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Defining the Thyroid-RLN Entry Triangle for Enhanced Recurrent Laryngeal Nerve Exposure in TOETVA: A Retrospective Study. 确定甲状腺- rln进入三角以增强TOETVA的喉返神经暴露:一项回顾性研究。
IF 2.6 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-01-01 DOI: 10.1177/19160216241301328
Shiwei Zhou, Hui Li, Peng Wu, Wu Li, Zhiyuan Wang, Lu Zhang, Jigang Li, Xiaowei Peng

Background: Injury to the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs) are the most common and serious complications during the transoral endoscopic thyroidectomy vestibular approach (TOETVA), and their exposure and protection are the most important factors affecting the operation time. Here, we report a novel anatomical landmark and surgical method to shorten the operative time and reduce the chance of injury to the RLN and PGs.

Methods: According to the different exposure methods of the RLN, patients were divided into the experimental group (from top to bottom, E-group) and the comparison group (from outside to inside, C-group), and 1:1 propensity score-matching (PSM) was performed. The demographics, operative data, postoperative data, and postoperative complications were analyzed by comparing the 2 groups.

Results: After PSM, a total of 206 patients were included. Except for tumor size, there were no significant differences between the 2 groups in terms of sex, age, body mass index, presence of Hashimoto's thyroiditis, or extent of surgery. Compared with the C-group, the operative time, in minutes, of the E-group was significantly shorter (hemithyroidectomy with central neck dissection (CND), C = 111.81 ± 25.83 vs E = 100.52 ± 16.47, P = .002 and bilateral thyroidectomy with CND, C = 177.87 ± 36.61 vs E = 156.05 ± 25.60, P = .004), the exposure time, in minutes, of the RLN was reduced (hemithyroidectomy with CND, C = 23.31 ± 7.07 vs E = 11.41 ± 2.75, P < .001 and bilateral thyroidectomy with CND, C = 45.64 ± 14.84 vs E = 21.76 ± 5.57, P < .001). The rate of postoperative temporary PGs and RLN injuries were also reduced (transient hypoparathyroidism, C = 13% vs E = 4%, P = .023 and transient RLN palsy, C = 10% vs E = 2%, P = .017). In addition, the remaining parameters such as the amount of bleeding, number of lymph node metastases, postoperative hospital stay, visual analog scale pain score, recurrence rate, and other complication rates were not significantly different between the 2 groups.

Conclusion: It is safe and feasible to construct Thyroid-RLN Entry Triangle (Peng's Triangle) for PGs and RLN protection in TOETVA. It is beneficial to shorten the operation time and reduce postoperative complications, both worthy of clinical promotion.

Trial registration: This study was registered at the Chinese Clinical Trial Registry (UIN: ChiCTR2300067673, https://www.chictr.org.cn) in accordance with the World Medical Association's Declaration of Helsinki, 2013.

背景:喉返神经(RLN)和甲状旁腺(pg)损伤是经口内窥镜甲状腺切除术前庭入路(TOETVA)中最常见和最严重的并发症,其暴露和保护是影响手术时间的最重要因素。在这里,我们报告了一种新的解剖标志和手术方法,以缩短手术时间,减少RLN和pg损伤的机会。方法:根据RLN暴露方式的不同,将患者分为实验组(由上至下,e组)和对照组(由外至内,c组),进行1:1的倾向评分匹配(PSM)。比较两组患者的人口学、手术资料、术后资料及术后并发症。结果:经PSM后,共纳入206例患者。除肿瘤大小外,两组患者在性别、年龄、体重指数、是否患有桥本甲状腺炎、手术程度等方面均无显著差异。与C组比较,E组手术时间(C = 111.81±25.83 vs E = 100.52±16.47,P = 0.05)明显短于C组(半甲状腺切除合并中央颈夹层)。(2)与双侧甲状腺切除术合并CND, C = 177.87±36.61 vs E = 156.05±25.60,P = 0.004), RLN暴露时间(分钟)减少(甲状腺切除术合并CND, C = 23.31±7.07 vs E = 11.41±2.75,P P P =。暂时性RLN麻痹(C = 10% vs E = 2%, P = 0.017)。另外,两组患者的出血量、淋巴结转移数、术后住院时间、视觉模拟量表疼痛评分、复发率及其他并发症发生率等其余参数差异无统计学意义。结论:构建甲状腺-RLN入口三角(Peng’s Triangle)用于治疗TOETVA的PGs和RLN保护是安全可行的。有利于缩短手术时间,减少术后并发症,值得临床推广。试验注册:本研究按照2013年世界医学协会赫尔辛基宣言在中国临床试验注册中心注册(编号:ChiCTR2300067673, https://www.chictr.org.cn)。
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引用次数: 0
Characterizing Dysphonia After Pediatric Open Airway Reconstruction: Systematic Review and Meta-Analysis. 小儿开放气道重建术后发音障碍的特征:系统性回顾和元分析。
IF 2.6 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-01-01 DOI: 10.1177/19160216241266570
Zachary Dahan, Alix Pincivy, Carol Nhan, Mathieu Bergeron

Background: Pediatric laryngotracheal stenosis often requires open airway reconstruction. While these surgeries establish an airway for adequate ventilation, many patients develop subsequent dysphonia. Numerous studies have reported outcomes related to voice.

