次范围界定综述旨在明确现有证据的范围,详细说明 PRRT 在新辅助治疗中的作用,包括临床背景、疗效和证据级别。我们对截至 2022 年 12 月的 PUBMED、SCOPUS 和 EMBASE 进行了全面的文献检索,以确定在局部治疗前将 PRRT 用作新辅助治疗的报告。研究纳入了观察性研究和临床试验。初步搜索共发现 369 条记录,其中 17 条被纳入最终分析,包括 179 名接受新辅助 PRRT 治疗的患者。文献包括病例报告、回顾性队列系列研究和一项二期试验。不可切除性疾病的定义各不相同。使用的放射性同位素包括177Lu(n = 142)和90Y(n = 36),分别使用(n = 178)或联合使用(n = 1)。还探讨了 PRRT 与化疗的联合应用(n = 2)。11/17 项研究报告了毒性数据。3/17 项研究报告了生存期分析。有报告称,PRRT 治疗后对原发肿瘤(71 例)和转移瘤(12 例)进行了手术切除。由于并非所有文献都报告了切除是否完成,因此无法计算切除率。探讨在新辅助治疗中使用 PRRT 的已发表文献大多局限于病例报告和回顾性队列研究。从这些有限的数据来看,有文献报道 PRRT 在新辅助治疗中的作用。然而,由于证据质量不高,因此无法就可从该应用中获益的疾病分级、原发部位、使用的同位素或同时使用的化疗得出明确结论。进一步的前瞻性研究需要多个中心合作才能获得足够的高质量证据。
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引用次数: 0
The research trend of hyperprolactinemia from 2011 to 2023 was analyzed by bibliometrics 通过文献计量学分析了 2011 至 2023 年高催乳素血症的研究趋势。
IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-18 DOI: 10.1111/jne.13422
Kaiyan Liu, Jin Zhao, Han Yu, Jing Yang, Yi Ren

The objective of this study is to conduct a bibliometric analysis of research trends in hyperprolactinemia from 2011 to 2023. This analysis aims to provide researchers with insights into the current hotspots and frontiers related to hyperprolactinemia. It is worth noting that there are currently no existing reports on bibliometric analyses of hyperprolactinemia. The Social Science Citation Index (SSCI) and Science Citation Index Expanded (SCIE) databases of the Web of Science Core Collection were systematically searched for “articles” and “review articles” related to the topic of hyperprolactinemia from 2011 to 2023. VOSviewer was employed to conduct bibliometric analysis, aiming to analyze the research trends in hyperprolactinemia over the past 13 years. A total of 1865 eligible articles were retrieved, with contributions from 9544 scholars representing 83 countries in the field of research. The United States had the highest number of publications, followed by China. The keywords were categorized into six clusters: (1) etiology of hyperprolactinemia and other related endocrine and metabolic diseases. (2) Hyperprolactinemia and mental illness. (3) Diagnosis and management of hyperprolactinemia. (4) Treatment of hyperprolactinemia and prolactinoma. (5) Detection of macroprolactin and macroprolactinemia. (6) Symptoms of male hyperprolactinemia. Over the past 13 years, there has been a consistent and slightly increasing trend in the number of research papers focusing on hyperprolactinemia. The primary areas of research focus are centered around the diagnosis and treatment of hyperprolactinemia caused by antipsychotic drugs or prolactinoma.

本研究旨在对 2011 年至 2023 年高泌乳素血症的研究趋势进行文献计量分析。该分析旨在让研究人员深入了解当前与高催乳素血症相关的热点和前沿领域。值得注意的是,目前还没有关于高催乳素血症的文献计量分析报告。我们在科学网核心数据库的社会科学引文索引(SSCI)和科学引文索引扩展(SCIE)数据库中系统检索了 2011 年至 2023 年与高泌乳素血症相关的 "文章 "和 "综述文章"。采用 VOSviewer 进行文献计量分析,旨在分析过去 13 年中有关高泌乳素血症的研究趋势。共检索到1865篇符合条件的文章,来自83个国家的9544名学者参与了该领域的研究。美国的论文数量最多,其次是中国。关键词分为六组:(1)高催乳素血症及其他相关内分泌和代谢疾病的病因学。(2) 高催乳素血症与精神疾病。(3) 高泌乳素血症的诊断和治疗。(4) 高泌乳素血症和泌乳素瘤的治疗。(5) 巨泌乳素和巨泌乳素血症的检测。(6) 男性高催乳素血症的症状。在过去 13 年中,以高泌乳素血症为重点的研究论文数量一直呈略微增长趋势。研究重点主要围绕抗精神病药物或催乳素瘤引起的高泌乳素血症的诊断和治疗。
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Journal of Neuroendocrinology
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