Objective: This study aims to evaluate dysphonia in pediatric patients following open airway reconstruction, focusing on acoustic parameters, perceptual voice quality, and voice-related quality of life.

Methods: A comprehensive search using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines across 6 databases identified articles involving pediatric patients who underwent open airway reconstruction and reported postoperative vocal acoustic parameters, perceptual voice quality, voice-related quality of life, or vocal mechanics. Articles were assessed for bias risk, and common outcomes were synthesized qualitatively and quantitatively using meta-analyses.

Results: Among 4089 articles, 21 were included, involving 497 pediatric patients. Laryngotracheoplasty was the most common procedure followed by cricotracheal resection. The Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) scale was frequently used to assess voice quality, with a mean score of 55.6 [95% confidence intervals (CIs): 47.9-63.3]. Voice-related quality of life was measured using the pediatric Voice Handicap Index (pVHI) and Pediatric Voice-Related Quality of Life Survey, with mean scores of 35.6 (95% CI: 21.4-49.7) and 83.7 (95% CI: 74.1-93.2), respectively. The fundamental frequency was 210.5 (95% CI: 174.6-246.3). Other common findings included supraglottic phonation, anterior commissure blunting, posterior glottic diastasis, and abnormal vocal cord mobility.

Conclusion: Pediatric patients experiencing dysphonia after open airway reconstruction exhibited moderately decreased voice quality and reduced voice-related quality of life. However, there was inconsistency in study protocols and outcome measures used. Preserving voice quality during airway reconstruction is crucial to avoid negative impacts on quality of life.

背景:小儿喉气管狭窄通常需要进行开放式气道重建。虽然这些手术可以为患者建立足够通气的气道,但许多患者随后会出现发音障碍。许多研究报告了与嗓音相关的结果:本研究旨在评估开放气道重建术后儿童患者的发音障碍情况,重点关注声学参数、感知嗓音质量以及与嗓音相关的生活质量:采用系统综述和荟萃分析首选报告项目(Preferred Reporting Items for Systematic Reviews and Meta-Analyses,PRISMA)指南在 6 个数据库中进行了全面检索,确定了涉及接受开放气道重建术的儿科患者的文章,并报告了术后声学参数、感知嗓音质量、与嗓音相关的生活质量或发声力学。对文章进行了偏倚风险评估,并通过荟萃分析对共同结果进行了定性和定量综合分析:结果:在 4089 篇文章中,有 21 篇被收录,涉及 497 名儿科患者。喉气管成形术是最常见的手术,其次是环状气管切除术。嗓音听觉知觉评估共识量表(CAPE-V)常用于评估嗓音质量,平均得分为 55.6 [95% 置信区间 (CIs):47.9-63.3]。与嗓音相关的生活质量采用小儿嗓音障碍指数(pVHI)和小儿嗓音相关生活质量调查进行测量,平均得分分别为 35.6(95% 置信区间:21.4-49.7)和 83.7(95% 置信区间:74.1-93.2)。基本频率为 210.5 (95% CI: 174.6-246.3)。其他常见发现包括声门上发音、前会厌变钝、声门后舒张和声带活动异常:结论:开放气道重建术后出现发音障碍的小儿患者的嗓音质量中度下降,与嗓音相关的生活质量也有所下降。然而,研究方案和采用的结果衡量标准并不一致。在气道重建过程中保持嗓音质量对避免生活质量受到负面影响至关重要。
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引用次数: 0
Post-tonsillectomy outcomes in children with mucopolysaccharidosis and obstructive sleep apnea 患有粘多糖病和阻塞性睡眠呼吸暂停的儿童扁桃体切除术后的效果
IF 3.4 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-24 DOI: 10.1186/s40463-023-00685-y
Zachary Elwell, David Mancuso, N. Wolter, E. Propst, Tulio Valdez, Patrick Scheffler
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引用次数: 0
Evaluation of the effectiveness of superficial parotidectomy and partial superficial parotidectomy for benign parotid tumours: a meta-analysis. 腮腺浅层切除术和腮腺部分浅层切除术治疗腮腺良性肿瘤的有效性评估:一项荟萃分析。
IF 3.4 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-22 DOI: 10.1186/s40463-023-00679-w
Hai-Tao Liu, Wei-Peng Jiang, Gang Xia, Jia-Min Liao

Objective: To quantify the results of superficial parotidectomy (SP) and partial SP (PSP) for benign parotid tumours using a systematic evaluation method.

Methods: A systematic search of English and Chinese databases (PubMed, Web of Science, Cochrane Library, China Knowledge Network, Wanfang and Vipshop) was conducted to include studies comparing the treatment outcomes of SP with PSP.

Results: Twenty-three qualified, high-quality studies involving 2844 patients were included in this study. The results of this study showed that compared to the SP surgical approach, the PSP surgical approach reduced the occurrence of temporary facial palsy (OR = 0.33; 95% confidence interval [CI] 0.26-0.41), permanent facial palsy (OR = 0.28; 95% CI 0.16-0.52) and Frey syndrome (OR = 0.36; 95% CI 0.23-0.56) in patients after surgery, and the surgery operative time was reduced by approximately 27.35 min (95% CI - 39.66, - 15.04). However, the effects of PSP versus SP on salivary fistula (OR = 0.70; 95% CI 0.40-1.24), sialocele (OR = 1.48; 95% CI 0.78-2.83), haematoma (OR = 0.34; 95% CI 0.11-1.01) and tumour recurrence rate (OR = 1.41; 95% CI 0.48-4.20) were not statistically significant.

Conclusion: Compared with SP, PSP has a lower postoperative complication rate and significantly shorter operative time, suggesting that it could be used as an alternative to SP in the treatment of benign parotid tumours with the right indications.

目的采用系统评价方法量化腮腺浅层切除术(SP)和腮腺部分切除术(PSP)治疗腮腺良性肿瘤的效果:方法:对中英文数据库(PubMed、Web of Science、Cochrane Library、中国知网、万方和唯品会)进行系统检索,纳入比较SP与PSP治疗效果的研究:本研究共纳入 23 项合格的高质量研究,涉及 2844 名患者。研究结果显示,与SP手术方法相比,PSP手术方法减少了患者术后暂时性面瘫(OR=0.33;95% 置信区间[CI] 0.26-0.41)、永久性面瘫(OR=0.28;95% CI 0.16-0.52)和Frey综合征(OR=0.36;95% CI 0.23-0.56)的发生,手术时间缩短了约27.35分钟(95% CI - 39.66, - 15.04)。然而,PSP 与 SP 相比,对唾液瘘(OR = 0.70;95% CI 0.40-1.24)、咽峡炎(OR = 1.48;95% CI 0.78-2.83)、血肿(OR = 0.34;95% CI 0.11-1.01)和肿瘤复发率(OR = 1.41;95% CI 0.48-4.20)的影响无统计学意义:结论:与SP相比,PSP的术后并发症发生率更低,手术时间明显更短,这表明在治疗腮腺良性肿瘤时,PSP可作为SP的替代方法,且适应症正确。
{"title":"Evaluation of the effectiveness of superficial parotidectomy and partial superficial parotidectomy for benign parotid tumours: a meta-analysis.","authors":"Hai-Tao Liu, Wei-Peng Jiang, Gang Xia, Jia-Min Liao","doi":"10.1186/s40463-023-00679-w","DOIUrl":"10.1186/s40463-023-00679-w","url":null,"abstract":"<p><strong>Objective: </strong>To quantify the results of superficial parotidectomy (SP) and partial SP (PSP) for benign parotid tumours using a systematic evaluation method.</p><p><strong>Methods: </strong>A systematic search of English and Chinese databases (PubMed, Web of Science, Cochrane Library, China Knowledge Network, Wanfang and Vipshop) was conducted to include studies comparing the treatment outcomes of SP with PSP.</p><p><strong>Results: </strong>Twenty-three qualified, high-quality studies involving 2844 patients were included in this study. The results of this study showed that compared to the SP surgical approach, the PSP surgical approach reduced the occurrence of temporary facial palsy (OR = 0.33; 95% confidence interval [CI] 0.26-0.41), permanent facial palsy (OR = 0.28; 95% CI 0.16-0.52) and Frey syndrome (OR = 0.36; 95% CI 0.23-0.56) in patients after surgery, and the surgery operative time was reduced by approximately 27.35 min (95% CI - 39.66, - 15.04). However, the effects of PSP versus SP on salivary fistula (OR = 0.70; 95% CI 0.40-1.24), sialocele (OR = 1.48; 95% CI 0.78-2.83), haematoma (OR = 0.34; 95% CI 0.11-1.01) and tumour recurrence rate (OR = 1.41; 95% CI 0.48-4.20) were not statistically significant.</p><p><strong>Conclusion: </strong>Compared with SP, PSP has a lower postoperative complication rate and significantly shorter operative time, suggesting that it could be used as an alternative to SP in the treatment of benign parotid tumours with the right indications.</p>","PeriodicalId":16615,"journal":{"name":"Journal of Otolaryngology - Head & Neck Surgery","volume":"52 1","pages":"86"},"PeriodicalIF":3.4,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10740346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138885155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experience in the management of sigmoid sinus thrombophlebitis secondary to middle ear cholesteatoma 中耳胆脂瘤继发乙状窦血栓性静脉炎的治疗经验
IF 3.4 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-19 DOI: 10.1186/s40463-023-00681-2
Jing Fei, Xiao-Wen Peng, Ting-Yu Yang, Xue-Li Shen, Lin Gao, Na Liao, Lei-Ji Li
To discuss the management of sigmoid sinus thrombophlebitis secondary to middle ear cholesteatoma. We retrospectively analyzed all cases of sigmoid sinus thrombophlebitis caused by middle ear cholesteatoma over a period of 7 years. 7 male and 2 female patients, ranging in age from 9 to 66 years, were diagnosed with sigmoid sinus thrombophlebitis by clinical presentation and radiological examination. By executing a modified mastoidectomy and tympanoplasty (canal wall-down tympanoplasty) to entirely remove the cholesteatoma-like mastoid epithelium, all patients were effectively treated surgically without opening the sigmoid sinus. All patients were treated with broad-spectrum antibiotics, but no anticoagulants were used. 9 patients had otogenic symptoms such as ear pus, tympanic membrane perforation, and hearing loss. In the initial stage of the surgery, modified mastoidectomy and tympanoplasty were performed on 8 of the 9 patients. 1 patient with a brain abscess underwent puncturing (drainage of the abscess) to relieve cranial pressure, and 4 months later, a modified mastoidectomy and tympanoplasty were carried out. Following surgery and medication, the clinical symptoms of every patient improved. After the follow-up of 6 months to 7 years, 3 patients were re-examined for MRV and showed partial sigmoid sinus recovery with recanalization. 4 months following middle ear surgery, the extent of a patient's brain abscess lesions was significantly reduced. 1 patient experienced facial paralysis after surgery and recovered in 3 months. None of the patients had a secondary illness, an infection, or an abscess in a distant organ. The key to a better prognosis is an adequate course of perioperative antibiotic medication coupled with surgical treatment. A stable sigmoid sinus thrombus can remain for a long time after middle ear lesions have been removed, and it is less likely to cause infection and abscesses in the distant organs. The restoration of middle ear ventilation is facilitated by tympanoplasty. It is important to work more closely with multidisciplinary teams such as neurology and neurosurgery when deciding whether to perform lateral sinusotomies to remove thrombus or whether to administer anticoagulation.
探讨中耳胆脂瘤继发乙状窦血栓性静脉炎的治疗方法。我们回顾性分析了 7 年来所有由中耳胆脂瘤引起的乙状窦血栓性静脉炎病例。根据临床表现和放射学检查,7 名男性和 2 名女性患者被诊断为乙状窦血栓性静脉炎,年龄从 9 岁到 66 岁不等。通过实施改良乳突切除术和鼓室成形术(管壁向下鼓室成形术),完全切除胆脂瘤样乳突上皮,所有患者都在不打开乙状窦的情况下得到了有效的手术治疗。所有患者均接受了广谱抗生素治疗,但未使用抗凝药物。9 名患者出现耳源性症状,如耳流脓、鼓膜穿孔和听力下降。在手术初期,9 名患者中有 8 人接受了改良乳突切除术和鼓室成形术。1 名患有脑脓肿的患者接受了穿刺(脓肿引流)以缓解颅压,4 个月后,进行了改良乳突切除术和鼓膜成形术。手术和药物治疗后,每位患者的临床症状都有所改善。随访 6 个月至 7 年后,3 名患者接受了 MRV 复查,结果显示乙状窦部分恢复并再通。中耳手术后 4 个月,一名患者的脑脓肿病灶范围明显缩小。一名患者术后出现面瘫,3 个月后痊愈。所有患者均未继发疾病、感染或远处器官脓肿。改善预后的关键在于围手术期充分使用抗生素药物并配合手术治疗。中耳病变切除后,稳定的乙状窦血栓可以保留很长时间,而且不太可能引起远处器官的感染和脓肿。鼓室成形术有助于恢复中耳通气。在决定是否进行侧窦切开术以清除血栓或是否进行抗凝治疗时,与神经内科和神经外科等多学科团队加强合作非常重要。
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引用次数: 0
Early-onset juvenile nasopharyngeal angiofibroma (JNA): a systematic review 早发型幼年鼻咽血管纤维瘤(JNA):系统综述
IF 3.4 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-19 DOI: 10.1186/s40463-023-00687-w
Matthew Newman, Thomas Boi Vu Nguyen, Tobial McHugh, Kesava Reddy, Doron Dov Sommer
Juvenile Nasopharyngeal Angiofibroma (JNA) is a fibrovascular tumor of the nasopharynx that classically presents in adolescent males. The reported mean age of onset is between 13 and 22 years old [1–6]. Significant androgen stimulation is hypothesized to explain the strong predisposition for JNA to present in young adolescent males. However, considerable variability in age at diagnosis exists with rare involvement of very young patients incongruent with typical male pubertal growth patterns. The purpose of this systematic review is to identify cases of early-onset JNA (EOJNA), (defined as age < 10 years) in the literature and to examine the disease characteristics and treatments used in this patient group. A case of a 7 year old boy with EOJNA at our institution is also described and presented. We searched Embase, Cochrane database and MEDLINE from 1996 to February 2021 for studies that reported cases of EOJNA. Relevant clinico-demographic data, disease severity and treatment outcomes were recorded and analyzed using descriptive statistics. We compared our findings with reported means for JNA in all ages. We identified 29 studies containing a total of 34 cases of EOJNA. The vast majority (31/34) of patients were males and the mean age of diagnosis was 8.15 years old. The most common presenting symptoms were nasal obstruction (65.2%) and epistaxis (60.9%). Patients were most commonly Radkowski stage II (39.4%) and III (39.4%). Primary treatment modalities included open surgery (66.7%), endoscopic surgery (24.2%), and radiotherapy (9.1%). Recurrence was evident in 30%. Radkowski stage and type of treatment did not differ significantly within the EOJNA group (p = 0.440 and p = 0.659, respectively). This systematic review suggests that rare cases of EOJNA have distinct disease characteristics. Patients in this cohort appeared to have more advanced disease and higher recurrence rates when compared with reported averages. We hope that this review prompts increased clinical awareness of this potentially more aggressive subtype of JNA. As more cases of EOJNA are reported, a more powered statistical analysis of this cohort would be feasible.
青少年鼻咽血管纤维瘤(JNA)是一种鼻咽纤维血管瘤,通常发生在青少年男性身上。据报道,其平均发病年龄在 13-22 岁之间 [1-6]。据推测,雄激素的显著刺激是 JNA 易发于青少年男性的原因。然而,确诊时的年龄存在很大的差异,极少数非常年轻的患者与典型的男性青春期发育模式不一致。本系统性综述的目的是在文献中找出早发 JNA(EOJNA)(定义为年龄小于 10 岁)的病例,并研究该患者群体的疾病特征和治疗方法。本文还描述并介绍了我院一名 7 岁男孩的 EOJNA 病例。我们检索了 Embase、Cochrane 数据库和 MEDLINE(1996 年至 2021 年 2 月)中报告 EOJNA 病例的研究。我们记录了相关的临床人口学数据、疾病严重程度和治疗结果,并使用描述性统计进行了分析。我们将研究结果与已报道的各年龄段 JNA 平均值进行了比较。我们确定了 29 项研究,共包含 34 个 EOJNA 病例。绝大多数患者(31/34)为男性,平均诊断年龄为 8.15 岁。最常见的症状是鼻塞(65.2%)和鼻衄(60.9%)。患者多为拉德考斯基 II 期(39.4%)和 III 期(39.4%)。主要治疗方式包括开放手术(66.7%)、内窥镜手术(24.2%)和放射治疗(9.1%)。复发率为 30%。在 EOJNA 组中,拉德考斯基分期和治疗类型没有显著差异(分别为 p = 0.440 和 p = 0.659)。本系统综述表明,罕见的EOJNA病例具有不同的疾病特征。与报告的平均值相比,该组患者的疾病似乎更晚期,复发率更高。我们希望本综述能提高临床对这种可能更具侵袭性的 JNA 亚型的认识。随着更多 EOJNA 病例的报道,对该队列进行更有力的统计分析将是可行的。
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引用次数: 0
Quantifying surgical completeness in patients with aspirin exacerbated respiratory disease 量化阿司匹林加重呼吸系统疾病患者的手术完整性
IF 3.4 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-17 DOI: 10.1186/s40463-023-00682-1
Marc Levin, Yvonne Chan, Doron D. Sommer, Andrew Thamboo, John M. Lee
Aspirin exacerbated respiratory disease (AERD) in patients who have had sinus surgery remains a management challenge. Aspirin desensitization and biologics are additional treatment options. It remains unclear if patients require a more comprehensive surgery prior to implementing such additional therapies. The purpose of this study was to quantify prior surgery completeness in AERD patients at a tertiary rhinology practice. Paranasal sinus CT scans were reviewed by four academic rhinologists to assess surgery completeness. Using a published CT grading system, each sinus was graded on the completeness of surgery and middle turbinate reduction. A score out of 14 was calculated for each patient (7 per side). Sixty-one patients with AERD out of 141 available were included. Mean inter-rater agreement across all sinuses was moderate (k = 0.42). The mean completeness score was 6.7/14. The following procedures were rated as complete (means): uncinectomy (L: 84%, R: 82%, k = 0.44), maxillary (L: 83%, R: 77%, k = 0.32), middle turbinate reduction (L: 45%, R: 46%, k = 0.31), anterior ethmoid (L: 35%, R: 39%, k = 0.51), sphenoid (L: 36%, R: 35%, k = 0.4), posterior ethmoid (L: 30%, R: 30%, k = 0.48), frontal (L: 22%, R: 21%, k = 0.46). Prior surgery in AERD patients were mostly deemed incomplete. Uncinectomy and maxillary antrostomy are the most common procedures previously performed. It remains toe seen whether this would be considered ‘adequate’ surgery or more ‘complete’ surgery is required to achieve greater disease control.
鼻窦手术患者的阿司匹林加重呼吸道疾病(AERD)仍然是一个治疗难题。阿司匹林脱敏和生物制剂是额外的治疗选择。目前仍不清楚患者在实施这些额外疗法之前是否需要进行更全面的手术。本研究的目的是对一家三级鼻科医院的急性鼻窦炎患者之前的手术完整性进行量化。副鼻窦 CT 扫描由四位学术鼻科专家进行审查,以评估手术的完整性。使用已公布的 CT 分级系统,对每个鼻窦的手术和中鼻甲缩小的完整性进行评分。每位患者的满分是 14 分(每侧 7 分)。在现有的 141 名 AERD 患者中,有 61 名患者被纳入其中。所有鼻窦的平均评分者间一致性为中等(k = 0.42)。平均完整评分为 6.7/14。以下手术被评为完整(平均值):钩突切除术(L:84%,R:82%,k = 0.44)、上颌窦(L:83%,R:77%,k = 0.32)、中鼻甲缩小术(L:45%,R:46%,k = 0.31)、乙状前叶(L:35%,R:39%,k = 0.51)、蝶窦(L:36%,R:35%,k = 0.4)、乙状后叶(L:30%,R:30%,k = 0.48)、额叶(L:22%,R:21%,k = 0.46)。AERD患者之前的手术大多被认为是不完全的。无骨切除术和上颌前突切除术是以前最常见的手术。这是否被认为是 "适当 "的手术,还是需要更 "彻底 "的手术才能达到更好的疾病控制效果,我们拭目以待。
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引用次数: 0
Stable long-term outcomes after cochlear implantation in subjects with TMPRSS3 associated hearing loss: a retrospective multicentre study TMPRSS3 相关性听力损失患者植入人工耳蜗后的长期稳定疗效:一项回顾性多中心研究
IF 3.4 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-15 DOI: 10.1186/s40463-023-00680-3
M. L. A. Fehrmann, W. J. Huinck, M. E. G. Thijssen, L. Haer-Wigman, H. G. Yntema, L. J. C. Rotteveel, J. C. C. Widdershoven, T. Goderie, M. F. van Dooren, E. H. Hoefsloot, M. P. van der Schroeff, E. A. M. Mylanus, C. P. Lanting, R. J. E. Pennings
The spiral ganglion hypothesis suggests that pathogenic variants in genes preferentially expressed in the spiral ganglion nerves (SGN), may lead to poor cochlear implant (CI) performance. It was long thought that TMPRSS3 was particularly expressed in the SGNs. However, this is not in line with recent reviews evaluating CI performance in subjects with TMPRSS3-associated sensorineural hearing loss (SNHL) reporting overall beneficial outcomes. These outcomes are, however, based on variable follow-up times of, in general, 1 year or less. Therefore, we aimed to 1. evaluate long-term outcomes after CI implantation of speech recognition in quiet in subjects with TMPRSS3-associated SNHL, and 2. test the spiral ganglion hypothesis using the TMPRSS3-group. This retrospective, multicentre study evaluated long-term CI performance in a Dutch population with TMPRSS3-associated SNHL. The phoneme scores at 70 dB with CI in the TMPRSS3-group were compared to a control group of fully genotyped cochlear implant users with post-lingual SNHL without genes affecting the SGN, or severe anatomical inner ear malformations. CI-recipients with a phoneme score ≤ 70% at least 1-year post-implantation were considered poor performers and were evaluated in more detail. The TMPRSS3 group consisted of 29 subjects (N = 33 ears), and the control group of 62 subjects (N = 67 ears). For the TMPRSS3-group, we found an average phoneme score of 89% after 5 years, which remained stable up to 10 years post-implantation. At both 5 and 10-year follow-up, no difference was found in speech recognition in quiet between both groups (p = 0.830 and p = 0.987, respectively). Despite these overall adequate CI outcomes, six CI recipients had a phoneme score of ≤ 70% and were considered poor performers. The latter was observed in subjects with residual hearing post-implantation or older age at implantation. Subjects with TMPRSS3-associated SNHL have adequate and stable long-term outcomes after cochlear implantation, equal to the performance of genotyped patient with affected genes not expressed in the SGN. These findings are not in line with the spiral ganglion hypothesis. However, more recent studies showed that TMPRSS3 is mainly expressed in the hair cells with only limited SGN expression. Therefore, we cannot confirm nor refute the spiral ganglion hypothesis.
螺旋神经节假说认为,在螺旋神经节神经(SGN)中优先表达的基因的致病变异可能会导致人工耳蜗(CI)性能低下。长期以来,人们一直认为 TMPRSS3 尤其在 SGN 中表达。然而,最近对 TMPRSS3 相关感音神经性听力损失(SNHL)受试者的 CI 性能进行评估的综述报告称,总体结果良好,但这与上述观点并不一致。然而,这些结果都是基于不同的随访时间(一般为 1 年或更短)得出的。因此,我们的目标是:1.评估 TMPRSS3 相关性感音神经性听力损失受试者植入 CI 后在安静环境中进行语音识别的长期效果;2.使用 TMPRSS3 组测试螺旋神经节假说。这项回顾性多中心研究评估了荷兰 TMPRSS3 相关 SNHL 患者的长期 CI 性能。研究人员将 TMPRSS3 组人工耳蜗植入者在 70 dB 时的音素分数与对照组进行了比较,对照组是完全基因分型的人工耳蜗植入者,他们患有语言后 SNHL,但没有影响 SGN 的基因,也没有严重的内耳解剖畸形。植入人工耳蜗至少 1 年后音素得分≤ 70% 的人工耳蜗植入者被视为表现不佳者,并接受更详细的评估。TMPRSS3 组有 29 名受试者(N = 33 耳),对照组有 62 名受试者(N = 67 耳)。在 TMPRSS3 组中,我们发现植入 5 年后的平均音素得分率为 89%,并在植入 10 年后保持稳定。在 5 年和 10 年的随访中,两组在安静环境下的语音识别能力均无差异(分别为 p = 0.830 和 p = 0.987)。尽管 CI 的总体效果良好,但仍有 6 名 CI 受试者的音素得分低于 70%,被认为表现不佳。后者出现在植入后有残余听力或植入年龄较大的受试者身上。TMPRSS3相关SNHL受试者在人工耳蜗植入术后具有充分和稳定的长期疗效,与SGN中未表达受影响基因的基因分型患者的疗效相当。这些发现与螺旋神经节假说不符。然而,最近的研究表明,TMPRSS3 主要在毛细胞中表达,而在 SGN 中表达有限。因此,我们既不能证实也不能反驳螺旋神经节假说。
{"title":"Stable long-term outcomes after cochlear implantation in subjects with TMPRSS3 associated hearing loss: a retrospective multicentre study","authors":"M. L. A. Fehrmann, W. J. Huinck, M. E. G. Thijssen, L. Haer-Wigman, H. G. Yntema, L. J. C. Rotteveel, J. C. C. Widdershoven, T. Goderie, M. F. van Dooren, E. H. Hoefsloot, M. P. van der Schroeff, E. A. M. Mylanus, C. P. Lanting, R. J. E. Pennings","doi":"10.1186/s40463-023-00680-3","DOIUrl":"https://doi.org/10.1186/s40463-023-00680-3","url":null,"abstract":"The spiral ganglion hypothesis suggests that pathogenic variants in genes preferentially expressed in the spiral ganglion nerves (SGN), may lead to poor cochlear implant (CI) performance. It was long thought that TMPRSS3 was particularly expressed in the SGNs. However, this is not in line with recent reviews evaluating CI performance in subjects with TMPRSS3-associated sensorineural hearing loss (SNHL) reporting overall beneficial outcomes. These outcomes are, however, based on variable follow-up times of, in general, 1 year or less. Therefore, we aimed to 1. evaluate long-term outcomes after CI implantation of speech recognition in quiet in subjects with TMPRSS3-associated SNHL, and 2. test the spiral ganglion hypothesis using the TMPRSS3-group. This retrospective, multicentre study evaluated long-term CI performance in a Dutch population with TMPRSS3-associated SNHL. The phoneme scores at 70 dB with CI in the TMPRSS3-group were compared to a control group of fully genotyped cochlear implant users with post-lingual SNHL without genes affecting the SGN, or severe anatomical inner ear malformations. CI-recipients with a phoneme score ≤ 70% at least 1-year post-implantation were considered poor performers and were evaluated in more detail. The TMPRSS3 group consisted of 29 subjects (N = 33 ears), and the control group of 62 subjects (N = 67 ears). For the TMPRSS3-group, we found an average phoneme score of 89% after 5 years, which remained stable up to 10 years post-implantation. At both 5 and 10-year follow-up, no difference was found in speech recognition in quiet between both groups (p = 0.830 and p = 0.987, respectively). Despite these overall adequate CI outcomes, six CI recipients had a phoneme score of ≤ 70% and were considered poor performers. The latter was observed in subjects with residual hearing post-implantation or older age at implantation. Subjects with TMPRSS3-associated SNHL have adequate and stable long-term outcomes after cochlear implantation, equal to the performance of genotyped patient with affected genes not expressed in the SGN. These findings are not in line with the spiral ganglion hypothesis. However, more recent studies showed that TMPRSS3 is mainly expressed in the hair cells with only limited SGN expression. Therefore, we cannot confirm nor refute the spiral ganglion hypothesis.","PeriodicalId":16615,"journal":{"name":"Journal of Otolaryngology - Head & Neck Surgery","volume":"37 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138689671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of topical antibiotic ointment in the lateral graft following underlay myringoplasty: a prospective randomised study 前瞻性随机研究:局部抗生素软膏在人工耳蜗植入术后外侧移植中的作用
IF 3.4 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-13 DOI: 10.1186/s40463-023-00674-1
Zhengcai Lou, Zihan Lou, Tian Lv, Zhengnong Chen
The objective of this study was to compare the graft outcome and postoperative infection of with and without the use of antibiotic ointment following myringoplasty for the treatment of chronic perforations. Randomized controlled trial. 135 chronic perforations were prospectively randomized to use of antibiotic ointment group (UAO, n = 68) or no use of antibiotic ointment group (NAO, n = 67) following myringoplasty. The graft outcomes and postoperative infection were compared among two groups at 6 months. At postoperative 6 months, the graft infection rate was 4.4% in the UAO group and 10.4% in the NAO group, the difference was not significant (P = 0.312).The graft success rates were 92.6% in the UAO group and 91.0% in the NAO group, the difference was not significant (P = 0.979). In the UAO group, 3 patients with purulence ear discharge resulted in a residual perforation although they received ofloxacin ear drops and intravenous antibiotic therapy treatment. In the NAO group, 6 patients with purulence ear discharge resulted in a residual perforation, only one, with mild purulence discharge was successfully treated and closed. In addition, no significant between-group differences were observed pre- (P = 0.746) or post- (P = 0.521) operative air bone gap (ABG) values or mean ABG gain (P = 0.745). However, granular myringitis with minimal moistness but without infection has been noted in 3 (4.4%) patients in the UAO group and in 5 (7.5%) in the NAO group, the difference was not significant (P = 0.699). Use and non-use of antibiotic ointments for lateral packing of graft are both comparable methods following myringoplasty for postoperative infection and graft outcomes.
本研究的目的是比较耳廓成形术治疗慢性穿孔后使用和不使用抗生素软膏的移植结果和术后感染情况。随机对照试验。135 例慢性穿孔患者被前瞻性随机分配到耳膜成形术后使用抗生素软膏组(UAO,n = 68)或不使用抗生素软膏组(NAO,n = 67)。两组患者术后 6 个月的移植效果和术后感染情况进行了比较。术后6个月时,UAO组的移植物感染率为4.4%,NAO组为10.4%,差异不显著(P = 0.312);UAO组的移植物成功率为92.6%,NAO组为91.0%,差异不显著(P = 0.979)。在 UAO 组中,虽然有 3 名患者接受了氧氟沙星滴耳液和静脉抗生素治疗,但他们的耳部脓性分泌物导致了穿孔残留。NAO 组中,有 6 名患者的脓性耳分泌物导致穿孔残留,只有一名轻度脓性耳分泌物患者成功治疗并闭合了穿孔。此外,手术前(P = 0.746)或手术后(P = 0.521)气骨间隙(ABG)值或平均ABG增量(P = 0.745)在组间无明显差异。不过,UAO 组有 3 名(4.4%)患者出现了湿度极低的颗粒状耳鸣炎,NAO 组有 5 名(7.5%)患者出现了这种情况,但差异不显著(P = 0.699)。就术后感染和移植物效果而言,使用和不使用抗生素软膏进行移植物侧向包扎都是耳环成形术后可比较的方法。
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引用次数: 0
Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review 喉疣状癌的流行病学、临床和肿瘤学结果:系统综述
IF 3.4 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-13 DOI: 10.1186/s40463-023-00666-1
Jérôme R. Lechien, Stéphane Hans
To investigate epidemiological, clinical and oncological outcomes of patients with laryngeal verrucous carcinomas (LVC). Two independent authors investigated PubMed, Scopus and Cochrane Library for studies dedicated to epidemiological, clinical and oncological outcomes of patients with LVC. The following outcomes were investigated with PRISMA criteria: age; gender; tobacco/alcohol consumption; HPV infection; anatomical, pathological, therapeutic and survival outcomes. Studies were analyzed for bias through a validated clinical tool. Of the 212 identified articles, 15 retrospective studies and one prospective uncontrolled study met our inclusion criteria. Three studies reported findings from national databases. The males/females ratio is 9/1. Mean age was 60.3 years, which was younger compared to other laryngeal malignancies. The alcohol, cigarette overuse and the HPV status of patients were lacking in most studies. Glottis and supraglottis were the most common anatomical locations, corresponding to 78.7% and 12.4% of cases, respectively. The main therapeutic approaches consisted of surgery, radiotherapy, surgery followed by radiotherapy. Treatments reported 5-year overall survival and disease-specific survival of 86.3 and 90.8, respectively. The 5- and 10-year local control rate were 83.6 and 72.6, respectively. The 10-year disease-specific survival was 80.2. Heterogeneity between studies was found for inclusion criteria, comorbidity data, and treatments. LVC is a rare laryngeal cancer associated with better survival and recurrence outcomes than laryngeal squamous cell carcinoma. The role of radiotherapy in the treatment regimen needs to be investigated in future prospective controlled studies.
调查喉疣状癌(LVC)患者的流行病学、临床和肿瘤学结果。两位独立作者在 PubMed、Scopus 和 Cochrane 图书馆中调查了有关喉疣患者流行病学、临床和肿瘤学结果的研究。根据 PRISMA 标准对以下结果进行了调查:年龄、性别、烟草/酒精消费、HPV 感染、解剖、病理、治疗和生存结果。研究通过一个有效的临床工具进行了偏倚分析。在确定的 212 篇文章中,有 15 项回顾性研究和 1 项前瞻性非对照研究符合我们的纳入标准。三项研究报告了来自国家数据库的结果。男女比例为 9/1。平均年龄为60.3岁,与其他喉恶性肿瘤相比更年轻。大多数研究都没有涉及患者的酗酒、过度吸烟和人乳头瘤病毒(HPV)状况。声门和声门上是最常见的解剖位置,分别占病例总数的78.7%和12.4%。主要治疗方法包括手术、放疗、先手术后放疗。治疗后的5年总生存率和疾病特异性生存率分别为86.3%和90.8%。5年和10年局部控制率分别为83.6和72.6。10年疾病特异性生存率为80.2。研究之间在纳入标准、合并症数据和治疗方法方面存在异质性。喉癌是一种罕见的喉癌,其生存率和复发率均优于喉鳞状细胞癌。放疗在治疗方案中的作用需要在未来的前瞻性对照研究中进行调查。
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引用次数: 0
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Journal of Otolaryngology - Head & Neck Surgery
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